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Protein

Solute carrier family 2, facilitated glucose transporter member 12

Gene

SLC2A12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Facilitative glucose transporter.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000146411-MONOMER.
ReactomeiR-HSA-428790. Facilitative Na+-independent glucose transporters.

Protein family/group databases

TCDBi2.A.1.1.87. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 12
Alternative name(s):
Glucose transporter type 12
Short name:
GLUT-12
Gene namesi
Name:SLC2A12
Synonyms:GLUT12, GLUT8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:18067. SLC2A12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44CytoplasmicSequence analysisAdd BLAST44
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Topological domaini66 – 80ExtracellularSequence analysisAdd BLAST15
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 115CytoplasmicSequence analysisAdd BLAST14
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137ExtracellularSequence analysis1
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 172CytoplasmicSequence analysisAdd BLAST14
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 197ExtracellularSequence analysis4
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 278CytoplasmicSequence analysisAdd BLAST60
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Topological domaini300 – 317ExtracellularSequence analysisAdd BLAST18
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Topological domaini339 – 345CytoplasmicSequence analysis7
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
Topological domaini367 – 466ExtracellularSequence analysisAdd BLAST100
Transmembranei467 – 487HelicalSequence analysisAdd BLAST21
Topological domaini488 – 498CytoplasmicSequence analysisAdd BLAST11
Transmembranei499 – 519HelicalSequence analysisAdd BLAST21
Topological domaini520 – 528ExtracellularSequence analysis9
Transmembranei529 – 549HelicalSequence analysisAdd BLAST21
Topological domaini550 – 617CytoplasmicSequence analysisAdd BLAST68

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi154091.
OpenTargetsiENSG00000146411.
PharmGKBiPA38288.

Polymorphism and mutation databases

BioMutaiSLC2A12.
DMDMi74762615.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002920141 – 617Solute carrier family 2, facilitated glucose transporter member 12Add BLAST617

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi371N-linked (GlcNAc...)Sequence analysis1
Glycosylationi383N-linked (GlcNAc...)Sequence analysis1
Glycosylationi396N-linked (GlcNAc...)Sequence analysis1
Glycosylationi401N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8TD20.
PeptideAtlasiQ8TD20.
PRIDEiQ8TD20.

PTM databases

iPTMnetiQ8TD20.
PhosphoSitePlusiQ8TD20.

Expressioni

Tissue specificityi

Predominantly expressed in skeletal muscle, heart and prostate, with lower levels in brain, placenta and kidney.1 Publication

Gene expression databases

BgeeiENSG00000146411.
CleanExiHS_SLC2A12.
GenevisibleiQ8TD20. HS.

Organism-specific databases

HPAiHPA031593.

Interactioni

Protein-protein interaction databases

BioGridi127535. 56 interactors.
STRINGi9606.ENSP00000275230.

Structurei

3D structure databases

ProteinModelPortaliQ8TD20.
SMRiQ8TD20.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0254. Eukaryota.
ENOG410XNQK. LUCA.
GeneTreeiENSGT00850000132274.
HOGENOMiHOG000202868.
HOVERGENiHBG051858.
InParanoidiQ8TD20.
KOiK08149.
OMAiWTSNFAI.
OrthoDBiEOG091G085H.
PhylomeDBiQ8TD20.
TreeFamiTF332408.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 2 hits.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TD20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPVENTEGP SLLNQKGTAV ETEGSGSRHP PWARGCGMFT FLSSVTAAVS
60 70 80 90 100
GLLVGYELGI ISGALLQIKT LLALSCHEQE MVVSSLVIGA LLASLTGGVL
110 120 130 140 150
IDRYGRRTAI ILSSCLLGLG SLVLILSLSY TVLIVGRIAI GVSISLSSIA
160 170 180 190 200
TCVYIAEIAP QHRRGLLVSL NELMIVIGIL SAYISNYAFA NVFHGWKYMF
210 220 230 240 250
GLVIPLGVLQ AIAMYFLPPS PRFLVMKGQE GAASKVLGRL RALSDTTEEL
260 270 280 290 300
TVIKSSLKDE YQYSFWDLFR SKDNMRTRIM IGLTLVFFVQ ITGQPNILFY
310 320 330 340 350
ASTVLKSVGF QSNEAASLAS TGVGVVKVIS TIPATLLVDH VGSKTFLCIG
360 370 380 390 400
SSVMAASLVT MGIVNLNIHM NFTHICRSHN SINQSLDESV IYGPGNLSTN
410 420 430 440 450
NNTLRDHFKG ISSHSRSSLM PLRNDVDKRG ETTSASLLNA GLSHTEYQIV
460 470 480 490 500
TDPGDVPAFL KWLSLASLLV YVAAFSIGLG PMPWLVLSEI FPGGIRGRAM
510 520 530 540 550
ALTSSMNWGI NLLISLTFLT VTDLIGLPWV CFIYTIMSLA SLLFVVMFIP
560 570 580 590 600
ETKGCSLEQI SMELAKVNYV KNNICFMSHH QEELVPKQPQ KRKPQEQLLE
610
CNKLCGRGQS RQLSPET
Length:617
Mass (Da):66,966
Last modified:June 1, 2002 - v1
Checksum:iF176325CDED15249
GO

