Q8TD17 (ZN398_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 398

Alternative name(s):
Zinc finger DNA-binding protein p52/p71

Gene names

Name:	ZNF398
Synonyms:	KIAA1339, ZER6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	642 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Function as a transcriptional activator.
Subcellular location	Nucleus Probable.
Induction	By estrogen receptor alpha.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 9 C2H2-type zinc fingers. Contains 1 KRAB domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of transcription, DNA-dependent Non-traceable author statement Ref.1. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Non-traceable author statement Ref.1. Source: UniProtKB
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TD17-1)

Also known as: p71;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TD17-2)

Also known as: p52;

The sequence of this isoform differs from the canonical sequence as follows:
     1-171: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 642	642	Zinc finger protein 398		PRO_0000047565
Regions
	Domain	143 – 214	72	KRAB
	Zinc finger	343 – 364	22	C2H2-type 1; atypical
	Zinc finger	370 – 392	23	C2H2-type 2; degenerate
	Zinc finger	398 – 420	23	C2H2-type 3
	Zinc finger	427 – 449	23	C2H2-type 4
	Zinc finger	455 – 477	23	C2H2-type 5
	Zinc finger	483 – 505	23	C2H2-type 6
	Zinc finger	511 – 533	23	C2H2-type 7
	Zinc finger	539 – 561	23	C2H2-type 8
	Zinc finger	567 – 590	24	C2H2-type 9
Natural variations
	Alternative sequence	1 – 171	171	Missing in isoform 2.		VSP_006926
	Natural variant	87	1	E → D. Ref.2 Corresponds to variant rs3801979 [ dbSNP | Ensembl ].		VAR_052817
	Natural variant	294	1	S → L. Corresponds to variant rs2240370 [ dbSNP | Ensembl ].		VAR_052818

