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Protein

Coiled-coil alpha-helical rod protein 1

Gene

CCHCR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be a regulator of keratinocyte proliferation or differentiation.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137320-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil alpha-helical rod protein 1
Alternative name(s):
Alpha-helical coiled-coil rod protein
Putative gene 8 protein
Short name:
Pg8
Gene namesi
Name:CCHCR1
Synonyms:C6orf18, HCR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13930. CCHCR1.

Subcellular locationi

GO - Cellular componenti

  • centriole Source: UniProtKB
  • cytoplasm Source: HPA
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi54535.
OpenTargetsiENSG00000204536.
ENSG00000206457.
PharmGKBiPA134942738.

Polymorphism and mutation databases

BioMutaiCCHCR1.
DMDMi42558938.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000894161 – 782Coiled-coil alpha-helical rod protein 1Add BLAST782

Proteomic databases

EPDiQ8TD31.
MaxQBiQ8TD31.
PaxDbiQ8TD31.
PeptideAtlasiQ8TD31.
PRIDEiQ8TD31.

PTM databases

iPTMnetiQ8TD31.
PhosphoSitePlusiQ8TD31.

Expressioni

Tissue specificityi

Found in all tissues tested, abundantly expressed in heart, liver, skeletal muscle, kidney and pancreas, and to a lesser extent in lung and placenta. Overexpressed in keratinocytes of psoriatic lesions.

Gene expression databases

BgeeiENSG00000204536.
CleanExiHS_CCHCR1.
ExpressionAtlasiQ8TD31. baseline and differential.
GenevisibleiQ8TD31. HS.

Organism-specific databases

HPAiHPA048299.
HPA054167.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ABI2Q9NYB93EBI-10175300,EBI-743598
ALAS1P131963EBI-10175300,EBI-3905054
AMOTL2Q9Y2J4-43EBI-10175300,EBI-10187270
ATG5A9UGY93EBI-10175300,EBI-10175276
BLOC1S6Q9UL453EBI-10175300,EBI-465781
C1orf94Q6P1W54EBI-10175300,EBI-946029
CARD9Q9H2573EBI-10175300,EBI-751319
CCDC102BA1A4H13EBI-10175300,EBI-10171570
CCDC136Q96JN2-23EBI-10175300,EBI-10171416
CCDC53Q9Y3C05EBI-10175300,EBI-712969
CDR2Q018505EBI-10175300,EBI-1181367
CEP55D3DR373EBI-10175300,EBI-10173536
COG6Q9Y2V74EBI-10175300,EBI-3866319
CTAGE5O153203EBI-10175300,EBI-1050253
DKFZp451B226Q5HYH73EBI-10175300,EBI-10173842
DTNBP1Q96EV83EBI-10175300,EBI-465804
EFHC2Q5JST65EBI-10175300,EBI-2349927
FSD2A1L4K15EBI-10175300,EBI-5661036
GOLGA2A0A0C4DGS54EBI-10175300,EBI-11522202
GOLGA2Q083793EBI-10175300,EBI-618309
HAUS1Q96CS23EBI-10175300,EBI-2514791
HSBP1O755067EBI-10175300,EBI-748664
KIFC3F5H3M24EBI-10175300,EBI-11953930
KRT13A1A4E93EBI-10175300,EBI-10171552
KRT15P190125EBI-10175300,EBI-739566
KRT31Q153235EBI-10175300,EBI-948001
KRT40Q6A1625EBI-10175300,EBI-10171697
MAD1L1Q9Y6D95EBI-10175300,EBI-742610
MED4Q9NPJ65EBI-10175300,EBI-394607
MID2Q9UJV3-27EBI-10175300,EBI-10172526
MTUS2Q5JR593EBI-10175300,EBI-742948
NAB2Q157423EBI-10175300,EBI-8641936
NDC80O147777EBI-10175300,EBI-715849
NDEL1Q9GZM83EBI-10175300,EBI-928842
NINLQ9Y2I63EBI-10175300,EBI-719716
NME7Q9Y5B85EBI-10175300,EBI-744782
NUP62P371985EBI-10175300,EBI-347978
NUTM1Q86Y263EBI-10175300,EBI-10178410
PIAS2O759283EBI-10175300,EBI-348555
RBM17Q96I255EBI-10175300,EBI-740272
SATQ6ICU93EBI-10175300,EBI-10178867
SAT1P216734EBI-10175300,EBI-711613
SPAG5Q96R065EBI-10175300,EBI-413317
SPERTQ8NA61-24EBI-10175300,EBI-11524851
SSX2IPQ9Y2D83EBI-10175300,EBI-2212028
TADA2AO754783EBI-10175300,EBI-742268
TEKT1Q969V45EBI-10175300,EBI-10180409
TFIP11Q9UBB97EBI-10175300,EBI-1105213
TPM3P067535EBI-10175300,EBI-355607
TPM3Q5VU623EBI-10175300,EBI-10184033
TRAF1Q130775EBI-10175300,EBI-359224
TRAF2Q129335EBI-10175300,EBI-355744
TRIM27P143733EBI-10175300,EBI-719493
TSGA10Q9BZW75EBI-10175300,EBI-744794
TXLNAP402223EBI-10175300,EBI-359793
USHBP1Q8N6Y07EBI-10175300,EBI-739895
ZFYVE19Q96K21-33EBI-10175300,EBI-10187928

