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Protein

Pleckstrin homology domain-containing family O member 2

Gene

PLEKHO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family O member 2
Short name:
PH domain-containing family O member 2
Alternative name(s):
Pleckstrin homology domain-containing family Q member 1
Short name:
PH domain-containing family Q member 1
Gene namesi
Name:PLEKHO2
Synonyms:PLEKHQ1
ORF Names:PP9099
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:30026. PLEKHO2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162399756.

Polymorphism and mutation databases

BioMutaiPLEKHO2.
DMDMi74739384.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Pleckstrin homology domain-containing family O member 2PRO_0000309483Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei164 – 1641PhosphoserineCombined sources
Modified residuei167 – 1671PhosphoserineCombined sources
Modified residuei232 – 2321PhosphothreonineBy similarity
Modified residuei235 – 2351PhosphoserineBy similarity
Modified residuei237 – 2371PhosphoserineBy similarity
Modified residuei238 – 2381PhosphoserineBy similarity
Modified residuei273 – 2731PhosphoserineCombined sources
Modified residuei298 – 2981PhosphothreonineBy similarity
Modified residuei311 – 3111PhosphothreonineCombined sources
Modified residuei390 – 3901PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TD55.
MaxQBiQ8TD55.
PaxDbiQ8TD55.
PRIDEiQ8TD55.

PTM databases

iPTMnetiQ8TD55.
PhosphoSiteiQ8TD55.

Expressioni

Gene expression databases

BgeeiQ8TD55.
CleanExiHS_PLEKHO2.
GenevisibleiQ8TD55. HS.

Organism-specific databases

HPAiHPA040055.

Interactioni

Protein-protein interaction databases

BioGridi123215. 20 interactions.
IntActiQ8TD55. 1 interaction.
STRINGi9606.ENSP00000326706.

Structurei

3D structure databases

ProteinModelPortaliQ8TD55.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 119102PHPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili439 – 48143Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi178 – 386209Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIX5. Eukaryota.
ENOG4111P17. LUCA.
GeneTreeiENSGT00530000063760.
HOGENOMiHOG000115564.
HOVERGENiHBG096634.
InParanoidiQ8TD55.
OMAiQAPCSET.
OrthoDBiEOG77HDDX.
PhylomeDBiQ8TD55.
TreeFamiTF333115.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TD55-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEEGVKEAG EKPRGAQMVD KAGWIKKSSG GLLGFWKDRY LLLCQAQLLV
60 70 80 90 100
YENEDDQKCV ETVELGSYEK CQDLRALLKR KHRFILLRSP GNKVSDIKFQ
110 120 130 140 150
APTGEEKESW IKALNEGINR GKNKAFDEVK VDKSCALEHV TRDRVRGGQR
160 170 180 190 200
RRPPTRVHLK EVASAASDGL LRLDLDVPDS GPPVFAPSNH VSEAQPRETP
210 220 230 240 250
RPLMPPTKPF LAPETTSPGD RVETPVGERA PTPVSASSEV SPESQEDSET
260 270 280 290 300
PAEEDSGSEQ PPNSVLPDKL KVSWENPSPQ EAPAAESAEP SQAPCSETSE
310 320 330 340 350
AAPREGGKPP TPPPKILSEK LKASMGEMQA SGPPAPGTVQ VSVNGMDDSP
360 370 380 390 400
EPAKPSQAEG TPGTPPKDAT TSTALPPWDL PPQFHPRCSS LGDLLGEGPR
410 420 430 440 450
HPLQPRERLY RAQLEVKVAS EQTEKLLNKV LGSEPAPVSA ETLLSQAVEQ
460 470 480 490
LRQATQVLQE MRDLGELSQE APGLREKRKE LVTLYRRSAP
Length:490
Mass (Da):53,350
Last modified:June 1, 2002 - v1
Checksum:i02099F6ECAFA8BF3
GO
Isoform 2 (identifier: Q8TD55-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     4-53: Missing.

