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Protein

Transient receptor potential cation channel subfamily M member 4

Gene

TRPM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca2+, it is impermeable to it. Mediates transport of monovalent cations (Na+ > K+ > Cs+ > Li+), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.8 Publications

Enzyme regulationi

Gating is voltage-dependent and repressed by decavanadate. Calmodulin-binding confers the Ca2+ sensitivity. ATP is able to restore Ca2+ sensitivity after desensitization. Phosphatidylinositol 4,5-bisphosphate (PIP2)-binding strongly enhances activity, by increasing the channel's Ca2+ sensitivity and shifting its voltage dependence of activation towards negative potentials. Activity is also enhanced by 3,5-bis(trifluoromethyl)pyrazole derivative (BTP2).5 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Adaptive immunity, Immunity, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Calcium, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130529-MONOMER.
ReactomeiR-HSA-3295583. TRP channels.
SIGNORiQ8TD43.

Protein family/group databases

TCDBi1.A.4.5.4. the transient receptor potential ca(2+) channel (trp-cc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily M member 4
Short name:
hTRPM4
Alternative name(s):
Calcium-activated non-selective cation channel 1
Long transient receptor potential channel 4
Short name:
LTrpC-4
Short name:
LTrpC4
Melastatin-4
Gene namesi
Name:TRPM4
Synonyms:LTRPC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:17993. TRPM4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 683CytoplasmicSequence analysisAdd BLAST683
Transmembranei684 – 704HelicalSequence analysisAdd BLAST21
Topological domaini705 – 776ExtracellularSequence analysisAdd BLAST72
Transmembranei777 – 797HelicalSequence analysisAdd BLAST21
Topological domaini798 – 868CytoplasmicSequence analysisAdd BLAST71
Transmembranei869 – 889HelicalSequence analysisAdd BLAST21
Topological domaini890 – 892ExtracellularSequence analysis3
Transmembranei893 – 913HelicalSequence analysisAdd BLAST21
Topological domaini914 – 929CytoplasmicSequence analysisAdd BLAST16
Transmembranei930 – 950HelicalSequence analysisAdd BLAST21
Topological domaini951 – 965ExtracellularSequence analysisAdd BLAST15
Intramembranei966 – 993Pore-formingSequence analysisAdd BLAST28
Topological domaini994 – 1019ExtracellularSequence analysisAdd BLAST26
Transmembranei1020 – 1040HelicalSequence analysisAdd BLAST21
Topological domaini1041 – 1214CytoplasmicSequence analysisAdd BLAST174

