ID CCHCR_HUMAN Reviewed; 782 AA. AC Q8TD31; A2ABH6; E9PE84; Q2TB67; Q5SQ82; Q5STE9; Q9NRK8; Q9NWY9; Q9NXJ4; AC Q9NXK3; Q9Y6W1; Q9Y6W2; DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot. DT 16-FEB-2004, sequence version 2. DT 27-MAR-2024, entry version 177. DE RecName: Full=Coiled-coil alpha-helical rod protein 1; DE AltName: Full=Alpha-helical coiled-coil rod protein; DE AltName: Full=Putative gene 8 protein; DE Short=Pg8; GN Name=CCHCR1; Synonyms=C6orf18, HCR; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS GLN-102; TRP-103; RP TRP-109; ARG-164; ASP-275; TRP-417; CYS-575; GLN-627; HIS-639 AND CYS-776. RX PubMed=11875053; DOI=10.1093/hmg/11.5.589; RA Asumalahti K., Veal A., Laitinen T., Suomela S., Allen M., Elomaa O., RA Moser M., de Cid R., Ripatti S., Vorechovsky I., Marcusson J.A., RA Nakagawa H., Lazaro C., Estivill X., Capon F., Novelli G., Burden D.B., RA Tillman D., Powis S.H., Balendran N., Ameen M., Vaughan R.W., Heath E.K., RA Itkonen-Vatjus R., Jansen C., Karvonen J., Karvonen S.-L., Kivekas K., RA Reunala T., Snellman E., Uurasmaa T., Toftgard R., Murakami T., Otsuki M., RA Asahina A., Saeki H., Barbera E., Ferrandiz C., Gimenez Arnau A., RA Grimalt F., Puig S., Sanchez A., Palacios A., Pujol J.A., Sanchez M., RA Simal E., Vazquez F., Ramirez B., Saarialho-Kere U., Barker J., RA Trembath R., Kere J.; RT "Coding haplotype analysis supports HCR as the putative susceptibility gene RT for psoriasis at the MHC PSORS1 locus."; RL Hum. Mol. Genet. 11:589-597(2002). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS ARG-164 AND RP ASP-275. RA Shiina S., Tamiya G., Oka A., Inoko H.; RT "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."; RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS ARG-164 AND RP ASP-275. RA Shiina T., Ota M., Katsuyama Y., Hashimoto N., Inoko H.; RT "Genome diversity in HLA: a new strategy for detection of genetic RT polymorphisms in expressed genes within the HLA class III and class I RT regions."; RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE RP [LARGE SCALE MRNA] OF 270-782 (ISOFORMS 1/2), AND VARIANTS ASP-275 AND RP GLN-417. RC TISSUE=Colon mucosa; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS TRP-103; RP TRP-109; ARG-164; TRP-417; CYS-575 AND CYS-776. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., RA Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANTS TRP-109; RP ARG-164; TRP-417; CYS-575 AND CYS-776. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 20-782 (ISOFORMS 1/2), AND RP VARIANTS TRP-103; TRP-109; ARG-164; ASP-275; TRP-417; CYS-575 AND CYS-776. RC TISSUE=Blood, and Lymphoblast; RX PubMed=10545595; DOI=10.1093/hmg/8.12.2165; RA Oka A., Tamiya G., Tomizawa M., Ota M., Katsuyama Y., Makino S., Shiina T., RA Yoshitome M., Lizuka M., Sasao Y., Iwashita K., Kawakubo Y., Sugai J., RA Ozawa A., Ohkido M., Kimura M., Bahram S., Inoko H.; RT "Association analysis using refined microsatellite markers localizes a RT susceptibility locus for psoriasis vulgaris within a 111kb segment RT telomeric to the HLA-C gene."; RL Hum. Mol. Genet. 8:2165-2170(1999). RN [8] RP NUCLEOTIDE SEQUENCE [MRNA] OF 20-782 (ISOFORMS 1/2), AND VARIANTS ARG-164; RP TRP-417; CYS-575 AND CYS-776. RX PubMed=10888604; DOI=10.1093/hmg/9.10.1533; RA Asumalahti K., Laitinen T., Itkonen-Vatjus R., Lokki M.-L., Suomela S., RA Snellman E., Saarialho-Kere U., Kere J.; RT "A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly RT polymorphic with a disease-associated susceptibility allele."; RL Hum. Mol. Genet. 