Q8TD57 (DYH3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dynein heavy chain 3, axonemal

Alternative name(s):
Axonemal beta dynein heavy chain 3
Short name=HsADHC3
Ciliary dynein heavy chain 3
Dnahc3-b

Gene names

Name:	DNAH3
Synonyms:	DNAHC3B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	4116 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly By similarity.
Subunit structure	Consists of at least two heavy chains and a number of intermediate and light chains.
Subcellular location	Cytoplasm › cytoskeleton › cilium axoneme Potential.
Tissue specificity	Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in lung. Ref.6
Domain	Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function By similarity.
Sequence similarities	Belongs to the dynein heavy chain family.

Ontologies

Keywords
Cellular component	Cell projection Cilium Cytoplasm Cytoskeleton Dynein Microtubule
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Motor protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC ciliary or flagellar motility Non-traceable author statement Ref.6. Source: UniProtKB microtubule-based movement Inferred from electronic annotation. Source: InterPro
Cellular_component	axonemal dynein complex Non-traceable author statement Ref.6. Source: UniProtKB cilium axoneme Inferred from electronic annotation. Source: UniProtKB-SubCell microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro microtubule motor activity Non-traceable author statement Ref.6. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TD57-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TD57-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: MGATGRLELTLAAPPHPGPAFQRSKARETQGEEEGSEMQ → MGDMDCSSQK
     528-566: KLKYIPLKFSFTAAAADRQCVKAAEPGEPSMHAAATAMA → KVESVLFP
     762-762: Y → YEDIKLNSTLFLWPD
     790-799: CSEFELRLEG → YRESLGLSWK
     800-4116: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8TD57-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1883-1887: VNDMF → MKSGQ
     1888-4116: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 4116	4116	Dynein heavy chain 3, axonemal		PRO_0000322544
Regions
	Nucleotide binding	1429 – 1436	8	ATP Potential
	Nucleotide binding	1710 – 1717	8	ATP Potential
	Nucleotide binding	2074 – 2081	8	ATP Potential
	Nucleotide binding	2434 – 2441	8	ATP Potential