Protein-protein interaction databases

BioGridi120022. 79 interactors.
DIPiDIP-40394N.
IntActiQ8TD31. 133 interactors.
STRINGi9606.ENSP00000379566.

Structurei

3D structure databases

ProteinModelPortaliQ8TD31.
SMRiQ8TD31.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili111 – 303Sequence analysisAdd BLAST193
Coiled coili344 – 437Sequence analysisAdd BLAST94
Coiled coili498 – 691Sequence analysisAdd BLAST194

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGTY. Eukaryota.
ENOG410YGAD. LUCA.
GeneTreeiENSGT00710000106841.
HOVERGENiHBG048718.
InParanoidiQ8TD31.
KOiK16760.
OMAiVMAWWCL.
OrthoDBiEOG091G01VU.
PhylomeDBiQ8TD31.
TreeFamiTF336947.

Family and domain databases

InterProiIPR009800. HCR.
[Graphical view]
PANTHERiPTHR23161:SF5. PTHR23161:SF5. 1 hit.
PfamiPF07111. HCR. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TD31-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFPPSGSTGL IPPSHFQARP LSTLPRMAPT WLSDIPLVQP PGHQDVSERR
60 70 80 90 100
LDTQRPQVTM WERDVSSDRQ EPGRRGRSWG LEGSQALSQQ AEVIVRQLQE
110 120 130 140 150
LRRLEEEVRL LRETSLQQKM RLEAQAMELE ALARAEKAGR AEAEGLRAAL
160 170 180 190 200
AGAEVVRKNL EEGSQRELEE VQRLHQEQLS SLTQAHEEAL SSLTSKAEGL
210 220 230 240 250
EKSLSSLETR RAGEAKELAE AQREAELLRK QLSKTQEDLE AQVTLVENLR
260 270 280 290 300
KYVGEQVPSE VHSQTWELER QKLLETMQHL QEDRDSLHAT AELLQVRVQS
310 320 330 340 350
LTHILALQEE ELTRKVQPSD SLEPEFTRKC QSLLNRWREK VFALMVQLKA
360 370 380 390 400
QELEHSDSVK QLKGQVASLQ EKVTSQSQEQ AILQRSLQDK AAEVEVERMG
410 420 430 440 450
AKGLQLELSR AQEARRRWQQ QTASAEEQLR LVVNAVSSSQ IWLETTMAKV
460 470 480 490 500
EGAAAQLPSL NNRLSYAVRK VHTIRGLIAR KLALAQLRQE SCPLPPPVTD
510 520 530 540 550
VSLELQQLRE ERNRLDAELQ LSARLIQQEV GRAREQGEAE RQQLSKVAQQ
560 570 580 590 600
LEQELQQTQE SLASLGLQLE VARQGQQEST EEAASLRQEL TQQQELYGQA
610 620 630 640 650
LQEKVAEVET RLREQLSDTE RRLNEARREH AKAVVSLRQI QRRAAQEKER
660 670 680 690 700
SQELRRLQEE ARKEEGQRLA RRLQELERDK NLMLATLQQE GLLSRYKQQR
710 720 730 740 750
LLTVLPSLLD KKKSVVSSPR PPECSASAPV AAAVPTRESI KGSLSVLLDD
760 770 780
LQDLSEAISK EEAVCQGDNL DRCSSSNPQM SS
Length:782
Mass (Da):88,671
Last modified:February 16, 2004 - v2
Checksum:i0E7DE742DB57B29E
GO
Isoform 2 (identifier: Q8TD31-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MWPHSAGARP...NLEPSNNVEM

