Reviewed, UniProtKB/Swiss-Prot Q8TD88 (CU109_HUMAN)

Names and origin

Protein names

Recommended name:
    Uncharacterized protein C21orf109

Gene names

Name:

C21orf109

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	51 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Predicted.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TD88-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TD88-2)

The sequence of this isoform differs from the canonical sequence as follows:
     36-51: LKMKILSNLTRLDNWL → DLQGMFQVEEGALGQ

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 51	51	Uncharacterized protein C21orf109		PRO_0000079547
Natural variations
	Alternative sequence	36 – 51	16	LKMKI…LDNWL → DLQGMFQVEEGALGQ in isoform 2.		VSP_008891

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: BC0F2A2AC4771A17	FASTA	51	6,031
	10 20 30 40 50 MTIWMTQEGC NSGLGEKTCK ERNMFEFQMC SSMNHLKMKI LSNLTRLDNW L
	Isoform 2. Checksum: F004B055BC1A7A8C	FASTA	50	5,694
	10 20 30 40 50 MTIWMTQEGC NSGLGEKTCK ERNMFEFQMC SSMNHDLQGM FQVEEGALGQ

References

[1]	"Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis." Gardiner K., Slavov D., Bechtel L., Davisson M. Genomics 79:833-843(2002) [PubMed: 12036298] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF490769 mRNA. Translation: AAM18047.1.
IPI	IPI00152485. IPI00394970.
UniGene	Hs.154276
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q8TD88.
Organism-specific databases
GeneCards	GC21U900117.
HGNC	HGNC:18461. C21orf109.
PharmGKB	PA38542.
GenAtlas	Search...
Gene expression databases
Genevestigator	Q8TD88.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

CU109_HUMAN

Accession

Primary (citable) accession number: Q8TD88

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 14, 2003
Last sequence update:	June 1, 2002
Last modified:	November 24, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.