	Region	1 – 1390	1390	Stem By similarity
	Region	1391 – 1612	222	AAA 1 By similarity
	Region	1672 – 1903	232	AAA 2 By similarity
	Region	2036 – 2284	249	AAA 3 By similarity
	Region	2395 – 2646	252	AAA 4 By similarity
	Region	2661 – 2960	300	Stalk By similarity
	Region	3045 – 3275	231	AAA 5 By similarity
	Region	3488 – 3712	225	AAA 6 By similarity
	Coiled coil	785 – 852	68	Potential
Amino acid modifications
	Modified residue	3614	1	Phosphoserine By similarity
	Modified residue	3617	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 39	39	MGATG…GSEMQ → MGDMDCSSQK in isoform 2.		VSP_031919
	Alternative sequence	528 – 566	39	KLKYI…ATAMA → KVESVLFP in isoform 2.		VSP_031920
	Alternative sequence	762	1	Y → YEDIKLNSTLFLWPD in isoform 2.		VSP_031921
	Alternative sequence	790 – 799	10	CSEFELRLEG → YRESLGLSWK in isoform 2.		VSP_031922
	Alternative sequence	800 – 4116	3317	Missing in isoform 2.		VSP_031923
	Alternative sequence	1883 – 1887	5	VNDMF → MKSGQ in isoform 3.		VSP_031924
	Alternative sequence	1888 – 4116	2229	Missing in isoform 3.		VSP_031925
	Natural variant	484	1	I → L in a colorectal cancer sample; somatic mutation. Ref.10		VAR_039412
	Natural variant	545	1	R → W. Corresponds to variant rs16970910 [ dbSNP | Ensembl ].		VAR_039413
	Natural variant	1565	1	I → M. Corresponds to variant rs330150 [ dbSNP | Ensembl ].		VAR_039414
	Natural variant	1583	1	V → I. Corresponds to variant rs16970832 [ dbSNP | Ensembl ].		VAR_039415
	Natural variant	1608	1	S → F in a colorectal cancer sample; somatic mutation. Ref.10		VAR_039416
	Natural variant	1752	1	T → M. Corresponds to variant rs13332291 [ dbSNP | Ensembl ].		VAR_039417
	Natural variant	2399	1	I → N. Corresponds to variant rs34179606 [ dbSNP | Ensembl ].		VAR_039418
	Natural variant	2804	1	I → V. Corresponds to variant rs12929546 [ dbSNP | Ensembl ].		VAR_039419
	Natural variant	2949	1	K → T. Corresponds to variant rs33928718 [ dbSNP | Ensembl ].		VAR_039420
	Natural variant	3457	1	E → K. Corresponds to variant rs3743695 [ dbSNP | Ensembl ].		VAR_039421
	Natural variant	3639	1	L → I. Corresponds to variant rs34771199 [ dbSNP | Ensembl ].		VAR_039422
	Natural variant	3645	1	R → C. Corresponds to variant rs12924551 [ dbSNP | Ensembl ].		VAR_039423
	Natural variant	3744	1	R → W. Corresponds to variant rs2301620 [ dbSNP | Ensembl ].		VAR_039424
