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Q8TD17

- ZN398_HUMAN

UniProt

Q8TD17 - ZN398_HUMAN

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Protein

Zinc finger protein 398

Gene
ZNF398, KIAA1339, ZER6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Function as a transcriptional activator.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri343 – 36422C2H2-type 1; atypicalAdd
BLAST
Zinc fingeri370 – 39223C2H2-type 2; degenerateAdd
BLAST
Zinc fingeri398 – 42023C2H2-type 3Add
BLAST
Zinc fingeri427 – 44923C2H2-type 4Add
BLAST
Zinc fingeri455 – 47723C2H2-type 5Add
BLAST
Zinc fingeri483 – 50523C2H2-type 6Add
BLAST
Zinc fingeri511 – 53323C2H2-type 7Add
BLAST
Zinc fingeri539 – 56123C2H2-type 8Add
BLAST
Zinc fingeri567 – 59024C2H2-type 9Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. positive regulation of transcription, DNA-templated Source: UniProtKB
  2. regulation of transcription, DNA-templated Source: UniProtKB
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 398
Alternative name(s):
Zinc finger DNA-binding protein p52/p71
Gene namesi
Name:ZNF398
Synonyms:KIAA1339, ZER6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:18373. ZNF398.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38532.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 642642Zinc finger protein 398PRO_0000047565Add
BLAST

Proteomic databases

MaxQBiQ8TD17.
PaxDbiQ8TD17.
PRIDEiQ8TD17.

PTM databases

PhosphoSiteiQ8TD17.

Expressioni

Inductioni

By estrogen receptor alpha.

Gene expression databases

ArrayExpressiQ8TD17.
BgeeiQ8TD17.
CleanExiHS_ZNF398.
GenevestigatoriQ8TD17.

Interactioni

Protein-protein interaction databases

BioGridi121600. 1 interaction.
IntActiQ8TD17. 1 interaction.
STRINGi9606.ENSP00000420418.

Structurei

3D structure databases

ProteinModelPortaliQ8TD17.
SMRiQ8TD17. Positions 339-588.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini143 – 21472KRABAdd
BLAST

Sequence similaritiesi

Contains 1 KRAB domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri343 – 36422C2H2-type 1; atypicalAdd
BLAST
Zinc fingeri370 – 39223C2H2-type 2; degenerateAdd
BLAST
Zinc fingeri398 – 42023C2H2-type 3Add
BLAST
Zinc fingeri427 – 44923C2H2-type 4Add
BLAST
Zinc fingeri455 – 47723C2H2-type 5Add
BLAST
Zinc fingeri483 – 50523C2H2-type 6Add
BLAST
Zinc fingeri511 – 53323C2H2-type 7Add
BLAST
Zinc fingeri539 – 56123C2H2-type 8Add
BLAST
Zinc fingeri567 – 59024C2H2-type 9Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000013125.
HOVERGENiHBG018163.
InParanoidiQ8TD17.
KOiK09228.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8TD17.
TreeFamiTF337777.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR022137. DUF3669_Znf.
IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF12417. DUF3669. 1 hit.
PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8TD17-1) [UniParc]FASTAAdd to Basket

Also known as: p71

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAEAAPAPTS EWDSECLTSL QPLPLPTPPA ANEAHLQTAA ISLWTVVAAV    50
QAIERKVEIH SRRLLHLEGR TGTAEKKLAS CEKTVTELGN QLEGKWAVLG 100
TLLQEYGLLQ RRLENLENLL RNRNFWILRL PPGIKGDIPK VPVAFDDVSI 150
YFSTPEWEKL EEWQKELYKN IMKGNYESLI SMDYAINQPD VLSQIQPEGE 200
HNTEDQAGPE ESEIPTDPSE EPGISTSDIL SWIKQEEEPQ VGAPPESKES 250
DVYKSTYADE ELVIKAEGLA RSSLCPEVPV PFSSPPAAAK DAFSDVAFKS 300
QQSTSMTPFG RPATDLPEAS EGQVTFTQLG SYPLPPPVGE QVFSCHHCGK 350
NLSQDMLLTH QCSHATEHPL PCAQCPKHFT PQADLSSTSQ DHASETPPTC 400
PHCARTFTHP SRLTYHLRVH NSTERPFPCP DCPKRFADQA RLTSHRRAHA 450
SERPFRCAQC GRSFSLKISL LLHQRGHAQE RPFSCPQCGI DFNGHSALIR 500
HQMIHTGERP YPCTDCSKSF MRKEHLLNHR RLHTGERPFS CPHCGKSFIR 550
KHHLMKHQRI HTGERPYPCS YCGRSFRYKQ TLKDHLRSGH NGGCGGDSDP 600
SGQPPNPPGP LITGLETSGL GVNTEGLETN QWYGEGSGGG VL 642
Length:642
Mass (Da):71,311
Last modified:June 1, 2002 - v1
Checksum:i69AA38FCD84FF633
GO
Isoform 2 (identifier: Q8TD17-2) [UniParc]FASTAAdd to Basket

Also known as: p52

The sequence of this isoform differs from the canonical sequence as follows:
     1-171: Missing.

