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Q8TD31 (CCHCR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Coiled-coil alpha-helical rod protein 1
Alternative name(s):
Alpha-helical coiled-coil rod protein
Putative gene 8 protein
Short name=Pg8
Gene names
Name:CCHCR1
Synonyms:C6orf18, HCR
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length782 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be a regulator of keratinocyte proliferation or differentiation.

Subcellular location

Cytoplasm. Nucleus.

Tissue specificity

Found in all tissues tested, abundantly expressed in heart, liver, skeletal muscle, kidney and pancreas, and to a lesser extent in lung and placenta. Overexpressed in keratinocytes of psoriatic lesions.

Polymorphism

HCR*WWCC is associated with susceptibility to psoriasis. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is a multifactorial disease characterized by red, scaly skin lesions that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. The lesions are caused by hyperproliferative keratinocytes and infiltration of inflammatory cells into the dermis and epidermis. The usual age of onset of psoriasis is between 15 and 30 years, although it can present at any age. Association of HCR with psoriasis seem to be due to linkage disequilibrium with Cw*06:02 (Ref.10). HCR is unlikely to be directly involved in psoriasis development.

Sequence caution

The sequence AAF74221.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAA81890.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAA82158.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence BAA91236.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAB63313.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence BAC54937.1 differs from that shown. Reason: Erroneous gene model prediction.

Isoform 2: The sequence AAI10536.1 differs from that shown. Reason: Erroneous termination at position 78. Translated as Trp.

Ontologies

Keywords
   Biological processDifferentiation
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

multicellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

protein export from nucleus

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcentriole

Inferred from direct assay PubMed 23644468. Source: UniProtKB

cytoplasm

Inferred from direct assay. Source: HPA

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8TD31-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8TD31-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MWPHSAGARP...NLEPSNNVEM
Isoform 3 (identifier: Q8TD31-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: MFPPSGSTGL...LSDIPLVQPP → MWPHSAGARP...SNNVEMFPPS
Note: Gene prediction based on EST data.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 782782Coiled-coil alpha-helical rod protein 1
PRO_0000089416

Regions

Coiled coil111 – 303193 Potential
Coiled coil344 – 43794 Potential
Coiled coil498 – 691194 Potential

Natural variations

Alternative sequence1 – 4141MFPPS…LVQPP → MWPHSAGARPWASTLTGKDP RVMACWCLDGLPSGLAEPWR ELWRWRSRPLHCVPPFSPLA RSSRDHRNLRRRGNIDGWRQ NLEPSNNVEMFPPS in isoform 3.
VSP_047069
Alternative sequence11M → MWPHSAGARPWASTLTGKDP RVMACWCLDGLPSGLAEPWR ELWRWRSRPLHCVPPFSPLA RSSRDHRNLRRRGNIDGWRQ NLEPSNNVEM in isoform 2.
VSP_038062
Natural variant1021R → Q. Ref.1 Ref.10
Corresponds to variant rs130075 [ dbSNP | Ensembl ].
VAR_017761
Natural variant1031R → W in allele HCR*WWCC; associated with psoriasis. Ref.1 Ref.5 Ref.7 Ref.10
Corresponds to variant rs130065 [ dbSNP | Ensembl ].
VAR_017762
Natural variant1091R → W in allele HCR*WWCC; associated with psoriasis. Ref.1 Ref.5 Ref.6 Ref.7 Ref.10
Corresponds to variant rs130076 [ dbSNP | Ensembl ].
VAR_017763
Natural variant1641S → R. Ref.1 Ref.2 Ref.3 Ref.5 Ref.6 Ref.7 Ref.8 Ref.10
Corresponds to variant rs130066 [ dbSNP | Ensembl ].
VAR_017764
Natural variant1791L → Q. Ref.10
Corresponds to variant rs11540822 [ dbSNP | Ensembl ].
VAR_017782
Natural variant2751E → D. Ref.1 Ref.2 Ref.3 Ref.4 Ref.7 Ref.10
Corresponds to variant rs130067 [ dbSNP | Ensembl ].
VAR_017765
Natural variant3671A → T. Ref.10
Corresponds to variant rs2027937 [ dbSNP | Ensembl ].
VAR_017783
Natural variant4171R → Q. Ref.4 Ref.10
Corresponds to variant rs130069 [ dbSNP | Ensembl ].
VAR_017767
Natural variant4171R → W. Ref.1 Ref.5 Ref.6 Ref.7 Ref.8 Ref.10
Corresponds to variant rs130068 [ dbSNP | Ensembl ].
VAR_017766
Natural variant5461K → R.
Corresponds to variant rs2073720 [ dbSNP | Ensembl ].
VAR_017768
Natural variant5751G → C in allele HCR*WWCC; associated with psoriasis. Ref.1 Ref.5 Ref.6 Ref.7 Ref.8 Ref.10
Corresponds to variant rs130079 [ dbSNP | Ensembl ].
VAR_017769
Natural variant6271R → Q. Ref.1 Ref.10
Corresponds to variant rs130072 [ dbSNP | Ensembl ].
VAR_017770
Natural variant6391Q → H. Ref.1
Corresponds to variant rs130074 [ dbSNP | Ensembl ].
VAR_017771
Natural variant7331A → V. Ref.10
VAR_017784
Natural variant7761S → C in allele HCR*WWCC; associated with psoriasis. Ref.1 Ref.5 Ref.6 Ref.7 Ref.8 Ref.10
Corresponds to variant rs1576 [ dbSNP | Ensembl ].
VAR_017772

