Q8TD47 (RS4Y2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
40S ribosomal protein S4, Y isoform 2

Gene names

Name:	RPS4Y2
Synonyms:	RPS4Y2P

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the ribosomal protein S4e family. Contains 1 S4 RNA-binding domain.

Ontologies

Keywords
Ligand	RNA-binding rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: InterPro
Cellular component	ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	rRNA binding Inferred from electronic annotation. Source: UniProtKB-KW structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 263	262	40S ribosomal protein S4, Y isoform 2		PRO_0000130818
Regions
	Domain	42 – 104	63	S4 RNA-binding
Amino acid modifications
	Modified residue	22	1	N6-acetyllysine Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q8TD47 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 7044C5C97361E3D0	FASTA	263	29,295
	10 20 30 40 50 60 MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIVFLRN RLKYALTGDE 70 80 90 100 110 120 VKKICMQHFL KIDGKVRVDI TYPAGFIDVI SIEKTGEHFR LVYNTKGCFA VHRITVEEAK 130 140 150 160 170 180 YKLCKVRKIT VGTKGIPHLV THDARTIRYP DPLIKVNDTV QIDLGTGKIT SFIKFDTGNV 190 200 210 220 230 240 CMVIAGANLG RVGVITNRER HPGSCDVVHV KDANGNSFAT RISNIFVIGN GNKPWISLPR 250 260 GKGIRLTIAE ERDKRLAAKQ SSG

References

[1]

"The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes." Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A. , Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H., Wilson R.K., Rozen S., Page D.C. Nature 423:825-837(2003) [PubMed: 12815422] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA / MRNA].

[2]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-22, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC009494 Genomic DNA. No translation available. AF497481 mRNA. Translation: AAM18074.1.
IPI	IPI00219894.
RefSeq	NP_001034656.1. NM_001039567.2.
UniGene	Hs.367761.
3D structure databases
ProteinModelPortal	Q8TD47.
SMR	Q8TD47. Positions 43-242.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8TD47.
PTM databases
PhosphoSite	Q8TD47.
Polymorphism databases
DMDM	27805713.
Proteomic databases
PRIDE	Q8TD47.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000288666; ENSP00000288666; ENSG00000157828.
GeneID	140032.
KEGG	hsa:140032.
NMPDR	fig|9606.3.peg.33816.
UCSC	uc004fum.1. human.
Organism-specific databases
CTD	140032.
GeneCards	GC0YP022917.
HGNC	HGNC:18501. RPS4Y2.
HPA	HPA000857.
MIM	400030. gene.
neXtProt	NX_Q8TD47.
PharmGKB	PA38563.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG13250.
GeneTree	ENSGT00390000005569.
HOGENOM	HBG392118.
HOVERGEN	HBG000935.
InParanoid	Q8TD47.
OMA	NSFATRI.
OrthoDB	EOG4FFD3Q.
PhylomeDB	Q8TD47.
Gene expression databases
Genevestigator	Q8TD47.
Family and domain databases
InterPro	IPR005824. KOW. IPR000876. Ribosomal_S4e. IPR013845. Ribosomal_S4e_central. IPR013843. Ribosomal_S4e_N. IPR018199. Ribosomal_S4e_N_CS. IPR002942. S4_RNA-bd. [Graphical view]
PANTHER	PTHR11581. Ribosomal_S4E. 1 hit.
Pfam	PF00467. KOW. 1 hit. PF00900. Ribosomal_S4e. 1 hit. PF08071. RS4NT. 1 hit. [Graphical view]
PIRSF	PIRSF002116. Ribosomal_S4. 1 hit.
ProDom	PD002667. Ribosomal_S4e_central. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00739. KOW. 1 hit. SM00363. S4. 1 hit. [Graphical view]
PROSITE	PS00528. RIBOSOMAL_S4E. 1 hit. PS50889. S4. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	84063.
SOURCE	Search...

Entry information

Entry name

RS4Y2_HUMAN

Accession

Primary (citable) accession number: Q8TD47
Secondary accession number(s): A6NIR6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 17, 2003
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 75 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.