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Protein

Cell surface glycoprotein CD200 receptor 1

Gene

CD200R1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell surface glycoprotein CD200 receptor 1
Alternative name(s):
CD200 cell surface glycoprotein receptor
Cell surface glycoprotein OX2 receptor 1
Gene namesi
Name:CD200R1
Synonyms:CD200R, CRTR2, MOX2R, OX2R
ORF Names:UNQ2522/PRO6015
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:24235. CD200R1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 243215ExtracellularSequence analysisAdd
BLAST
Transmembranei244 – 26421HelicalSequence analysisAdd
BLAST
Topological domaini265 – 32561CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: Reactome
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134922446.

Polymorphism and mutation databases

BioMutaiCD200R1.
DMDMi26006823.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 325297Cell surface glycoprotein CD200 receptor 1PRO_0000015128Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi37 – 371N-linked (GlcNAc...)Sequence analysis
Glycosylationi46 – 461N-linked (GlcNAc...)Sequence analysis
Disulfide bondi60 ↔ 132PROSITE-ProRule annotation
Disulfide bondi84 ↔ 100PROSITE-ProRule annotation
Glycosylationi93 – 931N-linked (GlcNAc...)Sequence analysis
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence analysis
Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence analysis
Disulfide bondi167 ↔ 216PROSITE-ProRule annotation
Disulfide bondi186 ↔ 204PROSITE-ProRule annotation
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence analysis
Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence analysis
Glycosylationi224 – 2241N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

The mature form of isoform 2 and/or isoform 4 starts at sequence position 27 of the corresponding isoform.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8TD46.

PTM databases

iPTMnetiQ8TD46.
PhosphoSiteiQ8TD46.
SwissPalmiQ8TD46.

Expressioni

Tissue specificityi

Expressed in granulocytes, monocytes, most T-cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells.1 Publication

Gene expression databases

BgeeiQ8TD46.
CleanExiHS_CD200R1.
ExpressionAtlasiQ8TD46. baseline and differential.
GenevisibleiQ8TD46. HS.

Interactioni

Subunit structurei

CD200 and CD200R1 interact via their respective N-terminal Ig-like domains (By similarity). Interacts with Human herpesvirus 8 vOX2 protein.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CD200P412172EBI-4314412,EBI-3910563

Protein-protein interaction databases

BioGridi126281. 8 interactions.
IntActiQ8TD46. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8TD46.
SMRiQ8TD46. Positions 42-231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 13987Ig-like V-typeAdd
BLAST
Domaini140 – 22889Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Belongs to the CD200R family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG108141.
InParanoidiQ8TD46.
OrthoDBiEOG7RZ5QQ.
PhylomeDBiQ8TD46.
TreeFamiTF335960.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TD46-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLCPWRTANL GLLLILTIFL VAASSSLCMD EKQITQNYSK VLAEVNTSWP
60 70 80 90 100
VKMATNAVLC CPPIALRNLI IITWEIILRG QPSCTKAYRK ETNETKETNC
110 120 130 140 150
TDERITWVSR PDQNSDLQIR PVAITHDGYY RCIMVTPDGN FHRGYHLQVL
160 170 180 190 200
VTPEVTLFQN RNRTAVCKAV AGKPAAQISW IPEGDCATKQ EYWSNGTVTV
210 220 230 240 250
KSTCHWEVHN VSTVTCHVSH LTGNKSLYIE LLPVPGAKKS AKLYIPYIIL
260 270 280 290 300
TIIILTIVGF IWLLKVNGCR KYKLNKTEST PVVEEDEMQP YASYTEKNNP
310 320
LYDTTNKVKA SEALQSEVDT DLHTL
Length:325
Mass (Da):36,620
Last modified:November 28, 2002 - v2
Checksum:iDD3F4B1F62337BBD
GO
Isoform 2 (identifier: Q8TD46-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-22: A → AEAEGAAQPNNSLMLQTSKENHAL
     151-165: VTPEVTLFQNRNRTA → GKEHHILRYFTSPDL
     166-325: Missing.

