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Protein

Melanoma-associated antigen E2

Gene

MAGEE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Keywords - Molecular functioni

Tumor antigen

Enzyme and pathway databases

BioCyciZFISH:G66-31907-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen E2
Alternative name(s):
Hepatocellular carcinoma-associated protein 3
MAGE-E2 antigen
Gene namesi
Name:MAGEE2
Synonyms:HCA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:24935. MAGEE2.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186675.
PharmGKBiPA134923697.

Polymorphism and mutation databases

BioMutaiMAGEE2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001567311 – 523Melanoma-associated antigen E2Add BLAST523

Proteomic databases

EPDiQ8TD90.
PaxDbiQ8TD90.
PeptideAtlasiQ8TD90.
PRIDEiQ8TD90.

Expressioni

Gene expression databases

BgeeiENSG00000186675.
CleanExiHS_MAGEE2.
GenevisibleiQ8TD90. HS.

Organism-specific databases

HPAiHPA030625.

Interactioni

Protein-protein interaction databases

BioGridi126577. 8 interactors.
IntActiQ8TD90. 1 interactor.
MINTiMINT-7944881.
STRINGi9606.ENSP00000362457.

Structurei

3D structure databases

ProteinModelPortaliQ8TD90.
SMRiQ8TD90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini88 – 288MAGE 1PROSITE-ProRule annotationAdd BLAST201
Domaini311 – 502MAGE 2PROSITE-ProRule annotationAdd BLAST192

Sequence similaritiesi

Contains 2 MAGE domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000113462.
HOVERGENiHBG095180.
InParanoidiQ8TD90.
OMAiSWPEEYN.
OrthoDBiEOG091G0TJ0.
PhylomeDBiQ8TD90.
TreeFamiTF328505.

Family and domain databases

InterProiIPR002190. MHD_dom.
[Graphical view]
SMARTiSM01373. MAGE. 2 hits.
[Graphical view]
PROSITEiPS50838. MAGE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TD90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLVSQNARH CSAEITADYG DGRGEIQATN ASGSPTSMLV VDAPQCPQAP
60 70 80 90 100
INSQCVNTSQ AVQDPNDLEV LIDEQSRRLG ALRVHDPLED RSIALVNFMR
110 120 130 140 150
MKSQTEGSIQ QSEMLEFLRE YSDQFPEILR RASAHLDQVF GLNLRVIDPQ
160 170 180 190 200
ADTYNLVSKR GFQITDRIAE SLDMPKASLL ALVLGHILLN GNRAREASIW
210 220 230 240 250
DLLLKVDMWD KPQRINNLFG NTRNLLTTDF VCMRFLEYWP VYGTNPLEFE
260 270 280 290 300
FLWGSRAHRE ITKMEALKFV SDAHDEEPWS WPEEYNKALE GDKTKERSLT
310 320 330 340 350
AGLEFWSEDT MNDKANDLVQ LAISVTEEML PIHQDELLAH TGKEFEDVFP
360 370 380 390 400
NILNRATLIL DMFYGLSLIE VDTSEHIYLL VQQPESEEEQ VMLESLGRPT
410 420 430 440 450
QEYVMPILGL IFLMGNRVKE ANVWNLLRRF SVDVGRKHSI TRKLMRQRYL
460 470 480 490 500
ECRPLSYSNP VEYELLWGPR AHHETIKMKV LEYMARLYRK RPQNWPEQYR
510 520
EAVEDEEARA KSEATIMFFL DPT
Length:523
Mass (Da):60,378
Last modified:June 1, 2002 - v1
Checksum:iFB668B47A2B72AFB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053509291G → C.Corresponds to variant rs12688600dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF490509 mRNA. Translation: AAM08356.1.
AK094624 mRNA. Translation: BAC04387.1.
AL391495 Genomic DNA. Translation: CAI40175.1.
BC093964 mRNA. Translation: AAH93964.1.
BC111949 mRNA. Translation: AAI11950.1.
CCDSiCCDS14431.1.
RefSeqiNP_619648.1. NM_138703.4.
UniGeneiHs.356869.

Genome annotation databases

EnsembliENST00000373359; ENSP00000362457; ENSG00000186675.
GeneIDi139599.
KEGGihsa:139599.
UCSCiuc004ecj.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF490509 mRNA. Translation: AAM08356.1.
AK094624 mRNA. Translation: BAC04387.1.
AL391495 Genomic DNA. Translation: CAI40175.1.
BC093964 mRNA. Translation: AAH93964.1.
BC111949 mRNA. Translation: AAI11950.1.
CCDSiCCDS14431.1.
RefSeqiNP_619648.1. NM_138703.4.
UniGeneiHs.356869.

3D structure databases

ProteinModelPortaliQ8TD90.
SMRiQ8TD90.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126577. 8 interactors.
IntActiQ8TD90. 1 interactor.
MINTiMINT-7944881.
STRINGi9606.ENSP00000362457.

Polymorphism and mutation databases

BioMutaiMAGEE2.

Proteomic databases

EPDiQ8TD90.
PaxDbiQ8TD90.
PeptideAtlasiQ8TD90.
PRIDEiQ8TD90.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373359; ENSP00000362457; ENSG00000186675.
GeneIDi139599.
KEGGihsa:139599.
UCSCiuc004ecj.3. human.

Organism-specific databases

CTDi139599.
GeneCardsiMAGEE2.
HGNCiHGNC:24935. MAGEE2.
HPAiHPA030625.
MIMi300760. gene.
neXtProtiNX_Q8TD90.
OpenTargetsiENSG00000186675.
PharmGKBiPA134923697.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000113462.
HOVERGENiHBG095180.
InParanoidiQ8TD90.
OMAiSWPEEYN.
OrthoDBiEOG091G0TJ0.
PhylomeDBiQ8TD90.
TreeFamiTF328505.

Enzyme and pathway databases

BioCyciZFISH:G66-31907-MONOMER.

Miscellaneous databases

GenomeRNAii139599.
PROiQ8TD90.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186675.
CleanExiHS_MAGEE2.
GenevisibleiQ8TD90. HS.

Family and domain databases

InterProiIPR002190. MHD_dom.
[Graphical view]
SMARTiSM01373. MAGE. 2 hits.
[Graphical view]
PROSITEiPS50838. MAGE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAGE2_HUMAN
AccessioniPrimary (citable) accession number: Q8TD90
Secondary accession number(s): Q5JSI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.