Experimental info
	Sequence conflict	1393	1	Y → F in CAA10558. Ref.4
	Sequence conflict	1441	1	D → V in CAB06059. Ref.5
	Sequence conflict	1601 – 1604	4	YGMR → FGLH in CAB06059. Ref.5
	Sequence conflict	3828	1	Q → M in CAB46377. Ref.8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: AF387246540D9DF2	FASTA	4,116	470,771
	10 20 30 40 50 60 MGATGRLELT LAAPPHPGPA FQRSKARETQ GEEEGSEMQI AKSDSIHHMS HSQGQPELPP 70 80 90 100 110 120 LPASANEEPS GLYQTVMSHS FYPPLMQRTS WTLAAPFKEQ HHHRGPSDSI ANNYSLMAQD 130 140 150 160 170 180 LKLKDLLKVY QPATISVPRD RTGQGLPSSG NRSSSEPMRK KTKFSSRNKE DSTRIKLAFK 190 200 210 220 230 240 TSIFSPMKKE VKTSLTFPGS RPMSPEQQLD VMLQQEMEME SKEKKPSESD LERYYYYLTN 250 260 270 280 290 300 GIRKDMIAPE EGEVMVRISK LISNTLLTSP FLEPLMVVLV QEKENDYYCS LMKSIVDYIL 310 320 330 340 350 360 MDPMERKRLF IESIPRLFPQ RVIRAPVPWH SVYRSAKKWN EEHLHTVNPM MLRLKELWFA 370 380 390 400 410 420 EFRDLRFVRT AEILAGKLPL QPQEFWDVIQ KHCLEAHQTL LNKWIPTCAQ LFTSRKEHWI 430 440 450 460 470 480 HFAPKSNYDS SRNIEEYFAS VASFMSLQLR ELVIKSLEDL VSLFMIHKDG NDFKEPYQEM 490 500 510 520 530 540 KFFIPQLIMI KLEVSEPIIV FNPSFDGCWE LIRDSFLEII KNSNGIPKLK YIPLKFSFTA 550 560 570 580 590 600 AAADRQCVKA AEPGEPSMHA AATAMAELKG YNLLLGTVNA EEKLVSDFLI QTFKVFQKNQ 610 620 630 640 650 660 VGPCKYLNVY KKYVDLLDNT AEQNIAAFLK ENHDIDDFVT KINAIKKRRN EIASMNITVP 670 680 690 700 710 720 LAMFCLDATA LNHDLCERAQ NLKDHLIQFQ VDVNRDTNTS ICNQYSHIAD KVSEVPANTK 730 740 750 760 770 780 ELVSLIEFLK KSSAVTVFKL RRQLRDASER LEFLMDYADL PYQIEDIFDN SRNLLLHKRD 790 800 810 820 830 840 QAEMDLIKRC SEFELRLEGY HRELESFRKR EVMTTEEMKH NVEKLNELSK NLNRAFAEFE 850 860 870 880 890 900 LINKEEELLE KEKSTYPLLQ AMLKNKVPYE QLWSTAYEFS IKSEEWMNGP LFLLNAEQIA 910 920 930 940 950 960 EEIGNMWRTT YKLIKTLSDV PAPRRLAENV KIKIDKFKQY IPILSISCNP GMKDRHWQQI 970 980 990 1000 1010 1020 SEIVGYEIKP TETTCLSNML EFGFGKFVEK LEPIGAAASK EYSLEKNLDR MKLDWVNVTF 1030 1040 1050 1060 1070 1080 SFVKYRDTDT NILCAIDDIQ MLLDDHVIKT QTMCGSPFIK PIEAECRKWE EKLIRIQDNL 1090 1100 1110 1120 1130 1140 DAWLKCQATW LYLEPIFSSE DIIAQMPEEG RKFGIVDSYW KSLMSQAVKD NRILVAADQP 1150 1160 1170 1180 1190 1200 RMAEKLQEAN FLLEDIQKGL NDYLEKKRLF FPRFFFLSND ELLEILSETK DPLRVQPHLK 1210 1220 1230 1240 1250 1260 KCFEGIAKLE FTDNLEIVGM ISSEKETVPF IQKIYPANAK GMVEKWLQQV EQMMLASMRE 1270 1280 1290 1300 1310 1320 VIGLGIEAYV KVPRNHWVLQ WPGQVVICVS SIFWTQEVSQ ALAENTLLDF LKKSNDQIAQ 