GO - Cellular componenti

  • cytosol Source: BHF-UCL
  • endoplasmic reticulum Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • neuronal cell body Source: BHF-UCL
  • nucleoplasm Source: HPA
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Progressive familial heart block 1B (PFHB1B)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA cardiac bundle branch disorder characterized by progressive alteration of cardiac conduction through the His-Purkinje system, with a pattern of a right bundle-branch block and/or left anterior hemiblock occurring individually or together. It leads to complete atrio-ventricular block causing syncope and sudden death.
See also OMIM:604559
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0640427E → K in PFHB1B; attenuated desumoylation of TRPM4 resulting in constitutive sumoylation of the channel leading to impaired endocytosis and elevated channel density at the cell surface. 1 PublicationCorresponds to variant rs267607142dbSNPEnsembl.1
Natural variantiVAR_066763131Q → H in PFHB1B; incomplete right bundle-branch block. 1 PublicationCorresponds to variant rs172146854dbSNPEnsembl.1
Natural variantiVAR_066764164R → W in PFHB1B. 1 PublicationCorresponds to variant rs387907216dbSNPEnsembl.1
Natural variantiVAR_066766293Q → R in PFHB1B; right bundle-branch block. 1 PublicationCorresponds to variant rs172147855dbSNPEnsembl.1
Natural variantiVAR_066767432A → T in PFHB1B; atrioventricular block. 2 PublicationsCorresponds to variant rs201907325dbSNPEnsembl.1
Natural variantiVAR_066770582G → S in PFHB1B; atrioventricular block. 1 PublicationCorresponds to variant rs172149856dbSNPEnsembl.1
Natural variantiVAR_066771790Y → H in PFHB1B; atrioventricular block. 1 PublicationCorresponds to variant rs172150857dbSNPEnsembl.1
Natural variantiVAR_066772844G → D in PFHB1B; right bundle-branch block. 2 PublicationsCorresponds to variant rs200038418dbSNPEnsembl.1
Natural variantiVAR_066774914K → R in PFHB1B; atrioventricular block. 1 PublicationCorresponds to variant rs172151858dbSNPEnsembl.1
Natural variantiVAR_066775970P → S in PFHB1B; incomplete right bundle-branch block. 1 PublicationCorresponds to variant rs172152859dbSNPEnsembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi275L → A or C: Abolishes ability to restore sensitivity to Ca(2+) after desensitization. 1 Publication1
Mutagenesisi278I → N: No effect. 1 Publication1
Mutagenesisi279D → N: No effect. 1 Publication1
Mutagenesisi324G → A: No effect. 1 Publication1
Mutagenesisi325G → A: Abolishes ability to restore sensitivity to Ca(2+) after desensitization. 1 Publication1
Mutagenesisi327R → A: No effect. 1 Publication1
Mutagenesisi977Q → E: Alters the monovalent cation permeability sequence and results in a pore with moderate Ca(2+) permeability. 1 Publication1
Mutagenesisi981 – 986EDMDVA → TIIDGP: Induces a functional channel that combines the gating hallmarks of TRPM4 (activation by Ca(2+)) with TRPV6-like sensitivity to block by extracellular Ca(2+) and Mg(2+) as well as Ca(2+) permeation. 1 Publication6
Mutagenesisi981E → A: Results in a channel with normal permeability properties but with a reduced sensitivity to block by intracellular spermine. 1 Publication1
Mutagenesisi982D → A: Results in a functional channel that exhibits extremely fast desensitization, possibly indicating destabilization of the pore. 1 Publication1
Mutagenesisi984D → A: Results in a non-functional channel with a dominant negative phenotype. 1 Publication1
Mutagenesisi1059K → Q: Does not affect PIP2-binding. 1 Publication1
Mutagenesisi1072R → Q: Does not affect PIP2-binding. 1 Publication1
Mutagenesisi1136 – 1141Missing : Results in a channel with very rapid desensitization and highly reduced sensitivity to PIP2. 1 Publication6
Mutagenesisi1145S → A: Decreases the sensitivity to Ca(2+). 1 Publication1
Mutagenesisi1152S → A: Decreases the sensitivity to Ca(2+). 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi54795.
MalaCardsiTRPM4.
MIMi604559. phenotype.
OpenTargetsiENSG00000130529.
Orphaneti130. Brugada syndrome.
871. Familial progressive cardiac conduction defect.
PharmGKBiPA38272.

Chemistry databases

GuidetoPHARMACOLOGYi496.

Polymorphism and mutation databases

BioMutaiTRPM4.
DMDMi74715868.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595291 – 1214Transient receptor potential cation channel subfamily M member 4Add BLAST1214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1145Phosphoserine; by PKC1 Publication1
Modified residuei1152Phosphoserine; by PKC1 Publication1

Post-translational modificationi

Phosphorylation by PKC leads to increase the sensitivity to Ca2+.1 Publication
Sumoylated. Desumoylated by SENP1.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8TD43.
MaxQBiQ8TD43.
PaxDbiQ8TD43.
PeptideAtlasiQ8TD43.
PRIDEiQ8TD43.

PTM databases

iPTMnetiQ8TD43.
PhosphoSitePlusiQ8TD43.

Expressioni

Tissue specificityi

Widely expressed with a high expression in intestine and prostate. In brain, it is both expressed in whole cerebral arteries and isolated vascular smooth muscle cells. Prominently expressed in Purkinje fibers. Expressed at higher levels in T-helper 2 (Th2) cells as compared to T-helper 1 (Th1) cells.7 Publications

Gene expression databases

BgeeiENSG00000130529.
CleanExiHS_TRPM4.
ExpressionAtlasiQ8TD43. baseline and differential.
GenevisibleiQ8TD43. HS.

Organism-specific databases

HPAiHPA041169.

Interactioni

Subunit structurei

Homomultimer.1 Publication

Protein-protein interaction databases

BioGridi120154. 8 interactors.
IntActiQ8TD43. 1 interactor.
STRINGi9606.ENSP00000252826.

