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Protein

Down syndrome cell adhesion molecule-like protein 1

Gene

DSCAML1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell adhesion molecule that plays a role in neuronal self-avoidance (PubMed:11453658). Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (By similarity). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity).By similarity1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • axonogenesis Source: UniProtKB
  • brain development Source: UniProtKB
  • cell fate determination Source: UniProtKB
  • central nervous system development Source: UniProtKB
  • dorsal/ventral pattern formation Source: UniProtKB
  • embryonic skeletal system morphogenesis Source: UniProtKB
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Neurogenesis

Enzyme and pathway databases

ReactomeiR-HSA-376172. DSCAM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Down syndrome cell adhesion molecule-like protein 1
Alternative name(s):
Down syndrome cell adhesion molecule 2
Gene namesi
Name:DSCAML1
Synonyms:DSCAM2, KIAA11321 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14656. DSCAML1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 1591ExtracellularSequence analysisAdd BLAST1573
Transmembranei1592 – 1612HelicalSequence analysisAdd BLAST21
Topological domaini1613 – 2053CytoplasmicSequence analysisAdd BLAST441

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • cell surface Source: UniProtKB
  • extracellular space Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: Reactome
  • synapse Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi57453.
PharmGKBiPA38384.

Polymorphism and mutation databases

BioMutaiDSCAML1.
DMDMi73620825.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001474819 – 2053Down syndrome cell adhesion molecule-like protein 1Add BLAST2035

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi47 ↔ 103PROSITE-ProRule annotation
Glycosylationi79N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi146 ↔ 198PROSITE-ProRule annotation
Disulfide bondi247 ↔ 294PROSITE-ProRule annotation
Disulfide bondi336 ↔ 386PROSITE-ProRule annotation
Glycosylationi368N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi429 ↔ 485PROSITE-ProRule annotation
Glycosylationi471N-linked (GlcNAc...)Sequence analysis1
Glycosylationi513N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi526 ↔ 575PROSITE-ProRule annotation
Glycosylationi556N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi617 ↔ 669PROSITE-ProRule annotation
Glycosylationi666N-linked (GlcNAc...)Sequence analysis1
Glycosylationi710N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi711 ↔ 767PROSITE-ProRule annotation
Glycosylationi749N-linked (GlcNAc...)Sequence analysis1
Glycosylationi796N-linked (GlcNAc...)Sequence analysis1
Glycosylationi809N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi810 ↔ 867PROSITE-ProRule annotation
Glycosylationi926N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1082N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1144N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1162N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1275N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1311 ↔ 1363PROSITE-ProRule annotation
Glycosylationi1345N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1492N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1531N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1561N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8TD84.
PaxDbiQ8TD84.
PeptideAtlasiQ8TD84.
PRIDEiQ8TD84.

PTM databases

iPTMnetiQ8TD84.
PhosphoSitePlusiQ8TD84.

Expressioni

Tissue specificityi

Detected in heart, liver, pancreas, skeletal muscle, kidney and in brain, in particular in the amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra, thalamus and subthalamus.2 Publications

Gene expression databases

BgeeiENSG00000177103.
CleanExiHS_DSCAML1.
ExpressionAtlasiQ8TD84. baseline and differential.
GenevisibleiQ8TD84. HS.

Organism-specific databases

HPAiHPA035230.

Interactioni

Subunit structurei

Homodimer; mediates homophilic interactions to promote cell adhesion.By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi121525. 3 interactors.
IntActiQ8TD84. 3 interactors.
STRINGi9606.ENSP00000315465.

Structurei

Secondary structure

12053
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi991 – 997Combined sources7
Beta strandi999 – 1008Combined sources10
Beta strandi1021 – 1030Combined sources10
Beta strandi1046 – 1055Combined sources10
Beta strandi1062 – 1070Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VA9NMR-A979-1087[»]
ProteinModelPortaliQ8TD84.
SMRiQ8TD84.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TD84.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 119Ig-like C2-type 1Add BLAST101
Domaini115 – 217Ig-like C2-type 2Add BLAST103
Domaini226 – 306Ig-like C2-type 3Add BLAST81
Domaini314 – 402Ig-like C2-type 4Add BLAST89
Domaini408 – 501Ig-like C2-type 5Add BLAST94
Domaini506 – 586Ig-like C2-type 6Add BLAST81
Domaini596 – 685Ig-like C2-type 7Add BLAST90
Domaini690 – 784Ig-like C2-type 8Add BLAST95
Domaini788 – 885Ig-like C2-type 9Add BLAST98
Domaini887 – 984Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST98
Domaini989 – 1088Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST100
Domaini1093 – 1189Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST97
Domaini1193 – 1288Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST96
Domaini1278 – 1377Ig-like C2-type 10Add BLAST100
Domaini1383 – 1477Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST95
Domaini1478 – 1578Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST101

