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Protein

Cell surface glycoprotein CD200 receptor 1

Gene

CD200R1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163606-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell surface glycoprotein CD200 receptor 1
Alternative name(s):
CD200 cell surface glycoprotein receptor
Cell surface glycoprotein OX2 receptor 1
Gene namesi
Name:CD200R1
Synonyms:CD200R, CRTR2, MOX2R, OX2R
ORF Names:UNQ2522/PRO6015
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:24235. CD200R1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 243ExtracellularSequence analysisAdd BLAST215
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Topological domaini265 – 325CytoplasmicSequence analysisAdd BLAST61

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi131450.
PharmGKBiPA134922446.

Polymorphism and mutation databases

BioMutaiCD200R1.
DMDMi26006823.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000001512829 – 325Cell surface glycoprotein CD200 receptor 1Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...)Sequence analysis1
Glycosylationi46N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi60 ↔ 132PROSITE-ProRule annotation
Disulfide bondi84 ↔ 100PROSITE-ProRule annotation
Glycosylationi93N-linked (GlcNAc...)Sequence analysis1
Glycosylationi99N-linked (GlcNAc...)Sequence analysis1
Glycosylationi162N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi167 ↔ 216PROSITE-ProRule annotation
Disulfide bondi186 ↔ 204PROSITE-ProRule annotation
Glycosylationi195N-linked (GlcNAc...)Sequence analysis1
Glycosylationi210N-linked (GlcNAc...)Sequence analysis1
Glycosylationi224N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

The mature form of isoform 2 and/or isoform 4 starts at sequence position 27 of the corresponding isoform.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiQ8TD46.
PRIDEiQ8TD46.

PTM databases

iPTMnetiQ8TD46.
PhosphoSitePlusiQ8TD46.
SwissPalmiQ8TD46.

Expressioni

Tissue specificityi

Expressed in granulocytes, monocytes, most T-cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells.1 Publication

Gene expression databases

BgeeiENSG00000163606.
CleanExiHS_CD200R1.
ExpressionAtlasiQ8TD46. baseline and differential.
GenevisibleiQ8TD46. HS.

Organism-specific databases

HPAiCAB013511.

Interactioni

Subunit structurei

CD200 and CD200R1 interact via their respective N-terminal Ig-like domains (By similarity). Interacts with Human herpesvirus 8 vOX2 protein.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CD200P412172EBI-4314412,EBI-3910563

Protein-protein interaction databases

BioGridi126281. 8 interactors.
IntActiQ8TD46. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ8TD46.
SMRiQ8TD46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 139Ig-like V-typeAdd BLAST87
Domaini140 – 228Ig-like C2-typeAdd BLAST89

Sequence similaritiesi

Belongs to the CD200R family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG108141.
InParanoidiQ8TD46.
OrthoDBiEOG091G0IYA.
PhylomeDBiQ8TD46.
TreeFamiTF335960.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TD46-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLCPWRTANL GLLLILTIFL VAASSSLCMD EKQITQNYSK VLAEVNTSWP
60 70 80 90 100
VKMATNAVLC CPPIALRNLI IITWEIILRG QPSCTKAYRK ETNETKETNC
110 120 130 140 150
TDERITWVSR PDQNSDLQIR PVAITHDGYY RCIMVTPDGN FHRGYHLQVL
160 170 180 190 200
VTPEVTLFQN RNRTAVCKAV AGKPAAQISW IPEGDCATKQ EYWSNGTVTV
210 220 230 240 250
KSTCHWEVHN VSTVTCHVSH LTGNKSLYIE LLPVPGAKKS AKLYIPYIIL
260 270 280 290 300
TIIILTIVGF IWLLKVNGCR KYKLNKTEST PVVEEDEMQP YASYTEKNNP
310 320
LYDTTNKVKA SEALQSEVDT DLHTL
Length:325
Mass (Da):36,620
Last modified:November 28, 2002 - v2
Checksum:iDD3F4B1F62337BBD
GO
Isoform 2 (identifier: Q8TD46-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-22: A → AEAEGAAQPNNSLMLQTSKENHAL
     151-165: VTPEVTLFQNRNRTA → GKEHHILRYFTSPDL
     166-325: Missing.

Show »
Length:188
Mass (Da):21,315
Checksum:i2C3ED65FE155D0E1
GO
Isoform 3 (identifier: Q8TD46-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-165: VTPEVTLFQNRNRTA → GKEHHILRYFTSPDL
     166-325: Missing.

Show »
Length:165
Mass (Da):18,879
Checksum:iA5D21A228D255202
GO
Isoform 4 (identifier: Q8TD46-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-22: A → AEAEGAAQPNNSLMLQTSKENHAL

Show »
Length:348
Mass (Da):39,056
Checksum:i32C0016F7757A5C1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti155V → L in AAQ89269 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01435289R → K in allele 2. 4 PublicationsCorresponds to variant rs2171509dbSNPEnsembl.1
Natural variantiVAR_014353121P → T in allele 2. 5 PublicationsCorresponds to variant rs4596117dbSNPEnsembl.1
Natural variantiVAR_014354177Q → H in allele 2. 5 PublicationsCorresponds to variant rs9826308dbSNPEnsembl.1
Natural variantiVAR_031022312E → Q.2 PublicationsCorresponds to variant rs9865242dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00261422A → AEAEGAAQPNNSLMLQTSKE NHAL in isoform 2 and isoform 4. 5 Publications1
Alternative sequenceiVSP_002615151 – 165VTPEV…RNRTA → GKEHHILRYFTSPDL in isoform 2 and isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_002616166 – 325Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST160