Structurei

3D structure databases

ProteinModelPortaliQ8TD43.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1076 – 1176Calmodulin-bindingAdd BLAST101
Regioni1136 – 1141Mediates modulation by decavanadate and PIP2-binding6

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1134 – 1187Sequence analysisAdd BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi981 – 986Selectivity filter6

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3614. Eukaryota.
ENOG410XR5B. LUCA.
GeneTreeiENSGT00760000119127.
HOGENOMiHOG000236350.
HOVERGENiHBG108337.
InParanoidiQ8TD43.
KOiK04979.
OMAiFLRLSCD.
OrthoDBiEOG091G017C.
PhylomeDBiQ8TD43.
TreeFamiTF314204.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR029581. TRPM4.
[Graphical view]
PANTHERiPTHR13800:SF6. PTHR13800:SF6. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TD43-1) [UniParc]FASTAAdd to basket
Also known as: TRPM4b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVVPEKEQSW IPKIFKKKTC TTFIVDSTDP GGTLCQCGRP RTAHPAVAME
60 70 80 90 100
DAFGAAVVTV WDSDAHTTEK PTDAYGELDF TGAGRKHSNF LRLSDRTDPA
110 120 130 140 150
AVYSLVTRTW GFRAPNLVVS VLGGSGGPVL QTWLQDLLRR GLVRAAQSTG
160 170 180 190 200
AWIVTGGLHT GIGRHVGVAV RDHQMASTGG TKVVAMGVAP WGVVRNRDTL
210 220 230 240 250
INPKGSFPAR YRWRGDPEDG VQFPLDYNYS AFFLVDDGTH GCLGGENRFR
260 270 280 290 300
LRLESYISQQ KTGVGGTGID IPVLLLLIDG DEKMLTRIEN ATQAQLPCLL
310 320 330 340 350
VAGSGGAADC LAETLEDTLA PGSGGARQGE ARDRIRRFFP KGDLEVLQAQ
360 370 380 390 400
VERIMTRKEL LTVYSSEDGS EEFETIVLKA LVKACGSSEA SAYLDELRLA
410 420 430 440 450
VAWNRVDIAQ SELFRGDIQW RSFHLEASLM DALLNDRPEF VRLLISHGLS
460 470 480 490 500
LGHFLTPMRL AQLYSAAPSN SLIRNLLDQA SHSAGTKAPA LKGGAAELRP
510 520 530 540 550
PDVGHVLRML LGKMCAPRYP SGGAWDPHPG QGFGESMYLL SDKATSPLSL
560 570 580 590 600
DAGLGQAPWS DLLLWALLLN RAQMAMYFWE MGSNAVSSAL GACLLLRVMA
610 620 630 640 650
RLEPDAEEAA RRKDLAFKFE GMGVDLFGEC YRSSEVRAAR LLLRRCPLWG
660 670 680 690 700
DATCLQLAMQ ADARAFFAQD GVQSLLTQKW WGDMASTTPI WALVLAFFCP
710 720 730 740 750
PLIYTRLITF RKSEEEPTRE ELEFDMDSVI NGEGPVGTAD PAEKTPLGVP
760 770 780 790 800
RQSGRPGCCG GRCGGRRCLR RWFHFWGAPV TIFMGNVVSY LLFLLLFSRV
810 820 830 840 850
LLVDFQPAPP GSLELLLYFW AFTLLCEELR QGLSGGGGSL ASGGPGPGHA
860 870 880 890 900
SLSQRLRLYL ADSWNQCDLV ALTCFLLGVG CRLTPGLYHL GRTVLCIDFM
910 920 930 940 950
VFTVRLLHIF TVNKQLGPKI VIVSKMMKDV FFFLFFLGVW LVAYGVATEG
960 970 980 990 1000
LLRPRDSDFP SILRRVFYRP YLQIFGQIPQ EDMDVALMEH SNCSSEPGFW
1010 1020 1030 1040 1050
AHPPGAQAGT CVSQYANWLV VLLLVIFLLV ANILLVNLLI AMFSYTFGKV
1060 1070 1080 1090 1100
QGNSDLYWKA QRYRLIREFH SRPALAPPFI VISHLRLLLR QLCRRPRSPQ
1110 1120 1130 1140 1150
PSSPALEHFR VYLSKEAERK LLTWESVHKE NFLLARARDK RESDSERLKR
1160 1170 1180 1190 1200
TSQKVDLALK QLGHIREYEQ RLKVLEREVQ QCSRVLGWVA EALSRSALLP
1210
PGGPPPPDLP GSKD
Length:1,214
Mass (Da):134,301
Last modified:June 1, 2002 - v1
Checksum:i76ADA452690ED8F5
GO
Isoform 2 (identifier: Q8TD43-2) [UniParc]FASTAAdd to basket
Also known as: TRPM4a

The sequence of this isoform differs from the canonical sequence as follows:
     1-174: Missing.

