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Protein

Zinc finger protein 675

Gene

ZNF675

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation. May play a role during osteoclast differentiation by modulating TRAF6 signaling activity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri144 – 16623C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri172 – 19423C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 33423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri340 – 36223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri368 – 39023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri396 – 41823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri424 – 44623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri452 – 47423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri480 – 50223C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri508 – 53023C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri536 – 55823C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: GO_Central
  • ubiquitin protein ligase binding Source: BHF-UCL
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • bone resorption Source: UniProtKB
  • cytokine-mediated signaling pathway Source: UniProtKB
  • I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  • negative regulation of interleukin-1-mediated signaling pathway Source: BHF-UCL
  • negative regulation of JNK cascade Source: UniProtKB
  • negative regulation of JUN kinase activity Source: BHF-UCL
  • negative regulation of NF-kappaB transcription factor activity Source: BHF-UCL
  • negative regulation of osteoclast differentiation Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • negative regulation of transcription regulatory region DNA binding Source: BHF-UCL
  • negative regulation of tumor necrosis factor-mediated signaling pathway Source: BHF-UCL
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 675
Alternative name(s):
TRAF6-binding zinc finger protein
TRAF6-inhibitory zinc finger protein
Gene namesi
Name:ZNF675
Synonyms:TIZ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:30768. ZNF675.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
  • perinuclear region of cytoplasm Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670476.

Polymorphism and mutation databases

BioMutaiZNF675.
DMDMi296453065.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568Zinc finger protein 675PRO_0000304875Add
BLAST

Proteomic databases

MaxQBiQ8TD23.
PaxDbiQ8TD23.
PeptideAtlasiQ8TD23.
PRIDEiQ8TD23.

PTM databases

iPTMnetiQ8TD23.
PhosphoSiteiQ8TD23.

Expressioni

Gene expression databases

BgeeiENSG00000197372.
CleanExiHS_ZNF675.
ExpressionAtlasiQ8TD23. baseline and differential.
GenevisibleiQ8TD23. HS.

Interactioni

Subunit structurei

Interacts with TRAF6.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TRAF6Q9Y4K34EBI-528190,EBI-359276

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi128116. 4 interactions.
IntActiQ8TD23. 3 interactions.
MINTiMINT-1198201.
STRINGi9606.ENSP00000352836.