9:1533-1542(2000). RN [9] RP INVOLVEMENT IN PSORIASIS. RX PubMed=14675183; DOI=10.1046/j.1523-1747.2003.12642.x; RA Suomela S., Elomaa O., Asumalahti K., Kariniemi A.L., Karvonen S.L., RA Peltonen J., Kere J., Saarialho-Kere U.; RT "HCR, a candidate gene for psoriasis, is expressed differently in psoriasis RT and other hyperproliferative skin disorders and is downregulated by RT interferon-gamma in keratinocytes."; RL J. Invest. Dermatol. 121:1360-1364(2003). RN [10] RP IDENTIFICATION BY MASS SPECTROMETRY. RC TISSUE=Lymphoblast; RX PubMed=14654843; DOI=10.1038/nature02166; RA Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.; RT "Proteomic characterization of the human centrosome by protein correlation RT profiling."; RL Nature 426:570-574(2003). RN [11] RP VARIANTS GLN-102; TRP-103; TRP-109; ARG-164; GLN-179; ASP-275; THR-367; RP TRP-417; GLN-417; CYS-575; GLN-627; VAL-733 AND CYS-776. RX PubMed=11348465; DOI=10.1046/j.0022-202x.2001.01323.x; RA O'Brien K.P., Holm S.J., Nilsson S., Carlen L., Rosenmuller T., RA Enerbaeck C., Inerot A., Staahle-Baeckdahl M.; RT "The HCR gene on 6p21 is unlikely to be a psoriasis susceptibility gene."; RL J. Invest. Dermatol. 116:750-754(2001). CC -!- FUNCTION: May be a regulator of keratinocyte proliferation or CC differentiation. CC -!- INTERACTION: CC Q8TD31; Q9NYB9: ABI2; NbExp=3; IntAct=EBI-949834, EBI-743598; CC Q8TD31-1; Q9BVG8-5: KIFC3; NbExp=4; IntAct=EBI-21238948, EBI-14069005; CC Q8TD31-3; Q8IZP0-5: ABI1; NbExp=5; IntAct=EBI-10175300, EBI-11743294; CC Q8TD31-3; Q9NYB9: ABI2; NbExp=3; IntAct=EBI-10175300, EBI-743598; CC Q8TD31-3; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-10175300, EBI-11096309; CC Q8TD31-3; Q9NX04: AIRIM; NbExp=3; IntAct=EBI-10175300, EBI-8643161; CC Q8TD31-3; P13196: ALAS1; NbExp=3; IntAct=EBI-10175300, EBI-3905054; CC Q8TD31-3; Q9Y2J4: AMOTL2; NbExp=3; IntAct=EBI-10175300, EBI-746752; CC Q8TD31-3; Q9Y2J4-4: AMOTL2; NbExp=3; IntAct=EBI-10175300, EBI-10187270; CC Q8TD31-3; X5D778: ANKRD11; NbExp=3; IntAct=EBI-10175300, EBI-17183751; CC Q8TD31-3; A9UGY9: ATG5; NbExp=3; IntAct=EBI-10175300, EBI-10175276; CC Q8TD31-3; Q9H1Y0: ATG5; NbExp=3; IntAct=EBI-10175300, EBI-1047414; CC Q8TD31-3; Q12934-2: BFSP1; NbExp=3; IntAct=EBI-10175300, EBI-12123320; CC Q8TD31-3; Q8TD16-2: BICD2; NbExp=3; IntAct=EBI-10175300, EBI-11975051; CC Q8TD31-3; Q6QNY1: BLOC1S2; NbExp=3; IntAct=EBI-10175300, EBI-465872; CC Q8TD31-3; Q9UL45: BLOC1S6; NbExp=3; IntAct=EBI-10175300, EBI-465781; CC Q8TD31-3; Q96GS4: BORCS6; NbExp=3; IntAct=EBI-10175300, EBI-10193358; CC Q8TD31-3; Q6P1W5: C1orf94; NbExp=4; IntAct=EBI-10175300, EBI-946029; CC Q8TD31-3; Q9H257: CARD9; NbExp=3; IntAct=EBI-10175300, EBI-751319; CC Q8TD31-3; Q8NA61-2: CBY2; NbExp=5; IntAct=EBI-10175300, EBI-11524851; CC Q8TD31-3; Q68D86: CCDC102B; NbExp=6; IntAct=EBI-10175300, EBI-10171570; CC Q8TD31-3; Q8IYE1: CCDC13; NbExp=6; IntAct=EBI-10175300, EBI-10961312; CC Q8TD31-3; Q96JN2-2: CCDC136; NbExp=3; IntAct=EBI-10175300, EBI-10171416; CC Q8TD31-3; Q8NCU1: CCDC197; NbExp=3; IntAct=EBI-10175300, EBI-750686; CC Q8TD31-3; A6NC98: CCDC88B; NbExp=3; IntAct=EBI-10175300, EBI-347573; CC Q8TD31-3; Q8TD31-3: CCHCR1; NbExp=4; IntAct=EBI-10175300, EBI-10175300; CC Q8TD31-3; P24863: CCNC; NbExp=3; IntAct=EBI-10175300, EBI-395261; CC Q8TD31-3; Q16543: CDC37; NbExp=3; IntAct=EBI-10175300, EBI-295634; CC Q8TD31-3; Q01850: CDR2; NbExp=6; IntAct=EBI-10175300, EBI-1181367; CC Q8TD31-3; Q86X02: CDR2L; NbExp=3; IntAct=EBI-10175300, EBI-11063830; CC Q8TD31-3; Q53EZ4: CEP55; NbExp=6; IntAct=EBI-10175300, EBI-747776; CC Q8TD31-3; Q86XR8-3: