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Q8TD17 (ZN398_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 398
Alternative name(s):
Zinc finger DNA-binding protein p52/p71
Gene names
Name:ZNF398
Synonyms:KIAA1339, ZER6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length642 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Function as a transcriptional activator.

Subcellular location

Nucleus Probable.

Induction

By estrogen receptor alpha.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 9 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpositive regulation of transcription, DNA-templated

Non-traceable author statement Ref.1. Source: UniProtKB

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Non-traceable author statement Ref.1. Source: UniProtKB

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8TD17-1)

Also known as: p71;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8TD17-2)

Also known as: p52;

The sequence of this isoform differs from the canonical sequence as follows:
     1-171: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 642642Zinc finger protein 398
PRO_0000047565

Regions

Domain143 – 21472KRAB
Zinc finger343 – 36422C2H2-type 1; atypical
Zinc finger370 – 39223C2H2-type 2; degenerate
Zinc finger398 – 42023C2H2-type 3
Zinc finger427 – 44923C2H2-type 4
Zinc finger455 – 47723C2H2-type 5
Zinc finger483 – 50523C2H2-type 6
Zinc finger511 – 53323C2H2-type 7
Zinc finger539 – 56123C2H2-type 8
Zinc finger567 – 59024C2H2-type 9

Natural variations

Alternative sequence1 – 171171Missing in isoform 2.
VSP_006926
Natural variant871E → D. Ref.2
Corresponds to variant rs3801979 [ dbSNP | Ensembl ].
VAR_052817
Natural variant2941S → L.
Corresponds to variant rs2240370 [ dbSNP | Ensembl ].
VAR_052818

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (p71) [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 69AA38FCD84FF633

FASTA64271,311
        10         20         30         40         50         60 
MAEAAPAPTS EWDSECLTSL QPLPLPTPPA ANEAHLQTAA ISLWTVVAAV QAIERKVEIH 

        70         80         90        100        110        120 
SRRLLHLEGR TGTAEKKLAS CEKTVTELGN QLEGKWAVLG TLLQEYGLLQ RRLENLENLL 

       130        140        150        160        170        180 
RNRNFWILRL PPGIKGDIPK VPVAFDDVSI YFSTPEWEKL EEWQKELYKN IMKGNYESLI 

       190        200        210        220        230        240 
SMDYAINQPD VLSQIQPEGE HNTEDQAGPE ESEIPTDPSE EPGISTSDIL SWIKQEEEPQ 

       250        260        270        280        290        300 
VGAPPESKES DVYKSTYADE ELVIKAEGLA RSSLCPEVPV PFSSPPAAAK DAFSDVAFKS 

       310        320        330        340        350        360 
QQSTSMTPFG RPATDLPEAS EGQVTFTQLG SYPLPPPVGE QVFSCHHCGK NLSQDMLLTH 

       370        380        390        400        410        420 
QCSHATEHPL PCAQCPKHFT PQADLSSTSQ DHASETPPTC PHCARTFTHP SRLTYHLRVH 

       430        440        450        460        470        480 
NSTERPFPCP DCPKRFADQA RLTSHRRAHA SERPFRCAQC GRSFSLKISL LLHQRGHAQE 

       490        500        510        520        530        540 
RPFSCPQCGI DFNGHSALIR HQMIHTGERP YPCTDCSKSF MRKEHLLNHR RLHTGERPFS 

       550        560        570        580        590        600 
CPHCGKSFIR KHHLMKHQRI HTGERPYPCS YCGRSFRYKQ TLKDHLRSGH NGGCGGDSDP 

       610        620        630        640 
SGQPPNPPGP LITGLETSGL GVNTEGLETN QWYGEGSGGG VL 

« Hide

Isoform 2 (p52) [UniParc].

Checksum: AF7BCF9677FC390B
Show »

FASTA47152,023

References

« Hide 'large scale' references
[1]"A novel zinc finger transcription factor with two isoforms that are differentially repressed by estrogen receptor-alpha."
Conroy A.T., Sharma M., Holtz A.E., Wu C., Sun Z., Weigel R.J.
J. Biol. Chem. 277:9326-9334(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ASP-87.
Tissue: Brain and Uterus.
[3]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Testis.
[6]"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 234-642.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY049744 mRNA. Translation: AAK92789.1.
AY049743 mRNA. Translation: AAK92788.1.
AK290499 mRNA. Translation: BAF83188.1.
AK304603 mRNA. Translation: BAG65389.1.
AC004890 Genomic DNA. No translation available.
CH471146 Genomic DNA. Translation: EAW80057.1.
BC043295 mRNA. Translation: AAH43295.1.
AB037760 mRNA. Translation: BAA92577.1.
RefSeqNP_065832.1. NM_020781.3.
NP_733787.1. NM_170686.2.
UniGeneHs.632032.

3D structure databases

ProteinModelPortalQ8TD17.
SMRQ8TD17. Positions 136-191, 338-592.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121600. 1 interaction.
IntActQ8TD17. 1 interaction.
STRING9606.ENSP00000420418.

PTM databases

PhosphoSiteQ8TD17.

Polymorphism databases

DMDM23396984.

Proteomic databases

PaxDbQ8TD17.
PRIDEQ8TD17.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000335901; ENSP00000338984; ENSG00000197024. [Q8TD17-2]
ENST00000420008; ENSP00000416751; ENSG00000197024. [Q8TD17-2]
ENST00000426851; ENSP00000389972; ENSG00000197024. [Q8TD17-2]
ENST00000475153; ENSP00000420418; ENSG00000197024. [Q8TD17-1]
ENST00000483892; ENSP00000418564; ENSG00000197024. [Q8TD17-2]
ENST00000491174; ENSP00000419391; ENSG00000197024. [Q8TD17-2]
GeneID57541.
KEGGhsa:57541.
UCSCuc003wfl.3. human. [Q8TD17-1]

Organism-specific databases

CTD57541.
GeneCardsGC07P148787.
HGNCHGNC:18373. ZNF398.
neXtProtNX_Q8TD17.
PharmGKBPA38532.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000013125.
HOVERGENHBG018163.
InParanoidQ8TD17.
KOK09228.
OrthoDBEOG7KSX7Q.
PhylomeDBQ8TD17.
TreeFamTF337777.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ8TD17.
BgeeQ8TD17.
CleanExHS_ZNF398.
GenevestigatorQ8TD17.

Family and domain databases

Gene3D3.30.160.60. 7 hits.
InterProIPR022137. DUF3669_Znf.
IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF12417. DUF3669. 1 hit.
PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZNF398. human.
GenomeRNAi57541.
NextBio63982.
PROQ8TD17.

Entry information

Entry nameZN398_HUMAN
AccessionPrimary (citable) accession number: Q8TD17
Secondary accession number(s): A8K384 expand/collapse secondary AC list , B4E377, Q8TD18, Q9P2K7, Q9UDV8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2002
Last modified: March 19, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM