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Q8TD20

- GTR12_HUMAN

UniProt

Q8TD20 - GTR12_HUMAN

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Protein

Solute carrier family 2, facilitated glucose transporter member 12

Gene
SLC2A12, GLUT12, GLUT8
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Facilitative glucose transporter By similarity.

GO - Molecular functioni

  1. substrate-specific transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. glucose transport Source: Ensembl
  2. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiREACT_19343. Facilitative Na+-independent glucose transporters.

Protein family/group databases

TCDBi2.A.1.1.87. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 12
Alternative name(s):
Glucose transporter type 12
Short name:
GLUT-12
Gene namesi
Name:SLC2A12
Synonyms:GLUT12, GLUT8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:18067. SLC2A12.

Subcellular locationi

Endomembrane system; Multi-pass membrane protein By similarity. Cytoplasmperinuclear region
Note: Localizes primarily perinuclear region in the absence of insulin.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei45 – 6521Helical; Reviewed predictionAdd
BLAST
Topological domaini66 – 8015Extracellular Reviewed predictionAdd
BLAST
Transmembranei81 – 10121Helical; Reviewed predictionAdd
BLAST
Topological domaini102 – 11514Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei116 – 13621Helical; Reviewed predictionAdd
BLAST
Topological domaini137 – 1371Extracellular Reviewed prediction
Transmembranei138 – 15821Helical; Reviewed predictionAdd
BLAST
Topological domaini159 – 17214Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei173 – 19321Helical; Reviewed predictionAdd
BLAST
Topological domaini194 – 1974Extracellular Reviewed prediction
Transmembranei198 – 21821Helical; Reviewed predictionAdd
BLAST
Topological domaini219 – 27860Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei279 – 29921Helical; Reviewed predictionAdd
BLAST
Topological domaini300 – 31718Extracellular Reviewed predictionAdd
BLAST
Transmembranei318 – 33821Helical; Reviewed predictionAdd
BLAST
Topological domaini339 – 3457Cytoplasmic Reviewed prediction
Transmembranei346 – 36621Helical; Reviewed predictionAdd
BLAST
Topological domaini367 – 466100Extracellular Reviewed predictionAdd
BLAST
Transmembranei467 – 48721Helical; Reviewed predictionAdd
BLAST
Topological domaini488 – 49811Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei499 – 51921Helical; Reviewed predictionAdd
BLAST
Topological domaini520 – 5289Extracellular Reviewed prediction
Transmembranei529 – 54921Helical; Reviewed predictionAdd
BLAST
Topological domaini550 – 61768Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endomembrane system Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. perinuclear region of cytoplasm Source: UniProtKB-SubCell
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38288.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 617617Solute carrier family 2, facilitated glucose transporter member 12PRO_0000292014Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi371 – 3711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi383 – 3831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi396 – 3961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi401 – 4011N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated By similarity.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8TD20.
PRIDEiQ8TD20.

PTM databases

PhosphoSiteiQ8TD20.

Expressioni

Tissue specificityi

Predominantly expressed in skeletal muscle, heart and prostate, with lower levels in brain, placenta and kidney.1 Publication

Gene expression databases

BgeeiQ8TD20.
CleanExiHS_SLC2A12.
GenevestigatoriQ8TD20.

Organism-specific databases

HPAiHPA031593.

Interactioni

Protein-protein interaction databases

BioGridi127535. 1 interaction.
STRINGi9606.ENSP00000275230.

Structurei

3D structure databases

ProteinModelPortaliQ8TD20.
SMRiQ8TD20. Positions 59-364, 463-560.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
HOGENOMiHOG000202868.
HOVERGENiHBG051858.
InParanoidiQ8TD20.
KOiK08149.
OMAiARGCGMF.
OrthoDBiEOG75B852.
PhylomeDBiQ8TD20.
TreeFamiTF332408.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 2 hits.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TD20-1 [UniParc]FASTAAdd to Basket

« Hide

MVPVENTEGP SLLNQKGTAV ETEGSGSRHP PWARGCGMFT FLSSVTAAVS    50
GLLVGYELGI ISGALLQIKT LLALSCHEQE MVVSSLVIGA LLASLTGGVL 100
IDRYGRRTAI ILSSCLLGLG SLVLILSLSY TVLIVGRIAI GVSISLSSIA 150
TCVYIAEIAP QHRRGLLVSL NELMIVIGIL SAYISNYAFA NVFHGWKYMF 200
GLVIPLGVLQ AIAMYFLPPS PRFLVMKGQE GAASKVLGRL RALSDTTEEL 250
TVIKSSLKDE YQYSFWDLFR SKDNMRTRIM IGLTLVFFVQ ITGQPNILFY 300
ASTVLKSVGF QSNEAASLAS TGVGVVKVIS TIPATLLVDH VGSKTFLCIG 350
SSVMAASLVT MGIVNLNIHM NFTHICRSHN SINQSLDESV IYGPGNLSTN 400
NNTLRDHFKG ISSHSRSSLM PLRNDVDKRG ETTSASLLNA GLSHTEYQIV 450
TDPGDVPAFL KWLSLASLLV YVAAFSIGLG PMPWLVLSEI FPGGIRGRAM 500
ALTSSMNWGI NLLISLTFLT VTDLIGLPWV CFIYTIMSLA SLLFVVMFIP 550
ETKGCSLEQI SMELAKVNYV KNNICFMSHH QEELVPKQPQ KRKPQEQLLE 600
CNKLCGRGQS RQLSPET 617
Length:617
Mass (Da):66,966
Last modified:June 1, 2002 - v1
Checksum:iF176325CDED15249
GO

