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Protein

Melanoma-associated antigen C3

Gene

MAGEC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Keywords - Molecular functioni

Tumor antigen

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165509-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen C3
Alternative name(s):
Cancer/testis antigen 7.2
Short name:
CT7.2
Hepatocellular carcinoma-associated antigen 2
MAGE-C3 antigen
Gene namesi
Name:MAGEC3
Synonyms:HCA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:23798. MAGEC3.

Pathology & Biotechi

Organism-specific databases

DisGeNETi139081.
OpenTargetsiENSG00000165509.
PharmGKBiPA134916199.

Polymorphism and mutation databases

BioMutaiMAGEC3.
DMDMi41017367.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001567221 – 643Melanoma-associated antigen C3Add BLAST643

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei478PhosphothreonineCombined sources1
Modified residuei484PhosphothreonineCombined sources1
Modified residuei485PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8TD91.
PeptideAtlasiQ8TD91.
PRIDEiQ8TD91.

PTM databases

iPTMnetiQ8TD91.
PhosphoSitePlusiQ8TD91.

Expressioni

Tissue specificityi

Expressed in testis. Not expressed in other normal tissues, but is expressed in tumors of different histological origins.1 Publication

Gene expression databases

BgeeiENSG00000165509.
CleanExiHS_MAGEC3.
ExpressionAtlasiQ8TD91. baseline and differential.
GenevisibleiQ8TD91. HS.

Organism-specific databases

HPAiHPA052067.

Interactioni

Protein-protein interaction databases

BioGridi126542. 2 interactors.
IntActiQ8TD91. 3 interactors.
STRINGi9606.ENSP00000298296.

Structurei

3D structure databases

ProteinModelPortaliQ8TD91.
SMRiQ8TD91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini184 – 384MAGE 1PROSITE-ProRule annotationAdd BLAST201
Domaini456 – 643MAGE 2PROSITE-ProRule annotationAdd BLAST188

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi380 – 415Pro-richAdd BLAST36

Sequence similaritiesi

Contains 2 MAGE domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
InParanoidiQ8TD91.
OMAiWVQRKYL.
OrthoDBiEOG091G0TJ0.
PhylomeDBiQ8TD91.
TreeFamiTF328505.

Family and domain databases

InterProiIPR002190. MHD_dom.
[Graphical view]
SMARTiSM01373. MAGE. 2 hits.
[Graphical view]
PROSITEiPS50838. MAGE. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TD91-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLPCHWVLD ATFSDGSLGQ WVKNTCATYA LSPVVLPPQP QPRKKATDKD
60 70 80 90 100
YSAFHLGHLR EVRLFLRGGT SDQRMDSLVL CPTYFKLWRT LSGSPGLQLS
110 120 130 140 150
DLHFGSQPEG KFSLRRAVSV KQREEPQDWP LNEKRTLWKD SDLPTWRRGT
160 170 180 190 200
GYTLSLPAVS PGKRLWGEKA GSLPESEPLF TYTLDEKVDK LVQFLLLKYQ
210 220 230 240 250
AKEPLTRAEM QMNVINTYTG YFPMIFRKAR EFIEILFGIS LTEVDPDHFY
260 270 280 290 300
VFVNTLDLTC EGSLSDEQGM PQNRLLILIL SVIFIKGNCA SEEVIWEVLN
310 320 330 340 350
AIGPWSALAG FADVLSRLAL WESEGPEAFC EESGLRSAEG SVLDLANPQG
360 370 380 390 400
LAGHRQEDGR RGLTEASPQQ KKGGEDEDMP AAGMPPLPQS PPEIPPQGPP
410 420 430 440 450
KISPQGPPQS PPQSPLDSCS SPLLWTRLDE ESSSEEEDTA TWHALPESES
460 470 480 490 500
LPRYALDEKV AELVQFLLLK YQTKEPVTKA EMLTTVIKKY KDYFPMIFGK
510 520 530 540 550
AHEFIELIFG IALTDMDPDN HSYFFEDTLD LTYEGSLIDD QGMPKNCLLI
560 570 580 590 600
LILSMIFIKG SCVPEEVIWE VLSAIGPIQR PAREVLEFLS KLSSIIPSAF
610 620 630 640
PSWYMDALKD MEDRAQAIID TTDDATAMAS ASPSVMSTNF CPE
Length:643
Mass (Da):71,909
Last modified:June 1, 2002 - v1
Checksum:i4EB342288B3FB8A6
GO
Isoform 2 (identifier: Q8TD91-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: MLLPCHWVLD...RGGTSDQRMD → MPLFPNLPRL...LPSTLILGVP
     77-374: Missing.
     577-643: PIQRPAREVL...SVMSTNFCPE → VCAGREHFIY...VFIQAIQYHP

Note: No experimental confirmation available.
Show »
Length:346
Mass (Da):38,906
Checksum:iDBE6CAEAB5623097
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti362 – 374GLTEA…QKKGG → SSPLPSTLILGVP (PubMed:15489334).CuratedAdd BLAST13