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY284975 mRNA. Translation: AAQ19772.1.
AF283760 mRNA. Translation: AAN61171.1.
AF497548 mRNA. Translation: AAM16157.2.
AF497549 mRNA. Translation: AAM16158.2.
AF497550 mRNA. Translation: AAM16159.2.
AF495380 mRNA. Translation: AAM14622.2.
AY358910 mRNA. Translation: AAQ89269.2.
AK126349 mRNA. Translation: BAG54311.1.
AK293071 mRNA. Translation: BAF85760.1.
AC074044 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79657.1.
CH471052 Genomic DNA. Translation: EAW79658.1.
BC069661 mRNA. Translation: AAH69661.1.
BC069721 mRNA. Translation: AAH69721.1.
BC069743 mRNA. Translation: AAH69743.1.
BC093890 mRNA. Translation: AAH93890.1.
CCDSiCCDS2969.1. [Q8TD46-4]
CCDS2970.1. [Q8TD46-1]
CCDS46889.1. [Q8TD46-2]
CCDS54623.1. [Q8TD46-3]
RefSeqiNP_620161.1. NM_138806.3.
NP_620385.1. NM_138939.2.
NP_620386.1. NM_138940.2.
NP_740750.1. NM_170780.2.
UniGeneiHs.309158.

Genome annotation databases

EnsembliENST00000308611; ENSP00000311035; ENSG00000163606.
ENST00000440122; ENSP00000405733; ENSG00000163606.
ENST00000471858; ENSP00000418928; ENSG00000163606.
ENST00000490004; ENSP00000418801; ENSG00000163606.
GeneIDi131450.
KEGGihsa:131450.
UCSCiuc003dzj.2. human. [Q8TD46-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY284975 mRNA. Translation: AAQ19772.1.
AF283760 mRNA. Translation: AAN61171.1.
AF497548 mRNA. Translation: AAM16157.2.
AF497549 mRNA. Translation: AAM16158.2.
AF497550 mRNA. Translation: AAM16159.2.
AF495380 mRNA. Translation: AAM14622.2.
AY358910 mRNA. Translation: AAQ89269.2.
AK126349 mRNA. Translation: BAG54311.1.
AK293071 mRNA. Translation: BAF85760.1.
AC074044 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79657.1.
CH471052 Genomic DNA. Translation: EAW79658.1.
BC069661 mRNA. Translation: AAH69661.1.
BC069721 mRNA. Translation: AAH69721.1.
BC069743 mRNA. Translation: AAH69743.1.
BC093890 mRNA. Translation: AAH93890.1.
CCDSiCCDS2969.1. [Q8TD46-4]
CCDS2970.1. [Q8TD46-1]
CCDS46889.1. [Q8TD46-2]
CCDS54623.1. [Q8TD46-3]
RefSeqiNP_620161.1. NM_138806.3.
NP_620385.1. NM_138939.2.
NP_620386.1. NM_138940.2.
NP_740750.1. NM_170780.2.
UniGeneiHs.309158.

3D structure databases

ProteinModelPortaliQ8TD46.
SMRiQ8TD46.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126281. 8 interactors.
IntActiQ8TD46. 1 interactor.

PTM databases

iPTMnetiQ8TD46.
PhosphoSitePlusiQ8TD46.
SwissPalmiQ8TD46.

Polymorphism and mutation databases

BioMutaiCD200R1.
DMDMi26006823.

Proteomic databases

PeptideAtlasiQ8TD46.
PRIDEiQ8TD46.

Protocols and materials databases

DNASUi131450.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308611; ENSP00000311035; ENSG00000163606.
ENST00000440122; ENSP00000405733; ENSG00000163606.
ENST00000471858; ENSP00000418928; ENSG00000163606.
ENST00000490004; ENSP00000418801; ENSG00000163606.
GeneIDi131450.
KEGGihsa:131450.
UCSCiuc003dzj.2. human. [Q8TD46-1]

Organism-specific databases

CTDi131450.
DisGeNETi131450.
GeneCardsiCD200R1.
HGNCiHGNC:24235. CD200R1.
HPAiCAB013511.
MIMi607546. gene.
neXtProtiNX_Q8TD46.
PharmGKBiPA134922446.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG108141.
InParanoidiQ8TD46.
OrthoDBiEOG091G0IYA.
PhylomeDBiQ8TD46.
TreeFamiTF335960.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163606-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

GeneWikiiCD200R1.
GenomeRNAii131450.
PROiQ8TD46.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163606.
CleanExiHS_CD200R1.
ExpressionAtlasiQ8TD46. baseline and differential.
GenevisibleiQ8TD46. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMO2R1_HUMAN
AccessioniPrimary (citable) accession number: Q8TD46
Secondary accession number(s): B3KWZ9
, E9PCM9, Q52LJ7, Q6IS95, Q6UW94, Q6WHB8, Q8TD44, Q8TD45, Q8TD52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: November 28, 2002
Last modified: November 2, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.