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Protein

Zinc finger protein 398

Gene

ZNF398

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Function as a transcriptional activator.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri343 – 36422C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri370 – 39223C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri398 – 42023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri427 – 44923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri455 – 47723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri483 – 50523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri511 – 53323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri539 – 56123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri567 – 59024C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. positive regulation of transcription, DNA-templated Source: UniProtKB
  2. regulation of transcription, DNA-templated Source: UniProtKB
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 398
Alternative name(s):
Zinc finger DNA-binding protein p52/p71
Gene namesi
Name:ZNF398
Synonyms:KIAA1339, ZER6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:18373. ZNF398.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38532.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 642642Zinc finger protein 398PRO_0000047565Add
BLAST

Proteomic databases

MaxQBiQ8TD17.
PaxDbiQ8TD17.
PRIDEiQ8TD17.

PTM databases

PhosphoSiteiQ8TD17.

Expressioni

Inductioni

By estrogen receptor alpha.

Gene expression databases

BgeeiQ8TD17.
CleanExiHS_ZNF398.
GenevestigatoriQ8TD17.

Interactioni

Protein-protein interaction databases

BioGridi121600. 13 interactions.
IntActiQ8TD17. 1 interaction.
STRINGi9606.ENSP00000420418.

Structurei

3D structure databases

ProteinModelPortaliQ8TD17.
SMRiQ8TD17. Positions 339-588.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini143 – 21472KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri343 – 36422C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri370 – 39223C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri398 – 42023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri427 – 44923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri455 – 47723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri483 – 50523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri511 – 53323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri539 – 56123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri567 – 59024C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00530000063032.
HOGENOMiHOG000013125.
HOVERGENiHBG018163.
InParanoidiQ8TD17.
KOiK09228.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8TD17.
TreeFamiTF337777.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR022137. DUF3669_Znf.
IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF12417. DUF3669. 1 hit.
PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8TD17-1) [UniParc]FASTAAdd to Basket

Also known as: p71

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAAPAPTS EWDSECLTSL QPLPLPTPPA ANEAHLQTAA ISLWTVVAAV
60 70 80 90 100
QAIERKVEIH SRRLLHLEGR TGTAEKKLAS CEKTVTELGN QLEGKWAVLG
110 120 130 140 150
TLLQEYGLLQ RRLENLENLL RNRNFWILRL PPGIKGDIPK VPVAFDDVSI
160 170 180 190 200
YFSTPEWEKL EEWQKELYKN IMKGNYESLI SMDYAINQPD VLSQIQPEGE
210 220 230 240 250
HNTEDQAGPE ESEIPTDPSE EPGISTSDIL SWIKQEEEPQ VGAPPESKES
260 270 280 290 300
DVYKSTYADE ELVIKAEGLA RSSLCPEVPV PFSSPPAAAK DAFSDVAFKS
310 320 330 340 350
QQSTSMTPFG RPATDLPEAS EGQVTFTQLG SYPLPPPVGE QVFSCHHCGK
360 370 380 390 400
NLSQDMLLTH QCSHATEHPL PCAQCPKHFT PQADLSSTSQ DHASETPPTC
410 420 430 440 450
PHCARTFTHP SRLTYHLRVH NSTERPFPCP DCPKRFADQA RLTSHRRAHA
460 470 480 490 500
SERPFRCAQC GRSFSLKISL LLHQRGHAQE RPFSCPQCGI DFNGHSALIR
510 520 530 540 550
HQMIHTGERP YPCTDCSKSF MRKEHLLNHR RLHTGERPFS CPHCGKSFIR
560 570 580 590 600
KHHLMKHQRI HTGERPYPCS YCGRSFRYKQ TLKDHLRSGH NGGCGGDSDP
610 620 630 640
SGQPPNPPGP LITGLETSGL GVNTEGLETN QWYGEGSGGG VL
Length:642
Mass (Da):71,311
Last modified:June 1, 2002 - v1
Checksum:i69AA38FCD84FF633
GO
Isoform 2 (identifier: Q8TD17-2) [UniParc]FASTAAdd to Basket

Also known as: p52

The sequence of this isoform differs from the canonical sequence as follows:
     1-171: Missing.

