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Q8TD17

- ZN398_HUMAN

UniProt

Q8TD17 - ZN398_HUMAN

Protein

Zinc finger protein 398

Gene

ZNF398

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Function as a transcriptional activator.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri343 – 36422C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri370 – 39223C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri398 – 42023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri427 – 44923C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri455 – 47723C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri483 – 50523C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri511 – 53323C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri539 – 56123C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri567 – 59024C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. positive regulation of transcription, DNA-templated Source: UniProtKB
    2. regulation of transcription, DNA-templated Source: UniProtKB
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 398
    Alternative name(s):
    Zinc finger DNA-binding protein p52/p71
    Gene namesi
    Name:ZNF398
    Synonyms:KIAA1339, ZER6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:18373. ZNF398.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38532.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 642642Zinc finger protein 398PRO_0000047565Add
    BLAST

    Proteomic databases

    MaxQBiQ8TD17.
    PaxDbiQ8TD17.
    PRIDEiQ8TD17.

    PTM databases

    PhosphoSiteiQ8TD17.

    Expressioni

    Inductioni

    By estrogen receptor alpha.

    Gene expression databases

    ArrayExpressiQ8TD17.
    BgeeiQ8TD17.
    CleanExiHS_ZNF398.
    GenevestigatoriQ8TD17.

    Interactioni

    Protein-protein interaction databases

    BioGridi121600. 1 interaction.
    IntActiQ8TD17. 1 interaction.
    STRINGi9606.ENSP00000420418.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TD17.
    SMRiQ8TD17. Positions 339-588.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini143 – 21472KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri343 – 36422C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri370 – 39223C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri398 – 42023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri427 – 44923C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri455 – 47723C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri483 – 50523C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri511 – 53323C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri539 – 56123C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri567 – 59024C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000013125.
    HOVERGENiHBG018163.
    InParanoidiQ8TD17.
    KOiK09228.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ8TD17.
    TreeFamiTF337777.

    Family and domain databases

    Gene3Di3.30.160.60. 7 hits.
    InterProiIPR022137. DUF3669_Znf.
    IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF12417. DUF3669. 1 hit.
    PF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 8 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 8 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TD17-1) [UniParc]FASTAAdd to Basket

    Also known as: p71

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAEAAPAPTS EWDSECLTSL QPLPLPTPPA ANEAHLQTAA ISLWTVVAAV    50
    QAIERKVEIH SRRLLHLEGR TGTAEKKLAS CEKTVTELGN QLEGKWAVLG 100
    TLLQEYGLLQ RRLENLENLL RNRNFWILRL PPGIKGDIPK VPVAFDDVSI 150
    YFSTPEWEKL EEWQKELYKN IMKGNYESLI SMDYAINQPD VLSQIQPEGE 200
    HNTEDQAGPE ESEIPTDPSE EPGISTSDIL SWIKQEEEPQ VGAPPESKES 250
    DVYKSTYADE ELVIKAEGLA RSSLCPEVPV PFSSPPAAAK DAFSDVAFKS 300
    QQSTSMTPFG RPATDLPEAS EGQVTFTQLG SYPLPPPVGE QVFSCHHCGK 350
    NLSQDMLLTH QCSHATEHPL PCAQCPKHFT PQADLSSTSQ DHASETPPTC 400
    PHCARTFTHP SRLTYHLRVH NSTERPFPCP DCPKRFADQA RLTSHRRAHA 450
    SERPFRCAQC GRSFSLKISL LLHQRGHAQE RPFSCPQCGI DFNGHSALIR 500
    HQMIHTGERP YPCTDCSKSF MRKEHLLNHR RLHTGERPFS CPHCGKSFIR 550
    KHHLMKHQRI HTGERPYPCS YCGRSFRYKQ TLKDHLRSGH NGGCGGDSDP 600
    SGQPPNPPGP LITGLETSGL GVNTEGLETN QWYGEGSGGG VL 642
    Length:642
    Mass (Da):71,311
    Last modified:June 1, 2002 - v1
    Checksum:i69AA38FCD84FF633
    GO
    Isoform 2 (identifier: Q8TD17-2) [UniParc]FASTAAdd to Basket

    Also known as: p52

    The sequence of this isoform differs from the canonical sequence as follows:
         1-171: Missing.

