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Protein

Melanoma-associated antigen C3

Gene

MAGEC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Keywords - Molecular functioni

Tumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen C3
Alternative name(s):
Cancer/testis antigen 7.2
Short name:
CT7.2
Hepatocellular carcinoma-associated antigen 2
MAGE-C3 antigen
Gene namesi
Name:MAGEC3
Synonyms:HCA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:23798. MAGEC3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134916199.

Polymorphism and mutation databases

BioMutaiMAGEC3.
DMDMi41017367.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 643643Melanoma-associated antigen C3PRO_0000156722Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei478 – 4781PhosphothreonineCombined sources
Modified residuei484 – 4841PhosphothreonineCombined sources
Modified residuei485 – 4851PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TD91.
PaxDbiQ8TD91.
PeptideAtlasiQ8TD91.
PRIDEiQ8TD91.

PTM databases

iPTMnetiQ8TD91.
PhosphoSiteiQ8TD91.

Expressioni

Tissue specificityi

Expressed in testis. Not expressed in other normal tissues, but is expressed in tumors of different histological origins.1 Publication

Gene expression databases

BgeeiQ8TD91.
CleanExiHS_MAGEC3.
ExpressionAtlasiQ8TD91. baseline and differential.
GenevisibleiQ8TD91. HS.

Organism-specific databases

HPAiHPA052067.

Interactioni

Protein-protein interaction databases

BioGridi126542. 2 interactions.
IntActiQ8TD91. 2 interactions.
STRINGi9606.ENSP00000298296.

Structurei

3D structure databases

ProteinModelPortaliQ8TD91.
SMRiQ8TD91. Positions 180-302, 455-616.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini184 – 384201MAGE 1PROSITE-ProRule annotationAdd
BLAST
Domaini456 – 643188MAGE 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi380 – 41536Pro-richAdd
BLAST

Sequence similaritiesi

Contains 2 MAGE domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
InParanoidiQ8TD91.
OMAiWVQRKYL.
OrthoDBiEOG75F4GM.
PhylomeDBiQ8TD91.
TreeFamiTF328505.

Family and domain databases

InterProiIPR002190. MHD_dom.
[Graphical view]
SMARTiSM01373. MAGE. 2 hits.
[Graphical view]
PROSITEiPS50838. MAGE. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TD91-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLPCHWVLD ATFSDGSLGQ WVKNTCATYA LSPVVLPPQP QPRKKATDKD
60 70 80 90 100
YSAFHLGHLR EVRLFLRGGT SDQRMDSLVL CPTYFKLWRT LSGSPGLQLS
110 120 130 140 150
DLHFGSQPEG KFSLRRAVSV KQREEPQDWP LNEKRTLWKD SDLPTWRRGT
160 170 180 190 200
GYTLSLPAVS PGKRLWGEKA GSLPESEPLF TYTLDEKVDK LVQFLLLKYQ
210 220 230 240 250
AKEPLTRAEM QMNVINTYTG YFPMIFRKAR EFIEILFGIS LTEVDPDHFY
260 270 280 290 300
VFVNTLDLTC EGSLSDEQGM PQNRLLILIL SVIFIKGNCA SEEVIWEVLN
310 320 330 340 350
AIGPWSALAG FADVLSRLAL WESEGPEAFC EESGLRSAEG SVLDLANPQG
360 370 380 390 400
LAGHRQEDGR RGLTEASPQQ KKGGEDEDMP AAGMPPLPQS PPEIPPQGPP
410 420 430 440 450
KISPQGPPQS PPQSPLDSCS SPLLWTRLDE ESSSEEEDTA TWHALPESES
460 470 480 490 500
LPRYALDEKV AELVQFLLLK YQTKEPVTKA EMLTTVIKKY KDYFPMIFGK
510 520 530 540 550
AHEFIELIFG IALTDMDPDN HSYFFEDTLD LTYEGSLIDD QGMPKNCLLI
560 570 580 590 600
LILSMIFIKG SCVPEEVIWE VLSAIGPIQR PAREVLEFLS KLSSIIPSAF
610 620 630 640
PSWYMDALKD MEDRAQAIID TTDDATAMAS ASPSVMSTNF CPE
Length:643
Mass (Da):71,909
Last modified:June 1, 2002 - v1
Checksum:i4EB342288B3FB8A6
GO
Isoform 2 (identifier: Q8TD91-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: MLLPCHWVLD...RGGTSDQRMD → MPLFPNLPRL...LPSTLILGVP
     77-374: Missing.
     577-643: PIQRPAREVL...SVMSTNFCPE → VCAGREHFIY...VFIQAIQYHP

Note: No experimental confirmation available.
Show »
Length:346
Mass (Da):38,906
Checksum:iDBE6CAEAB5623097
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti362 – 37413GLTEA…QKKGG → SSPLPSTLILGVP (PubMed:15489334).CuratedAdd
BLAST

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti155 – 1551S → P.
Corresponds to variant rs11095909 [ dbSNP | Ensembl ].
VAR_060069
Natural varianti165 – 1651L → M.
Corresponds to variant rs11095910 [ dbSNP | Ensembl ].
VAR_053505
Natural varianti307 – 3071A → T.
Corresponds to variant rs176024 [ dbSNP | Ensembl ].
VAR_053506
Natural varianti328 – 3281A → T.
Corresponds to variant rs176026 [ dbSNP | Ensembl ].
VAR_053507