CEP57; NbExp=3; IntAct=EBI-10175300, EBI-11752486; CC Q8TD31-3; Q96MT8-3: CEP63; NbExp=7; IntAct=EBI-10175300, EBI-11522539; CC Q8TD31-3; Q96M91: CFAP53; NbExp=6; IntAct=EBI-10175300, EBI-742422; CC Q8TD31-3; O43247-2: CIMIP4; NbExp=3; IntAct=EBI-10175300, EBI-12093053; CC Q8TD31-3; Q9NZN8: CNOT2; NbExp=3; IntAct=EBI-10175300, EBI-743033; CC Q8TD31-3; Q9Y2V7: COG6; NbExp=5; IntAct=EBI-10175300, EBI-3866319; CC Q8TD31-3; Q9BSW2: CRACR2A; NbExp=3; IntAct=EBI-10175300, EBI-739773; CC Q8TD31-3; P78358: CTAG1B; NbExp=3; IntAct=EBI-10175300, EBI-1188472; CC Q8TD31-3; Q05D60: DEUP1; NbExp=3; IntAct=EBI-10175300, EBI-748597; CC Q8TD31-3; Q9NRI5-2: DISC1; NbExp=3; IntAct=EBI-10175300, EBI-11988027; CC Q8TD31-3; Q9NPF5: DMAP1; NbExp=3; IntAct=EBI-10175300, EBI-399105; CC Q8TD31-3; O60941-5: DTNB; NbExp=6; IntAct=EBI-10175300, EBI-11984733; CC Q8TD31-3; Q96EV8: DTNBP1; NbExp=3; IntAct=EBI-10175300, EBI-465804; CC Q8TD31-3; Q8WWB3: DYDC1; NbExp=3; IntAct=EBI-10175300, EBI-740680; CC Q8TD31-3; Q5JST6: EFHC2; NbExp=6; IntAct=EBI-10175300, EBI-2349927; CC Q8TD31-3; Q9NV70: EXOC1; NbExp=3; IntAct=EBI-10175300, EBI-1045313; CC Q8TD31-3; Q96A65-2: EXOC4; NbExp=3; IntAct=EBI-10175300, EBI-17869840; CC Q8TD31-3; Q9UPT5-1: EXOC7; NbExp=3; IntAct=EBI-10175300, EBI-6251402; CC Q8TD31-3; Q8IYI6: EXOC8; NbExp=3; IntAct=EBI-10175300, EBI-742102; CC Q8TD31-3; O15287: FANCG; NbExp=3; IntAct=EBI-10175300, EBI-81610; CC Q8TD31-3; O94868-3: FCHSD2; NbExp=5; IntAct=EBI-10175300, EBI-11958845; CC Q8TD31-3; A1L4K1: FSD2; NbExp=6; IntAct=EBI-10175300, EBI-5661036; CC Q8TD31-3; O95995: GAS8; NbExp=3; IntAct=EBI-10175300, EBI-1052570; CC Q8TD31-3; Q9P2W3: GNG13; NbExp=3; IntAct=EBI-10175300, EBI-11427343; CC Q8TD31-3; Q08379: GOLGA2; NbExp=8; IntAct=EBI-10175300, EBI-618309; CC Q8TD31-3; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-10175300, EBI-5916454; CC Q8TD31-3; Q96CS2: HAUS1; NbExp=6; IntAct=EBI-10175300, EBI-2514791; CC Q8TD31-3; Q9BT25: HAUS8; NbExp=5; IntAct=EBI-10175300, EBI-2558143; CC Q8TD31-3; Q8N4P3-2: HDDC3; NbExp=3; IntAct=EBI-10175300, EBI-12037393; CC Q8TD31-3; Q04756: HGFAC; NbExp=3; IntAct=EBI-10175300, EBI-1041722; CC Q8TD31-3; Q9UGU5: HMGXB4; NbExp=3; IntAct=EBI-10175300, EBI-7261162; CC Q8TD31-3; O75506: HSBP1; NbExp=6; IntAct=EBI-10175300, EBI-748664; CC Q8TD31-3; O75031: HSF2BP; NbExp=3; IntAct=EBI-10175300, EBI-7116203; CC Q8TD31-3; Q8IY31-3: IFT20; NbExp=3; IntAct=EBI-10175300, EBI-9091197; CC Q8TD31-3; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-10175300, EBI-747204; CC Q8TD31-3; Q8WYH8: ING5; NbExp=3; IntAct=EBI-10175300, EBI-488533; CC Q8TD31-3; Q4KMZ1: IQCC; NbExp=3; IntAct=EBI-10175300, EBI-12206419; CC Q8TD31-3; Q2KHM9: KIAA0753; NbExp=3; IntAct=EBI-10175300, EBI-2805604; CC Q8TD31-3; Q86T90: KIAA1328; NbExp=3; IntAct=EBI-10175300, EBI-3437878; CC Q8TD31-3; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-10175300, EBI-14069005; CC Q8TD31-3; A1A4E9: KRT13; NbExp=3; IntAct=EBI-10175300, EBI-10171552; CC Q8TD31-3; P19012: KRT15; NbExp=6; IntAct=EBI-10175300, EBI-739566; CC Q8TD31-3; P08779: KRT16; NbExp=3; IntAct=EBI-10175300, EBI-356410; CC Q8TD31-3; P05783: KRT18; NbExp=3; IntAct=EBI-10175300, EBI-297888; CC Q8TD31-3; P08727: KRT19; NbExp=3; IntAct=EBI-10175300, EBI-742756; CC Q8TD31-3; Q2M2I5: KRT24; NbExp=3; IntAct=EBI-10175300, EBI-2952736; CC Q8TD31-3; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-10175300, EBI-3044087; CC Q8TD31-3; Q15323: KRT31; NbExp=6; IntAct=EBI-10175300, EBI-948001; CC Q8TD31-3; O76011: KRT34; NbExp=3; IntAct=EBI-10175300, EBI-1047093; CC Q8TD31-3; Q92764: KRT35; NbExp=3; IntAct=EBI-10175300, EBI-1058674; CC Q8TD31-3; O76013-2: KRT36; NbExp=3; IntAct=EBI-10175300, EBI-11958506; CC Q8TD31-3; Q6A162: KRT40; NbExp=6; IntAct=EBI-10175300, EBI-10171697; CC Q8TD31-3; O95678: KRT75; NbExp=3; IntAct=EBI-10175300, EBI-2949715; CC Q8TD31-3; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-10175300, EBI-726510; CC Q8TD31-3; Q68G74: LHX8; NbExp=3; IntAct=EBI-10175300, EBI-8474075; CC Q8TD31-3; Q9Y250: LZTS1; NbExp=3; IntAct=EBI-10175300, EBI-1216080; CC Q8TD31-3; Q9Y6D9: MAD1L1; NbExp=6; IntAct=EBI-10175300, EBI-742610; CC Q8TD31-3; O95983-2: MBD3; NbExp=3; IntAct=EBI-10175300, EBI-11978579; CC Q8TD31-3; Q96EZ8: MCRS1; NbExp=3; IntAct=EBI-10175300, EBI-348259; CC Q8TD31-3; Q9NPJ6: MED4; NbExp=6; IntAct=EBI-10175300, EBI-394607; CC Q8TD31-3; Q96PC5: MIA2; NbExp=3; IntAct=EBI-10175300, EBI-1050253; CC Q8TD31-3; Q9UJV3-2: MID2; NbExp=6; IntAct=EBI-10175300, EBI-10172526; CC Q8TD31-3; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-10175300, EBI-742948; CC Q8TD31-3; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-10175300, EBI-11522433; CC Q8TD31-3; Q15742: NAB2; NbExp=3; IntAct=EBI-10175300, EBI-8641936; CC Q8TD31-3; O14777: NDC80; NbExp=6; IntAct=EBI-10175300, EBI-715849; CC Q8TD31-3; Q9GZM8: NDEL1; NbExp=3; IntAct=EBI-10175300, EBI-928842; CC Q8TD31-3; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-10175300, EBI-10271199; CC Q8TD31-3; Q9Y2I6: NINL; NbExp=3; IntAct=EBI-10175300, EBI-719716; CC Q8TD31-3; Q9Y5B8: NME7; NbExp=6; IntAct=EBI-10175300, EBI-744782; CC Q8TD31-3; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-10175300, EBI-741158; CC Q8TD31-3; Q7Z3B4: NUP54; NbExp=3; IntAct=EBI-10175300, EBI-741048; CC Q8TD31-3; P37198: NUP62; NbExp=6; IntAct=EBI-10175300, EBI-347978; CC Q8TD31-3; Q86Y26: NUTM1; NbExp=3; IntAct=EBI-10175300, EBI-10178410; CC Q8TD31-3; O43482: OIP5; NbExp=3; IntAct=EBI-10175300, EBI-536879; CC Q8TD31-3; Q15154-3: PCM1; NbExp=5; IntAct=EBI-10175300, EBI-11742977; CC Q8TD31-3; O15212: PFDN6; NbExp=3; IntAct=EBI-10175300, EBI-356973; CC Q8TD31-3; O75928: PIAS2; NbExp=3; IntAct=EBI-10175300, EBI-348555; CC Q8TD31-3; Q4G0R1: PIBF1; NbExp=3; IntAct=EBI-10175300, EBI-14066006; CC Q8TD31-3; Q99959-2: PKP2; NbExp=3; IntAct=EBI-10175300, EBI-10987518; CC Q8TD31-3; Q6IQ23-2: PLEKHA7; NbExp=3; IntAct=EBI-10175300, EBI-12069346; CC Q8TD31-3; P78424: POU6F2; NbExp=3; IntAct=EBI-10175300, EBI-12029004; CC Q8TD31-3; Q96KQ4: PPP1R13B; NbExp=3; IntAct=EBI-10175300, EBI-1105153; CC Q8TD31-3; Q9NQX0: PRDM6; NbExp=3; IntAct=EBI-10175300, EBI-11320284; CC Q8TD31-3; Q2NL68: PROSER3; NbExp=5; IntAct=EBI-10175300, EBI-11336487; CC Q8TD31-3; Q9UJ41-4: RABGEF1; NbExp=3; IntAct=EBI-10175300, EBI-14093916; CC Q8TD31-3; Q15311: RALBP1; NbExp=3; IntAct=EBI-10175300, EBI-749285; CC Q8TD31-3; Q96I25: RBM17; NbExp=6; IntAct=EBI-10175300, EBI-740272; CC Q8TD31-3; Q96IZ5: RBM41; NbExp=3; IntAct=EBI-10175300, EBI-740773; CC Q8TD31-3; Q9P2K3-2: RCOR3; NbExp=3; IntAct=EBI-10175300, EBI-1504830; CC Q8TD31-3; Q6NUQ1: RINT1; NbExp=5; IntAct=EBI-10175300, EBI-726876; CC Q8TD31-3; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-10175300, EBI-6257312; CC Q8TD31-3; Q96NU1: SAMD11; NbExp=3; IntAct=EBI-10175300, EBI-14067109; CC Q8TD31-3; P21673: SAT1; NbExp=6; IntAct=EBI-10175300, EBI-711613; CC Q8TD31-3; Q969G3: SMARCE1; NbExp=3; IntAct=EBI-10175300, EBI-455078; CC Q8TD31-3; O60504: SORBS3; NbExp=3; IntAct=EBI-10175300, EBI-741237; CC Q8TD31-3; Q96R06: SPAG5; NbExp=6; IntAct=EBI-10175300, EBI-413317; CC Q8TD31-3; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-10175300, EBI-742688; CC