Q8TD91 (MAGC3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Melanoma-associated antigen C3

Alternative name(s):
Cancer/testis antigen 7.2
Short name=CT7.2
Hepatocellular carcinoma-associated antigen 2
MAGE-C3 antigen

Gene names

Name:	MAGEC3
Synonyms:	HCA2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	643 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Expressed in testis. Not expressed in other normal tissues, but is expressed in tumors of different histological origins. Ref.4
Sequence similarities	Contains 2 MAGE domains.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Molecular function	Tumor antigen
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TD91-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TD91-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: MLLPCHWVLD...RGGTSDQRMD → MPLFPNLPRL...LPSTLILGVP
     77-374: Missing.
     577-643: PIQRPAREVL...SVMSTNFCPE → VCAGREHFIY...VFIQAIQYHP

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 643	643	Melanoma-associated antigen C3		PRO_0000156722
Regions
	Domain	184 – 384	201	MAGE 1
	Domain	456 – 643	188	MAGE 2
	Compositional bias	380 – 415	36	Pro-rich
Amino acid modifications
	Modified residue	478	1	Phosphothreonine Ref.5
	Modified residue	484	1	Phosphothreonine Ref.5
	Modified residue	485	1	Phosphothreonine Ref.5
Natural variations
	Alternative sequence	1 – 76	76	MLLPC…DQRMD → MPLFPNLPRLSFEEDFQNPS VTEDLVDAQDSIDEEEEDAS STSSSSFHFLFPSSSSLSSS SPLSSPLPSTLILGVP in isoform 2.		VSP_043489
	Alternative sequence	77 – 374	298	Missing in isoform 2.		VSP_043490
	Alternative sequence	577 – 643	67	PIQRP…NFCPE → VCAGREHFIYGDPRKLLTIH WVQRKYLEYREVPNSAPPRY EFLWGPRAHSEASKRSLRVF IQAIQYHP in isoform 2.		VSP_043491
	Natural variant	155	1	S → P. Corresponds to variant rs11095909 [ dbSNP | Ensembl ].		VAR_060069
	Natural variant	165	1	L → M. Corresponds to variant rs11095910 [ dbSNP | Ensembl ].		VAR_053505
	Natural variant	307	1	A → T. Corresponds to variant rs176024 [ dbSNP | Ensembl ].		VAR_053506
	Natural variant	328	1	A → T. Corresponds to variant rs176026 [ dbSNP | Ensembl ].		VAR_053507
Experimental info
	Sequence conflict	362 – 374	13	GLTEA…QKKGG → SSPLPSTLILGVP Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 4EB342288B3FB8A6	FASTA	643	71,909
	10 20 30 40 50 60 MLLPCHWVLD ATFSDGSLGQ WVKNTCATYA LSPVVLPPQP QPRKKATDKD YSAFHLGHLR 70 80 90 100 110 120 EVRLFLRGGT SDQRMDSLVL CPTYFKLWRT LSGSPGLQLS DLHFGSQPEG KFSLRRAVSV 130 140 150 160 170 180 KQREEPQDWP LNEKRTLWKD SDLPTWRRGT GYTLSLPAVS PGKRLWGEKA GSLPESEPLF 190 200 210 220 230 240 TYTLDEKVDK LVQFLLLKYQ AKEPLTRAEM QMNVINTYTG YFPMIFRKAR EFIEILFGIS 250 260 270 280 290 300 LTEVDPDHFY VFVNTLDLTC EGSLSDEQGM PQNRLLILIL SVIFIKGNCA SEEVIWEVLN 310 320 330 340 350 360 AIGPWSALAG FADVLSRLAL WESEGPEAFC EESGLRSAEG SVLDLANPQG LAGHRQEDGR 370 380 390 400 410 420 RGLTEASPQQ KKGGEDEDMP AAGMPPLPQS PPEIPPQGPP KISPQGPPQS PPQSPLDSCS 430 440 450 460 470 480 SPLLWTRLDE ESSSEEEDTA TWHALPESES LPRYALDEKV AELVQFLLLK YQTKEPVTKA 490 500 510 520 530 540 EMLTTVIKKY KDYFPMIFGK AHEFIELIFG IALTDMDPDN HSYFFEDTLD LTYEGSLIDD 550 560 570 580 590 600 QGMPKNCLLI LILSMIFIKG SCVPEEVIWE VLSAIGPIQR PAREVLEFLS KLSSIIPSAF 610 620 630 640 PSWYMDALKD MEDRAQAIID TTDDATAMAS ASPSVMSTNF CPE