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7676MLLPC…DQRMD → MPLFPNLPRLSFEEDFQNPS VTEDLVDAQDSIDEEEEDAS STSSSSFHFLFPSSSSLSSS SPLSSPLPSTLILGVP in isoform 2. 1 PublicationVSP_043489Add
BLAST
Alternative sequencei77 – 374298Missing in isoform 2. 1 PublicationVSP_043490Add
BLAST
Alternative sequencei577 – 64367PIQRP…NFCPE → VCAGREHFIYGDPRKLLTIH WVQRKYLEYREVPNSAPPRY EFLWGPRAHSEASKRSLRVF IQAIQYHP in isoform 2. 1 PublicationVSP_043491Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF490508 mRNA. Translation: AAM08355.1.
AL022152, AL023279, AL049177 Genomic DNA. Translation: CAI42088.1.
AL023279, AL049177, AL022152 Genomic DNA. Translation: CAI42601.1.
AL049177, AL022152, AL023279 Genomic DNA. Translation: CAI42947.1.
AL022152 Genomic DNA. Translation: CAX15113.1.
BC103893 mRNA. Translation: AAI03894.1.
AF333706 Genomic DNA. Translation: AAK00358.1.
CCDSiCCDS14676.1. [Q8TD91-1]
CCDS14677.1. [Q8TD91-2]
RefSeqiNP_619647.1. NM_138702.1. [Q8TD91-1]
NP_803251.1. NM_177456.2. [Q8TD91-2]
XP_011529568.1. XM_011531266.1. [Q8TD91-2]
XP_011529569.1. XM_011531267.1. [Q8TD91-2]
UniGeneiHs.356870.

Genome annotation databases

EnsembliENST00000298296; ENSP00000298296; ENSG00000165509. [Q8TD91-1]
ENST00000409007; ENSP00000386566; ENSG00000165509. [Q8TD91-2]
ENST00000544766; ENSP00000440444; ENSG00000165509. [Q8TD91-2]
GeneIDi139081.
KEGGihsa:139081.
UCSCiuc004fbs.3. human. [Q8TD91-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF490508 mRNA. Translation: AAM08355.1.
AL022152, AL023279, AL049177 Genomic DNA. Translation: CAI42088.1.
AL023279, AL049177, AL022152 Genomic DNA. Translation: CAI42601.1.
AL049177, AL022152, AL023279 Genomic DNA. Translation: CAI42947.1.
AL022152 Genomic DNA. Translation: CAX15113.1.
BC103893 mRNA. Translation: AAI03894.1.
AF333706 Genomic DNA. Translation: AAK00358.1.
CCDSiCCDS14676.1. [Q8TD91-1]
CCDS14677.1. [Q8TD91-2]
RefSeqiNP_619647.1. NM_138702.1. [Q8TD91-1]
NP_803251.1. NM_177456.2. [Q8TD91-2]
XP_011529568.1. XM_011531266.1. [Q8TD91-2]
XP_011529569.1. XM_011531267.1. [Q8TD91-2]
UniGeneiHs.356870.

3D structure databases

ProteinModelPortaliQ8TD91.
SMRiQ8TD91. Positions 180-302, 455-616.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126542. 2 interactions.
IntActiQ8TD91. 2 interactions.
STRINGi9606.ENSP00000298296.

PTM databases

iPTMnetiQ8TD91.
PhosphoSiteiQ8TD91.

Polymorphism and mutation databases

BioMutaiMAGEC3.
DMDMi41017367.

Proteomic databases

EPDiQ8TD91.
PaxDbiQ8TD91.
PeptideAtlasiQ8TD91.
PRIDEiQ8TD91.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298296; ENSP00000298296; ENSG00000165509. [Q8TD91-1]
ENST00000409007; ENSP00000386566; ENSG00000165509. [Q8TD91-2]
ENST00000544766; ENSP00000440444; ENSG00000165509. [Q8TD91-2]
GeneIDi139081.
KEGGihsa:139081.
UCSCiuc004fbs.3. human. [Q8TD91-1]

Organism-specific databases

CTDi139081.
GeneCardsiMAGEC3.
HGNCiHGNC:23798. MAGEC3.
HPAiHPA052067.
MIMi300469. gene.
neXtProtiNX_Q8TD91.
PharmGKBiPA134916199.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
InParanoidiQ8TD91.
OMAiWVQRKYL.
OrthoDBiEOG75F4GM.
PhylomeDBiQ8TD91.
TreeFamiTF328505.

Miscellaneous databases

GenomeRNAii139081.
PROiQ8TD91.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TD91.
CleanExiHS_MAGEC3.
ExpressionAtlasiQ8TD91. baseline and differential.
GenevisibleiQ8TD91. HS.

Family and domain databases

InterProiIPR002190. MHD_dom.
[Graphical view]
SMARTiSM01373. MAGE. 2 hits.
[Graphical view]
PROSITEiPS50838. MAGE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of genes in the chromosome X that are differentially expressed in hepatocellular carcinoma."
    Dong X.-Y., Chen W.-F.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression."
    Lucas S., De Plaen E., Boon T.
    Int. J. Cancer 87:55-60(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 362-538, TISSUE SPECIFICITY.
    Tissue: Blood.
  5. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
    Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
    Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-478; THR-484 AND THR-485, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiMAGC3_HUMAN
AccessioniPrimary (citable) accession number: Q8TD91
Secondary accession number(s): Q3SYA7, Q5JZ43, Q9BZ80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2002
Last modified: July 6, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.