1330 1340 1350 1360 1370 1380 IVQLVRGKLS SGARLTLGAL TVIDVHARDV VAKLSEDRVS DLNDFQWISQ LRYYWVAKDV 1390 1400 1410 1420 1430 1440 QVQIITTEAL YGYEYLGNSP RLVITPLTDR CYRTLMGALK LNLGGAPEGP AGTGKTETTK 1450 1460 1470 1480 1490 1500 DLAKALAKQC VVFNCSDGLD YKAMGKFFKG LAQAGAWACF DEFNRIEVEV LSVVAQQILS 1510 1520 1530 1540 1550 1560 IQQAIIRKLK TFIFEGTELS LNPTCAVFIT MNPGYAGRAE LPDNLKALFR TVAMMVPDYA 1570 1580 1590 1600 1610 1620 LIGEISLYSM GFLDSRSLAQ KIVATYRLCS EQLSSQHHYD YGMRAVKSVL TAAGNLKLKY 1630 1640 1650 1660 1670 1680 PEENESVLLL RALLDVNLAK FLAQDVPLFQ GIISDLFPGV VLPKPDYEVF LKVLNDNIKK 1690 1700 1710 1720 1730 1740 MKLQPVPWFI GKIIQIYEMM LVRHGYMIVG DPMGGKTSAY KVLAAALGDL HAANQMEEFA 1750 1760 1770 1780 1790 1800 VEYKIINPKA ITMGQLYGCF DQVSHEWMDG VLANAFREQA SSLSDDRKWI IFDGPVDAIW 1810 1820 1830 1840 1850 1860 IENMNTVLDD NKKLCLMSGE IIQMNSKMSL IFEPADLEQA SPATVSRCGM IYMEPHQLGW 1870 1880 1890 1900 1910 1920 KPLKDSYMDT LPSSLTKEHK ELVNDMFMWL VQPCLEFGRL HCKFVVQTSP IHLAFSMMRL 1930 1940 1950 1960 1970 1980 YSSLLDEIRA VEEEEMELGE GLSSQQIFLW LQGLFLFSLV WTVAGTINAD SRKKFDVFFR 1990 2000 2010 2020 2030 2040 NLIMGMDDNH PRPKSVKLTK NNIFPERGSI YDFYFIKQAS GHWETWTQYI TKEEEKVPAG 2050 2060 2070 2080 2090 2100 AKVSELIIPT METARQSFFL KTYLDHEIPM LFVGPTGTGK SAITNNFLLH LPKNTYLPNC 2110 2120 2130 2140 2150 2160 INFSARTSAN QTQDIIMSKL DRRRKGLFGP PIGKKAVVFV DDLNMPAKEV YGAQPPIELL 2170 2180 2190 2200 2210 2220 RQWIDHGYWF DKKDTTRLDI VDMLLVTAMG PPGGGRNDIT GRFTRHLNII SINAFEDDIL 2230 2240 2250 2260 2270 2280 TKIFSSIVDW HFGKGFDVMF LRYGKMLVQA TKTIYRDAVE NFLPTPSKSH YVFNLRDFSR 2290 2300 2310 2320 2330 2340 VIQGVLLCPH THLQDVEKCI RLWIHEVYRV FYDRLIDKED RQVFFNMVKE TTSNCFKQTI 2350 2360 2370 2380 2390 2400 EKVLIHLSPT GKIVDDNIRS LFFGDYFKPE SDQKIYDEIT DLKQLTVVME HYLEEFNNIS 2410 2420 2430 2440 2450 2460 KAPMSLVMFR FAIEHISRIC RVLKQDKGHL LLVGIGGSGR QSAAKLSTFM NAYELYQIEI 2470 2480 2490 2500 2510 2520 TKNYAGNDWR EDLKKIILQV GVATKSTVFL FADNQIKDES FVEDINMLLN TGDVPNIFPA 2530 2540 2550 2560 2570 2580 DEKADIVEKM QTAARTQGEK VEVTPLSMYN FFIERVINKI SFSLAMSPIG DAFRNRLRMF 2590 2600 2610 2620 2630 2640 PSLINCCTID WFQSWPTDAL ELVANKFLED VELDDNIRVE VVSMCKYFQE SVKKLSLDYY 2650 2660 2670 2680 2690 2700 NKLRRHNYVT PTSYLELILT FKTLLNSKRQ EVAMMRNRYL TGLQKLDFAA SQVAVMQREL 2710 2720 2730 2740 2750 2760 TALQPQLILT SEETAKMMVK IEAETREADG KKLLVQADEK EANVAAAIAQ GIKNECEGDL 2770 2780 2790 2800 2810 2820 