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1956 – 2016Pro-richAdd BLAST61

Sequence similaritiesi

Contains 6 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQJM. Eukaryota.
ENOG410XQX7. LUCA.
HOGENOMiHOG000112277.
HOVERGENiHBG051409.
InParanoidiQ8TD84.
KOiK06768.
OrthoDBiEOG091G005W.
PhylomeDBiQ8TD84.
TreeFamiTF316846.

Family and domain databases

CDDicd00063. FN3. 6 hits.
Gene3Di2.60.40.10. 16 hits.
InterProiIPR033029. DSCAML1.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PANTHERiPTHR10489:SF171. PTHR10489:SF171. 1 hit.
PfamiPF00041. fn3. 5 hits.
PF07679. I-set. 4 hits.
[Graphical view]
SMARTiSM00060. FN3. 6 hits.
SM00409. IG. 10 hits.
SM00408. IGc2. 9 hits.
SM00406. IGv. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 10 hits.
SSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 6 hits.
PS50835. IG_LIKE. 9 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TD84-1) [UniParc]FASTAAdd to basket
Also known as: 1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWLVTFLLLL DSLHKARPED VGTSLYFVND SLQQVTFSSS VGVVVPCPAA
60 70 80 90 100
GSPSAALRWY LATGDDIYDV PHIRHVHANG TLQLYPFSPS AFNSFIHDND
110 120 130 140 150
YFCTAENAAG KIRSPNIRVK AVFREPYTVR VEDQRSMRGN VAVFKCLIPS
160 170 180 190 200
SVQEYVSVVS WEKDTVSIIP EHRFFITYHG GLYISDVQKE DALSTYRCIT
210 220 230 240 250
KHKYSGETRQ SNGARLSVTD PAESIPTILD GFHSQEVWAG HTVELPCTAS
260 270 280 290 300
GYPIPAIRWL KDGRPLPADS RWTKRITGLT ISDLRTEDSG TYICEVTNTF
310 320 330 340 350
GSAEATGILM VIDPLHVTLT PKKLKTGIGS TVILSCALTG SPEFTIRWYR
360 370 380 390 400
NTELVLPDEA ISIRGLSNET LLITSAQKSH SGAYQCFATR KAQTAQDFAI
410 420 430 440 450
IALEDGTPRI VSSFSEKVVN PGEQFSLMCA AKGAPPPTVT WALDDEPIVR
460 470 480 490 500
DGSHRTNQYT MSDGTTISHM NVTGPQIRDG GVYRCTARNL VGSAEYQARI
510 520 530 540 550
NVRGPPSIRA MRNITAVAGR DTLINCRVIG YPYYSIKWYK DALLLPDNHR
560 570 580 590 600
QVVFENGTLK LTDVQKGMDE GEYLCSVLIQ PQLSISQSVH VAVKVPPLIQ
610 620 630 640 650
PFEFPPASIG QLLYIPCVVS SGDMPIRITW RKDGQVIISG SGVTIESKEF
660 670 680 690 700
MSSLQISSVS LKHNGNYTCI ASNAAATVSR ERQLIVRVPP RFVVQPNNQD
710 720 730 740 750
GIYGKAGVLN CSVDGYPPPK VMWKHAKGSG NPQQYHPVPL TGRIQILPNS