Show »
Length:471
Mass (Da):52,023
Checksum:iAF7BCF9677FC390B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti87 – 871E → D.1 Publication
Corresponds to variant rs3801979 [ dbSNP | Ensembl ].
VAR_052817
Natural varianti294 – 2941S → L.
Corresponds to variant rs2240370 [ dbSNP | Ensembl ].
VAR_052818

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 171171Missing in isoform 2. VSP_006926Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY049744 mRNA. Translation: AAK92789.1.
AY049743 mRNA. Translation: AAK92788.1.
AK290499 mRNA. Translation: BAF83188.1.
AK304603 mRNA. Translation: BAG65389.1.
AC004890 Genomic DNA. No translation available.
CH471146 Genomic DNA. Translation: EAW80057.1.
BC043295 mRNA. Translation: AAH43295.1.
AB037760 mRNA. Translation: BAA92577.1.
CCDSiCCDS47739.1. [Q8TD17-2]
CCDS5894.1. [Q8TD17-1]
RefSeqiNP_065832.1. NM_020781.3. [Q8TD17-2]
NP_733787.1. NM_170686.2. [Q8TD17-1]
UniGeneiHs.632032.

Genome annotation databases

EnsembliENST00000335901; ENSP00000338984; ENSG00000197024. [Q8TD17-2]
ENST00000420008; ENSP00000416751; ENSG00000197024. [Q8TD17-2]
ENST00000426851; ENSP00000389972; ENSG00000197024. [Q8TD17-2]
ENST00000475153; ENSP00000420418; ENSG00000197024. [Q8TD17-1]
ENST00000483892; ENSP00000418564; ENSG00000197024. [Q8TD17-2]
ENST00000491174; ENSP00000419391; ENSG00000197024. [Q8TD17-2]
GeneIDi57541.
KEGGihsa:57541.
UCSCiuc003wfl.3. human. [Q8TD17-1]

Polymorphism databases

DMDMi23396984.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY049744 mRNA. Translation: AAK92789.1 .
AY049743 mRNA. Translation: AAK92788.1 .
AK290499 mRNA. Translation: BAF83188.1 .
AK304603 mRNA. Translation: BAG65389.1 .
AC004890 Genomic DNA. No translation available.
CH471146 Genomic DNA. Translation: EAW80057.1 .
BC043295 mRNA. Translation: AAH43295.1 .
AB037760 mRNA. Translation: BAA92577.1 .
CCDSi CCDS47739.1. [Q8TD17-2 ]
CCDS5894.1. [Q8TD17-1 ]
RefSeqi NP_065832.1. NM_020781.3. [Q8TD17-2 ]
NP_733787.1. NM_170686.2. [Q8TD17-1 ]
UniGenei Hs.632032.

3D structure databases

ProteinModelPortali Q8TD17.
SMRi Q8TD17. Positions 339-588.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121600. 1 interaction.
IntActi Q8TD17. 1 interaction.
STRINGi 9606.ENSP00000420418.

PTM databases

PhosphoSitei Q8TD17.

Polymorphism databases

DMDMi 23396984.

Proteomic databases

MaxQBi Q8TD17.
PaxDbi Q8TD17.
PRIDEi Q8TD17.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000335901 ; ENSP00000338984 ; ENSG00000197024 . [Q8TD17-2 ]
ENST00000420008 ; ENSP00000416751 ; ENSG00000197024 . [Q8TD17-2 ]
ENST00000426851 ; ENSP00000389972 ; ENSG00000197024 . [Q8TD17-2 ]
ENST00000475153 ; ENSP00000420418 ; ENSG00000197024 . [Q8TD17-1 ]
ENST00000483892 ; ENSP00000418564 ; ENSG00000197024 . [Q8TD17-2 ]
ENST00000491174 ; ENSP00000419391 ; ENSG00000197024 . [Q8TD17-2 ]
GeneIDi 57541.
KEGGi hsa:57541.
UCSCi uc003wfl.3. human. [Q8TD17-1 ]

Organism-specific databases

CTDi 57541.
GeneCardsi GC07P148787.
HGNCi HGNC:18373. ZNF398.
neXtProti NX_Q8TD17.
PharmGKBi PA38532.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000013125.
HOVERGENi HBG018163.
InParanoidi Q8TD17.
KOi K09228.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q8TD17.
TreeFami TF337777.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSi ZNF398. human.
GenomeRNAii 57541.
NextBioi 63982.
PROi Q8TD17.

Gene expression databases

ArrayExpressi Q8TD17.
Bgeei Q8TD17.
CleanExi HS_ZNF398.
Genevestigatori Q8TD17.

Family and domain databases

Gene3Di 3.30.160.60. 7 hits.
InterProi IPR022137. DUF3669_Znf.
IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF12417. DUF3669. 1 hit.
PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel zinc finger transcription factor with two isoforms that are differentially repressed by estrogen receptor-alpha."
    Conroy A.T., Sharma M., Holtz A.E., Wu C., Sun Z., Weigel R.J.
    J. Biol. Chem. 277:9326-9334(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ASP-87.
    Tissue: Brain and Uterus.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  6. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 234-642.
    Tissue: Brain.

Entry informationi

Entry nameiZN398_HUMAN
AccessioniPrimary (citable) accession number: Q8TD17
Secondary accession number(s): A8K384
, B4E377, Q8TD18, Q9P2K7, Q9UDV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2002
Last modified: September 3, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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