Experimental info

Sequence conflict201P → A in BAA81890. Ref.7
Sequence conflict431H → Y in BAA91007. Ref.4
Sequence conflict3951E → G in BAA91236. Ref.4
Sequence conflict4721H → L in BAA91007. Ref.4
Sequence conflict4981V → A in BAA91007. Ref.4
Sequence conflict6671Q → L in BAA91236. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 16, 2004. Version 2.
Checksum: 0E7DE742DB57B29E

FASTA78288,671
        10         20         30         40         50         60 
MFPPSGSTGL IPPSHFQARP LSTLPRMAPT WLSDIPLVQP PGHQDVSERR LDTQRPQVTM 

        70         80         90        100        110        120 
WERDVSSDRQ EPGRRGRSWG LEGSQALSQQ AEVIVRQLQE LRRLEEEVRL LRETSLQQKM 

       130        140        150        160        170        180 
RLEAQAMELE ALARAEKAGR AEAEGLRAAL AGAEVVRKNL EEGSQRELEE VQRLHQEQLS 

       190        200        210        220        230        240 
SLTQAHEEAL SSLTSKAEGL EKSLSSLETR RAGEAKELAE AQREAELLRK QLSKTQEDLE 

       250        260        270        280        290        300 
AQVTLVENLR KYVGEQVPSE VHSQTWELER QKLLETMQHL QEDRDSLHAT AELLQVRVQS 

       310        320        330        340        350        360 
LTHILALQEE ELTRKVQPSD SLEPEFTRKC QSLLNRWREK VFALMVQLKA QELEHSDSVK 

       370        380        390        400        410        420 
QLKGQVASLQ EKVTSQSQEQ AILQRSLQDK AAEVEVERMG AKGLQLELSR AQEARRRWQQ 

       430        440        450        460        470        480 
QTASAEEQLR LVVNAVSSSQ IWLETTMAKV EGAAAQLPSL NNRLSYAVRK VHTIRGLIAR 

       490        500        510        520        530        540 
KLALAQLRQE SCPLPPPVTD VSLELQQLRE ERNRLDAELQ LSARLIQQEV GRAREQGEAE 

       550        560        570        580        590        600 
RQQLSKVAQQ LEQELQQTQE SLASLGLQLE VARQGQQEST EEAASLRQEL TQQQELYGQA 

       610        620        630        640        650        660 
LQEKVAEVET RLREQLSDTE RRLNEARREH AKAVVSLRQI QRRAAQEKER SQELRRLQEE 

       670        680        690        700        710        720 
ARKEEGQRLA RRLQELERDK NLMLATLQQE GLLSRYKQQR LLTVLPSLLD KKKSVVSSPR 

       730        740        750        760        770        780 
PPECSASAPV AAAVPTRESI KGSLSVLLDD LQDLSEAISK EEAVCQGDNL DRCSSSNPQM 


SS 

« Hide

Isoform 2 [UniParc].

Checksum: CFB1EF2739BCCE8D
Show »

FASTA87199,007
Isoform 3 [UniParc].

