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Protein

40S ribosomal protein S4, Y isoform 2

Gene

RPS4Y2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S4, Y isoform 2
Alternative name(s):
Small ribosomal subunit protein eS41 Publication
Gene namesi
Name:RPS4Y2
Synonyms:RPS4Y2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome Y

Organism-specific databases

EuPathDBiHostDB:ENSG00000280969.1
HGNCiHGNC:18501 RPS4Y2
MIMi400030 gene
neXtProtiNX_Q8TD47

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

GeneReviewsiRPS4Y2
OpenTargetsiENSG00000280969
PharmGKBiPA38563

Polymorphism and mutation databases

BioMutaiRPS4Y2
DMDMi27805713

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001308181 – 26340S ribosomal protein S4, Y isoform 2Add BLAST263

Proteomic databases

EPDiQ8TD47
MaxQBiQ8TD47
PaxDbiQ8TD47
PeptideAtlasiQ8TD47
PRIDEiQ8TD47
TopDownProteomicsiQ8TD47

PTM databases

iPTMnetiQ8TD47
PhosphoSitePlusiQ8TD47
SwissPalmiQ8TD47

Expressioni

Gene expression databases

BgeeiENSG00000280969

Organism-specific databases

HPAiHPA000857

Interactioni

Protein-protein interaction databases

BioGridi126595, 3 interactors
STRINGi9606.ENSP00000288666

Structurei

3D structure databases

ProteinModelPortaliQ8TD47
SMRiQ8TD47
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 104S4 RNA-bindingAdd BLAST63

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0378 Eukaryota
COG1471 LUCA
GeneTreeiENSGT00390000005569
HOGENOMiHOG000231325
HOVERGENiHBG000935
InParanoidiQ8TD47
KOiK02987
OMAiERHPGSC
OrthoDBiEOG091G0MYF
PhylomeDBiQ8TD47
TreeFamiTF300612

Family and domain databases

Gene3Di2.30.30.30, 1 hit
2.40.50.740, 1 hit
HAMAPiMF_00485 Ribosomal_S4e, 1 hit
InterProiView protein in InterPro
IPR032277 40S_S4_C
IPR005824 KOW
IPR014722 Rib_L2_dom2
IPR000876 Ribosomal_S4e
IPR013845 Ribosomal_S4e_central_region
IPR038237 Ribosomal_S4e_central_sf
IPR013843 Ribosomal_S4e_N
IPR018199 Ribosomal_S4e_N_CS
IPR002942 S4_RNA-bd
PANTHERiPTHR11581 PTHR11581, 1 hit
PfamiView protein in Pfam
PF16121 40S_S4_C, 1 hit
PF00467 KOW, 1 hit
PF00900 Ribosomal_S4e, 1 hit
PF08071 RS4NT, 1 hit
PIRSFiPIRSF002116 Ribosomal_S4, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002667 Ribosomal_S4e_central, 1 hit
PROSITEiView protein in PROSITE
PS00528 RIBOSOMAL_S4E, 1 hit
PS50889 S4, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TD47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIVFLRN
60 70 80 90 100
RLKYALTGDE VKKICMQHFL KIDGKVRVDI TYPAGFIDVI SIEKTGEHFR
110 120 130 140 150
LVYNTKGCFA VHRITVEEAK YKLCKVRKIT VGTKGIPHLV THDARTIRYP
160 170 180 190 200
DPLIKVNDTV QIDLGTGKIT SFIKFDTGNV CMVIAGANLG RVGVITNRER
210 220 230 240 250
HPGSCDVVHV KDANGNSFAT RISNIFVIGN GNKPWISLPR GKGIRLTIAE
260
ERDKRLAAKQ SSG
Length:263
Mass (Da):29,295
Last modified:January 23, 2007 - v3
Checksum:i7044C5C97361E3D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009494 Genomic DNA No translation available.
AF497481 mRNA Translation: AAM18074.1
CCDSiCCDS44028.1
RefSeqiNP_001034656.1, NM_001039567.2
UniGeneiHs.367761

Genome annotation databases

EnsembliENST00000629237; ENSP00000486252; ENSG00000280969
GeneIDi140032
KEGGihsa:140032
UCSCiuc011nbb.3 human

Similar proteinsi

Entry informationi

Entry nameiRS4Y2_HUMAN
AccessioniPrimary (citable) accession number: Q8TD47
Secondary accession number(s): A6NIR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health