ID GTR12_HUMAN Reviewed; 617 AA. AC Q8TD20; B3KV17; Q7Z6U3; Q96MR8; DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2002, sequence version 1. DT 27-MAR-2024, entry version 173. DE RecName: Full=Solute carrier family 2, facilitated glucose transporter member 12 {ECO:0000305}; DE AltName: Full=Glucose transporter type 12 {ECO:0000303|PubMed:11832379}; DE Short=GLUT-12 {ECO:0000303|PubMed:11832379}; GN Name=SLC2A12 {ECO:0000312|HGNC:HGNC:18067}; GN Synonyms=GLUT12 {ECO:0000303|PubMed:11832379}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY. RX PubMed=11832379; DOI=10.1152/ajpendo.2002.282.3.e733; RA Rogers S., Macheda M.L., Docherty S.E., Carty M.D., Henderson M.A., RA Soeller W.C., Gibbs E.M., James D.E., Best J.D.; RT "Identification of a novel glucose transporter-like protein -- GLUT-12."; RL Am. J. Physiol. 282:E733-E738(2002). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., RA Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Meninges, and Skin; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Insulin-independent facilitative glucose transporter. CC {ECO:0000250|UniProtKB:Q8BFW9}. CC -!- CATALYTIC ACTIVITY: CC Reaction=D-glucose(out) = D-glucose(in); Xref=Rhea:RHEA:60376, CC ChEBI:CHEBI:4167; Evidence={ECO:0000250|UniProtKB:Q8BFW9}; CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BFW9}; CC Multi-pass membrane protein {ECO:0000255}. Endomembrane system CC {ECO:0000250|UniProtKB:Q5J316}; Multi-pass membrane protein CC {ECO:0000255}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:11832379}. Note=Localizes primarily perinuclear CC region in the absence of insulin. {ECO:0000269|PubMed:11832379}. CC -!- TISSUE SPECIFICITY: Predominantly expressed in skeletal muscle, heart CC and prostate, with lower levels in brain, placenta and kidney. CC {ECO:0000269|PubMed:11832379}. CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar CC transporter (TC 2.A.1.1) family. Glucose transporter subfamily. CC {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=BAB71214.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY046419; AAL02327.1; -; mRNA. DR EMBL; AK056554; BAB71214.1; ALT_INIT; mRNA. DR EMBL; AK122628; BAG53629.1; -; mRNA. DR EMBL; AL035699; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL449363; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471051; EAW47994.1; -; Genomic_DNA. DR EMBL; BC070149; AAH70149.1; -; mRNA. DR CCDS; CCDS5169.1; -. DR RefSeq; NP_660159.1; NM_145176.2. DR AlphaFoldDB; Q8TD20; -. DR SMR; Q8TD20; -. DR BioGRID; 127535; 76. DR IntAct; Q8TD20; 55. DR STRING; 9606.ENSP00000275230; -. DR DrugBank; DB01914; D-glucose. DR DrugBank; DB09341; Dextrose, unspecified form. DR DrugBank; DB09502; Fludeoxyglucose (18F). DR TCDB; 2.A.1.1.87; the major facilitator superfamily (mfs). DR GlyCosmos; Q8TD20; 4 sites, No reported glycans. DR GlyGen; Q8TD20; 9 sites, 1 O-linked glycan (5 sites). DR iPTMnet; Q8TD20; -. DR PhosphoSitePlus; Q8TD20; -. DR SwissPalm; Q8TD20; -. DR BioMuta; SLC2A12; -. DR DMDM; 74762615; -. DR CPTAC; CPTAC-2738; -. DR EPD; Q8TD20; -. DR MassIVE; Q8TD20; -. DR PaxDb; 9606-ENSP00000275230; -. DR PeptideAtlas; Q8TD20; -. DR ProteomicsDB; 74220; -. DR Antibodypedia; 32959; 161 antibodies from 24 providers. DR DNASU; 154091; -. DR Ensembl; ENST00000275230.6; ENSP00000275230.5; ENSG00000146411.6. DR GeneID; 154091; -. DR KEGG; hsa:154091; -. DR MANE-Select; ENST00000275230.6; ENSP00000275230.5; NM_145176.3; NP_660159.1. DR UCSC; uc003qem.2; human. DR AGR; HGNC:18067; -. DR CTD; 154091; -. DR DisGeNET; 154091; -. DR GeneCards; SLC2A12; -. DR HGNC; HGNC:18067; SLC2A12. DR HPA; ENSG00000146411; Tissue enriched (choroid). DR MIM; 610372; gene. DR neXtProt; NX_Q8TD20; -. DR OpenTargets; ENSG00000146411; -. DR PharmGKB; PA38288; -. DR VEuPathDB; HostDB:ENSG00000146411; -. DR eggNOG; KOG0254; Eukaryota. DR GeneTree; ENSGT00940000159614; -. DR HOGENOM; CLU_001265_30_5_1; -. DR InParanoid; Q8TD20; -. DR OMA; VMVVFAC; -. DR OrthoDB; 2013244at2759; -. DR PhylomeDB; Q8TD20; -. DR TreeFam; TF332408; -. DR PathwayCommons; Q8TD20; -. DR Reactome; R-HSA-189200; Cellular hexose transport. DR SignaLink; Q8TD20; -. DR BioGRID-ORCS; 154091; 12 hits in 1158 CRISPR screens. DR ChiTaRS; SLC2A12; human. DR GeneWiki; SLC2A12; -. DR GenomeRNAi; 154091; -. DR Pharos; Q8TD20; Tbio. DR PRO; PR:Q8TD20; -. DR Proteomes; UP000005640; Chromosome 6. DR RNAct; Q8TD20; Protein. DR Bgee; ENSG00000146411; Expressed in jejunal mucosa and 150 other cell types or tissues. DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IBA:GO_Central. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0055056; F:D-glucose transmembrane transporter activity; TAS:Reactome. DR GO; GO:0005355; F:glucose transmembrane transporter activity; IBA:GO_Central. DR GO; GO:0015293; F:symporter activity; IBA:GO_Central. DR GO; GO:0072359; P:circulatory system development; IBA:GO_Central. DR GO; GO:1904659; P:glucose transmembrane transport; IBA:GO_Central. DR GO; GO:0008645; P:hexose transmembrane transport; TAS:Reactome. DR CDD; cd17435; MFS_GLUT12_Class3; 1. DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2. DR InterPro; IPR020846; MFS_dom. DR InterPro; IPR005828; MFS_sugar_transport-like. DR InterPro; IPR036259; MFS_trans_sf. DR InterPro; IPR003663; Sugar/inositol_transpt. DR InterPro; IPR005829; Sugar_transporter_CS. DR PANTHER; PTHR48023; D-XYLOSE-PROTON SYMPORTER-LIKE 2; 1. DR PANTHER; PTHR48023:SF2; SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 12; 1. DR Pfam; PF00083; Sugar_tr; 2. DR PRINTS; PR00171; SUGRTRNSPORT. DR SUPFAM; SSF103473; MFS general substrate transporter; 1. DR PROSITE; PS50850; MFS; 1. DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1. DR Genevisible; Q8TD20; HS. PE 2: Evidence at transcript level; KW Cell membrane; Cytoplasm; Glycoprotein; Membrane; Reference proteome; KW Sugar transport; Transmembrane; Transmembrane helix; Transport. FT CHAIN 1..617 FT /note="Solute carrier family 2, facilitated glucose FT transporter member 12" FT /id="PRO_0000292014" FT TOPO_DOM 1..44 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 45..65 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 66..80 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 81..101 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 102..115 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 116..136 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 137 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 138..158 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 159..172 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 173..193 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 194..197 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 198..218 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 219..278 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 279..299 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 300..317 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 318..338 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 339..345 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 346..366 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 367..466 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 467..487 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 488..498 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 499..519 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 520..528 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 529..549 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 550..617 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT REGION 1..29 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 8..22 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT CARBOHYD 371 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 383 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 396 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 401 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" SQ SEQUENCE 617 AA; 66966 MW; F176325CDED15249 CRC64; MVPVENTEGP SLLNQKGTAV ETEGSGSRHP PWARGCGMFT FLSSVTAAVS GLLVGYELGI ISGALLQIKT LLALSCHEQE MVVSSLVIGA LLASLTGGVL IDRYGRRTAI ILSSCLLGLG SLVLILSLSY TVLIVGRIAI GVSISLSSIA TCVYIAEIAP QHRRGLLVSL NELMIVIGIL SAYISNYAFA NVFHGWKYMF GLVIPLGVLQ AIAMYFLPPS PRFLVMKGQE GAASKVLGRL RALSDTTEEL TVIKSSLKDE YQYSFWDLFR SKDNMRTRIM IGLTLVFFVQ ITGQPNILFY ASTVLKSVGF QSNEAASLAS TGVGVVKVIS TIPATLLVDH VGSKTFLCIG SSVMAASLVT MGIVNLNIHM NFTHICRSHN SINQSLDESV IYGPGNLSTN NNTLRDHFKG ISSHSRSSLM PLRNDVDKRG ETTSASLLNA GLSHTEYQIV TDPGDVPAFL KWLSLASLLV YVAAFSIGLG PMPWLVLSEI FPGGIRGRAM ALTSSMNWGI NLLISLTFLT VTDLIGLPWV CFIYTIMSLA SLLFVVMFIP ETKGCSLEQI SMELAKVNYV KNNICFMSHH QEELVPKQPQ KRKPQEQLLE CNKLCGRGQS RQLSPET //