Show »
Length:871
Mass (Da):99,007
Checksum:iCFB1EF2739BCCE8D
GO
Isoform 3 (identifier: Q8TD31-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: MFPPSGSTGL...LSDIPLVQPP → MWPHSAGARP...SNNVEMFPPS

Note: Gene prediction based on EST data.
Show »
Length:835
Mass (Da):95,145
Checksum:i9207F3B3D2D68D64
GO

Sequence cautioni

The sequence AAF74221 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
Isoform 2 : The sequence AAI10536 differs from that shown. Reason: Erroneous termination at position 78. Translated as Trp.Curated
The sequence BAA81890 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA82158 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA91236 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB63313 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAC54937 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20P → A in BAA81890 (PubMed:10545595).Curated1
Sequence conflicti43H → Y in BAA91007 (PubMed:14702039).Curated1
Sequence conflicti395E → G in BAA91236 (PubMed:14702039).Curated1
Sequence conflicti472H → L in BAA91007 (PubMed:14702039).Curated1
Sequence conflicti498V → A in BAA91007 (PubMed:14702039).Curated1
Sequence conflicti667Q → L in BAA91236 (PubMed:14702039).Curated1

Polymorphismi

HCR*WWCC is associated with susceptibility to psoriasis. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is a multifactorial disease characterized by red, scaly skin lesions that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. The lesions are caused by hyperproliferative keratinocytes and infiltration of inflammatory cells into the dermis and epidermis. The usual age of onset of psoriasis is between 15 and 30 years, although it can present at any age. Association of HCR with psoriasis seem to be due to linkage disequilibrium with Cw*06:02 (PubMed:11348465). HCR is unlikely to be directly involved in psoriasis development.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017761102R → Q.2 PublicationsCorresponds to variant rs130075dbSNPEnsembl.1
Natural variantiVAR_017762103R → W in allele HCR*WWCC; associated with psoriasis. 4 PublicationsCorresponds to variant rs130065dbSNPEnsembl.1
Natural variantiVAR_017763109R → W in allele HCR*WWCC; associated with psoriasis. 5 PublicationsCorresponds to variant rs130076dbSNPEnsembl.1
Natural variantiVAR_017764164S → R.8 PublicationsCorresponds to variant rs130066dbSNPEnsembl.1
Natural variantiVAR_017782179L → Q.1 PublicationCorresponds to variant rs11540822dbSNPEnsembl.1
Natural variantiVAR_017765275E → D.6 PublicationsCorresponds to variant rs130067dbSNPEnsembl.1
Natural variantiVAR_017783367A → T.1 PublicationCorresponds to variant rs2027937dbSNPEnsembl.1
Natural variantiVAR_017767417R → Q.2 PublicationsCorresponds to variant rs130069dbSNPEnsembl.1
Natural variantiVAR_017766417R → W.6 PublicationsCorresponds to variant rs130068dbSNPEnsembl.1
Natural variantiVAR_017768546K → R.Corresponds to variant rs2073720dbSNPEnsembl.1
Natural variantiVAR_017769575G → C in allele HCR*WWCC; associated with psoriasis. 6 PublicationsCorresponds to variant rs130079dbSNPEnsembl.1
Natural variantiVAR_017770627R → Q.2 PublicationsCorresponds to variant rs130072dbSNPEnsembl.1
Natural variantiVAR_017771639Q → H.1 PublicationCorresponds to variant rs130074dbSNPEnsembl.1
Natural variantiVAR_017784733A → V.1 PublicationCorresponds to variant rs140560656dbSNPEnsembl.1
Natural variantiVAR_017772776S → C in allele HCR*WWCC; associated with psoriasis. 6 PublicationsCorresponds to variant rs1576dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0470691 – 41MFPPS…LVQPP → MWPHSAGARPWASTLTGKDP RVMACWCLDGLPSGLAEPWR ELWRWRSRPLHCVPPFSPLA RSSRDHRNLRRRGNIDGWRQ NLEPSNNVEMFPPS in isoform 3. CuratedAdd BLAST41
Alternative sequenceiVSP_0380621M → MWPHSAGARPWASTLTGKDP RVMACWCLDGLPSGLAEPWR ELWRWRSRPLHCVPPFSPLA RSSRDHRNLRRRGNIDGWRQ NLEPSNNVEM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029160 mRNA. Translation: AAK55759.1.
BA000025 Genomic DNA. Translation: BAB63313.1. Sequence problems.
AB088104 Genomic DNA. Translation: BAC54937.1. Sequence problems.
AK000204 mRNA. Translation: BAA91007.1.
AK000217 mRNA. Translation: BAA91016.1.
AK000533 mRNA. Translation: BAA91236.1. Different initiation.
AL662833 Genomic DNA. Translation: CAI17405.1.
AL662844 Genomic DNA. Translation: CAI18328.1.
AL662844 Genomic DNA. Translation: CAM25639.1.
AL773544 Genomic DNA. Translation: CAI18483.1.
AL773544 Genomic DNA. Translation: CAX15089.1.
CR753819 Genomic DNA. Translation: CAQ10597.1.
BC110535 mRNA. Translation: AAI10536.1.
AB029331 mRNA. Translation: BAA81890.1. Different initiation.
AB029343 Genomic DNA. Translation: BAA82158.1. Sequence problems.
AF216493 mRNA. Translation: AAF74221.1. Different initiation.
CCDSiCCDS43445.1. [Q8TD31-2]
CCDS4695.1. [Q8TD31-1]
CCDS47397.1. [Q8TD31-3]
RefSeqiNP_001099033.1. NM_001105563.1. [Q8TD31-3]
NP_001099034.1. NM_001105564.1. [Q8TD31-2]
NP_061925.2. NM_019052.3. [Q8TD31-1]
XP_011513005.1. XM_011514703.1. [Q8TD31-1]
XP_016866451.1. XM_017010962.1. [Q8TD31-1]
XP_016866452.1. XM_017010963.1. [Q8TD31-1]
XP_016866453.1. XM_017010964.1. [Q8TD31-1]
XP_016866454.1. XM_017010965.1. [Q8TD31-1]
XP_016866455.1. XM_017010966.1. [Q8TD31-1]
XP_016866456.1. XM_017010967.1. [Q8TD31-1]
XP_016866457.1. XM_017010968.1. [Q8TD31-1]
UniGeneiHs.485075.