AEAMPALEAA LAALDTLNPA DISLVKSMQN PPGPVKLVME SICIMKGMKP ERKPDPSGSG 2830 2840 2850 2860 2870 2880 KMIEDYWGVS KKILGDLKFL ESLKTYDKDN IPPLTMKRIR ERFINHPEFQ PAVIKNVSSA 2890 2900 2910 2920 2930 2940 CEGLCKWVRA MEVYDRVAKV VAPKRERLRE AEGKLAAQMQ KLNQKRAELK LVVDRLQALN 2950 2960 2970 2980 2990 3000 DDFEEMNTKK KDLEENIEIC SQKLVRAEKL ISGLGGEKDR WTEAARQLGI RYTNLTGDVL 3010 3020 3030 3040 3050 3060 LSSGTVAYLG AFTVDYRVQC QNQWLAECKD KVIPGFSDFS LSHTLGDPIK IRAWQIAGLP 3070 3080 3090 3100 3110 3120 VDSFSIDNGI IVSNSRRWAL MIDPHGQANK WIKNMEKANK LAVIKFSDSN YMRMLENALQ 3130 3140 3150 3160 3170 3180 LGTPVLIENI GEELDASIEP ILLKATFKQQ GVEYMRLGEN IIEYSRDFKL YITTRLRNPH 3190 3200 3210 3220 3230 3240 YLPEVAVKVC LLNFMITPLG LQDQLLGIVA AKEKPELEEK KNQLIVESAK NKKHLKEIED 3250 3260 3270 3280 3290 3300 KILEVLSMSK GNILEDETAI KVLSSSKVLS EEISEKQKVA SMTETQIDET RMGYKPVAVH 3310 3320 3330 3340 3350 3360 SATIFFCISD LANIEPMYQY SLTWFINLYM HSLTHSTKSE ELNLRIKYII DHFTLSIYNN 3370 3380 3390 3400 3410 3420 VCRSLFEKDK LLFSLLLTIG IMKQKKEITE EVWYFLLTGG IALDNPYPNP APQWLSEKAW 3430 3440 3450 3460 3470 3480 AEIVRASALP KLHGLMEHLE QNLGEWKLIY DSAWPHEEQL PGSWKFSQGL EKMVILRCLR 3490 3500 3510 3520 3530 3540 PDKMVPAVRE FIAEHMGKLY IEAPTFDLQG SYNDSSCCAP LIFVLSPSAD PMAGLLKFAD 3550 3560 3570 3580 3590 3600 DLGMGGTRTQ TISLGQGQGP IAAKMINNAI KDGTWVVLQN CHLAASWMPT LEKICEEVIV 3610 3620 3630 3640 3650 3660 PESTNARFRL WLTSYPSEKF PVSILQNGIK MTNEPPKGLR ANLLRSYLND PISDPVFFQS 3670 3680 3690 3700 3710 3720 CAKAVMWQKM LFGLCFFHAV VQERRNFGPL GWNIPYEFNE SDLRISMWQI QMFLNDYKEV 3730 3740 3750 3760 3770 3780 PFDALTYLTG ECNYGGRVTD DKDRRLLLSL LSMFYCKEIE EDYYSLAPGD TYYIPPHGSY 3790 3800 3810 3820 3830 3840 QSYIDYLRNL PITAHPEVFG LHENADITKD NQETNQLFEG VLLTLPRQSG GSGKSPQEVV 3850 3860 3870 3880 3890 3900 EELAQDILSK LPRDFDLEEV MKLYPVVYEE SMNTVLRQEL IRFNRLTKVV RRSLINLGRA 3910 3920 3930 3940 3950 3960 IKGQVLMSSE LEEVFNSMLV GKVPAMWAAK SYPSLKPLGG YVADLLARLT FFQEWIDKGP 3970 3980 3990 4000 4010 4020 PVVFWISGFY FTQSFLTGVS QNYARKYTIP IDHIGFEFEV TPQETVMENN PEDGAYIKGL 4030 4040 4050 4060 4070 4080 FLEGARWDRK TMQIGESLPK ILYDPLPIIW LKPGESAMFL HQDIYVCPVY KTSARRGTLS 4090 4100 4110 TTGHSTNYVL SIELPTDMPQ KHWINRGVAS LCQLDN
	Isoform 2 [UniParc]. Checksum: 0BDED2AED898AD0C	FASTA	753	87,501