Sequence cautioni

The sequence BAB71214 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY046419 mRNA. Translation: AAL02327.1.
AK056554 mRNA. Translation: BAB71214.1. Different initiation.
AK122628 mRNA. Translation: BAG53629.1.
AL035699, AL449363 Genomic DNA. Translation: CAD92514.2.
AL449363, AL035699 Genomic DNA. Translation: CAI17977.1.
CH471051 Genomic DNA. Translation: EAW47994.1.
BC070149 mRNA. Translation: AAH70149.1.
CCDSiCCDS5169.1.
RefSeqiNP_660159.1. NM_145176.2.
UniGeneiHs.486508.

Genome annotation databases

EnsembliENST00000275230; ENSP00000275230; ENSG00000146411.
GeneIDi154091.
KEGGihsa:154091.
UCSCiuc003qem.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY046419 mRNA. Translation: AAL02327.1.
AK056554 mRNA. Translation: BAB71214.1. Different initiation.
AK122628 mRNA. Translation: BAG53629.1.
AL035699, AL449363 Genomic DNA. Translation: CAD92514.2.
AL449363, AL035699 Genomic DNA. Translation: CAI17977.1.
CH471051 Genomic DNA. Translation: EAW47994.1.
BC070149 mRNA. Translation: AAH70149.1.
CCDSiCCDS5169.1.
RefSeqiNP_660159.1. NM_145176.2.
UniGeneiHs.486508.

3D structure databases

ProteinModelPortaliQ8TD20.
SMRiQ8TD20.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127535. 56 interactors.
STRINGi9606.ENSP00000275230.

Protein family/group databases

TCDBi2.A.1.1.87. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ8TD20.
PhosphoSitePlusiQ8TD20.

Polymorphism and mutation databases

BioMutaiSLC2A12.
DMDMi74762615.

Proteomic databases

PaxDbiQ8TD20.
PeptideAtlasiQ8TD20.
PRIDEiQ8TD20.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275230; ENSP00000275230; ENSG00000146411.
GeneIDi154091.
KEGGihsa:154091.
UCSCiuc003qem.2. human.

Organism-specific databases

CTDi154091.
DisGeNETi154091.
GeneCardsiSLC2A12.
H-InvDBHIX0006232.
HGNCiHGNC:18067. SLC2A12.
HPAiHPA031593.
MIMi610372. gene.
neXtProtiNX_Q8TD20.
OpenTargetsiENSG00000146411.
PharmGKBiPA38288.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0254. Eukaryota.
ENOG410XNQK. LUCA.
GeneTreeiENSGT00850000132274.
HOGENOMiHOG000202868.
HOVERGENiHBG051858.
InParanoidiQ8TD20.
KOiK08149.
OMAiWTSNFAI.
OrthoDBiEOG091G085H.
PhylomeDBiQ8TD20.
TreeFamiTF332408.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000146411-MONOMER.
ReactomeiR-HSA-428790. Facilitative Na+-independent glucose transporters.

Miscellaneous databases

ChiTaRSiSLC2A12. human.
GeneWikiiSLC2A12.
GenomeRNAii154091.
PROiQ8TD20.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000146411.
CleanExiHS_SLC2A12.
GenevisibleiQ8TD20. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 2 hits.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGTR12_HUMAN
AccessioniPrimary (citable) accession number: Q8TD20
Secondary accession number(s): B3KV17, Q7Z6U3, Q96MR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.