Show »
Length:471
Mass (Da):52,023
Checksum:iAF7BCF9677FC390B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti87 – 871E → D.1 Publication
Corresponds to variant rs3801979 [ dbSNP | Ensembl ].
VAR_052817
Natural varianti294 – 2941S → L.
Corresponds to variant rs2240370 [ dbSNP | Ensembl ].
VAR_052818

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 171171Missing in isoform 2. 2 PublicationsVSP_006926Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049744 mRNA. Translation: AAK92789.1.
AY049743 mRNA. Translation: AAK92788.1.
AK290499 mRNA. Translation: BAF83188.1.
AK304603 mRNA. Translation: BAG65389.1.
AC004890 Genomic DNA. No translation available.
CH471146 Genomic DNA. Translation: EAW80057.1.
BC043295 mRNA. Translation: AAH43295.1.
AB037760 mRNA. Translation: BAA92577.1.
CCDSiCCDS47739.1. [Q8TD17-2]
CCDS5894.1. [Q8TD17-1]
RefSeqiNP_065832.1. NM_020781.3. [Q8TD17-2]
NP_733787.1. NM_170686.2. [Q8TD17-1]
UniGeneiHs.632032.

Genome annotation databases

EnsembliENST00000426851; ENSP00000389972; ENSG00000197024. [Q8TD17-2]
ENST00000475153; ENSP00000420418; ENSG00000197024. [Q8TD17-1]
ENST00000483892; ENSP00000418564; ENSG00000197024. [Q8TD17-2]
ENST00000491174; ENSP00000419391; ENSG00000197024. [Q8TD17-2]
GeneIDi57541.
KEGGihsa:57541.
UCSCiuc003wfl.3. human. [Q8TD17-1]

Polymorphism databases

DMDMi23396984.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049744 mRNA. Translation: AAK92789.1.
AY049743 mRNA. Translation: AAK92788.1.
AK290499 mRNA. Translation: BAF83188.1.
AK304603 mRNA. Translation: BAG65389.1.
AC004890 Genomic DNA. No translation available.
CH471146 Genomic DNA. Translation: EAW80057.1.
BC043295 mRNA. Translation: AAH43295.1.
AB037760 mRNA. Translation: BAA92577.1.
CCDSiCCDS47739.1. [Q8TD17-2]
CCDS5894.1. [Q8TD17-1]
RefSeqiNP_065832.1. NM_020781.3. [Q8TD17-2]
NP_733787.1. NM_170686.2. [Q8TD17-1]
UniGeneiHs.632032.

3D structure databases

ProteinModelPortaliQ8TD17.
SMRiQ8TD17. Positions 339-588.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121600. 13 interactions.
IntActiQ8TD17. 1 interaction.
STRINGi9606.ENSP00000420418.

PTM databases

PhosphoSiteiQ8TD17.

Polymorphism databases

DMDMi23396984.

Proteomic databases

MaxQBiQ8TD17.
PaxDbiQ8TD17.
PRIDEiQ8TD17.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000426851; ENSP00000389972; ENSG00000197024. [Q8TD17-2]
ENST00000475153; ENSP00000420418; ENSG00000197024. [Q8TD17-1]
ENST00000483892; ENSP00000418564; ENSG00000197024. [Q8TD17-2]
ENST00000491174; ENSP00000419391; ENSG00000197024. [Q8TD17-2]
GeneIDi57541.
KEGGihsa:57541.
UCSCiuc003wfl.3. human. [Q8TD17-1]

Organism-specific databases

CTDi57541.
GeneCardsiGC07P148787.
HGNCiHGNC:18373. ZNF398.
neXtProtiNX_Q8TD17.
PharmGKBiPA38532.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00530000063032.
HOGENOMiHOG000013125.
HOVERGENiHBG018163.
InParanoidiQ8TD17.
KOiK09228.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8TD17.
TreeFamiTF337777.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF398. human.
GenomeRNAii57541.
NextBioi63982.
PROiQ8TD17.

Gene expression databases

BgeeiQ8TD17.
CleanExiHS_ZNF398.
GenevestigatoriQ8TD17.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR022137. DUF3669_Znf.
IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF12417. DUF3669. 1 hit.
PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel zinc finger transcription factor with two isoforms that are differentially repressed by estrogen receptor-alpha."
    Conroy A.T., Sharma M., Holtz A.E., Wu C., Sun Z., Weigel R.J.
    J. Biol. Chem. 277:9326-9334(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ASP-87.
    Tissue: Brain and Uterus.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  6. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 234-642.
    Tissue: Brain.

Entry informationi

Entry nameiZN398_HUMAN
AccessioniPrimary (citable) accession number: Q8TD17
Secondary accession number(s): A8K384
, B4E377, Q8TD18, Q9P2K7, Q9UDV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2002
Last modified: February 4, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.