Sequence cautioni

The sequence BAB71214.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY046419 mRNA. Translation: AAL02327.1.
AK056554 mRNA. Translation: BAB71214.1. Different initiation.
AK122628 mRNA. Translation: BAG53629.1.
AL035699, AL449363 Genomic DNA. Translation: CAD92514.2.
AL449363, AL035699 Genomic DNA. Translation: CAI17977.1.
CH471051 Genomic DNA. Translation: EAW47994.1.
BC070149 mRNA. Translation: AAH70149.1.
CCDSiCCDS5169.1.
RefSeqiNP_660159.1. NM_145176.2.
UniGeneiHs.486508.

Genome annotation databases

EnsembliENST00000275230; ENSP00000275230; ENSG00000146411.
GeneIDi154091.
KEGGihsa:154091.
UCSCiuc003qem.1. human.

Polymorphism databases

DMDMi74762615.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY046419 mRNA. Translation: AAL02327.1 .
AK056554 mRNA. Translation: BAB71214.1 . Different initiation.
AK122628 mRNA. Translation: BAG53629.1 .
AL035699 , AL449363 Genomic DNA. Translation: CAD92514.2 .
AL449363 , AL035699 Genomic DNA. Translation: CAI17977.1 .
CH471051 Genomic DNA. Translation: EAW47994.1 .
BC070149 mRNA. Translation: AAH70149.1 .
CCDSi CCDS5169.1.
RefSeqi NP_660159.1. NM_145176.2.
UniGenei Hs.486508.

3D structure databases

ProteinModelPortali Q8TD20.
SMRi Q8TD20. Positions 59-364, 463-560.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127535. 1 interaction.
STRINGi 9606.ENSP00000275230.

Protein family/group databases

TCDBi 2.A.1.1.87. the major facilitator superfamily (mfs).

PTM databases

PhosphoSitei Q8TD20.

Polymorphism databases

DMDMi 74762615.

Proteomic databases

PaxDbi Q8TD20.
PRIDEi Q8TD20.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000275230 ; ENSP00000275230 ; ENSG00000146411 .
GeneIDi 154091.
KEGGi hsa:154091.
UCSCi uc003qem.1. human.

Organism-specific databases

CTDi 154091.
GeneCardsi GC06M134349.
H-InvDB HIX0006232.
HGNCi HGNC:18067. SLC2A12.
HPAi HPA031593.
MIMi 610372. gene.
neXtProti NX_Q8TD20.
PharmGKBi PA38288.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0477.
HOGENOMi HOG000202868.
HOVERGENi HBG051858.
InParanoidi Q8TD20.
KOi K08149.
OMAi ARGCGMF.
OrthoDBi EOG75B852.
PhylomeDBi Q8TD20.
TreeFami TF332408.

Enzyme and pathway databases

Reactomei REACT_19343. Facilitative Na+-independent glucose transporters.

Miscellaneous databases

ChiTaRSi SLC2A12. human.
GeneWikii SLC2A12.
GenomeRNAii 154091.
NextBioi 87232.
PROi Q8TD20.
SOURCEi Search...

Gene expression databases

Bgeei Q8TD20.
CleanExi HS_SLC2A12.
Genevestigatori Q8TD20.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view ]
Pfami PF00083. Sugar_tr. 2 hits.
[Graphical view ]
PRINTSi PR00171. SUGRTRNSPORT.
SUPFAMi SSF103473. SSF103473. 2 hits.
PROSITEi PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel glucose transporter-like protein -- GLUT-12."
    Rogers S., Macheda M.L., Docherty S.E., Carty M.D., Henderson M.A., Soeller W.C., Gibbs E.M., James D.E., Best J.D.
    Am. J. Physiol. 282:E733-E738(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Meninges and Skin.

Entry informationi

Entry nameiGTR12_HUMAN
AccessioniPrimary (citable) accession number: Q8TD20
Secondary accession number(s): B3KV17, Q7Z6U3, Q96MR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 1, 2002
Last modified: September 3, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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