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Protein

Sideroflexin-5

Gene

SFXN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Transports citrate. Potential iron transporter (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Names & Taxonomyi

Protein namesi
Recommended name:
Sideroflexin-5
Gene namesi
Name:SFXN5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:16073. SFXN5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei103 – 12321HelicalSequence analysisAdd
BLAST
Transmembranei163 – 18321HelicalSequence analysisAdd
BLAST
Transmembranei254 – 27421HelicalSequence analysisAdd
BLAST
Transmembranei287 – 30721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38088.

Polymorphism and mutation databases

BioMutaiSFXN5.
DMDMi30580506.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Sideroflexin-5PRO_0000177043Add
BLAST

Proteomic databases

EPDiQ8TD22.
MaxQBiQ8TD22.
PaxDbiQ8TD22.
PRIDEiQ8TD22.

PTM databases

iPTMnetiQ8TD22.
PhosphoSiteiQ8TD22.

Expressioni

Tissue specificityi

Primarily expressed in the brain.1 Publication

Gene expression databases

BgeeiQ8TD22.
CleanExiHS_SFXN5.
ExpressionAtlasiQ8TD22. baseline and differential.
GenevisibleiQ8TD22. HS.

Organism-specific databases

HPAiHPA015473.
HPA056866.

Interactioni

Protein-protein interaction databases

BioGridi125109. 22 interactions.
STRINGi9606.ENSP00000272433.

Structurei

3D structure databases

ProteinModelPortaliQ8TD22.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sideroflexin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3767. Eukaryota.
ENOG410YU8V. LUCA.
GeneTreeiENSGT00390000002026.
HOGENOMiHOG000203440.
HOVERGENiHBG056083.
InParanoidiQ8TD22.
OMAiKHGTLPP.
OrthoDBiEOG7034H9.
PhylomeDBiQ8TD22.
TreeFamiTF313205.

Family and domain databases

InterProiIPR004686. Mtc.
[Graphical view]
PANTHERiPTHR11153. PTHR11153. 1 hit.
PfamiPF03820. Mtc. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00798. mtc. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TD22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADTATTASA AAASAASASS DAPPFQLGKP RFQQTSFYGR FRHFLDIIDP
60 70 80 90 100
RTLFVTERRL REAVQLLEDY KHGTLRPGVT NEQLWSAQKI KQAILHPDTN
110 120 130 140 150
EKIFMPFRMS GYIPFGTPIV VGLLLPNQTL ASTVFWQWLN QSHNACVNYA
160 170 180 190 200
NRNATKPSPA SKFIQGYLGA VISAVSIAVG LNVLVQKANK FTPATRLLIQ
210 220 230 240 250
RFVPFPAVAS ANICNVVLMR YGELEEGIDV LDSDGNLVGS SKIAARHALL
260 270 280 290 300
ETALTRVVLP MPILVLPPIV MSMLEKTALL QARPRLLLPV QSLVCLAAFG
310 320 330 340
LALPLAISLF PQMSEIETSQ LEPEIAQATS SRTVVYNKGL
Length:340
Mass (Da):37,124
Last modified:June 1, 2002 - v1
Checksum:iAF4103C7DB3F2DAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044437 mRNA. Translation: AAK95826.1.
AK289731 mRNA. Translation: BAF82420.1.
AC012366 Genomic DNA. Translation: AAY14745.1.
CH471053 Genomic DNA. Translation: EAW99754.1.
BC101311 mRNA. Translation: AAI01312.1.
BC101312 mRNA. Translation: AAI01313.1.
BC101313 mRNA. Translation: AAI01314.1.
CCDSiCCDS1922.1.
RefSeqiNP_653180.1. NM_144579.2.
UniGeneiHs.368171.

Genome annotation databases

EnsembliENST00000272433; ENSP00000272433; ENSG00000144040.
GeneIDi94097.
KEGGihsa:94097.
UCSCiuc002siq.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044437 mRNA. Translation: AAK95826.1.
AK289731 mRNA. Translation: BAF82420.1.
AC012366 Genomic DNA. Translation: AAY14745.1.
CH471053 Genomic DNA. Translation: EAW99754.1.
BC101311 mRNA. Translation: AAI01312.1.
BC101312 mRNA. Translation: AAI01313.1.
BC101313 mRNA. Translation: AAI01314.1.
CCDSiCCDS1922.1.
RefSeqiNP_653180.1. NM_144579.2.
UniGeneiHs.368171.

3D structure databases

ProteinModelPortaliQ8TD22.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125109. 22 interactions.
STRINGi9606.ENSP00000272433.

PTM databases

iPTMnetiQ8TD22.
PhosphoSiteiQ8TD22.

Polymorphism and mutation databases

BioMutaiSFXN5.
DMDMi30580506.

Proteomic databases

EPDiQ8TD22.
MaxQBiQ8TD22.
PaxDbiQ8TD22.
PRIDEiQ8TD22.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272433; ENSP00000272433; ENSG00000144040.
GeneIDi94097.
KEGGihsa:94097.
UCSCiuc002siq.3. human.

Organism-specific databases

CTDi94097.
GeneCardsiSFXN5.
HGNCiHGNC:16073. SFXN5.
HPAiHPA015473.
HPA056866.
MIMi615572. gene.
neXtProtiNX_Q8TD22.
PharmGKBiPA38088.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3767. Eukaryota.
ENOG410YU8V. LUCA.
GeneTreeiENSGT00390000002026.
HOGENOMiHOG000203440.
HOVERGENiHBG056083.
InParanoidiQ8TD22.
OMAiKHGTLPP.
OrthoDBiEOG7034H9.
PhylomeDBiQ8TD22.
TreeFamiTF313205.

Miscellaneous databases

ChiTaRSiSFXN5. human.
GenomeRNAii94097.
PROiQ8TD22.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TD22.
CleanExiHS_SFXN5.
ExpressionAtlasiQ8TD22. baseline and differential.
GenevisibleiQ8TD22. HS.

Family and domain databases

InterProiIPR004686. Mtc.
[Graphical view]
PANTHERiPTHR11153. PTHR11153. 1 hit.
PfamiPF03820. Mtc. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00798. mtc. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human sideroflexin 5 (SFXN5) gene: sequence, expression analysis and exclusion as a candidate for PARK3."
    Lockhart P.J., Holtom B., Lincoln S., Hussey J., Zimprich A., Gasser T., Wszolek Z.K., Hardy J., Farrer M.J.
    Gene 285:229-237(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSFXN5_HUMAN
AccessioniPrimary (citable) accession number: Q8TD22
Secondary accession number(s): A8K116, Q494Y3, Q53T29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.