Reviewed, UniProtKB/Swiss-Prot Q8TD06 (AGR3_HUMAN)

Names and origin

Protein names

Recommended name:
    Anterior gradient protein 3 homolog
      Short name=hAG-3
      Short name=AG-3
      Short name=AG3
Alternative name(s):
    Breast cancer membrane protein 11

Gene names

Name:	AGR3
Synonyms:	BCMP11
ORF Names:	UNQ642/PRO1272

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	166 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Interacts with LYPD3 and alpha-dystroglycan. Ref.5
Subcellular location	Secreted Probable.
Sequence similarities	Belongs to the AGR family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Ref.4
	Chain	22 – 166	145	Anterior gradient protein 3 homolog		PRO_0000001040

Sequences

	Sequence		Length	Mass (Da)
	Q8TD06-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: B1A4804B47705D65	FASTA	166	19,171
	10 20 30 40 50 60 MMLHSALGLC LLLVTVSSNL AIAIKKEKRP PQTLSRGWGD DITWVQTYEE GLFYAQKSKK 70 80 90 100 110 120 PLMVIHHLED CQYSQALKKV FAQNEEIQEM AQNKFIMLNL MHETTDKNLS PDGQYVPRIM 130 140 150 160 FVDPSLTVRA DIAGRYSNRL YTYEPRDLPL LIENMKKALR LIQSEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comprehensive proteomic analysis of breast cancer cell membranes reveals unique proteins with potential roles in clinical cancer." Adam P.J., Boyd R., Tyson K.L., Fletcher G.C., Stamps A., Hudson L., Poyser H.R., Redpath N., Griffiths M., Steers G., Harris A.L., Patel S., Berry J., Loader J.A., Townsend R.R., Daviet L., Legrain P., Parekh R., Terrett J.A. J. Biol. Chem. 278:6482-6489(2003) [PubMed: 12477722] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[4]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-36.
[5]	"hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan." Fletcher G.C., Patel S., Tyson K., Adam P.J., Schenker M., Loader J.A., Daviet L., Legrain P., Parekh R., Harris A.L., Terrett J.A. Br. J. Cancer 88:579-585(2003) [PubMed: 12592373] [Abstract] Cited for: INTERACTION WITH LYPD3 AND ALPHA-DYSTROGLYCAN.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY069977 mRNA. Translation: AAL55402.1. AY359065 mRNA. Translation: AAQ89424.1. BC058284 mRNA. Translation: AAH58284.1.
IPI	IPI00152409.
RefSeq	NP_789783.1.
UniGene	Hs.100686
3D structure databases
ModBase	Search...
Proteomic databases
PeptideAtlas	Q8TD06.
PRIDE	Q8TD06.
Genome annotation databases
Ensembl	ENSG00000173467. Homo sapiens. [Contig view]
GeneID	155465.
KEGG	hsa:155465.
Organism-specific databases
GeneCards	GC07M016866.
H-InvDB	HIX0033593.
HGNC	HGNC:24167. AGR3.
MIM	609482. gene.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q8TD06.
HOVERGEN	Q8TD06.
OMA	Q8TD06. SKKPLMV.
Gene expression databases
ArrayExpress	Q8TD06.
Bgee	Q8TD06.
CleanEx	HS_AGR3.
Family and domain databases
InterPro	IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	87431.
SOURCE	Search...

Entry information

Entry name

AGR3_HUMAN

Accession

Primary (citable) accession number: Q8TD06

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	June 1, 2002
Last modified:	June 16, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)