Q8TD31-3; Q9Y2D8: SSX2IP; NbExp=3; IntAct=EBI-10175300, EBI-2212028; CC Q8TD31-3; Q96DR4: STARD4; NbExp=3; IntAct=EBI-10175300, EBI-17217258; CC Q8TD31-3; Q93045: STMN2; NbExp=3; IntAct=EBI-10175300, EBI-714194; CC Q8TD31-3; O75558: STX11; NbExp=3; IntAct=EBI-10175300, EBI-714135; CC Q8TD31-3; Q8N0S2: SYCE1; NbExp=3; IntAct=EBI-10175300, EBI-6872807; CC Q8TD31-3; Q9Y6A5: TACC3; NbExp=3; IntAct=EBI-10175300, EBI-2554984; CC Q8TD31-3; O75478: TADA2A; NbExp=3; IntAct=EBI-10175300, EBI-742268; CC Q8TD31-3; Q969V4: TEKT1; NbExp=6; IntAct=EBI-10175300, EBI-10180409; CC Q8TD31-3; Q8N6V9: TEX9; NbExp=3; IntAct=EBI-10175300, EBI-746341; CC Q8TD31-3; Q9UBB9: TFIP11; NbExp=8; IntAct=EBI-10175300, EBI-1105213; CC Q8TD31-3; P09493-10: TPM1; NbExp=3; IntAct=EBI-10175300, EBI-12123928; CC Q8TD31-3; P06753: TPM3; NbExp=13; IntAct=EBI-10175300, EBI-355607; CC Q8TD31-3; Q5VU62: TPM3; NbExp=3; IntAct=EBI-10175300, EBI-10184033; CC Q8TD31-3; Q13077: TRAF1; NbExp=6; IntAct=EBI-10175300, EBI-359224; CC Q8TD31-3; Q12933: TRAF2; NbExp=8; IntAct=EBI-10175300, EBI-355744; CC Q8TD31-3; P14373: TRIM27; NbExp=3; IntAct=EBI-10175300, EBI-719493; CC Q8TD31-3; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-10175300, EBI-2130429; CC Q8TD31-3; Q8N7C3: TRIML2; NbExp=3; IntAct=EBI-10175300, EBI-11059915; CC Q8TD31-3; Q99816: TSG101; NbExp=3; IntAct=EBI-10175300, EBI-346882; CC Q8TD31-3; Q9BZW7: TSGA10; NbExp=6; IntAct=EBI-10175300, EBI-744794; CC Q8TD31-3; Q63HK5: TSHZ3; NbExp=3; IntAct=EBI-10175300, EBI-9053916; CC Q8TD31-3; P40222: TXLNA; NbExp=6; IntAct=EBI-10175300, EBI-359793; CC Q8TD31-3; Q8N3L3: TXLNB; NbExp=6; IntAct=EBI-10175300, EBI-6116822; CC Q8TD31-3; Q8N6Y0: USHBP1; NbExp=6; IntAct=EBI-10175300, EBI-739895; CC Q8TD31-3; Q8N1B4: VPS52; NbExp=3; IntAct=EBI-10175300, EBI-2799833; CC Q8TD31-3; Q9Y2B5: VPS9D1; NbExp=3; IntAct=EBI-10175300, EBI-9031083; CC Q8TD31-3; Q9Y3C0: WASHC3; NbExp=6; IntAct=EBI-10175300, EBI-712969; CC Q8TD31-3; Q05516: ZBTB16; NbExp=3; IntAct=EBI-10175300, EBI-711925; CC Q8TD31-3; Q96K21-3: ZFYVE19; NbExp=3; IntAct=EBI-10175300, EBI-10187928; CC Q8TD31-3; Q8N5A5-2: ZGPAT; NbExp=3; IntAct=EBI-10175300, EBI-10183064; CC Q8TD31-3; Q6ZNG0: ZNF620; NbExp=3; IntAct=EBI-10175300, EBI-4395669; CC Q8TD31-3; Q9UEG4: ZNF629; NbExp=3; IntAct=EBI-10175300, EBI-9977294; CC Q8TD31-3; Q8N720: ZNF655; NbExp=3; IntAct=EBI-10175300, EBI-625509; CC Q8TD31-3; Q6NX45: ZNF774; NbExp=3; IntAct=EBI-10175300, EBI-10251462; CC Q8TD31-3; O95229: ZWINT; NbExp=3; IntAct=EBI-10175300, EBI-1001132; CC Q8TD31-3; A0A1U9X8X8; NbExp=3; IntAct=EBI-10175300, EBI-17234977; CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q8TD31-1; Sequence=Displayed; CC Name=2; CC IsoId=Q8TD31-2; Sequence=VSP_038062; CC Name=3; CC IsoId=Q8TD31-3; Sequence=VSP_047069; CC -!- TISSUE SPECIFICITY: Found in all tissues tested, abundantly expressed CC in heart, liver, skeletal muscle, kidney and pancreas, and to a lesser CC extent in lung and placenta. Overexpressed in keratinocytes of CC psoriatic lesions. CC -!- POLYMORPHISM: HCR*WWCC is associated with susceptibility to psoriasis. CC Psoriasis is a chronic inflammatory dermatosis that affects CC approximately 2% of the population. It is a multifactorial disease CC characterized by red, scaly skin lesions that are usually found on the CC scalp, elbows, and knees, and may be associated with severe arthritis. CC The lesions are caused by hyperproliferative keratinocytes and CC infiltration of inflammatory cells into the dermis and epidermis. The CC usual age of onset of psoriasis is between 15 and 30 years, although it CC can present at any age. Association of HCR with psoriasis seem to be CC due to linkage disequilibrium with Cw*06:02 (PubMed:11348465). HCR is CC unlikely to be directly involved in psoriasis development. CC {ECO:0000269|PubMed:11348465}. CC -!