Structurei

3D structure databases

ProteinModelPortaliQ8TD23.
SMRiQ8TD23. Positions 142-562.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri144 – 16623C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri172 – 19423C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 33423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri340 – 36223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri368 – 39023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri396 – 41823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri424 – 44623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri452 – 47423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri480 – 50223C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri508 – 53023C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri536 – 55823C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8TD23.
KOiK09228.
OMAiKRIYTCE.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8TD23.
TreeFamiTF342117.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 8 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TD23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLTFRDVA IEFSLEEWQC LDTAQRNLYK NVILENYRNL VFLGIAVSKQ
60 70 80 90 100
DLITCLEQEK EPLTVKRHEM VNEPPVMCSH FAQEFWPEQN IKDSFEKVTL
110 120 130 140 150
RRYEKCGNDN FQLKGCKSVD ECKLHKGGYN GLNQCLPTMQ SKMFQCDKYV
160 170 180 190 200
KVFNKFSHSD RHKIKHMENK PFKCKECGRS FCMLSHLTRH ERNYTKVNFC
210 220 230 240 250
KCEECEKAVN QSSKLTKHKR IYTCEKLYKC QECDRTFNQF SNLTEYKKDY
260 270 280 290 300
AREKPYKCEE CGKAFNQSSH LTTHKIIHTG EKPYKCEECG KAFNQFSNLT
310 320 330 340 350
THKKIHTGEQ PYICEECGKA FTQSSTLTTH KRIHTGEKPY KCEECGKAFN
360 370 380 390 400
RSSKLTEHKN IHTGEQPYKC EECGKAFNRS SNLTEHRKIH TEEKPYKCKE
410 420 430 440 450
CGKAFKHSSA LTTHKRIHTG EKPYKCEECG KAFNRSSKLT EHKKLHTGKK
460 470 480 490 500
PYKCEECGKA FIQSSKLTEH KKIHSGEIPY KCEECGKAFK HSSSLTTHKR
510 520 530 540 550
IHTGEKPYKC EECGKAFSRS SKLTEHKIIH TGEKPYKCER CDKAFNQSAN
560
LTKHKKIHTG EKLQNWNV
Length:568
Mass (Da):66,299
Last modified:May 18, 2010 - v3
Checksum:iD11640BF26D10B04
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291Y → C in AAK95822 (PubMed:11751921).Curated
Sequence conflicti148 – 1481K → E in AAK95822 (PubMed:11751921).Curated
Sequence conflicti191 – 21828Missing in BAC04216 (PubMed:14702039).CuratedAdd
BLAST
Sequence conflicti293 – 2931F → S in AAK95822 (PubMed:11751921).Curated
Sequence conflicti442 – 4421H → Y in AAK95822 (PubMed:11751921).Curated
Sequence conflicti514 – 5141G → S in AAK95822 (PubMed:11751921).Curated
Sequence conflicti537 – 5371K → E in AAK95822 (PubMed:11751921).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti124 – 1241L → V.2 Publications
Corresponds to variant rs4380159 [ dbSNP | Ensembl ].
VAR_060430
Natural varianti197 – 1971V → A.
Corresponds to variant rs11671053 [ dbSNP | Ensembl ].
VAR_057440
Natural varianti410 – 4101A → T.
Corresponds to variant rs73029758 [ dbSNP | Ensembl ].
VAR_060431

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044432 mRNA. Translation: AAK95822.1.
AK093669 mRNA. Translation: BAC04216.1.
AC073544 Genomic DNA. No translation available.
CCDSiCCDS32981.1.
PIRiF42075.
RefSeqiNP_612203.2. NM_138330.2.
UniGeneiHs.264345.

Genome annotation databases

EnsembliENST00000359788; ENSP00000352836; ENSG00000197372.
GeneIDi171392.
KEGGihsa:171392.
UCSCiuc002nri.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044432 mRNA. Translation: AAK95822.1.
AK093669 mRNA. Translation: BAC04216.1.
AC073544 Genomic DNA. No translation available.
CCDSiCCDS32981.1.
PIRiF42075.
RefSeqiNP_612203.2. NM_138330.2.
UniGeneiHs.264345.

3D structure databases

ProteinModelPortaliQ8TD23.
SMRiQ8TD23. Positions 142-562.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128116. 4 interactions.
IntActiQ8TD23. 3 interactions.
MINTiMINT-1198201.
STRINGi9606.ENSP00000352836.

PTM databases

iPTMnetiQ8TD23.
PhosphoSiteiQ8TD23.

Polymorphism and mutation databases

BioMutaiZNF675.
DMDMi296453065.

Proteomic databases

MaxQBiQ8TD23.
PaxDbiQ8TD23.
PeptideAtlasiQ8TD23.
PRIDEiQ8TD23.

Protocols and materials databases

DNASUi171392.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359788; ENSP00000352836; ENSG00000197372.
GeneIDi171392.
KEGGihsa:171392.
UCSCiuc002nri.4. human.

Organism-specific databases

CTDi171392.
GeneCardsiZNF675.
HGNCiHGNC:30768. ZNF675.
neXtProtiNX_Q8TD23.
PharmGKBiPA142670476.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8TD23.
KOiK09228.
OMAiKRIYTCE.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8TD23.
TreeFamiTF342117.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii171392.
PROiQ8TD23.

Gene expression databases

BgeeiENSG00000197372.
CleanExiHS_ZNF675.
ExpressionAtlasiQ8TD23. baseline and differential.
GenevisibleiQ8TD23. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 8 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN675_HUMAN
AccessioniPrimary (citable) accession number: Q8TD23
Secondary accession number(s): Q8N211
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.