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Protein

Zinc finger protein 398

Gene

ZNF398

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Function as a transcriptional activator.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri343 – 364C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST22
Zinc fingeri370 – 392C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri427 – 449C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri455 – 477C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri511 – 533C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri539 – 561C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri567 – 590C2H2-type 9PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170265-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 398
Alternative name(s):
Zinc finger DNA-binding protein p52/p71
Gene namesi
Name:ZNF398
Synonyms:KIAA1339, ZER6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:18373. ZNF398.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi57541.
OpenTargetsiENSG00000197024.
PharmGKBiPA38532.

Polymorphism and mutation databases

BioMutaiZNF398.
DMDMi23396984.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475651 – 642Zinc finger protein 398Add BLAST642

Proteomic databases

EPDiQ8TD17.
MaxQBiQ8TD17.
PaxDbiQ8TD17.
PeptideAtlasiQ8TD17.
PRIDEiQ8TD17.

PTM databases

iPTMnetiQ8TD17.
PhosphoSitePlusiQ8TD17.

Expressioni

Inductioni

By estrogen receptor alpha.

Gene expression databases

BgeeiENSG00000197024.
CleanExiHS_ZNF398.
ExpressionAtlasiQ8TD17. baseline and differential.
GenevisibleiQ8TD17. HS.

Organism-specific databases

HPAiHPA071533.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
C1orf109Q9NX046EBI-8643207,EBI-8643161
CIB3Q96Q775EBI-8643207,EBI-10292696
CLK2P497605EBI-8643207,EBI-750020
ELMO1Q925563EBI-8643207,EBI-346417
GPATCH2LQ9NWQ43EBI-8643207,EBI-5666657
MAGOHBQ96A725EBI-8643207,EBI-746778
MFAP1P550813EBI-8643207,EBI-1048159
OPTNQ96CV93EBI-8643207,EBI-748974
PLEKHF2Q9H8W43EBI-8643207,EBI-742388
ZNF783Q6ZMS75EBI-8643207,EBI-10254978

Protein-protein interaction databases

BioGridi121600. 21 interactors.
IntActiQ8TD17. 16 interactors.
STRINGi9606.ENSP00000420418.

Structurei

3D structure databases

ProteinModelPortaliQ8TD17.
SMRiQ8TD17.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini143 – 214KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri343 – 364C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST22
Zinc fingeri370 – 392C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri427 – 449C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri455 – 477C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri511 – 533C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri539 – 561C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri567 – 590C2H2-type 9PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063032.
HOGENOMiHOG000013125.
HOVERGENiHBG018163.
InParanoidiQ8TD17.
KOiK09228.
OMAiHQRGHAQ.
OrthoDBiEOG091G0P6J.
PhylomeDBiQ8TD17.
TreeFamiTF337777.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 7 hits.
InterProiIPR022137. DUF3669_Znf.
IPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF12417. DUF3669. 1 hit.
PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TD17-1) [UniParc]FASTAAdd to basket
Also known as: p71

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAAPAPTS EWDSECLTSL QPLPLPTPPA ANEAHLQTAA ISLWTVVAAV
60 70 80 90 100
QAIERKVEIH SRRLLHLEGR TGTAEKKLAS CEKTVTELGN QLEGKWAVLG
110 120 130 140 150
TLLQEYGLLQ RRLENLENLL RNRNFWILRL PPGIKGDIPK VPVAFDDVSI
160 170 180 190 200
YFSTPEWEKL EEWQKELYKN IMKGNYESLI SMDYAINQPD VLSQIQPEGE
210 220 230 240 250
HNTEDQAGPE ESEIPTDPSE EPGISTSDIL SWIKQEEEPQ VGAPPESKES
260 270 280 290 300
DVYKSTYADE ELVIKAEGLA RSSLCPEVPV PFSSPPAAAK DAFSDVAFKS
310 320 330 340 350
QQSTSMTPFG RPATDLPEAS EGQVTFTQLG SYPLPPPVGE QVFSCHHCGK
360 370 380 390 400
NLSQDMLLTH QCSHATEHPL PCAQCPKHFT PQADLSSTSQ DHASETPPTC
410 420 430 440 450
PHCARTFTHP SRLTYHLRVH NSTERPFPCP DCPKRFADQA RLTSHRRAHA
460 470 480 490 500
SERPFRCAQC GRSFSLKISL LLHQRGHAQE RPFSCPQCGI DFNGHSALIR
510 520 530 540 550
HQMIHTGERP YPCTDCSKSF MRKEHLLNHR RLHTGERPFS CPHCGKSFIR
560 570 580 590 600
KHHLMKHQRI HTGERPYPCS YCGRSFRYKQ TLKDHLRSGH NGGCGGDSDP
610 620 630 640
SGQPPNPPGP LITGLETSGL GVNTEGLETN QWYGEGSGGG VL
Length:642
Mass (Da):71,311
Last modified:June 1, 2002 - v1
Checksum:i69AA38FCD84FF633
GO
Isoform 2 (identifier: Q8TD17-2) [UniParc]FASTAAdd to basket
Also known as: p52

The sequence of this isoform differs from the canonical sequence as follows:
     1-171: Missing.