Show »
Length:1,040
Mass (Da):115,566
Checksum:i684A8C554B2B0F2E
GO
Isoform 3 (identifier: Q8TD43-3) [UniParc]FASTAAdd to basket
Also known as: TRPM4c

The sequence of this isoform differs from the canonical sequence as follows:
     738-882: Missing.

Show »
Length:1,069
Mass (Da):118,630
Checksum:i80DEBD935A55F200
GO

Sequence cautioni

The sequence BAA90907 differs from that shown. Reason: Erroneous termination at position 1191. Translated as Glu.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1149K → E in BAA90907 (PubMed:14702039).Curated1
Sequence conflicti1207P → L in BAA90907 (PubMed:14702039).Curated1
Sequence conflicti1210P → H in BAA90907 (PubMed:14702039).Curated1
Sequence conflicti1214D → E in BAA90907 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0640427E → K in PFHB1B; attenuated desumoylation of TRPM4 resulting in constitutive sumoylation of the channel leading to impaired endocytosis and elevated channel density at the cell surface. 1 PublicationCorresponds to variant rs267607142dbSNPEnsembl.1
Natural variantiVAR_066761101A → T.1 PublicationCorresponds to variant rs113984787dbSNPEnsembl.1
Natural variantiVAR_066762103Y → C.1 PublicationCorresponds to variant rs144781529dbSNPEnsembl.1
Natural variantiVAR_066763131Q → H in PFHB1B; incomplete right bundle-branch block. 1 PublicationCorresponds to variant rs172146854dbSNPEnsembl.1
Natural variantiVAR_066764164R → W in PFHB1B. 1 PublicationCorresponds to variant rs387907216dbSNPEnsembl.1
Natural variantiVAR_066765252R → H.1 PublicationCorresponds to variant rs146564314dbSNPEnsembl.1
Natural variantiVAR_066766293Q → R in PFHB1B; right bundle-branch block. 1 PublicationCorresponds to variant rs172147855dbSNPEnsembl.1
Natural variantiVAR_066767432A → T in PFHB1B; atrioventricular block. 2 PublicationsCorresponds to variant rs201907325dbSNPEnsembl.1
Natural variantiVAR_066768487 – 498Missing .Add BLAST12
Natural variantiVAR_066769561D → A.1 PublicationCorresponds to variant rs56355369dbSNPEnsembl.1
Natural variantiVAR_066770582G → S in PFHB1B; atrioventricular block. 1 PublicationCorresponds to variant rs172149856dbSNPEnsembl.1
Natural variantiVAR_066771790Y → H in PFHB1B; atrioventricular block. 1 PublicationCorresponds to variant rs172150857dbSNPEnsembl.1
Natural variantiVAR_066772844G → D in PFHB1B; right bundle-branch block. 2 PublicationsCorresponds to variant rs200038418dbSNPEnsembl.1
Natural variantiVAR_066773854Q → R.1 PublicationCorresponds to variant rs172155862dbSNPEnsembl.1
Natural variantiVAR_066774914K → R in PFHB1B; atrioventricular block. 1 PublicationCorresponds to variant rs172151858dbSNPEnsembl.1
Natural variantiVAR_066775970P → S in PFHB1B; incomplete right bundle-branch block. 1 PublicationCorresponds to variant rs172152859dbSNPEnsembl.1
Natural variantiVAR_0667761204P → L.1 PublicationCorresponds to variant rs150391806dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0214421 – 174Missing in isoform 2. 2 PublicationsAdd BLAST174
Alternative sequenceiVSP_021443738 – 882Missing in isoform 3. 1 PublicationAdd BLAST145

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY046396 mRNA. Translation: AAL02142.1.
AF497623 mRNA. Translation: AAM18083.1.
AY297044 mRNA. Translation: AAP44473.1.
AY297045 mRNA. Translation: AAP44474.1.
AY297046 mRNA. Translation: AAP44475.1.
AJ575813 mRNA. Translation: CAE05941.1.
AK000048 mRNA. Translation: BAA90907.1. Sequence problems.
AK292862 mRNA. Translation: BAF85551.1.
BC132727 mRNA. Translation: AAI32728.1.
CCDSiCCDS33073.1. [Q8TD43-1]
CCDS56098.1. [Q8TD43-3]
RefSeqiNP_001182156.1. NM_001195227.1. [Q8TD43-3]
NP_001308212.1. NM_001321283.1. [Q8TD43-2]
NP_060106.2. NM_017636.3. [Q8TD43-1]
UniGeneiHs.467101.