	10 20 30 40 50 60 MGDMDCSSQK IAKSDSIHHM SHSQGQPELP PLPASANEEP SGLYQTVMSH SFYPPLMQRT 70 80 90 100 110 120 SWTLAAPFKE QHHHRGPSDS IANNYSLMAQ DLKLKDLLKV YQPATISVPR DRTGQGLPSS 130 140 150 160 170 180 GNRSSSEPMR KKTKFSSRNK EDSTRIKLAF KTSIFSPMKK EVKTSLTFPG SRPMSPEQQL 190 200 210 220 230 240 DVMLQQEMEM ESKEKKPSES DLERYYYYLT NGIRKDMIAP EEGEVMVRIS KLISNTLLTS 250 260 270 280 290 300 PFLEPLMVVL VQEKENDYYC SLMKSIVDYI LMDPMERKRL FIESIPRLFP QRVIRAPVPW 310 320 330 340 350 360 HSVYRSAKKW NEEHLHTVNP MMLRLKELWF AEFRDLRFVR TAEILAGKLP LQPQEFWDVI 370 380 390 400 410 420 QKHCLEAHQT LLNKWIPTCA QLFTSRKEHW IHFAPKSNYD SSRNIEEYFA SVASFMSLQL 430 440 450 460 470 480 RELVIKSLED LVSLFMIHKD GNDFKEPYQE MKFFIPQLIM IKLEVSEPII VFNPSFDGCW 490 500 510 520 530 540 ELIRDSFLEI IKNSNGIPKV ESVLFPELKG YNLLLGTVNA EEKLVSDFLI QTFKVFQKNQ 550 560 570 580 590 600 VGPCKYLNVY KKYVDLLDNT AEQNIAAFLK ENHDIDDFVT KINAIKKRRN EIASMNITVP 610 620 630 640 650 660 LAMFCLDATA LNHDLCERAQ NLKDHLIQFQ VDVNRDTNTS ICNQYSHIAD KVSEVPANTK 670 680 690 700 710 720 ELVSLIEFLK KSSAVTVFKL RRQLRDASER LEFLMDYADL PYEDIKLNST LFLWPDQIED 730 740 750 IFDNSRNLLL HKRDQAEMDL IKRYRESLGL SWK
	Isoform 3 [UniParc]. Checksum: DC3B4B00F469AD22	FASTA	1,887	216,078
	10 20 30 40 50 60 MGATGRLELT LAAPPHPGPA FQRSKARETQ GEEEGSEMQI AKSDSIHHMS HSQGQPELPP 70 80 90 100 110 120 LPASANEEPS GLYQTVMSHS FYPPLMQRTS WTLAAPFKEQ HHHRGPSDSI ANNYSLMAQD 130 140 150 160 170 180 LKLKDLLKVY QPATISVPRD RTGQGLPSSG NRSSSEPMRK KTKFSSRNKE DSTRIKLAFK 190 200 210 220 230 240 TSIFSPMKKE VKTSLTFPGS RPMSPEQQLD VMLQQEMEME SKEKKPSESD LERYYYYLTN 250 260 270 280 290 300 GIRKDMIAPE EGEVMVRISK LISNTLLTSP FLEPLMVVLV QEKENDYYCS LMKSIVDYIL 310 320 330 340 350 360 MDPMERKRLF IESIPRLFPQ RVIRAPVPWH SVYRSAKKWN EEHLHTVNPM MLRLKELWFA 370 380 390 400 410 420 EFRDLRFVRT AEILAGKLPL QPQEFWDVIQ KHCLEAHQTL LNKWIPTCAQ LFTSRKEHWI 430 440 450 460 470 480 HFAPKSNYDS SRNIEEYFAS VASFMSLQLR ELVIKSLEDL VSLFMIHKDG NDFKEPYQEM 490 500 510 520 530 540 KFFIPQLIMI KLEVSEPIIV FNPSFDGCWE LIRDSFLEII KNSNGIPKLK YIPLKFSFTA 550 560 570 580 590 600 AAADRQCVKA AEPGEPSMHA AATAMAELKG YNLLLGTVNA EEKLVSDFLI QTFKVFQKNQ 610 620 630 640 650 660 VGPCKYLNVY KKYVDLLDNT AEQNIAAFLK ENHDIDDFVT KINAIKKRRN EIASMNITVP 670 680 690 700 710 720 LAMFCLDATA LNHDLCERAQ NLKDHLIQFQ VDVNRDTNTS ICNQYSHIAD KVSEVPANTK 730 740 750 760 770 780 ELVSLIEFLK KSSAVTVFKL RRQLRDASER LEFLMDYADL PYQIEDIFDN SRNLLLHKRD 790 800 810 820 830 840 QAEMDLIKRC SEFELRLEGY HRELESFRKR EVMTTEEMKH NVEKLNELSK NLNRAFAEFE 850 860 870 