	Isoform 2 [UniParc]. Checksum: DBE6CAEAB5623097	FASTA	346	38,906
	10 20 30 40 50 60 MPLFPNLPRL SFEEDFQNPS VTEDLVDAQD SIDEEEEDAS STSSSSFHFL FPSSSSLSSS 70 80 90 100 110 120 SPLSSPLPST LILGVPEDED MPAAGMPPLP QSPPEIPPQG PPKISPQGPP QSPPQSPLDS 130 140 150 160 170 180 CSSPLLWTRL DEESSSEEED TATWHALPES ESLPRYALDE KVAELVQFLL LKYQTKEPVT 190 200 210 220 230 240 KAEMLTTVIK KYKDYFPMIF GKAHEFIELI FGIALTDMDP DNHSYFFEDT LDLTYEGSLI 250 260 270 280 290 300 DDQGMPKNCL LILILSMIFI KGSCVPEEVI WEVLSAIGVC AGREHFIYGD PRKLLTIHWV 310 320 330 340 QRKYLEYREV PNSAPPRYEF LWGPRAHSEA SKRSLRVFIQ AIQYHP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of genes in the chromosome X that are differentially expressed in hepatocellular carcinoma." Dong X.-Y., Chen W.-F. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]	"MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression." Lucas S., De Plaen E., Boon T. Int. J. Cancer 87:55-60(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 362-538, TISSUE SPECIFICITY. Tissue: Blood.
[5]	"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-478; THR-484 AND THR-485, MASS SPECTROMETRY. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF490508 mRNA. Translation: AAM08355.1. AL022152, AL023279, AL049177 Genomic DNA. Translation: CAI42088.1. AL023279, AL049177, AL022152 Genomic DNA. Translation: CAI42601.1. AL049177, AL022152, AL023279 Genomic DNA. Translation: CAI42947.1. AL022152 Genomic DNA. Translation: CAX15113.1. BC103893 mRNA. Translation: AAI03894.1. AF333706 Genomic DNA. Translation: AAK00358.1.
IPI	IPI00152490. IPI00334726.
RefSeq	NP_619647.1. NM_138702.1. NP_803251.1. NM_177456.2.
UniGene	Hs.356870.
3D structure databases
ProteinModelPortal	Q8TD91.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000298296.
PTM databases
PhosphoSite	Q8TD91.
Polymorphism databases
DMDM	41017367.
Proteomic databases
PaxDb	Q8TD91.
PRIDE	Q8TD91.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000298296; ENSP00000298296; ENSG00000165509. ENST00000409007; ENSP00000386566; ENSG00000165509. ENST00000536088; ENSP00000441107; ENSG00000165509. ENST00000544766; ENSP00000440444; ENSG00000165509.
GeneID	139081.
KEGG	hsa:139081.
UCSC	uc011mwp.2. human.
Organism-specific databases
CTD	139081.
GeneCards	GC0XP140926.
HGNC	HGNC:23798. MAGEC3.
HPA	HPA052067.
MIM	300469. gene.
neXtProt	NX_Q8TD91.
PharmGKB	PA134916199.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG264673.
HOGENOM	HOG000231161.
InParanoid	Q8TD91.
OMA	WVQRKYL.
OrthoDB	EOG4C87S5.
PhylomeDB	Q8TD91.
Gene expression databases
ArrayExpress	Q8TD91.
Bgee	Q8TD91.
CleanEx	HS_MAGEC3.
Genevestigator	Q8TD91.
GermOnline	ENSG00000165509. Homo sapiens.
Family and domain databases
InterPro	IPR002190. MAGE. [Graphical view]
PANTHER	PTHR11736. PTHR11736. 1 hit.
Pfam	PF01454. MAGE. 2 hits. [Graphical view]
PROSITE	PS50838. MAGE. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	139081.
NextBio	83890.
SOURCE	Search...

Entry information

Entry name

MAGC3_HUMAN

Accession

Primary (citable) accession number: Q8TD91
Secondary accession number(s): Q3SYA7, Q5JZ43, Q9BZ80

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.