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Protein

40S ribosomal protein S4, Y isoform 2

Gene

RPS4Y2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-KW
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S4, Y isoform 2
Gene namesi
Name:RPS4Y2
Synonyms:RPS4Y2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome Y

Organism-specific databases

HGNCiHGNC:18501. RPS4Y2.

Subcellular locationi

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38563.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 26326240S ribosomal protein S4, Y isoform 2PRO_0000130818Add
BLAST

Proteomic databases

MaxQBiQ8TD47.
PaxDbiQ8TD47.
PRIDEiQ8TD47.

PTM databases

PhosphoSiteiQ8TD47.

Expressioni

Gene expression databases

BgeeiQ8TD47.
GenevestigatoriQ8TD47.

Organism-specific databases

HPAiHPA000857.

Interactioni

Protein-protein interaction databases

BioGridi126595. 2 interactions.
STRINGi9606.ENSP00000288666.

Structurei

3D structure databases

ProteinModelPortaliQ8TD47.
SMRiQ8TD47. Positions 2-257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 10463S4 RNA-bindingAdd
BLAST

Sequence similaritiesi

Belongs to the ribosomal protein S4e family.Curated
Contains 1 S4 RNA-binding domain.Curated

Phylogenomic databases

eggNOGiCOG1471.
GeneTreeiENSGT00390000005569.
HOGENOMiHOG000231325.
HOVERGENiHBG000935.
InParanoidiQ8TD47.
OMAiERHPGSC.
OrthoDBiEOG77WWD1.
PhylomeDBiQ8TD47.
TreeFamiTF300612.

Family and domain databases

HAMAPiMF_00485. Ribosomal_S4e.
InterProiIPR005824. KOW.
IPR000876. Ribosomal_S4e.
IPR013845. Ribosomal_S4e_central_region.
IPR013843. Ribosomal_S4e_N.
IPR018199. Ribosomal_S4e_N_CS.
IPR002942. S4_RNA-bd.
[Graphical view]
PANTHERiPTHR11581. PTHR11581. 1 hit.
PfamiPF00467. KOW. 1 hit.
PF00900. Ribosomal_S4e. 1 hit.
PF08071. RS4NT. 1 hit.
[Graphical view]
PIRSFiPIRSF002116. Ribosomal_S4. 1 hit.
ProDomiPD002667. Ribosomal_S4e_central. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00739. KOW. 1 hit.
SM00363. S4. 1 hit.
[Graphical view]
PROSITEiPS00528. RIBOSOMAL_S4E. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TD47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIVFLRN
60 70 80 90 100
RLKYALTGDE VKKICMQHFL KIDGKVRVDI TYPAGFIDVI SIEKTGEHFR
110 120 130 140 150
LVYNTKGCFA VHRITVEEAK YKLCKVRKIT VGTKGIPHLV THDARTIRYP
160 170 180 190 200
DPLIKVNDTV QIDLGTGKIT SFIKFDTGNV CMVIAGANLG RVGVITNRER
210 220 230 240 250
HPGSCDVVHV KDANGNSFAT RISNIFVIGN GNKPWISLPR GKGIRLTIAE
260
ERDKRLAAKQ SSG
Length:263
Mass (Da):29,295
Last modified:January 23, 2007 - v3
Checksum:i7044C5C97361E3D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009494 Genomic DNA. No translation available.
AF497481 mRNA. Translation: AAM18074.1.
CCDSiCCDS44028.1.
RefSeqiNP_001034656.1. NM_001039567.2.
UniGeneiHs.367761.

Genome annotation databases

EnsembliENST00000624653; ENSP00000485299; ENSG00000279854.
ENST00000625126; ENSP00000485666; ENSG00000280146.
GeneIDi140032.
KEGGihsa:140032.
UCSCiuc011nbb.2. human.

Polymorphism databases

DMDMi27805713.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009494 Genomic DNA. No translation available.
AF497481 mRNA. Translation: AAM18074.1.
CCDSiCCDS44028.1.
RefSeqiNP_001034656.1. NM_001039567.2.
UniGeneiHs.367761.

3D structure databases

ProteinModelPortaliQ8TD47.
SMRiQ8TD47. Positions 2-257.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126595. 2 interactions.
STRINGi9606.ENSP00000288666.

PTM databases

PhosphoSiteiQ8TD47.

Polymorphism databases

DMDMi27805713.

Proteomic databases

MaxQBiQ8TD47.
PaxDbiQ8TD47.
PRIDEiQ8TD47.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000624653; ENSP00000485299; ENSG00000279854.
ENST00000625126; ENSP00000485666; ENSG00000280146.
GeneIDi140032.
KEGGihsa:140032.
UCSCiuc011nbb.2. human.

Organism-specific databases

CTDi140032.
GeneCardsiGC0YP022917.
GeneReviewsiRPS4Y2.
HGNCiHGNC:18501. RPS4Y2.
HPAiHPA000857.
MIMi400030. gene.
neXtProtiNX_Q8TD47.
PharmGKBiPA38563.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1471.
GeneTreeiENSGT00390000005569.
HOGENOMiHOG000231325.
HOVERGENiHBG000935.
InParanoidiQ8TD47.
OMAiERHPGSC.
OrthoDBiEOG77WWD1.
PhylomeDBiQ8TD47.
TreeFamiTF300612.

Miscellaneous databases

GenomeRNAii140032.
NextBioi84063.
PROiQ8TD47.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TD47.
GenevestigatoriQ8TD47.

Family and domain databases

HAMAPiMF_00485. Ribosomal_S4e.
InterProiIPR005824. KOW.
IPR000876. Ribosomal_S4e.
IPR013845. Ribosomal_S4e_central_region.
IPR013843. Ribosomal_S4e_N.
IPR018199. Ribosomal_S4e_N_CS.
IPR002942. S4_RNA-bd.
[Graphical view]
PANTHERiPTHR11581. PTHR11581. 1 hit.
PfamiPF00467. KOW. 1 hit.
PF00900. Ribosomal_S4e. 1 hit.
PF08071. RS4NT. 1 hit.
[Graphical view]
PIRSFiPIRSF002116. Ribosomal_S4. 1 hit.
ProDomiPD002667. Ribosomal_S4e_central. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00739. KOW. 1 hit.
SM00363. S4. 1 hit.
[Graphical view]
PROSITEiPS00528. RIBOSOMAL_S4E. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA / MRNA].

Entry informationi

Entry nameiRS4Y2_HUMAN
AccessioniPrimary (citable) accession number: Q8TD47
Secondary accession number(s): A6NIR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: January 23, 2007
Last modified: March 4, 2015
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.