760 770 780 790 800
SLLIRHVLEE DIGYYLCQAS NGVGTDISKS MFLTVKIPAM ITSHPNTTIA
810 820 830 840 850
IKGHAKELNC TARGERPIII RWEKGDTVID PDRVMRYAIA TKDNGDEVVS
860 870 880 890 900
TLKLKPADRG DSVFFSCHAI NSYGEDRGLI QLTVQEPPDP PELEIREVKA
910 920 930 940 950
RSMNLRWTQR FDGNSIITGF DIEYKNKSDS WDFKQSTRNI SPTINQANIV
960 970 980 990 1000
DLHPASVYSI RMYSFNKIGR SEPSKELTIS TEEAAPDGPP MDVTLQPVTS
1010 1020 1030 1040 1050
QSIQVTWKAP KKELQNGVIR GYQIGYRENS PGSNGQYSIV EMKATGDSEV
1060 1070 1080 1090 1100
YTLDNLKKFA QYGVVVQAFN RAGTGPSSSE INATTLEDVP SQPPENVRAL
1110 1120 1130 1140 1150
SITSDVAVIS WSEPPRSTLN GVLKGYRVIF WSLYVDGEWG EMQNITTTRE
1160 1170 1180 1190 1200
RVELRGMEKF TNYSVQVLAY TQAGDGVRSS VLYIQTKEDV PGPPAGIKAV
1210 1220 1230 1240 1250
PSSASSVVVS WLPPTKPNGV IRKYTIFCSS PGSGQPAPSE YETSPEQLFY
1260 1270 1280 1290 1300
RIAHLNRGQQ YLLWVAAVTS AGRGNSSEKV TIEPAGKAPA KIISFGGTVT
1310 1320 1330 1340 1350
TPWMKDVRLP CNSVGDPAPA VKWTKDSEDS AIPVSMDGHR LIHTNGTLLL
1360 1370 1380 1390 1400
RAVKAEDSGY YTCTATNTGG FDTIIVNLLV QVPPDQPRLT VSKTSASSIT
1410 1420 1430 1440 1450
LTWIPGDNGG SSIRGFVLQY SVDNSEEWKD VFISSSERSF KLDSLKCGTW
1460 1470 1480 1490 1500
YKVKLAAKNS VGSGRISEII EAKTHGREPS FSKDQHLFTH INSTHARLNL
1510 1520 1530 1540 1550
QGWNNGGCPI TAIVLEYRPK GTWAWQGLRA NSSGEVFLTE LREATWYELR
1560 1570 1580 1590 1600
MRACNSAGCG NETAQFATLD YDGSTIPPIK SAQGEGDDVK KLFTIGCPVI
1610 1620 1630 1640 1650
LATLGVALLF IVRKKRKEKR LKRLRDAKSL AEMLISKNNR SFDTPVKGPP
1660 1670 1680 1690 1700
QGPRLHIDIP RVQLLIEDKE GIKQLGDDKA TIPVTDAEFS QAVNPQSFCT
1710 1720 1730 1740 1750
GVSLHHPTLI QSTGPLIDMS DIRPGTNPVS RKNVKSAHST RNRYSSQWTL
1760 1770 1780 1790 1800
TKCQASTPAR TLTSDWRTVG SQHGVTVTES DSYSASLSQD TDKGRNSMVS
1810 1820 1830 1840 1850
TESASSTYEE LARAYEHAKL EEQLQHAKFE ITECFISDSS SDQMTTGTNE
1860 1870 1880 1890 1900
NADSMTSMST PSEPGICRFT ASPPKPQDAD RGKNVAVPIP HRANKSDYCN
1910 1920 1930 1940 1950
LPLYAKSEAF FRKADGREPC PVVPPREASI RNLARTYHTQ ARHLTLDPAS
1960 1970 1980 1990 2000
KSLGLPHPGA PAAASTATLP QRTLAMPAPP AGTAPPAPGP TPAEPPTAPS
2010 2020 2030 2040 2050
AAPPAPSTEP PRAGGPHTKM GGSRDSLLEM STSGVGRSQK QGAGAYSKSY