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (p71) [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 69AA38FCD84FF633	FASTA	642	71,311
	10 20 30 40 50 60 MAEAAPAPTS EWDSECLTSL QPLPLPTPPA ANEAHLQTAA ISLWTVVAAV QAIERKVEIH 70 80 90 100 110 120 SRRLLHLEGR TGTAEKKLAS CEKTVTELGN QLEGKWAVLG TLLQEYGLLQ RRLENLENLL 130 140 150 160 170 180 RNRNFWILRL PPGIKGDIPK VPVAFDDVSI YFSTPEWEKL EEWQKELYKN IMKGNYESLI 190 200 210 220 230 240 SMDYAINQPD VLSQIQPEGE HNTEDQAGPE ESEIPTDPSE EPGISTSDIL SWIKQEEEPQ 250 260 270 280 290 300 VGAPPESKES DVYKSTYADE ELVIKAEGLA RSSLCPEVPV PFSSPPAAAK DAFSDVAFKS 310 320 330 340 350 360 QQSTSMTPFG RPATDLPEAS EGQVTFTQLG SYPLPPPVGE QVFSCHHCGK NLSQDMLLTH 370 380 390 400 410 420 QCSHATEHPL PCAQCPKHFT PQADLSSTSQ DHASETPPTC PHCARTFTHP SRLTYHLRVH 430 440 450 460 470 480 NSTERPFPCP DCPKRFADQA RLTSHRRAHA SERPFRCAQC GRSFSLKISL LLHQRGHAQE 490 500 510 520 530 540 RPFSCPQCGI DFNGHSALIR HQMIHTGERP YPCTDCSKSF MRKEHLLNHR RLHTGERPFS 550 560 570 580 590 600 CPHCGKSFIR KHHLMKHQRI HTGERPYPCS YCGRSFRYKQ TLKDHLRSGH NGGCGGDSDP 610 620 630 640 SGQPPNPPGP LITGLETSGL GVNTEGLETN QWYGEGSGGG VL
	Isoform 2 (p52) [UniParc]. Checksum: AF7BCF9677FC390B	FASTA	471	52,023
	10 20 30 40 50 60 MKGNYESLIS MDYAINQPDV LSQIQPEGEH NTEDQAGPEE SEIPTDPSEE PGISTSDILS 70 80 90 100 110 120 WIKQEEEPQV GAPPESKESD VYKSTYADEE LVIKAEGLAR SSLCPEVPVP FSSPPAAAKD 130 140 150 160 170 180 AFSDVAFKSQ QSTSMTPFGR PATDLPEASE GQVTFTQLGS YPLPPPVGEQ VFSCHHCGKN 190 200 210 220 230 240 LSQDMLLTHQ CSHATEHPLP CAQCPKHFTP QADLSSTSQD HASETPPTCP HCARTFTHPS 250 260 270 280 290 300 RLTYHLRVHN STERPFPCPD CPKRFADQAR LTSHRRAHAS ERPFRCAQCG RSFSLKISLL 310 320 330 340 350 360 LHQRGHAQER PFSCPQCGID FNGHSALIRH QMIHTGERPY PCTDCSKSFM RKEHLLNHRR 370 380 390 400 410 420 LHTGERPFSC PHCGKSFIRK HHLMKHQRIH TGERPYPCSY CGRSFRYKQT LKDHLRSGHN 430 440 450 460 470 GGCGGDSDPS GQPPNPPGPL ITGLETSGLG VNTEGLETNQ WYGEGSGGGV L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel zinc finger transcription factor with two isoforms that are differentially repressed by estrogen receptor-alpha." Conroy A.T., Sharma M., Holtz A.E., Wu C., Sun Z., Weigel R.J. J. Biol. Chem. 277:9326-9334(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ASP-87. Tissue: Brain and Uterus.
[3]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[6]	"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 234-642. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY049744 mRNA. Translation: AAK92789.1. AY049743 mRNA. Translation: AAK92788.1. AK290499 mRNA. Translation: BAF83188.1. AK304603 mRNA. Translation: BAG65389.1. AC004890 Genomic DNA. No translation available. CH471146 Genomic DNA. Translation: EAW80057.1. BC043295 mRNA. Translation: AAH43295.1. AB037760 mRNA. Translation: BAA92577.1.
IPI	IPI00170773. IPI00940686.
RefSeq	NP_065832.1. NM_020781.3. NP_733787.1. NM_170686.2.
UniGene	Hs.632032.
3D structure databases
ProteinModelPortal	Q8TD17.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000420418.
PTM databases
PhosphoSite	Q8TD17.
Polymorphism databases
DMDM	23396984.
Proteomic databases
PaxDb	Q8TD17.
PRIDE	Q8TD17.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000335901; ENSP00000338984; ENSG00000197024. ENST00000420008; ENSP00000416751; ENSG00000197024. ENST00000426851; ENSP00000389972; ENSG00000197024. ENST00000475153; ENSP00000420418; ENSG00000197024. ENST00000483892; ENSP00000418564; ENSG00000197024. ENST00000491174; ENSP00000419391; ENSG00000197024.
GeneID	57541.
KEGG	hsa:57541.
UCSC	uc003wfl.3. human.
Organism-specific databases
CTD	57541.
GeneCards	GC07P148787.
HGNC	HGNC:18373. ZNF398.
neXtProt	NX_Q8TD17.
PharmGKB	PA38532.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000013125.
HOVERGEN	HBG018163.
InParanoid	Q8TD17.
KO	K09228.
OrthoDB	EOG43R3M8.
PhylomeDB	Q8TD17.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q8TD17.
Bgee	Q8TD17.
CleanEx	HS_ZNF398.
Genevestigator	Q8TD17.
GermOnline	ENSG00000197024. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 7 hits.
InterPro	IPR022137. DUF3669_Znf. IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF12417. DUF3669. 1 hit. PF01352. KRAB. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 8 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 7 hits. PS50157. ZINC_FINGER_C2H2_2. 8 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ZNF398. human.
GenomeRNAi	57541.
NextBio	63982.

Entry information

Entry name

ZN398_HUMAN

Accession

Primary (citable) accession number: Q8TD17
Secondary accession number(s): A8K384 , B4E377, Q8TD18, Q9P2K7, Q9UDV8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.