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Reviewed, UniProtKB/Swiss-Prot Q8TD47 (RS4Y2_HUMAN)

Last modified November 24, 2009. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    40S ribosomal protein S4, Y isoform 2
Gene names
Name: RPS4Y2
Synonyms: RPS4Y2P
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Miscellaneous

This isoform is encoded on the Y chromosome.

Sequence similarities

Belongs to the ribosomal protein S4e family.

Contains 1 S4 RNA-binding domain.

Ontologies

Keywords
   LigandRNA-binding
rRNA-binding
   Molecular functionRibonucleoprotein
Ribosomal protein
   PTMAcetylation
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtranslation

Inferred from electronic annotation. Source: InterPro

   Cellular componentribosome

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionrRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

structural constituent of ribosome

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 26326240S ribosomal protein S4, Y isoform 2
PRO_0000130818

Regions

Domain42 – 10463S4 RNA-binding

Amino acid modifications

Modified residue221N6-acetyllysine Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8TD47-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 7044C5C97361E3D0

FASTA26329,295
        10         20         30         40         50         60 
MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIVFLRN RLKYALTGDE 

        70         80         90        100        110        120 
VKKICMQHFL KIDGKVRVDI TYPAGFIDVI SIEKTGEHFR LVYNTKGCFA VHRITVEEAK 

       130        140        150        160        170        180 
YKLCKVRKIT VGTKGIPHLV THDARTIRYP DPLIKVNDTV QIDLGTGKIT SFIKFDTGNV 

       190        200        210        220        230        240 
CMVIAGANLG RVGVITNRER HPGSCDVVHV KDANGNSFAT RISNIFVIGN GNKPWISLPR 

       250        260 
GKGIRLTIAE ERDKRLAAKQ SSG 

« Hide

References

[1]"The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes."
Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A. expand/collapse author list , Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H., Wilson R.K., Rozen S., Page D.C.
Nature 423:825-837(2003) [PubMed: 12815422] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA / MRNA].
[2]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed: 19608861] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-22, MASS SPECTROMETRY.

Cross-references

Sequence databases

AC009494 Genomic DNA. No translation available.
AF497481 mRNA. Translation: AAM18074.1.
IPIIPI00219894.
RefSeqNP_001034656.1.
UniGeneHs.367761

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ8TD47.

PTM databases

PhosphoSiteQ8TD47.

Proteomic databases

PRIDEQ8TD47.

Genome annotation databases

EnsemblENST00000288666; ENSP00000288666; ENSG00000157828; Homo sapiens. [Genome view]
GeneID140032.
KEGGhsa:140032.
NMPDRfig|9606.3.peg.33816.
UCSCuc004fum.1. human.

Organism-specific databases

CTD140032.
GeneCardsGC0YP021256.
H-InvDBHIX0056683.
HGNCHGNC:18501. RPS4Y2.
HPAHPA000857.
MIM400030. gene.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ8TD47.
HOVERGENQ8TD47.
OMANSFATRI
OrthoDBEOG95MQQS

Gene expression databases

GenevestigatorQ8TD47.

Family and domain databases

InterProIPR005824. KOW.
IPR000876. Ribosomal_S4e.
IPR013845. Ribosomal_S4e_central.
IPR013843. Ribosomal_S4e_N.
IPR018199. Ribosomal_S4e_N_CS.
IPR002942. S4_RNA_bd.
[Graphical view]
PANTHERPTHR11581. Ribosomal_S4E. 1 hit.
PfamPF00467. KOW. 1 hit.
PF00900. Ribosomal_S4e. 1 hit.
PF08071. RS4NT. 1 hit.
[Graphical view]
PIRSFPIRSF002116. Ribosomal_S4. 1 hit.
ProDomPD002667. Ribosomal_S4e_central. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00739. KOW. 1 hit.
SM00363. S4. 1 hit.
[Graphical view]
PROSITEPS00528. RIBOSOMAL_S4E. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio84063.
SOURCESearch...

Entry information

Entry nameRS4Y2_HUMAN
AccessionPrimary (citable) accession number: Q8TD47
Secondary accession number(s): A6NIR6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: January 23, 2007
Last modified: November 24, 2009
This is version 59 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome Y

Human chromosome Y: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Ribosomal proteins

Ribosomal proteins families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents