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Protein

Sideroflexin-5

Gene

SFXN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transports citrate. Potential iron transporter (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron

Names & Taxonomyi

Protein namesi
Recommended name:
Sideroflexin-5
Gene namesi
Name:SFXN5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000144040.12
HGNCiHGNC:16073 SFXN5
MIMi615572 gene
neXtProtiNX_Q8TD22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Transmembranei254 – 274HelicalSequence analysisAdd BLAST21
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000144040
PharmGKBiPA38088

Polymorphism and mutation databases

BioMutaiSFXN5
DMDMi30580506

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001770431 – 340Sideroflexin-5Add BLAST340

Proteomic databases

EPDiQ8TD22
MaxQBiQ8TD22
PaxDbiQ8TD22
PeptideAtlasiQ8TD22
PRIDEiQ8TD22
ProteomicsDBi74221

PTM databases

iPTMnetiQ8TD22
PhosphoSitePlusiQ8TD22

Expressioni

Tissue specificityi

Primarily expressed in the brain.1 Publication

Gene expression databases

BgeeiENSG00000144040
CleanExiHS_SFXN5
ExpressionAtlasiQ8TD22 baseline and differential
GenevisibleiQ8TD22 HS

Organism-specific databases

HPAiHPA015473
HPA056866

Interactioni

Protein-protein interaction databases

BioGridi125109, 26 interactors
STRINGi9606.ENSP00000272433

Structurei

3D structure databases

ProteinModelPortaliQ8TD22
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sideroflexin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3767 Eukaryota
ENOG410YU8V LUCA
GeneTreeiENSGT00390000002026
HOGENOMiHOG000203440
HOVERGENiHBG056083
InParanoidiQ8TD22
OMAiKHGTLPP
OrthoDBiEOG091G0C6A
PhylomeDBiQ8TD22
TreeFamiTF313205

Family and domain databases

InterProiView protein in InterPro
IPR004686 Mtc
PANTHERiPTHR11153 PTHR11153, 1 hit
PfamiView protein in Pfam
PF03820 Mtc, 1 hit
TIGRFAMsiTIGR00798 mtc, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TD22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADTATTASA AAASAASASS DAPPFQLGKP RFQQTSFYGR FRHFLDIIDP
60 70 80 90 100
RTLFVTERRL REAVQLLEDY KHGTLRPGVT NEQLWSAQKI KQAILHPDTN
110 120 130 140 150
EKIFMPFRMS GYIPFGTPIV VGLLLPNQTL ASTVFWQWLN QSHNACVNYA
160 170 180 190 200
NRNATKPSPA SKFIQGYLGA VISAVSIAVG LNVLVQKANK FTPATRLLIQ
210 220 230 240 250
RFVPFPAVAS ANICNVVLMR YGELEEGIDV LDSDGNLVGS SKIAARHALL
260 270 280 290 300
ETALTRVVLP MPILVLPPIV MSMLEKTALL QARPRLLLPV QSLVCLAAFG
310 320 330 340
LALPLAISLF PQMSEIETSQ LEPEIAQATS SRTVVYNKGL
Length:340
Mass (Da):37,124
Last modified:June 1, 2002 - v1
Checksum:iAF4103C7DB3F2DAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044437 mRNA Translation: AAK95826.1
AK289731 mRNA Translation: BAF82420.1
AC012366 Genomic DNA Translation: AAY14745.1
CH471053 Genomic DNA Translation: EAW99754.1
BC101311 mRNA Translation: AAI01312.1
BC101312 mRNA Translation: AAI01313.1
BC101313 mRNA Translation: AAI01314.1
CCDSiCCDS1922.1
RefSeqiNP_653180.1, NM_144579.2
UniGeneiHs.368171

Genome annotation databases

EnsembliENST00000272433; ENSP00000272433; ENSG00000144040
GeneIDi94097
KEGGihsa:94097
UCSCiuc002siq.3 human

Similar proteinsi

Entry informationi

Entry nameiSFXN5_HUMAN
AccessioniPrimary (citable) accession number: Q8TD22
Secondary accession number(s): A8K116, Q494Y3, Q53T29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: June 1, 2002
Last modified: June 20, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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