TLV
Length:2,053
Mass (Da):224,463
Last modified:August 16, 2005 - v2
Checksum:i9CC9644214FF19C4
GO
Isoform 2 (identifier: Q8TD84-2) [UniParc]FASTAAdd to basket
Also known as: 1b

The sequence of this isoform differs from the canonical sequence as follows:
     34-244: Missing.

Show »
Length:1,842
Mass (Da):200,982
Checksum:i238314CA48D908D2
GO

Sequence cautioni

The sequence AAM09558 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA86446 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4V → L in AAN32613 (Ref. 3) Curated1
Sequence conflicti4V → L in AAN32614 (Ref. 3) Curated1
Sequence conflicti150 – 152SSV → FLG in AAN32613 (Ref. 3) Curated3
Sequence conflicti172H → N in AAL57166 (PubMed:11453658).Curated1
Sequence conflicti172H → N in BAA86446 (PubMed:10574461).Curated1
Sequence conflicti250S → P in AAN32614 (Ref. 3) Curated1
Sequence conflicti469H → Y in AAN32613 (Ref. 3) Curated1
Sequence conflicti667Y → D in AAN32613 (Ref. 3) Curated1
Sequence conflicti667Y → D in AAN32614 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035512659V → I in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0355131702V → I in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01497834 – 244Missing in isoform 2. 1 PublicationAdd BLAST211

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334384 mRNA. Translation: AAL57166.1.
AF491813 mRNA. Translation: AAM09558.1. Different initiation.
AF304304 mRNA. Translation: AAN32613.1.
AF304305 mRNA. Translation: AAN32614.1.
AB032958 mRNA. Translation: BAA86446.2. Different initiation.
AP000711 Genomic DNA. No translation available.
AP000757 Genomic DNA. No translation available.
AP001554 Genomic DNA. No translation available.
AP002342 Genomic DNA. No translation available.
RefSeqiNP_065744.2. NM_020693.3.
UniGeneiHs.659513.

Genome annotation databases

EnsembliENST00000321322; ENSP00000315465; ENSG00000177103.
GeneIDi57453.
KEGGihsa:57453.
UCSCiuc001prh.1. human. [Q8TD84-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334384 mRNA. Translation: AAL57166.1.
AF491813 mRNA. Translation: AAM09558.1. Different initiation.
AF304304 mRNA. Translation: AAN32613.1.
AF304305 mRNA. Translation: AAN32614.1.
AB032958 mRNA. Translation: BAA86446.2. Different initiation.
AP000711 Genomic DNA. No translation available.
AP000757 Genomic DNA. No translation available.
AP001554 Genomic DNA. No translation available.
AP002342 Genomic DNA. No translation available.
RefSeqiNP_065744.2. NM_020693.3.
UniGeneiHs.659513.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VA9NMR-A979-1087[»]
ProteinModelPortaliQ8TD84.
SMRiQ8TD84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121525. 3 interactors.
IntActiQ8TD84. 3 interactors.
STRINGi9606.ENSP00000315465.

PTM databases

iPTMnetiQ8TD84.
PhosphoSitePlusiQ8TD84.

Polymorphism and mutation databases

BioMutaiDSCAML1.
DMDMi73620825.

Proteomic databases

EPDiQ8TD84.
PaxDbiQ8TD84.
PeptideAtlasiQ8TD84.
PRIDEiQ8TD84.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321322; ENSP00000315465; ENSG00000177103.
GeneIDi57453.
KEGGihsa:57453.
UCSCiuc001prh.1. human. [Q8TD84-1]

Organism-specific databases

CTDi57453.
DisGeNETi57453.
GeneCardsiDSCAML1.
HGNCiHGNC:14656. DSCAML1.
HPAiHPA035230.
MIMi611782. gene.
neXtProtiNX_Q8TD84.
PharmGKBiPA38384.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQJM. Eukaryota.
ENOG410XQX7. LUCA.
HOGENOMiHOG000112277.
HOVERGENiHBG051409.
InParanoidiQ8TD84.
KOiK06768.
OrthoDBiEOG091G005W.
PhylomeDBiQ8TD84.
TreeFamiTF316846.

Enzyme and pathway databases

ReactomeiR-HSA-376172. DSCAM interactions.

Miscellaneous databases

ChiTaRSiDSCAML1. human.
EvolutionaryTraceiQ8TD84.
GenomeRNAii57453.
PROiQ8TD84.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177103.
CleanExiHS_DSCAML1.
ExpressionAtlasiQ8TD84. baseline and differential.
GenevisibleiQ8TD84. HS.

Family and domain databases

CDDicd00063. FN3. 6 hits.
Gene3Di2.60.40.10. 16 hits.
InterProiIPR033029. DSCAML1.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PANTHERiPTHR10489:SF171. PTHR10489:SF171. 1 hit.
PfamiPF00041. fn3. 5 hits.
PF07679. I-set. 4 hits.
[Graphical view]
SMARTiSM00060. FN3. 6 hits.
SM00409. IG. 10 hits.
SM00408. IGc2. 9 hits.
SM00406. IGv. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 10 hits.
SSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 6 hits.
PS50835. IG_LIKE. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDSCL1_HUMAN
AccessioniPrimary (citable) accession number: Q8TD84
Secondary accession number(s): Q76MU9
, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: November 30, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.