880 890 900 LINKEEELLE KEKSTYPLLQ AMLKNKVPYE QLWSTAYEFS IKSEEWMNGP LFLLNAEQIA 910 920 930 940 950 960 EEIGNMWRTT YKLIKTLSDV PAPRRLAENV KIKIDKFKQY IPILSISCNP GMKDRHWQQI 970 980 990 1000 1010 1020 SEIVGYEIKP TETTCLSNML EFGFGKFVEK LEPIGAAASK EYSLEKNLDR MKLDWVNVTF 1030 1040 1050 1060 1070 1080 SFVKYRDTDT NILCAIDDIQ MLLDDHVIKT QTMCGSPFIK PIEAECRKWE EKLIRIQDNL 1090 1100 1110 1120 1130 1140 DAWLKCQATW LYLEPIFSSE DIIAQMPEEG RKFGIVDSYW KSLMSQAVKD NRILVAADQP 1150 1160 1170 1180 1190 1200 RMAEKLQEAN FLLEDIQKGL NDYLEKKRLF FPRFFFLSND ELLEILSETK DPLRVQPHLK 1210 1220 1230 1240 1250 1260 KCFEGIAKLE FTDNLEIVGM ISSEKETVPF IQKIYPANAK GMVEKWLQQV EQMMLASMRE 1270 1280 1290 1300 1310 1320 VIGLGIEAYV KVPRNHWVLQ WPGQVVICVS SIFWTQEVSQ ALAENTLLDF LKKSNDQIAQ 1330 1340 1350 1360 1370 1380 IVQLVRGKLS SGARLTLGAL TVIDVHARDV VAKLSEDRVS DLNDFQWISQ LRYYWVAKDV 1390 1400 1410 1420 1430 1440 QVQIITTEAL YGYEYLGNSP RLVITPLTDR CYRTLMGALK LNLGGAPEGP AGTGKTETTK 1450 1460 1470 1480 1490 1500 DLAKALAKQC VVFNCSDGLD YKAMGKFFKG LAQAGAWACF DEFNRIEVEV LSVVAQQILS 1510 1520 1530 1540 1550 1560 IQQAIIRKLK TFIFEGTELS LNPTCAVFIT MNPGYAGRAE LPDNLKALFR TVAMMVPDYA 1570 1580 1590 1600 1610 1620 LIGEISLYSM GFLDSRSLAQ KIVATYRLCS EQLSSQHHYD YGMRAVKSVL TAAGNLKLKY 1630 1640 1650 1660 1670 1680 PEENESVLLL RALLDVNLAK FLAQDVPLFQ GIISDLFPGV VLPKPDYEVF LKVLNDNIKK 1690 1700 1710 1720 1730 1740 MKLQPVPWFI GKIIQIYEMM LVRHGYMIVG DPMGGKTSAY KVLAAALGDL HAANQMEEFA 1750 1760 1770 1780 1790 1800 VEYKIINPKA ITMGQLYGCF DQVSHEWMDG VLANAFREQA SSLSDDRKWI IFDGPVDAIW 1810 1820 1830 1840 1850 1860 IENMNTVLDD NKKLCLMSGE IIQMNSKMSL IFEPADLEQA SPATVSRCGM IYMEPHQLGW 1870 1880 KPLKDSYMDT LPSSLTKEHK ELMKSGQ

References

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[1]	"DNAH3: characterization of the full length gene and mutation search in patients with primary ciliary dyskinesia." Blouin J.-L., Gehrig C., Jeganathan D., Bartoloni L., Rossier C., Duriaux Sail G., Scamuffa N., Mitchison H.M., DeLozier Blanchet C.D., Antonarakis S.E. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Chromosomal localization of human dynein heavy chain genes." Maiti A.K., Mattei M.-G., Jorissen M., Volz A., Ziegler A., Bouvagnet P. Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1391-1533 (ISOFORM 1), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1435-1449. Tissue: Nasal polyp.