Genome annotation databases

EnsembliENST00000376266; ENSP00000365442; ENSG00000204536. [Q8TD31-1]
ENST00000383341; ENSP00000372832; ENSG00000206355.
ENST00000383527; ENSP00000373019; ENSG00000206457. [Q8TD31-1]
ENST00000396268; ENSP00000379566; ENSG00000204536. [Q8TD31-2]
ENST00000400352; ENSP00000383205; ENSG00000206355.
ENST00000400412; ENSP00000383263; ENSG00000206457. [Q8TD31-2]
ENST00000416163; ENSP00000408012; ENSG00000234114.
ENST00000425620; ENSP00000393042; ENSG00000234114.
ENST00000451521; ENSP00000401039; ENSG00000204536. [Q8TD31-3]
GeneIDi54535.
KEGGihsa:54535.
UCSCiuc003nsp.4. human. [Q8TD31-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029160 mRNA. Translation: AAK55759.1.
BA000025 Genomic DNA. Translation: BAB63313.1. Sequence problems.
AB088104 Genomic DNA. Translation: BAC54937.1. Sequence problems.
AK000204 mRNA. Translation: BAA91007.1.
AK000217 mRNA. Translation: BAA91016.1.
AK000533 mRNA. Translation: BAA91236.1. Different initiation.
AL662833 Genomic DNA. Translation: CAI17405.1.
AL662844 Genomic DNA. Translation: CAI18328.1.
AL662844 Genomic DNA. Translation: CAM25639.1.
AL773544 Genomic DNA. Translation: CAI18483.1.
AL773544 Genomic DNA. Translation: CAX15089.1.
CR753819 Genomic DNA. Translation: CAQ10597.1.
BC110535 mRNA. Translation: AAI10536.1.
AB029331 mRNA. Translation: BAA81890.1. Different initiation.
AB029343 Genomic DNA. Translation: BAA82158.1. Sequence problems.
AF216493 mRNA. Translation: AAF74221.1. Different initiation.
CCDSiCCDS43445.1. [Q8TD31-2]
CCDS4695.1. [Q8TD31-1]
CCDS47397.1. [Q8TD31-3]
RefSeqiNP_001099033.1. NM_001105563.1. [Q8TD31-3]
NP_001099034.1. NM_001105564.1. [Q8TD31-2]
NP_061925.2. NM_019052.3. [Q8TD31-1]
XP_011513005.1. XM_011514703.1. [Q8TD31-1]
XP_016866451.1. XM_017010962.1. [Q8TD31-1]
XP_016866452.1. XM_017010963.1. [Q8TD31-1]
XP_016866453.1. XM_017010964.1. [Q8TD31-1]
XP_016866454.1. XM_017010965.1. [Q8TD31-1]
XP_016866455.1. XM_017010966.1. [Q8TD31-1]
XP_016866456.1. XM_017010967.1. [Q8TD31-1]
XP_016866457.1. XM_017010968.1. [Q8TD31-1]
UniGeneiHs.485075.