- SEQUENCE CAUTION: CC Sequence=AAF74221.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC Sequence=BAA81890.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC Sequence=BAA82158.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC Sequence=BAA91236.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC Sequence=BAB63313.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC Sequence=BAC54937.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC Sequence=AAI10536.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY029160; AAK55759.1; -; mRNA. DR EMBL; BA000025; BAB63313.1; ALT_SEQ; Genomic_DNA. DR EMBL; AB088104; BAC54937.1; ALT_SEQ; Genomic_DNA. DR EMBL; AK000204; BAA91007.1; -; mRNA. DR EMBL; AK000217; BAA91016.1; -; mRNA. DR EMBL; AK000533; BAA91236.1; ALT_INIT; mRNA. DR EMBL; AL662833; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL662844; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL773544; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR753819; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC110535; AAI10536.1; ALT_SEQ; mRNA. DR EMBL; AB029331; BAA81890.1; ALT_INIT; mRNA. DR EMBL; AB029343; BAA82158.1; ALT_SEQ; Genomic_DNA. DR EMBL; AF216493; AAF74221.1; ALT_INIT; mRNA. DR CCDS; CCDS43445.1; -. [Q8TD31-2] DR CCDS; CCDS4695.1; -. [Q8TD31-1] DR CCDS; CCDS47397.1; -. [Q8TD31-3] DR RefSeq; NP_001099033.1; NM_001105563.1. [Q8TD31-3] DR RefSeq; NP_001099034.1; NM_001105564.1. [Q8TD31-2] DR RefSeq; NP_061925.2; NM_019052.3. [Q8TD31-1] DR RefSeq; XP_011513005.1; XM_011514703.1. DR RefSeq; XP_016866451.1; XM_017010962.1. DR RefSeq; XP_016866452.1; XM_017010963.1. [Q8TD31-1] DR RefSeq; XP_016866453.1; XM_017010964.1. [Q8TD31-1] DR RefSeq; XP_016866454.1; XM_017010965.1. DR RefSeq; XP_016866455.1; XM_017010966.1. [Q8TD31-1] DR RefSeq; XP_016866456.1; XM_017010967.1. DR RefSeq; XP_016866457.1; XM_017010968.1. [Q8TD31-1] DR AlphaFoldDB; Q8TD31; -. DR SMR; Q8TD31; -. DR BioGRID; 120022; 234. DR DIP; DIP-40394N; -. DR IntAct; Q8TD31; 196. DR MINT; Q8TD31; -. DR STRING; 9606.ENSP00000379566; -. DR iPTMnet; Q8TD31; -. DR PhosphoSitePlus; Q8TD31; -. DR BioMuta; CCHCR1; -. DR DMDM; 42558938; -. DR EPD; Q8TD31; -. DR jPOST; Q8TD31; -. DR MassIVE; Q8TD31; -. DR MaxQB; Q8TD31; -. DR PaxDb; 9606-ENSP00000379566; -. DR PeptideAtlas; Q8TD31; -. DR ProteomicsDB; 19833; -. DR ProteomicsDB; 74228; -. [Q8TD31-1] DR ProteomicsDB; 74229; -. [Q8TD31-2] DR Pumba; Q8TD31; -. DR Antibodypedia; 53233; 112 antibodies from 22 providers. DR DNASU; 54535; -. DR Ensembl; ENST00000376266.9; ENSP00000365442.5; ENSG00000204536.15. [Q8TD31-1] DR Ensembl; ENST00000383341.8; ENSP00000372832.4; ENSG00000206355.11. DR Ensembl; ENST00000383527.8; ENSP00000373019.4; ENSG00000206457.10. [Q8TD31-1] DR Ensembl; ENST00000396268.8; ENSP00000379566.3; ENSG00000204536.15. [Q8TD31-2] DR Ensembl; ENST00000400352.7; ENSP00000383205.3; ENSG00000206355.11. DR Ensembl; ENST00000400412.7; ENSP00000383263.3; ENSG00000206457.10. [Q8TD31-2] DR Ensembl; ENST00000416163.6; ENSP00000408012.2; ENSG00000234114.8. DR Ensembl; ENST00000425620.6; ENSP00000393042.2; ENSG00000234114.8. DR Ensembl; ENST00000451521.6; ENSP00000401039.2; ENSG00000204536.15. [Q8TD31-3] DR GeneID; 54535; -. DR KEGG; hsa:54535; -. DR