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060069155S → P.Corresponds to variant rs11095909dbSNPEnsembl.1
Natural variantiVAR_053505165L → M.Corresponds to variant rs11095910dbSNPEnsembl.1
Natural variantiVAR_053506307A → T.Corresponds to variant rs176024dbSNPEnsembl.1
Natural variantiVAR_053507328A → T.Corresponds to variant rs176026dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0434891 – 76MLLPC…DQRMD → MPLFPNLPRLSFEEDFQNPS VTEDLVDAQDSIDEEEEDAS STSSSSFHFLFPSSSSLSSS SPLSSPLPSTLILGVP in isoform 2. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_04349077 – 374Missing in isoform 2. 1 PublicationAdd BLAST298
Alternative sequenceiVSP_043491577 – 643PIQRP…NFCPE → VCAGREHFIYGDPRKLLTIH WVQRKYLEYREVPNSAPPRY EFLWGPRAHSEASKRSLRVF IQAIQYHP in isoform 2. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF490508 mRNA. Translation: AAM08355.1.
AL022152, AL023279, AL049177 Genomic DNA. Translation: CAI42088.1.
AL023279, AL049177, AL022152 Genomic DNA. Translation: CAI42601.1.
AL049177, AL022152, AL023279 Genomic DNA. Translation: CAI42947.1.
AL022152 Genomic DNA. Translation: CAX15113.1.
BC103893 mRNA. Translation: AAI03894.1.
AF333706 Genomic DNA. Translation: AAK00358.1.
CCDSiCCDS14676.1. [Q8TD91-1]
CCDS14677.1. [Q8TD91-2]
RefSeqiNP_619647.1. NM_138702.1. [Q8TD91-1]
NP_803251.1. NM_177456.2. [Q8TD91-2]
XP_011529569.1. XM_011531267.2. [Q8TD91-2]
XP_016884754.1. XM_017029265.1. [Q8TD91-2]
UniGeneiHs.356870.

Genome annotation databases

EnsembliENST00000298296; ENSP00000298296; ENSG00000165509. [Q8TD91-1]
ENST00000409007; ENSP00000386566; ENSG00000165509. [Q8TD91-2]
ENST00000544766; ENSP00000440444; ENSG00000165509. [Q8TD91-2]
GeneIDi139081.
KEGGihsa:139081.
UCSCiuc004fbs.3. human. [Q8TD91-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF490508 mRNA. Translation: AAM08355.1.
AL022152, AL023279, AL049177 Genomic DNA. Translation: CAI42088.1.
AL023279, AL049177, AL022152 Genomic DNA. Translation: CAI42601.1.
AL049177, AL022152, AL023279 Genomic DNA. Translation: CAI42947.1.
AL022152 Genomic DNA. Translation: CAX15113.1.
BC103893 mRNA. Translation: AAI03894.1.
AF333706 Genomic DNA. Translation: AAK00358.1.
CCDSiCCDS14676.1. [Q8TD91-1]
CCDS14677.1. [Q8TD91-2]
RefSeqiNP_619647.1. NM_138702.1. [Q8TD91-1]
NP_803251.1. NM_177456.2. [Q8TD91-2]
XP_011529569.1. XM_011531267.2. [Q8TD91-2]
XP_016884754.1. XM_017029265.1. [Q8TD91-2]
UniGeneiHs.356870.

3D structure databases

ProteinModelPortaliQ8TD91.
SMRiQ8TD91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126542. 2 interactors.
IntActiQ8TD91. 3 interactors.
STRINGi9606.ENSP00000298296.

PTM databases

iPTMnetiQ8TD91.
PhosphoSitePlusiQ8TD91.

Polymorphism and mutation databases

BioMutaiMAGEC3.
DMDMi41017367.

Proteomic databases

PaxDbiQ8TD91.
PeptideAtlasiQ8TD91.
PRIDEiQ8TD91.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298296; ENSP00000298296; ENSG00000165509. [Q8TD91-1]
ENST00000409007; ENSP00000386566; ENSG00000165509. [Q8TD91-2]
ENST00000544766; ENSP00000440444; ENSG00000165509. [Q8TD91-2]
GeneIDi139081.
KEGGihsa:139081.
UCSCiuc004fbs.3. human. [Q8TD91-1]

Organism-specific databases

CTDi139081.
DisGeNETi139081.
GeneCardsiMAGEC3.
HGNCiHGNC:23798. MAGEC3.
HPAiHPA052067.
MIMi300469. gene.
neXtProtiNX_Q8TD91.
OpenTargetsiENSG00000165509.
PharmGKBiPA134916199.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
InParanoidiQ8TD91.
OMAiWVQRKYL.
OrthoDBiEOG091G0TJ0.
PhylomeDBiQ8TD91.
TreeFamiTF328505.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165509-MONOMER.

Miscellaneous databases

GenomeRNAii139081.
PROiQ8TD91.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165509.
CleanExiHS_MAGEC3.
ExpressionAtlasiQ8TD91. baseline and differential.
GenevisibleiQ8TD91. HS.

Family and domain databases

InterProiIPR002190. MHD_dom.
[Graphical view]
SMARTiSM01373. MAGE. 2 hits.
[Graphical view]
PROSITEiPS50838. MAGE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAGC3_HUMAN
AccessioniPrimary (citable) accession number: Q8TD91
Secondary accession number(s): Q3SYA7, Q5JZ43, Q9BZ80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.