Q8TD33 (SG1C1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Secretoglobin family 1C member 1

Alternative name(s):
Secretoglobin RYD5

Gene names

Name:

SCGB1C1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	95 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the secretoglobin family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 95	72	Secretoglobin family 1C member 1		PRO_0000223332
Amino acid modifications
	Modified residue	53	1	Phosphotyrosine By similarity
Natural variations
	Natural variant	70	1	I → R. Ref.1 Ref.3 Ref.4 Corresponds to variant rs2686894 [ dbSNP | Ensembl ].		VAR_063102

Sequences

	Sequence		Length	Mass (Da)
	Q8TD33 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: F6331EADC96D2392	FASTA	95	10,414
	10 20 30 40 50 60 MKGSRALLLV ALTLFCICRM ATGEDNDEFF MDFLQTLLVG TPEELYEGTL GKYNVNEDAK 70 80 90 AAMTELKSCI DGLQPMHKAE LVKLLVQVLG SQDGA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human RYD5, a new secretoglobin." Bingle C.D. Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-70.
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-70.
[4]	"Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse and human airways." Reynolds S.D., Reynolds P.R., Pryhuber G.S., Finder J.D., Stripp B.R. Am. J. Respir. Crit. Care Med. 166:1498-1509(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, VARIANT ARG-70.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY026938 mRNA. Translation: AAK08972.1. AC069287 Genomic DNA. No translation available. BC069287 mRNA. Translation: AAH69287.1. BC111427 mRNA. Translation: AAI11428.1. BC111433 mRNA. Translation: AAI11434.1. BK000201 mRNA. Translation: DAA00358.1.
IPI	IPI00152435.
RefSeq	NP_001091079.1. NM_001097610.2. NP_663626.2. NM_145651.2.
UniGene	Hs.127059.
3D structure databases
ProteinModelPortal	Q8TD33.
SMR	Q8TD33. Positions 25-94.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000344545.
PTM databases
PhosphoSite	Q8TD33.
Polymorphism databases
DMDM	296452904.
Proteomic databases
PRIDE	Q8TD33.
Protocols and materials databases
DNASU	147199.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000342878; ENSP00000344545; ENSG00000188076.
GeneID	147199. 653486.
KEGG	hsa:147199. hsa:653486.
UCSC	uc001loa.1. human.
Organism-specific databases
CTD	147199.
GeneCards	GC11P000187.
H-InvDB	HIX0201712.
HGNC	HGNC:18394. SCGB1C1.
MIM	610176. gene.
neXtProt	NX_Q8TD33.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG27764.
HOGENOM	HOG000220914.
HOVERGEN	HBG098533.
InParanoid	Q8TD33.
OMA	CIDGLQP.
OrthoDB	EOG4PZJ89.
Gene expression databases
Bgee	Q8TD33.
CleanEx	HS_SCGB1C1.
Genevestigator	Q8TD33.
GermOnline	ENSG00000188076. Homo sapiens.
Family and domain databases
InterPro	IPR016126. Secretoglobin. IPR000329. Uteroglobin-like. IPR006039. Uteroglobin-like_fam. IPR006038. Uteroglobin-like_superfam. [Graphical view]
PANTHER	PTHR10136. PTHR10136. 1 hit.
Pfam	PF01099. Uteroglobin. 1 hit. [Graphical view]
SMART	SM00096. UTG. 1 hit. [Graphical view]
SUPFAM	SSF48201. Secretoglobin. 1 hit.
PROSITE	PS51311. SCGB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	85574.
SOURCE	Search...

Entry information

Entry name

SG1C1_HUMAN

Accession

Primary (citable) accession number: Q8TD33
Secondary accession number(s): A8MSI9, Q14DW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2006
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.