MANE-Select; ENST00000396268.8; ENSP00000379566.3; NM_001105564.2; NP_001099034.1. [Q8TD31-2] DR UCSC; uc003nsp.4; human. [Q8TD31-1] DR AGR; HGNC:13930; -. DR CTD; 54535; -. DR DisGeNET; 54535; -. DR GeneCards; CCHCR1; -. DR HGNC; HGNC:13930; CCHCR1. DR HPA; ENSG00000204536; Tissue enriched (testis). DR MIM; 605310; gene. DR neXtProt; NX_Q8TD31; -. DR OpenTargets; ENSG00000204536; -. DR PharmGKB; PA134942738; -. DR VEuPathDB; HostDB:ENSG00000204536; -. DR eggNOG; KOG3802; Eukaryota. DR GeneTree; ENSGT00940000153251; -. DR InParanoid; Q8TD31; -. DR OMA; CFANRRV; -. DR OrthoDB; 2913557at2759; -. DR PhylomeDB; Q8TD31; -. DR TreeFam; TF336947; -. DR PathwayCommons; Q8TD31; -. DR SignaLink; Q8TD31; -. DR BioGRID-ORCS; 54535; 10 hits in 1157 CRISPR screens. DR ChiTaRS; CCHCR1; human. DR GeneWiki; CCHCR1; -. DR GenomeRNAi; 54535; -. DR Pharos; Q8TD31; Tbio. DR PRO; PR:Q8TD31; -. DR Proteomes; UP000005640; Chromosome 6. DR RNAct; Q8TD31; Protein. DR Bgee; ENSG00000204536; Expressed in left testis and 97 other cell types or tissues. DR ExpressionAtlas; Q8TD31; baseline and differential. DR GO; GO:0005814; C:centriole; IDA:UniProtKB. DR GO; GO:0005829; C:cytosol; IDA:HPA. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0042802; F:identical protein binding; IPI:IntAct. DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. DR GO; GO:0006611; P:protein export from nucleus; IBA:GO_Central. DR InterPro; IPR009800; HCR. DR PANTHER; PTHR46822; COILED-COIL ALPHA-HELICAL ROD PROTEIN 1; 1. DR PANTHER; PTHR46822:SF1; COILED-COIL ALPHA-HELICAL ROD PROTEIN 1; 1. DR Pfam; PF07111; HCR; 1. DR Genevisible; Q8TD31; HS. PE 1: Evidence at protein level; KW Alternative splicing; Coiled coil; Cytoplasm; Developmental protein; KW Differentiation; Nucleus; Reference proteome. FT CHAIN 1..782 FT /note="Coiled-coil alpha-helical rod protein 1" FT /id="PRO_0000089416" FT REGION 62..82 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 177..218 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 111..303 FT /evidence="ECO:0000255" FT COILED 344..437 FT /evidence="ECO:0000255" FT COILED 498..691 FT /evidence="ECO:0000255" FT COMPBIAS 62..76 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 177..202 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 203..218 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VAR_SEQ 1..41 FT /note="MFPPSGSTGLIPPSHFQARPLSTLPRMAPTWLSDIPLVQPP -> MWPHSAG FT ARPWASTLTGKDPRVMACWCLDGLPSGLAEPWRELWRWRSRPLHCVPPFSPLARSSRDH FT RNLRRRGNIDGWRQNLEPSNNVEMFPPS (in isoform 3)" FT /evidence="ECO:0000305" FT /id="VSP_047069" FT VAR_SEQ 1 FT /note="M -> MWPHSAGARPWASTLTGKDPRVMACWCLDGLPSGLAEPWRELWRWRS FT RPLHCVPPFSPLARSSRDHRNLRRRGNIDGWRQNLEPSNNVEM (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_038062" FT VARIANT 102 FT /note="R -> Q (in dbSNP:rs130075)" FT /evidence="ECO:0000269|PubMed:11348465, FT ECO:0000269|PubMed:11875053" FT /id="VAR_017761" FT VARIANT 103 FT /note="R -> W (in allele HCR*WWCC; risk factor for FT psoriasis; dbSNP:rs130065)" FT /evidence="ECO:0000269|PubMed:10545595, FT ECO:0000269|PubMed:11348465, ECO:0000269|PubMed:11875053, FT ECO:0000269|PubMed:14574404" FT /id="VAR_017762" FT VARIANT 109 FT /note="R -> W (in allele HCR*WWCC; risk factor for FT psoriasis; dbSNP:rs130076)" FT /evidence="ECO:0000269|PubMed:10545595, FT ECO:0000269|PubMed:11348465, ECO:0000269|PubMed:11875053, FT ECO:0000269|PubMed:14574404, ECO:0000269|PubMed:15489334" FT /id="VAR_017763" FT VARIANT 164 FT /note="S -> R (in dbSNP:rs130066)" FT /evidence="ECO:0000269|PubMed:10545595, FT ECO:0000269|PubMed:10888604, ECO:0000269|PubMed:11348465, FT