3D structure databases

ProteinModelPortaliQ8TD31.
SMRiQ8TD31.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120022. 79 interactors.
DIPiDIP-40394N.
IntActiQ8TD31. 133 interactors.
STRINGi9606.ENSP00000379566.

PTM databases

iPTMnetiQ8TD31.
PhosphoSitePlusiQ8TD31.

Polymorphism and mutation databases

BioMutaiCCHCR1.
DMDMi42558938.

Proteomic databases

EPDiQ8TD31.
MaxQBiQ8TD31.
PaxDbiQ8TD31.
PeptideAtlasiQ8TD31.
PRIDEiQ8TD31.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376266; ENSP00000365442; ENSG00000204536. [Q8TD31-1]
ENST00000383341; ENSP00000372832; ENSG00000206355.
ENST00000383527; ENSP00000373019; ENSG00000206457. [Q8TD31-1]
ENST00000396268; ENSP00000379566; ENSG00000204536. [Q8TD31-2]
ENST00000400352; ENSP00000383205; ENSG00000206355.
ENST00000400412; ENSP00000383263; ENSG00000206457. [Q8TD31-2]
ENST00000416163; ENSP00000408012; ENSG00000234114.
ENST00000425620; ENSP00000393042; ENSG00000234114.
ENST00000451521; ENSP00000401039; ENSG00000204536. [Q8TD31-3]
GeneIDi54535.
KEGGihsa:54535.
UCSCiuc003nsp.4. human. [Q8TD31-1]

Organism-specific databases

CTDi54535.
DisGeNETi54535.
GeneCardsiCCHCR1.
HGNCiHGNC:13930. CCHCR1.
HPAiHPA048299.
HPA054167.
MIMi605310. gene.
neXtProtiNX_Q8TD31.
OpenTargetsiENSG00000204536.
ENSG00000206457.
PharmGKBiPA134942738.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGTY. Eukaryota.
ENOG410YGAD. LUCA.
GeneTreeiENSGT00710000106841.
HOVERGENiHBG048718.
InParanoidiQ8TD31.
KOiK16760.
OMAiVMAWWCL.
OrthoDBiEOG091G01VU.
PhylomeDBiQ8TD31.
TreeFamiTF336947.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137320-MONOMER.

Miscellaneous databases

ChiTaRSiCCHCR1. human.
GeneWikiiCCHCR1.
GenomeRNAii54535.
PROiQ8TD31.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204536.
CleanExiHS_CCHCR1.
ExpressionAtlasiQ8TD31. baseline and differential.
GenevisibleiQ8TD31. HS.

Family and domain databases

InterProiIPR009800. HCR.
[Graphical view]
PANTHERiPTHR23161:SF5. PTHR23161:SF5. 1 hit.
PfamiPF07111. HCR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCHCR_HUMAN
AccessioniPrimary (citable) accession number: Q8TD31
Secondary accession number(s): A2ABH6
, E9PE84, Q2TB67, Q5SQ82, Q5STE9, Q9NRK8, Q9NWY9, Q9NXJ4, Q9NXK3, Q9Y6W1, Q9Y6W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: November 30, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.