Show »
Length:188
Mass (Da):21,315
Checksum:i2C3ED65FE155D0E1
GO
Isoform 3 (identifier: Q8TD46-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-165: VTPEVTLFQNRNRTA → GKEHHILRYFTSPDL
     166-325: Missing.

Show »
Length:165
Mass (Da):18,879
Checksum:iA5D21A228D255202
GO
Isoform 4 (identifier: Q8TD46-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-22: A → AEAEGAAQPNNSLMLQTSKENHAL

Show »
Length:348
Mass (Da):39,056
Checksum:i32C0016F7757A5C1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti155 – 1551V → L in AAQ89269 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti89 – 891R → K in allele 2. 4 Publications
Corresponds to variant rs2171509 [ dbSNP | Ensembl ].
VAR_014352
Natural varianti121 – 1211P → T in allele 2. 5 Publications
Corresponds to variant rs4596117 [ dbSNP | Ensembl ].
VAR_014353
Natural varianti177 – 1771Q → H in allele 2. 5 Publications
Corresponds to variant rs9826308 [ dbSNP | Ensembl ].
VAR_014354
Natural varianti312 – 3121E → Q.2 Publications
Corresponds to variant rs9865242 [ dbSNP | Ensembl ].
VAR_031022

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei22 – 221A → AEAEGAAQPNNSLMLQTSKE NHAL in isoform 2 and isoform 4. 5 PublicationsVSP_002614
Alternative sequencei151 – 16515VTPEV…RNRTA → GKEHHILRYFTSPDL in isoform 2 and isoform 3. 1 PublicationVSP_002615Add
BLAST
Alternative sequencei166 – 325160Missing in isoform 2 and isoform 3. 1 PublicationVSP_002616Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY284975 mRNA. Translation: AAQ19772.1.
AF283760 mRNA. Translation: AAN61171.1.
AF497548 mRNA. Translation: AAM16157.2.
AF497549 mRNA. Translation: AAM16158.2.
AF497550 mRNA. Translation: AAM16159.2.
AF495380 mRNA. Translation: AAM14622.2.
AY358910 mRNA. Translation: AAQ89269.2.
AK126349 mRNA. Translation: BAG54311.1.
AK293071 mRNA. Translation: BAF85760.1.
AC074044 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79657.1.
CH471052 Genomic DNA. Translation: EAW79658.1.
BC069661 mRNA. Translation: AAH69661.1.
BC069721 mRNA. Translation: AAH69721.1.
BC069743 mRNA. Translation: AAH69743.1.
BC093890 mRNA. Translation: AAH93890.1.
CCDSiCCDS2969.1. [Q8TD46-4]
CCDS2970.1. [Q8TD46-1]
CCDS46889.1. [Q8TD46-2]
CCDS54623.1. [Q8TD46-3]
RefSeqiNP_620161.1. NM_138806.3.
NP_620385.1. NM_138939.2.
NP_620386.1. NM_138940.2.
NP_740750.1. NM_170780.2.
UniGeneiHs.309158.

Genome annotation databases

EnsembliENST00000308611; ENSP00000311035; ENSG00000163606.
ENST00000440122; ENSP00000405733; ENSG00000163606.
ENST00000471858; ENSP00000418928; ENSG00000163606.
ENST00000490004; ENSP00000418801; ENSG00000163606.
GeneIDi131450.
KEGGihsa:131450.
UCSCiuc003dzj.2. human. [Q8TD46-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY284975 mRNA. Translation: AAQ19772.1.
AF283760 mRNA. Translation: AAN61171.1.
AF497548 mRNA. Translation: AAM16157.2.
AF497549 mRNA. Translation: AAM16158.2.
AF497550 mRNA. Translation: AAM16159.2.
AF495380 mRNA. Translation: AAM14622.2.
AY358910 mRNA. Translation: AAQ89269.2.
AK126349 mRNA. Translation: BAG54311.1.
AK293071 mRNA. Translation: BAF85760.1.
AC074044 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79657.1.
CH471052 Genomic DNA. Translation: EAW79658.1.
BC069661 mRNA. Translation: AAH69661.1.
BC069721 mRNA. Translation: AAH69721.1.
BC069743 mRNA. Translation: AAH69743.1.
BC093890 mRNA. Translation: AAH93890.1.
CCDSiCCDS2969.1. [Q8TD46-4]
CCDS2970.1. [Q8TD46-1]
CCDS46889.1. [Q8TD46-2]
CCDS54623.1. [Q8TD46-3]
RefSeqiNP_620161.1. NM_138806.3.
NP_620385.1. NM_138939.2.
NP_620386.1. NM_138940.2.
NP_740750.1. NM_170780.2.
UniGeneiHs.309158.