Genome annotation databases

EnsembliENST00000252826; ENSP00000252826; ENSG00000130529. [Q8TD43-1]
ENST00000427978; ENSP00000407492; ENSG00000130529. [Q8TD43-3]
GeneIDi54795.
KEGGihsa:54795.
UCSCiuc002pmw.4. human. [Q8TD43-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY046396 mRNA. Translation: AAL02142.1.
AF497623 mRNA. Translation: AAM18083.1.
AY297044 mRNA. Translation: AAP44473.1.
AY297045 mRNA. Translation: AAP44474.1.
AY297046 mRNA. Translation: AAP44475.1.
AJ575813 mRNA. Translation: CAE05941.1.
AK000048 mRNA. Translation: BAA90907.1. Sequence problems.
AK292862 mRNA. Translation: BAF85551.1.
BC132727 mRNA. Translation: AAI32728.1.
CCDSiCCDS33073.1. [Q8TD43-1]
CCDS56098.1. [Q8TD43-3]
RefSeqiNP_001182156.1. NM_001195227.1. [Q8TD43-3]
NP_001308212.1. NM_001321283.1. [Q8TD43-2]
NP_060106.2. NM_017636.3. [Q8TD43-1]
UniGeneiHs.467101.

3D structure databases

ProteinModelPortaliQ8TD43.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120154. 8 interactors.
IntActiQ8TD43. 1 interactor.
STRINGi9606.ENSP00000252826.

Chemistry databases

GuidetoPHARMACOLOGYi496.

Protein family/group databases

TCDBi1.A.4.5.4. the transient receptor potential ca(2+) channel (trp-cc) family.

PTM databases

iPTMnetiQ8TD43.
PhosphoSitePlusiQ8TD43.

Polymorphism and mutation databases

BioMutaiTRPM4.
DMDMi74715868.

Proteomic databases

EPDiQ8TD43.
MaxQBiQ8TD43.
PaxDbiQ8TD43.
PeptideAtlasiQ8TD43.
PRIDEiQ8TD43.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252826; ENSP00000252826; ENSG00000130529. [Q8TD43-1]
ENST00000427978; ENSP00000407492; ENSG00000130529. [Q8TD43-3]
GeneIDi54795.
KEGGihsa:54795.
UCSCiuc002pmw.4. human. [Q8TD43-1]

Organism-specific databases

CTDi54795.
DisGeNETi54795.
GeneCardsiTRPM4.
HGNCiHGNC:17993. TRPM4.
HPAiHPA041169.
MalaCardsiTRPM4.
MIMi604559. phenotype.
606936. gene.
neXtProtiNX_Q8TD43.
OpenTargetsiENSG00000130529.
Orphaneti130. Brugada syndrome.
871. Familial progressive cardiac conduction defect.
PharmGKBiPA38272.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3614. Eukaryota.
ENOG410XR5B. LUCA.
GeneTreeiENSGT00760000119127.
HOGENOMiHOG000236350.
HOVERGENiHBG108337.
InParanoidiQ8TD43.
KOiK04979.
OMAiFLRLSCD.
OrthoDBiEOG091G017C.
PhylomeDBiQ8TD43.
TreeFamiTF314204.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130529-MONOMER.
ReactomeiR-HSA-3295583. TRP channels.
SIGNORiQ8TD43.

Miscellaneous databases

GeneWikiiTRPM4.
GenomeRNAii54795.
PROiQ8TD43.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130529.
CleanExiHS_TRPM4.
ExpressionAtlasiQ8TD43. baseline and differential.
GenevisibleiQ8TD43. HS.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR029581. TRPM4.
[Graphical view]
PANTHERiPTHR13800:SF6. PTHR13800:SF6. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRPM4_HUMAN
AccessioniPrimary (citable) accession number: Q8TD43
Secondary accession number(s): A2RU25
, Q7Z5D9, Q96L84, Q9NXV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.