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Protein

Calmodulin-like protein 6

Gene

CALML6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi156 – 16712PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-like protein 6
Alternative name(s):
Calglandulin-like protein
Gene namesi
Name:CALML6
Synonyms:CAGLP, CALGP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24193. CALML6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134968051.

Polymorphism and mutation databases

BioMutaiCALML6.
DMDMi74762617.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181Calmodulin-like protein 6PRO_0000073548Add
BLAST

Proteomic databases

PaxDbiQ8TD86.
PRIDEiQ8TD86.

PTM databases

iPTMnetiQ8TD86.

Expressioni

Tissue specificityi

Expressed in prostate, thymus, heart, skeleton muscle, bone marrow and ovary.1 Publication

Gene expression databases

BgeeiQ8TD86.
CleanExiHS_CALML6.
ExpressionAtlasiQ8TD86. baseline and differential.
GenevisibleiQ8TD86. HS.

Organism-specific databases

HPAiHPA005912.

Interactioni

Protein-protein interaction databases

BioGridi127872. 1 interaction.
STRINGi9606.ENSP00000304643.

Structurei

3D structure databases

ProteinModelPortaliQ8TD86.
SMRiQ8TD86. Positions 29-174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 6836EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini69 – 10436EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini107 – 14236EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini143 – 17836EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ8TD86.
KOiK02183.
OMAiMTGESFK.
OrthoDBiEOG7SJD62.
PhylomeDBiQ8TD86.
TreeFamiTF354258.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TD86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLQQEISLQ PWCHHPAESC QTTTDMTERL SAEQIKEYKG VFEMFDEEGN
60 70 80 90 100
GEVKTGELEW LMSLLGINPT KSELASMAKD VDRDNKGFFN CDGFLALMGV
110 120 130 140 150
YHEKAQNQES ELRAAFRVFD KEGKGYIDWN TLKYVLMNAG EPLNEVEAEQ
160 170 180
MMKEADKDGD RTIDYEEFVA MMTGESFKLI Q
Length:181
Mass (Da):20,690
Last modified:September 13, 2004 - v2
Checksum:iF29C088AFC42BB13
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti60 – 601W → R.
Corresponds to variant rs28581776 [ dbSNP | Ensembl ].
VAR_048588

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY566229 mRNA. Translation: AAS67001.1.
AF490905 mRNA. Translation: AAM08411.2.
AL109917 Genomic DNA. Translation: CAM12839.1.
CCDSiCCDS30566.1.
RefSeqiNP_619650.2. NM_138705.2.
UniGeneiHs.85902.

Genome annotation databases

EnsembliENST00000307786; ENSP00000304643; ENSG00000169885.
GeneIDi163688.
KEGGihsa:163688.
UCSCiuc001aih.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY566229 mRNA. Translation: AAS67001.1.
AF490905 mRNA. Translation: AAM08411.2.
AL109917 Genomic DNA. Translation: CAM12839.1.
CCDSiCCDS30566.1.
RefSeqiNP_619650.2. NM_138705.2.
UniGeneiHs.85902.

3D structure databases

ProteinModelPortaliQ8TD86.
SMRiQ8TD86. Positions 29-174.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127872. 1 interaction.
STRINGi9606.ENSP00000304643.

PTM databases

iPTMnetiQ8TD86.

Polymorphism and mutation databases

BioMutaiCALML6.
DMDMi74762617.

Proteomic databases

PaxDbiQ8TD86.
PRIDEiQ8TD86.

Protocols and materials databases

DNASUi163688.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307786; ENSP00000304643; ENSG00000169885.
GeneIDi163688.
KEGGihsa:163688.
UCSCiuc001aih.1. human.

Organism-specific databases

CTDi163688.
GeneCardsiCALML6.
HGNCiHGNC:24193. CALML6.
HPAiHPA005912.
MIMi610171. gene.
neXtProtiNX_Q8TD86.
PharmGKBiPA134968051.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ8TD86.
KOiK02183.
OMAiMTGESFK.
OrthoDBiEOG7SJD62.
PhylomeDBiQ8TD86.
TreeFamiTF354258.

Miscellaneous databases

GenomeRNAii163688.
PROiQ8TD86.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TD86.
CleanExiHS_CALML6.
ExpressionAtlasiQ8TD86. baseline and differential.
GenevisibleiQ8TD86. HS.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of human CAGLP gene encoding a novel EF-hand protein."
    Chen S., Guo J.-H., Saiyin H., Chen L., Zhou G.-J., Huang C.-Q., Yu L.
    DNA Seq. 15:365-368(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Skeletal muscle.
  2. Guo J.-H., Yu L.
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCALL6_HUMAN
AccessioniPrimary (citable) accession number: Q8TD86
Secondary accession number(s): A2A2M3, Q6Q2C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: September 13, 2004
Last modified: June 8, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.