Show »
Length:471
Mass (Da):52,023
Checksum:iAF7BCF9677FC390B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05281787E → D.1 PublicationCorresponds to variant rs3801979dbSNPEnsembl.1
Natural variantiVAR_052818294S → L.Corresponds to variant rs2240370dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0069261 – 171Missing in isoform 2. 2 PublicationsAdd BLAST171

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049744 mRNA. Translation: AAK92789.1.
AY049743 mRNA. Translation: AAK92788.1.
AK290499 mRNA. Translation: BAF83188.1.
AK304603 mRNA. Translation: BAG65389.1.
AC004890 Genomic DNA. No translation available.
CH471146 Genomic DNA. Translation: EAW80057.1.
BC043295 mRNA. Translation: AAH43295.1.
AB037760 mRNA. Translation: BAA92577.1.
CCDSiCCDS47739.1. [Q8TD17-2]
CCDS5894.1. [Q8TD17-1]
RefSeqiNP_065832.1. NM_020781.3. [Q8TD17-2]
NP_733787.1. NM_170686.2. [Q8TD17-1]
XP_011514743.1. XM_011516441.2. [Q8TD17-2]
UniGeneiHs.632032.

Genome annotation databases

EnsembliENST00000426851; ENSP00000389972; ENSG00000197024. [Q8TD17-2]
ENST00000475153; ENSP00000420418; ENSG00000197024. [Q8TD17-1]
ENST00000483892; ENSP00000418564; ENSG00000197024. [Q8TD17-2]
ENST00000491174; ENSP00000419391; ENSG00000197024. [Q8TD17-2]
GeneIDi57541.
KEGGihsa:57541.
UCSCiuc003wfl.4. human. [Q8TD17-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049744 mRNA. Translation: AAK92789.1.
AY049743 mRNA. Translation: AAK92788.1.
AK290499 mRNA. Translation: BAF83188.1.
AK304603 mRNA. Translation: BAG65389.1.
AC004890 Genomic DNA. No translation available.
CH471146 Genomic DNA. Translation: EAW80057.1.
BC043295 mRNA. Translation: AAH43295.1.
AB037760 mRNA. Translation: BAA92577.1.
CCDSiCCDS47739.1. [Q8TD17-2]
CCDS5894.1. [Q8TD17-1]
RefSeqiNP_065832.1. NM_020781.3. [Q8TD17-2]
NP_733787.1. NM_170686.2. [Q8TD17-1]
XP_011514743.1. XM_011516441.2. [Q8TD17-2]
UniGeneiHs.632032.

3D structure databases

ProteinModelPortaliQ8TD17.
SMRiQ8TD17.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121600. 21 interactors.
IntActiQ8TD17. 16 interactors.
STRINGi9606.ENSP00000420418.

PTM databases

iPTMnetiQ8TD17.
PhosphoSitePlusiQ8TD17.

Polymorphism and mutation databases

BioMutaiZNF398.
DMDMi23396984.

Proteomic databases

EPDiQ8TD17.
MaxQBiQ8TD17.
PaxDbiQ8TD17.
PeptideAtlasiQ8TD17.
PRIDEiQ8TD17.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000426851; ENSP00000389972; ENSG00000197024. [Q8TD17-2]
ENST00000475153; ENSP00000420418; ENSG00000197024. [Q8TD17-1]
ENST00000483892; ENSP00000418564; ENSG00000197024. [Q8TD17-2]
ENST00000491174; ENSP00000419391; ENSG00000197024. [Q8TD17-2]
GeneIDi57541.
KEGGihsa:57541.
UCSCiuc003wfl.4. human. [Q8TD17-1]

Organism-specific databases

CTDi57541.
DisGeNETi57541.
GeneCardsiZNF398.
HGNCiHGNC:18373. ZNF398.
HPAiHPA071533.
neXtProtiNX_Q8TD17.
OpenTargetsiENSG00000197024.
PharmGKBiPA38532.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063032.
HOGENOMiHOG000013125.
HOVERGENiHBG018163.
InParanoidiQ8TD17.
KOiK09228.
OMAiHQRGHAQ.
OrthoDBiEOG091G0P6J.
PhylomeDBiQ8TD17.
TreeFamiTF337777.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170265-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF398. human.
GenomeRNAii57541.
PROiQ8TD17.

Gene expression databases

BgeeiENSG00000197024.
CleanExiHS_ZNF398.
ExpressionAtlasiQ8TD17. baseline and differential.
GenevisibleiQ8TD17. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 7 hits.
InterProiIPR022137. DUF3669_Znf.
IPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF12417. DUF3669. 1 hit.
PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN398_HUMAN
AccessioniPrimary (citable) accession number: Q8TD17
Secondary accession number(s): A8K384
, B4E377, Q8TD18, Q9P2K7, Q9UDV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.