Checksum: 9207F3B3D2D68D64
Show »

FASTA83595,145

References

« Hide 'large scale' references
[1]"Coding haplotype analysis supports HCR as the putative susceptibility gene for psoriasis at the MHC PSORS1 locus."
Asumalahti K., Veal A., Laitinen T., Suomela S., Allen M., Elomaa O., Moser M., de Cid R., Ripatti S., Vorechovsky I., Marcusson J.A., Nakagawa H., Lazaro C., Estivill X., Capon F., Novelli G., Burden D.B., Tillman D. expand/collapse author list , Powis S.H., Balendran N., Ameen M., Vaughan R.W., Heath E.K., Itkonen-Vatjus R., Jansen C., Karvonen J., Karvonen S.-L., Kivekas K., Reunala T., Snellman E., Uurasmaa T., Toftgard R., Murakami T., Otsuki M., Asahina A., Saeki H., Barbera E., Ferrandiz C., Gimenez Arnau A., Grimalt F., Puig S., Sanchez A., Palacios A., Pujol J.A., Sanchez M., Simal E., Vazquez F., Ramirez B., Saarialho-Kere U., Barker J., Trembath R., Kere J.
Hum. Mol. Genet. 11:589-597(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS GLN-102; TRP-103; TRP-109; ARG-164; ASP-275; TRP-417; CYS-575; GLN-627; HIS-639 AND CYS-776.
[2]"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
Shiina S., Tamiya G., Oka A., Inoko H.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ARG-164 AND ASP-275.
[3]"Genome diversity in HLA: a new strategy for detection of genetic polymorphisms in expressed genes within the HLA class III and class I regions."
Shiina T., Ota M., Katsuyama Y., Hashimoto N., Inoko H.
Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ARG-164 AND ASP-275.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 270-782 (ISOFORMS 1/2), VARIANTS ASP-275 AND GLN-417.
Tissue: Colon mucosa.
[5]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS TRP-103; TRP-109; ARG-164; TRP-417; CYS-575 AND CYS-776.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS TRP-109; ARG-164; TRP-417; CYS-575 AND CYS-776.
[7]"Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111kb segment telomeric to the HLA-C gene."
Oka A., Tamiya G., Tomizawa M., Ota M., Katsuyama Y., Makino S., Shiina T., Yoshitome M., Lizuka M., Sasao Y., Iwashita K., Kawakubo Y., Sugai J., Ozawa A., Ohkido M., Kimura M., Bahram S., Inoko H.
Hum. Mol. Genet. 8:2165-2170(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 20-782 (ISOFORMS 1/2), VARIANTS TRP-103; TRP-109; ARG-164; ASP-275; TRP-417; CYS-575 AND CYS-776.
Tissue: Blood and Lymphoblast.
[8]"A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele."
Asumalahti K., Laitinen T., Itkonen-Vatjus R., Lokki M.-L., Suomela S., Snellman E., Saarialho-Kere U., Kere J.
Hum. Mol. Genet. 9:1533-1542(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-782 (ISOFORMS 1/2), VARIANTS ARG-164; TRP-417; CYS-575 AND CYS-776.
[9]"HCR, a candidate gene for psoriasis, is expressed differently in psoriasis and other hyperproliferative skin disorders and is downregulated by interferon-gamma in keratinocytes."
Suomela S., Elomaa O., Asumalahti K., Kariniemi A.L., Karvonen S.L., Peltonen J., Kere J., Saarialho-Kere U.
J. Invest. Dermatol. 121:1360-1364(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN PSORIASIS.
[10]"The HCR gene on 6p21 is unlikely to be a psoriasis susceptibility gene."
O'Brien K.P., Holm S.J., Nilsson S., Carlen L., Rosenmuller T., Enerbaeck C., Inerot A., Staahle-Baeckdahl M.
J. Invest. Dermatol. 116:750-754(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS GLN-102; TRP-103; TRP-109; ARG-164; GLN-179; ASP-275; THR-367; TRP-417; GLN-417; CYS-575; GLN-627; VAL-733 AND CYS-776.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY029160 mRNA. Translation: AAK55759.1.
BA000025 Genomic DNA. Translation: BAB63313.1. Sequence problems.
AB088104 Genomic DNA. Translation: BAC54937.1. Sequence problems.
AK000204 mRNA. Translation: BAA91007.1.
AK000217 mRNA. Translation: BAA91016.1.
AK000533 mRNA. Translation: BAA91236.1. Different initiation.
AL662833 Genomic DNA. Translation: CAI17405.1.
AL662844 Genomic DNA. Translation: CAI18328.1.
AL662844 Genomic DNA. Translation: CAM25639.1.
AL773544 Genomic DNA. Translation: CAI18483.1.
AL773544 Genomic DNA. Translation: CAX15089.1.
CR753819 Genomic DNA. Translation: CAQ10597.1.
BC110535 mRNA. Translation: AAI10536.1.
AB029331 mRNA. Translation: BAA81890.1. Different initiation.
AB029343 Genomic DNA. Translation: BAA82158.1. Sequence problems.
AF216493 mRNA. Translation: AAF74221.1. Different initiation.
CCDSCCDS43445.1. [Q8TD31-2]
CCDS4695.1. [Q8TD31-1]
CCDS47397.1. [Q8TD31-3]
RefSeqNP_001099033.1. NM_001105563.1. [Q8TD31-3]
NP_001099034.1. NM_001105564.1. [Q8TD31-2]
NP_061925.2. NM_019052.3. [Q8TD31-1]
XP_005272889.1. XM_005272832.1.
XP_005272890.1. XM_005272833.2.
XP_005272892.1. XM_005272835.2.
XP_005272893.1. XM_005272836.2.
XP_005275044.1. XM_005274987.1.
XP_005275045.1. XM_005274988.2.
XP_005275047.1. XM_005274990.2.
XP_005275048.1. XM_005274991.2.
XP_005275480.1. XM_005275423.1. [Q8TD31-1]
XP_006725551.1. XM_006725488.1.
XP_006725765.1. XM_006725702.1.
XP_006726067.1. XM_006726004.1. [Q8TD31-1]
UniGeneHs.485075.

