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Protein

40S ribosomal protein S4, Y isoform 2

Gene

RPS4Y2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-9010553. Regulation of expression of SLITs and ROBOs.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S4, Y isoform 2
Alternative name(s):
Small ribosomal subunit protein eS41 Publication
Gene namesi
Name:RPS4Y2
Synonyms:RPS4Y2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome Y

Organism-specific databases

EuPathDBiHostDB:ENSG00000280969.1.
HGNCiHGNC:18501. RPS4Y2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

GeneReviewsiRPS4Y2.
OpenTargetsiENSG00000280969.
PharmGKBiPA38563.

Polymorphism and mutation databases

BioMutaiRPS4Y2.
DMDMi27805713.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001308181 – 26340S ribosomal protein S4, Y isoform 2Add BLAST263

Proteomic databases

EPDiQ8TD47.
MaxQBiQ8TD47.
PaxDbiQ8TD47.
PeptideAtlasiQ8TD47.
PRIDEiQ8TD47.
TopDownProteomicsiQ8TD47.

PTM databases

iPTMnetiQ8TD47.
PhosphoSitePlusiQ8TD47.
SwissPalmiQ8TD47.

Expressioni

Gene expression databases

BgeeiENSG00000280969.

Organism-specific databases

HPAiHPA000857.

Interactioni

Protein-protein interaction databases

BioGridi126595. 3 interactors.
STRINGi9606.ENSP00000288666.

Structurei

3D structure databases

ProteinModelPortaliQ8TD47.
SMRiQ8TD47.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 104S4 RNA-bindingAdd BLAST63

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0378. Eukaryota.
COG1471. LUCA.
GeneTreeiENSGT00390000005569.
HOGENOMiHOG000231325.
HOVERGENiHBG000935.
InParanoidiQ8TD47.
KOiK02987.
OMAiERHPGSC.
OrthoDBiEOG091G0MYF.
PhylomeDBiQ8TD47.
TreeFamiTF300612.

Family and domain databases

Gene3Di3.10.290.10. 2 hits.
HAMAPiMF_00485. Ribosomal_S4e. 1 hit.
InterProiView protein in InterPro
IPR032277. 40S_S4_C.
IPR005824. KOW.
IPR000876. Ribosomal_S4e.
IPR013845. Ribosomal_S4e_central_region.
IPR013843. Ribosomal_S4e_N.
IPR018199. Ribosomal_S4e_N_CS.
IPR002942. S4_RNA-bd.
IPR036986. S4_RNA-bd_sf.
PANTHERiPTHR11581. PTHR11581. 1 hit.
PfamiView protein in Pfam
PF16121. 40S_S4_C. 1 hit.
PF00467. KOW. 1 hit.
PF00900. Ribosomal_S4e. 1 hit.
PF08071. RS4NT. 1 hit.
PIRSFiPIRSF002116. Ribosomal_S4. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002667. Ribosomal_S4e_central. 1 hit.
PROSITEiView protein in PROSITE
PS00528. RIBOSOMAL_S4E. 1 hit.
PS50889. S4. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TD47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIVFLRN
60 70 80 90 100
RLKYALTGDE VKKICMQHFL KIDGKVRVDI TYPAGFIDVI SIEKTGEHFR
110 120 130 140 150
LVYNTKGCFA VHRITVEEAK YKLCKVRKIT VGTKGIPHLV THDARTIRYP
160 170 180 190 200
DPLIKVNDTV QIDLGTGKIT SFIKFDTGNV CMVIAGANLG RVGVITNRER
210 220 230 240 250
HPGSCDVVHV KDANGNSFAT RISNIFVIGN GNKPWISLPR GKGIRLTIAE
260
ERDKRLAAKQ SSG
Length:263
Mass (Da):29,295
Last modified:January 23, 2007 - v3
Checksum:i7044C5C97361E3D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009494 Genomic DNA. No translation available.
AF497481 mRNA. Translation: AAM18074.1.
CCDSiCCDS44028.1.
RefSeqiNP_001034656.1. NM_001039567.2.
UniGeneiHs.367761.

Genome annotation databases

EnsembliENST00000629237; ENSP00000486252; ENSG00000280969.
GeneIDi140032.
KEGGihsa:140032.
UCSCiuc011nbb.3. human.

Similar proteinsi

Entry informationi

Entry nameiRS4Y2_HUMAN
AccessioniPrimary (citable) accession number: Q8TD47
Secondary accession number(s): A6NIR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families