3D structure databases

ProteinModelPortaliQ8TD46.
SMRiQ8TD46. Positions 42-231.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126281. 8 interactions.
IntActiQ8TD46. 1 interaction.

PTM databases

iPTMnetiQ8TD46.
PhosphoSiteiQ8TD46.
SwissPalmiQ8TD46.

Polymorphism and mutation databases

BioMutaiCD200R1.
DMDMi26006823.

Proteomic databases

PRIDEiQ8TD46.

Protocols and materials databases

DNASUi131450.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308611; ENSP00000311035; ENSG00000163606.
ENST00000440122; ENSP00000405733; ENSG00000163606.
ENST00000471858; ENSP00000418928; ENSG00000163606.
ENST00000490004; ENSP00000418801; ENSG00000163606.
GeneIDi131450.
KEGGihsa:131450.
UCSCiuc003dzj.2. human. [Q8TD46-1]

Organism-specific databases

CTDi131450.
GeneCardsiCD200R1.
HGNCiHGNC:24235. CD200R1.
MIMi607546. gene.
neXtProtiNX_Q8TD46.
PharmGKBiPA134922446.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG108141.
InParanoidiQ8TD46.
OrthoDBiEOG7RZ5QQ.
PhylomeDBiQ8TD46.
TreeFamiTF335960.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

GeneWikiiCD200R1.
GenomeRNAii131450.
PROiQ8TD46.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TD46.
CleanExiHS_CD200R1.
ExpressionAtlasiQ8TD46. baseline and differential.
GenevisibleiQ8TD46. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural and functional heterogeneity in the CD200R family of immunoregulatory molecules and their expression at the feto-maternal interface."
    Gorczynski R.M., Chen Z., Clark D.A., Kai Y., Lee L., Nachman J., Wong S., Marsden P.
    Am. J. Reprod. Immunol. 52:147-163(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), VARIANTS THR-121 AND HIS-177.
  2. "K14, the HHV-8 viral OX2 homolog interacts with the human OX2 receptor with identical affinity and kinetics as the host OX2 protein."
    Wright G.J., Brown M.H., Barclay N.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Characterization of human CD200R gene."
    Suarez A., Vieites J.M., De la Torre R., Ortega M.A., Gil A., Sanchez-Pozo A.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), VARIANTS LYS-89; THR-121 AND HIS-177.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT GLN-312.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANTS LYS-89; THR-121; HIS-177 AND GLN-312.
    Tissue: Trachea and Uterus.
  6. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS LYS-89; THR-121 AND HIS-177.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANTS LYS-89; THR-121 AND HIS-177.
  9. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF N-TERMINUS (ISOFORMS 2 AND 4).
  10. Cited for: FUNCTION, TISSUE SPECIFICITY.
  11. "The CD200-CD200R1 inhibitory signaling pathway: immune regulation and host-pathogen interactions."
    Vaine C.A., Soberman R.J.
    Adv. Immunol. 121:191-211(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiMO2R1_HUMAN
AccessioniPrimary (citable) accession number: Q8TD46
Secondary accession number(s): B3KWZ9
, E9PCM9, Q52LJ7, Q6IS95, Q6UW94, Q6WHB8, Q8TD44, Q8TD45, Q8TD52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: November 28, 2002
Last modified: June 8, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.