3D structure databases

ProteinModelPortalQ8TD31.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120022. 7 interactions.
IntActQ8TD31. 6 interactions.

PTM databases

PhosphoSiteQ8TD31.

Polymorphism databases

DMDM42558938.

Proteomic databases

MaxQBQ8TD31.
PaxDbQ8TD31.
PRIDEQ8TD31.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000376266; ENSP00000365442; ENSG00000204536. [Q8TD31-1]
ENST00000383341; ENSP00000372832; ENSG00000206355.
ENST00000383527; ENSP00000373019; ENSG00000206457. [Q8TD31-1]
ENST00000396268; ENSP00000379566; ENSG00000204536. [Q8TD31-2]
ENST00000400352; ENSP00000383205; ENSG00000206355.
ENST00000400412; ENSP00000383263; ENSG00000206457. [Q8TD31-2]
ENST00000416163; ENSP00000408012; ENSG00000234114.
ENST00000425620; ENSP00000393042; ENSG00000234114.
ENST00000451521; ENSP00000401039; ENSG00000204536. [Q8TD31-3]
GeneID54535.
KEGGhsa:54535.
UCSCuc003nsp.4. human. [Q8TD31-2]
uc003nsr.4. human. [Q8TD31-1]

Organism-specific databases

CTD54535.
GeneCardsGC06M031110.
GC06Mj31102.
GC06Mk31103.
GC06Mn31102.
HGNCHGNC:13930. CCHCR1.
HPAHPA048299.
HPA054167.
MIM605310. gene.
neXtProtNX_Q8TD31.
PharmGKBPA134942738.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG130491.
HOVERGENHBG048718.
InParanoidQ8TD31.
KOK16760.
OMARRYVGEQ.
PhylomeDBQ8TD31.
TreeFamTF336947.

Gene expression databases

ArrayExpressQ8TD31.
BgeeQ8TD31.
CleanExHS_CCHCR1.
GenevestigatorQ8TD31.

Family and domain databases

InterProIPR009800. HCR.
[Graphical view]
PANTHERPTHR23161:SF4. PTHR23161:SF4. 1 hit.
PfamPF07111. HCR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCCHCR1.
GenomeRNAi54535.
NextBio56956.
PROQ8TD31.
SOURCESearch...

Entry information

Entry nameCCHCR_HUMAN
AccessionPrimary (citable) accession number: Q8TD31
Secondary accession number(s): A2ABH6 expand/collapse secondary AC list , E9PE84, Q2TB67, Q5SQ82, Q5STE9, Q9NRK8, Q9NWY9, Q9NXJ4, Q9NXK3, Q9Y6W1, Q9Y6W2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: July 9, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM