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Protein

Pleckstrin homology domain-containing family O member 2

Gene

PLEKHO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family O member 2
Short name:
PH domain-containing family O member 2
Alternative name(s):
Pleckstrin homology domain-containing family Q member 1
Short name:
PH domain-containing family Q member 1
Gene namesi
Name:PLEKHO2
Synonyms:PLEKHQ1
ORF Names:PP9099
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000241839.9
HGNCiHGNC:30026 PLEKHO2
neXtProtiNX_Q8TD55

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000241839
PharmGKBiPA162399756

Polymorphism and mutation databases

BioMutaiPLEKHO2
DMDMi74739384

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003094831 – 490Pleckstrin homology domain-containing family O member 2Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei164PhosphoserineCombined sources1
Modified residuei167PhosphoserineCombined sources1
Modified residuei232PhosphothreonineBy similarity1
Modified residuei235PhosphoserineBy similarity1
Modified residuei237PhosphoserineBy similarity1
Modified residuei238PhosphoserineBy similarity1
Modified residuei273PhosphoserineCombined sources1
Modified residuei298PhosphothreonineBy similarity1
Modified residuei311PhosphothreonineCombined sources1
Modified residuei390PhosphoserineCombined sources1
Modified residuei468PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TD55
MaxQBiQ8TD55
PaxDbiQ8TD55
PeptideAtlasiQ8TD55
PRIDEiQ8TD55

PTM databases

CarbonylDBiQ8TD55
iPTMnetiQ8TD55
PhosphoSitePlusiQ8TD55

Expressioni

Gene expression databases

BgeeiENSG00000241839
CleanExiHS_PLEKHO2
GenevisibleiQ8TD55 HS

Organism-specific databases

HPAiHPA040055

Interactioni

Protein-protein interaction databases

BioGridi123215, 21 interactors
IntActiQ8TD55, 2 interactors
STRINGi9606.ENSP00000326706

Structurei

3D structure databases

ProteinModelPortaliQ8TD55
SMRiQ8TD55
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 119PHPROSITE-ProRule annotationAdd BLAST102

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili439 – 481Sequence analysisAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi178 – 386Pro-richAdd BLAST209

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIX5 Eukaryota
ENOG4111P17 LUCA
GeneTreeiENSGT00530000063760
HOGENOMiHOG000115564
HOVERGENiHBG096634
InParanoidiQ8TD55
OMAiQAPCSET
OrthoDBiEOG091G042X
PhylomeDBiQ8TD55
TreeFamiTF333115

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TD55-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEEGVKEAG EKPRGAQMVD KAGWIKKSSG GLLGFWKDRY LLLCQAQLLV
60 70 80 90 100
YENEDDQKCV ETVELGSYEK CQDLRALLKR KHRFILLRSP GNKVSDIKFQ
110 120 130 140 150
APTGEEKESW IKALNEGINR GKNKAFDEVK VDKSCALEHV TRDRVRGGQR
160 170 180 190 200
RRPPTRVHLK EVASAASDGL LRLDLDVPDS GPPVFAPSNH VSEAQPRETP
210 220 230 240 250
RPLMPPTKPF LAPETTSPGD RVETPVGERA PTPVSASSEV SPESQEDSET
260 270 280 290 300
PAEEDSGSEQ PPNSVLPDKL KVSWENPSPQ EAPAAESAEP SQAPCSETSE
310 320 330 340 350
AAPREGGKPP TPPPKILSEK LKASMGEMQA SGPPAPGTVQ VSVNGMDDSP
360 370 380 390 400
EPAKPSQAEG TPGTPPKDAT TSTALPPWDL PPQFHPRCSS LGDLLGEGPR
410 420 430 440 450
HPLQPRERLY RAQLEVKVAS EQTEKLLNKV LGSEPAPVSA ETLLSQAVEQ
460 470 480 490
LRQATQVLQE MRDLGELSQE APGLREKRKE LVTLYRRSAP
Length:490
Mass (Da):53,350
Last modified:June 1, 2002 - v1
Checksum:i02099F6ECAFA8BF3
GO
Isoform 2 (identifier: Q8TD55-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     4-53: Missing.

Note: No experimental confirmation available.
Show »
Length:440
Mass (Da):47,785
Checksum:iB5E567A9A0F70E37
GO

Sequence cautioni

The sequence AAL55880 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036964290P → S1 PublicationCorresponds to variant dbSNP:rs2010875Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0292124 – 53Missing in isoform 2. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494534 mRNA Translation: AAM18053.1
AC069368 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77697.1
CH471082 Genomic DNA Translation: EAW77699.1
BC008744 mRNA Translation: AAH08744.2
AF318373 mRNA Translation: AAL55880.1 Different initiation.
CCDSiCCDS10196.1 [Q8TD55-1]
CCDS73739.1 [Q8TD55-2]
RefSeqiNP_001181988.1, NM_001195059.1 [Q8TD55-2]
NP_079477.2, NM_025201.4 [Q8TD55-1]
UniGeneiHs.709337

Genome annotation databases

EnsembliENST00000323544; ENSP00000326706; ENSG00000241839 [Q8TD55-1]
ENST00000616065; ENSP00000483505; ENSG00000241839 [Q8TD55-2]
GeneIDi80301
KEGGihsa:80301
UCSCiuc002anv.4 human [Q8TD55-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPKHO2_HUMAN
AccessioniPrimary (citable) accession number: Q8TD55
Secondary accession number(s): Q7L4H4, Q8WYS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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