[5]	"Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene." Neesen J., Koehler M.R., Kirschner R., Steinlein C., Kreutzberger J., Engel W., Schmid M. Gene 200:193-202(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1429-1605 (ISOFORM 1). Tissue: Testis.
[6]	"Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment." Chapelin C., Duriez B., Magnino F., Goossens M., Escudier E., Amselem S. FEBS Lett. 412:325-330(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1429-1478, TISSUE SPECIFICITY.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1574-4116 (ISOFORM 3). Tissue: Ovary.
[8]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3152-4116 (ISOFORM 1). Tissue: Testis.
[9]	"Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q." Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., Fuhrmann J., Mason T., Crosby M.L., Barnstead M., Cronin L., Mays A.D., Cao Y., Xu R.X., Kang H.-L., Mitchell S., Eichler E.E., Harris P.C., Venter J.C., Adams M.D. Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 3544-4116.
[10]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-484 AND PHE-1608.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF494040 mRNA. Translation: AAM12861.1. AK056509 mRNA. Translation: BAE46616.1. CH471228 Genomic DNA. Translation: EAW66851.1. AJ132085 mRNA. Translation: CAA10558.1. AJ132092 Genomic DNA. Translation: CAA10565.1. Z83805 mRNA. Translation: CAB06059.1. U83574 Genomic DNA. Translation: AAB82763.1. BC019878 mRNA. Translation: AAH19878.1. AL096732 mRNA. Translation: CAB46377.1. AC002394 Genomic DNA. Translation: AAC05809.1.
IPI	IPI00152462. IPI00743808. IPI00885160.
PIR	T12545.
RefSeq	NP_060009.1. NM_017539.1.
UniGene	Hs.526500.
3D structure databases
ProteinModelPortal	Q8TD57.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TD57. 1 interaction.
PTM databases
PhosphoSite	Q8TD57.
Polymorphism databases
DMDM	74762616.
Proteomic databases
PaxDb	Q8TD57.
PRIDE	Q8TD57.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000261383; ENSP00000261383; ENSG00000158486. ENST00000415178; ENSP00000394245; ENSG00000158486.
GeneID	55567.
KEGG	hsa:55567.
UCSC	uc002die.2. human. uc010vbe.2. human.
Organism-specific databases
CTD	55567.
GeneCards	GC16M020944.
HGNC	HGNC:2949. DNAH3.
MIM	603334. gene.
neXtProt	NX_Q8TD57.
PharmGKB	PA27402.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5245.
HOVERGEN	HBG107830.
InParanoid	Q8TD57.
KO	K10408.
OMA	SEEWMNG.
OrthoDB	EOG4K6G38.
PhylomeDB	Q8TD57.
Gene expression databases
Bgee	Q8TD57.
Genevestigator	Q8TD57.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR026983. DHC_fam. IPR026977. DNAH3. IPR024743. Dynein_HC_stalk. IPR024317. Dynein_heavy_chain_D4_dom. IPR004273. Dynein_heavy_dom. IPR013602. Dynein_heavy_dom-2. [Graphical view]
PANTHER	PTHR10676. PTHR10676. 1 hit. PTHR10676:SF21. PTHR10676:SF21. 1 hit.
Pfam	PF12780. AAA_8. 1 hit. PF08393. DHC_N2. 1 hit. PF03028. Dynein_heavy. 1 hit. PF12777. MT. 1 hit. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	55567.
NextBio	60052.
SOURCE	Search...

Entry information

Entry name

DYH3_HUMAN

Accession

Primary (citable) accession number: Q8TD57
Secondary accession number(s): O00437 , O15437, O43326, Q3C0H2, Q8WUP9, Q9UEM3, Q9UEM5, Q9UG35

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.