ECO:0000269|PubMed:11875053, ECO:0000269|PubMed:14574404, FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2, FT ECO:0000269|Ref.3" FT /id="VAR_017764" FT VARIANT 179 FT /note="L -> Q (in dbSNP:rs11540822)" FT /evidence="ECO:0000269|PubMed:11348465" FT /id="VAR_017782" FT VARIANT 275 FT /note="E -> D (in dbSNP:rs130067)" FT /evidence="ECO:0000269|PubMed:10545595, FT ECO:0000269|PubMed:11348465, ECO:0000269|PubMed:11875053, FT ECO:0000269|PubMed:14702039, ECO:0000269|Ref.2, FT ECO:0000269|Ref.3" FT /id="VAR_017765" FT VARIANT 367 FT /note="A -> T (in dbSNP:rs2027937)" FT /evidence="ECO:0000269|PubMed:11348465" FT /id="VAR_017783" FT VARIANT 417 FT /note="R -> Q (in dbSNP:rs130069)" FT /evidence="ECO:0000269|PubMed:11348465, FT ECO:0000269|PubMed:14702039" FT /id="VAR_017767" FT VARIANT 417 FT /note="R -> W (in dbSNP:rs130068)" FT /evidence="ECO:0000269|PubMed:10545595, FT ECO:0000269|PubMed:10888604, ECO:0000269|PubMed:11348465, FT ECO:0000269|PubMed:11875053, ECO:0000269|PubMed:14574404, FT ECO:0000269|PubMed:15489334" FT /id="VAR_017766" FT VARIANT 546 FT /note="K -> R (in dbSNP:rs2073720)" FT /id="VAR_017768" FT VARIANT 575 FT /note="G -> C (in allele HCR*WWCC; risk factor for FT psoriasis; dbSNP:rs130079)" FT /evidence="ECO:0000269|PubMed:10545595, FT ECO:0000269|PubMed:10888604, ECO:0000269|PubMed:11348465, FT ECO:0000269|PubMed:11875053, ECO:0000269|PubMed:14574404, FT ECO:0000269|PubMed:15489334" FT /id="VAR_017769" FT VARIANT 627 FT /note="R -> Q (in dbSNP:rs130072)" FT /evidence="ECO:0000269|PubMed:11348465, FT ECO:0000269|PubMed:11875053" FT /id="VAR_017770" FT VARIANT 639 FT /note="Q -> H (in dbSNP:rs130074)" FT /evidence="ECO:0000269|PubMed:11875053" FT /id="VAR_017771" FT VARIANT 733 FT /note="A -> V (in dbSNP:rs140560656)" FT /evidence="ECO:0000269|PubMed:11348465" FT /id="VAR_017784" FT VARIANT 776 FT /note="S -> C (in allele HCR*WWCC; risk factor for FT psoriasis; dbSNP:rs1576)" FT /evidence="ECO:0000269|PubMed:10545595, FT ECO:0000269|PubMed:10888604, ECO:0000269|PubMed:11348465, FT ECO:0000269|PubMed:11875053, ECO:0000269|PubMed:14574404, FT ECO:0000269|PubMed:15489334" FT /id="VAR_017772" FT CONFLICT 20 FT /note="P -> A (in Ref. 7; BAA81890)" FT /evidence="ECO:0000305" FT CONFLICT 43 FT /note="H -> Y (in Ref. 4; BAA91007)" FT /evidence="ECO:0000305" FT CONFLICT 395 FT /note="E -> G (in Ref. 4; BAA91236)" FT /evidence="ECO:0000305" FT CONFLICT 472 FT /note="H -> L (in Ref. 4; BAA91007)" FT /evidence="ECO:0000305" FT CONFLICT 498 FT /note="V -> A (in Ref. 4; BAA91007)" FT /evidence="ECO:0000305" FT CONFLICT 667 FT /note="Q -> L (in Ref. 4; BAA91236)" FT /evidence="ECO:0000305" SQ SEQUENCE 782 AA; 88671 MW; 0E7DE742DB57B29E CRC64; MFPPSGSTGL IPPSHFQARP LSTLPRMAPT WLSDIPLVQP PGHQDVSERR LDTQRPQVTM WERDVSSDRQ EPGRRGRSWG LEGSQALSQQ AEVIVRQLQE LRRLEEEVRL LRETSLQQKM RLEAQAMELE ALARAEKAGR AEAEGLRAAL AGAEVVRKNL EEGSQRELEE VQRLHQEQLS SLTQAHEEAL SSLTSKAEGL EKSLSSLETR RAGEAKELAE AQREAELLRK QLSKTQEDLE AQVTLVENLR KYVGEQVPSE VHSQTWELER QKLLETMQHL QEDRDSLHAT AELLQVRVQS LTHILALQEE ELTRKVQPSD SLEPEFTRKC QSLLNRWREK VFALMVQLKA QELEHSDSVK QLKGQVASLQ EKVTSQSQEQ AILQRSLQDK AAEVEVERMG AKGLQLELSR AQEARRRWQQ QTASAEEQLR LVVNAVSSSQ IWLETTMAKV EGAAAQLPSL NNRLSYAVRK VHTIRGLIAR KLALAQLRQE SCPLPPPVTD VSLELQQLRE ERNRLDAELQ LSARLIQQEV GRAREQGEAE RQQLSKVAQQ LEQELQQTQE SLASLGLQLE VARQGQQEST EEAASLRQEL TQQQELYGQA LQEKVAEVET RLREQLSDTE RRLNEARREH AKAVVSLRQI QRRAAQEKER SQELRRLQEE ARKEEGQRLA RRLQELERDK NLMLATLQQE GLLSRYKQQR LLTVLPSLLD KKKSVVSSPR PPECSASAPV AAAVPTRESI KGSLSVLLDD LQDLSEAISK EEAVCQGDNL DRCSSSNPQM SS //