Note: No experimental confirmation available.
Show »
Length:440
Mass (Da):47,785
Checksum:iB5E567A9A0F70E37
GO

Sequence cautioni

The sequence AAL55880.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti290 – 2901P → S.1 Publication
Corresponds to variant rs2010875 [ dbSNP | Ensembl ].
VAR_036964

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei4 – 5350Missing in isoform 2. 1 PublicationVSP_029212Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494534 mRNA. Translation: AAM18053.1.
AC069368 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77697.1.
CH471082 Genomic DNA. Translation: EAW77699.1.
BC008744 mRNA. Translation: AAH08744.2.
AF318373 mRNA. Translation: AAL55880.1. Different initiation.
CCDSiCCDS10196.1. [Q8TD55-1]
CCDS73739.1. [Q8TD55-2]
RefSeqiNP_001181988.1. NM_001195059.1. [Q8TD55-2]
NP_079477.2. NM_025201.4. [Q8TD55-1]
UniGeneiHs.709337.

Genome annotation databases

EnsembliENST00000323544; ENSP00000326706; ENSG00000241839. [Q8TD55-1]
ENST00000616065; ENSP00000483505; ENSG00000241839. [Q8TD55-2]
GeneIDi80301.
KEGGihsa:80301.
UCSCiuc002anv.4. human. [Q8TD55-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494534 mRNA. Translation: AAM18053.1.
AC069368 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77697.1.
CH471082 Genomic DNA. Translation: EAW77699.1.
BC008744 mRNA. Translation: AAH08744.2.
AF318373 mRNA. Translation: AAL55880.1. Different initiation.
CCDSiCCDS10196.1. [Q8TD55-1]
CCDS73739.1. [Q8TD55-2]
RefSeqiNP_001181988.1. NM_001195059.1. [Q8TD55-2]
NP_079477.2. NM_025201.4. [Q8TD55-1]
UniGeneiHs.709337.

3D structure databases

ProteinModelPortaliQ8TD55.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123215. 20 interactions.
IntActiQ8TD55. 1 interaction.
STRINGi9606.ENSP00000326706.

PTM databases

iPTMnetiQ8TD55.
PhosphoSiteiQ8TD55.

Polymorphism and mutation databases

BioMutaiPLEKHO2.
DMDMi74739384.

Proteomic databases

EPDiQ8TD55.
MaxQBiQ8TD55.
PaxDbiQ8TD55.
PRIDEiQ8TD55.

Protocols and materials databases

DNASUi80301.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323544; ENSP00000326706; ENSG00000241839. [Q8TD55-1]
ENST00000616065; ENSP00000483505; ENSG00000241839. [Q8TD55-2]
GeneIDi80301.
KEGGihsa:80301.
UCSCiuc002anv.4. human. [Q8TD55-1]

Organism-specific databases

CTDi80301.
GeneCardsiPLEKHO2.
HGNCiHGNC:30026. PLEKHO2.
HPAiHPA040055.
neXtProtiNX_Q8TD55.
PharmGKBiPA162399756.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIX5. Eukaryota.
ENOG4111P17. LUCA.
GeneTreeiENSGT00530000063760.
HOGENOMiHOG000115564.
HOVERGENiHBG096634.
InParanoidiQ8TD55.
OMAiQAPCSET.
OrthoDBiEOG77HDDX.
PhylomeDBiQ8TD55.
TreeFamiTF333115.

Miscellaneous databases

GenomeRNAii80301.
NextBioi70760.
PROiQ8TD55.

Gene expression databases

BgeeiQ8TD55.
CleanExiHS_PLEKHO2.
GenevisibleiQ8TD55. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Li N., Wan T., Zhang W., Cao X.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Skin.
  5. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 204-490, VARIANT SER-290.
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164; SER-167; SER-273; THR-311 AND SER-390, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPKHO2_HUMAN
AccessioniPrimary (citable) accession number: Q8TD55
Secondary accession number(s): Q7L4H4, Q8WYS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 1, 2002
Last modified: March 16, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.