    Show »
    Length:471
    Mass (Da):52,023
    Checksum:iAF7BCF9677FC390B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti87 – 871E → D.1 Publication
    Corresponds to variant rs3801979 [ dbSNP | Ensembl ].
    VAR_052817
    Natural varianti294 – 2941S → L.
    Corresponds to variant rs2240370 [ dbSNP | Ensembl ].
    VAR_052818

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 171171Missing in isoform 2. 2 PublicationsVSP_006926Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY049744 mRNA. Translation: AAK92789.1.
    AY049743 mRNA. Translation: AAK92788.1.
    AK290499 mRNA. Translation: BAF83188.1.
    AK304603 mRNA. Translation: BAG65389.1.
    AC004890 Genomic DNA. No translation available.
    CH471146 Genomic DNA. Translation: EAW80057.1.
    BC043295 mRNA. Translation: AAH43295.1.
    AB037760 mRNA. Translation: BAA92577.1.
    CCDSiCCDS47739.1. [Q8TD17-2]
    CCDS5894.1. [Q8TD17-1]
    RefSeqiNP_065832.1. NM_020781.3. [Q8TD17-2]
    NP_733787.1. NM_170686.2. [Q8TD17-1]
    UniGeneiHs.632032.

    Genome annotation databases

    EnsembliENST00000426851; ENSP00000389972; ENSG00000197024. [Q8TD17-2]
    ENST00000475153; ENSP00000420418; ENSG00000197024. [Q8TD17-1]
    ENST00000483892; ENSP00000418564; ENSG00000197024. [Q8TD17-2]
    ENST00000491174; ENSP00000419391; ENSG00000197024. [Q8TD17-2]
    GeneIDi57541.
    KEGGihsa:57541.
    UCSCiuc003wfl.3. human. [Q8TD17-1]

    Polymorphism databases

    DMDMi23396984.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY049744 mRNA. Translation: AAK92789.1 .
    AY049743 mRNA. Translation: AAK92788.1 .
    AK290499 mRNA. Translation: BAF83188.1 .
    AK304603 mRNA. Translation: BAG65389.1 .
    AC004890 Genomic DNA. No translation available.
    CH471146 Genomic DNA. Translation: EAW80057.1 .
    BC043295 mRNA. Translation: AAH43295.1 .
    AB037760 mRNA. Translation: BAA92577.1 .
    CCDSi CCDS47739.1. [Q8TD17-2 ]
    CCDS5894.1. [Q8TD17-1 ]
    RefSeqi NP_065832.1. NM_020781.3. [Q8TD17-2 ]
    NP_733787.1. NM_170686.2. [Q8TD17-1 ]
    UniGenei Hs.632032.

    3D structure databases

    ProteinModelPortali Q8TD17.
    SMRi Q8TD17. Positions 339-588.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121600. 1 interaction.
    IntActi Q8TD17. 1 interaction.
    STRINGi 9606.ENSP00000420418.

    PTM databases

    PhosphoSitei Q8TD17.

    Polymorphism databases

    DMDMi 23396984.

    Proteomic databases

    MaxQBi Q8TD17.
    PaxDbi Q8TD17.
    PRIDEi Q8TD17.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000426851 ; ENSP00000389972 ; ENSG00000197024 . [Q8TD17-2 ]
    ENST00000475153 ; ENSP00000420418 ; ENSG00000197024 . [Q8TD17-1 ]
    ENST00000483892 ; ENSP00000418564 ; ENSG00000197024 . [Q8TD17-2 ]
    ENST00000491174 ; ENSP00000419391 ; ENSG00000197024 . [Q8TD17-2 ]
    GeneIDi 57541.
    KEGGi hsa:57541.
    UCSCi uc003wfl.3. human. [Q8TD17-1 ]

    Organism-specific databases

    CTDi 57541.
    GeneCardsi GC07P148787.
    HGNCi HGNC:18373. ZNF398.
    neXtProti NX_Q8TD17.
    PharmGKBi PA38532.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000013125.
    HOVERGENi HBG018163.
    InParanoidi Q8TD17.
    KOi K09228.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q8TD17.
    TreeFami TF337777.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    ChiTaRSi ZNF398. human.
    GenomeRNAii 57541.
    NextBioi 63982.
    PROi Q8TD17.

    Gene expression databases

    ArrayExpressi Q8TD17.
    Bgeei Q8TD17.
    CleanExi HS_ZNF398.
    Genevestigatori Q8TD17.

    Family and domain databases

    Gene3Di 3.30.160.60. 7 hits.
    InterProi IPR022137. DUF3669_Znf.
    IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF12417. DUF3669. 1 hit.
    PF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 8 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 8 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel zinc finger transcription factor with two isoforms that are differentially repressed by estrogen receptor-alpha."
      Conroy A.T., Sharma M., Holtz A.E., Wu C., Sun Z., Weigel R.J.
      J. Biol. Chem. 277:9326-9334(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ASP-87.
      Tissue: Brain and Uterus.
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    6. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 234-642.
      Tissue: Brain.

    Entry informationi

    Entry nameiZN398_HUMAN
    AccessioniPrimary (citable) accession number: Q8TD17
    Secondary accession number(s): A8K384
    , B4E377, Q8TD18, Q9P2K7, Q9UDV8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3