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Protein

Anterior gradient protein 3

Gene

AGR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells.By similarity

GO - Molecular functioni

  • dystroglycan binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Anterior gradient protein 3
Short name:
AG-3
Short name:
AG3
Short name:
hAG-3
Alternative name(s):
Anterior gradient 3 homologImported
Breast cancer membrane protein 11Imported
Protein disulfide isomerase family A, member 18Imported
Gene namesi
Name:AGR3
Synonyms:BCMP11, PDIA18
ORF Names:UNQ642/PRO1272
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:24167. AGR3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi163 – 1664Missing : Leads to Golgi localization;. 1 Publication

Organism-specific databases

PharmGKBiPA162375917.

Polymorphism and mutation databases

BioMutaiAGR3.
DMDMi66774045.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 166145Anterior gradient protein 3PRO_0000001040Add
BLAST

Proteomic databases

MaxQBiQ8TD06.
PaxDbiQ8TD06.
PeptideAtlasiQ8TD06.
PRIDEiQ8TD06.

PTM databases

iPTMnetiQ8TD06.
PhosphoSiteiQ8TD06.

Expressioni

Tissue specificityi

Expressed in the lung, in the ciliated cells of the airway epithelium (PubMed:25751668). Expression increased with differentiation of airway epithelial cells (PubMed:25751668). Not detected in the mucous cells (PubMed:25751668). Expressed in ciliated cells in the oviduct (PubMed:26170690). Also detected in stomach, colon, prostate and liver (PubMed:25751668). Expressed in breast, ovary, prostate and liver cancer (PubMed:26170690). Expression is associated with the level of differentiation of breast cancer (at protein level) (PubMed:26170690).2 Publications

Inductioni

Not induced as part of the cellular response to endoplasmic reticulum stress (PubMed:25751668). Up-regulated by androgens and by estrogens in prostate cancer cells (PubMed:23294566) Up-regulated by a hormone (estrogen-receptor alpha) independent mechanism in ovarian cancer (PubMed:22361111).3 Publications

Gene expression databases

BgeeiENSG00000173467.
CleanExiHS_AGR3.
ExpressionAtlasiQ8TD06. baseline and differential.
GenevisibleiQ8TD06. HS.

Organism-specific databases

HPAiHPA053942.

Interactioni

Subunit structurei

Interacts with LYPD3 and DAG1 (alphaDAG1).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ERLIN1O754773EBI-3925742,EBI-359299
NUP62P371983EBI-3925742,EBI-347978
SGTAO437653EBI-3925742,EBI-347996
UBQLN1Q9UMX0-23EBI-3925742,EBI-10173939

GO - Molecular functioni

  • dystroglycan binding Source: UniProtKB

Protein-protein interaction databases

BioGridi127586. 17 interactions.
IntActiQ8TD06. 12 interactions.
STRINGi9606.ENSP00000308606.

Structurei

Secondary structure

1
166
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi33 – 353Combined sources
Helixi48 – 5811Combined sources
Beta strandi62 – 665Combined sources
Helixi72 – 8312Combined sources
Helixi85 – 939Combined sources
Beta strandi96 – 1027Combined sources
Helixi107 – 1093Combined sources
Beta strandi116 – 1227Combined sources
Helixi145 – 1473Combined sources
Helixi148 – 15912Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3PH9X-ray1.83A/B24-166[»]
ProteinModelPortaliQ8TD06.
SMRiQ8TD06. Positions 31-165.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi163 – 1664Prevents secretion from ER1 Publication

Sequence similaritiesi

Belongs to the AGR family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWAH. Eukaryota.
ENOG4111K70. LUCA.
GeneTreeiENSGT00530000063273.
HOGENOMiHOG000231100.
HOVERGENiHBG006516.
InParanoidiQ8TD06.
OMAiAQNNFIM.
OrthoDBiEOG091G0RHV.
PhylomeDBiQ8TD06.
TreeFamiTF321449.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TD06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLHSALGLC LLLVTVSSNL AIAIKKEKRP PQTLSRGWGD DITWVQTYEE
60 70 80 90 100
GLFYAQKSKK PLMVIHHLED CQYSQALKKV FAQNEEIQEM AQNKFIMLNL
110 120 130 140 150
MHETTDKNLS PDGQYVPRIM FVDPSLTVRA DIAGRYSNRL YTYEPRDLPL
160
LIENMKKALR LIQSEL
Length:166
Mass (Da):19,171
Last modified:June 1, 2002 - v1
Checksum:iB1A4804B47705D65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY069977 mRNA. Translation: AAL55402.1.
AY359065 mRNA. Translation: AAQ89424.1.
CH236948 Genomic DNA. Translation: EAL24282.1.
CH471073 Genomic DNA. Translation: EAW93685.1.
BC058284 mRNA. Translation: AAH58284.1.
CCDSiCCDS5365.1.
RefSeqiNP_789783.1. NM_176813.4.
XP_005249684.1. XM_005249627.2.
UniGeneiHs.100686.

Genome annotation databases

EnsembliENST00000310398; ENSP00000308606; ENSG00000173467.
GeneIDi155465.
KEGGihsa:155465.
UCSCiuc003sts.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY069977 mRNA. Translation: AAL55402.1.
AY359065 mRNA. Translation: AAQ89424.1.
CH236948 Genomic DNA. Translation: EAL24282.1.
CH471073 Genomic DNA. Translation: EAW93685.1.
BC058284 mRNA. Translation: AAH58284.1.
CCDSiCCDS5365.1.
RefSeqiNP_789783.1. NM_176813.4.
XP_005249684.1. XM_005249627.2.
UniGeneiHs.100686.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3PH9X-ray1.83A/B24-166[»]
ProteinModelPortaliQ8TD06.
SMRiQ8TD06. Positions 31-165.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127586. 17 interactions.
IntActiQ8TD06. 12 interactions.
STRINGi9606.ENSP00000308606.

PTM databases

iPTMnetiQ8TD06.
PhosphoSiteiQ8TD06.

Polymorphism and mutation databases

BioMutaiAGR3.
DMDMi66774045.

Proteomic databases

MaxQBiQ8TD06.
PaxDbiQ8TD06.
PeptideAtlasiQ8TD06.
PRIDEiQ8TD06.

Protocols and materials databases

DNASUi155465.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310398; ENSP00000308606; ENSG00000173467.
GeneIDi155465.
KEGGihsa:155465.
UCSCiuc003sts.4. human.

Organism-specific databases

CTDi155465.
GeneCardsiAGR3.
HGNCiHGNC:24167. AGR3.
HPAiHPA053942.
MIMi609482. gene.
neXtProtiNX_Q8TD06.
PharmGKBiPA162375917.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWAH. Eukaryota.
ENOG4111K70. LUCA.
GeneTreeiENSGT00530000063273.
HOGENOMiHOG000231100.
HOVERGENiHBG006516.
InParanoidiQ8TD06.
OMAiAQNNFIM.
OrthoDBiEOG091G0RHV.
PhylomeDBiQ8TD06.
TreeFamiTF321449.

Miscellaneous databases

GeneWikiiAGR3.
GenomeRNAii155465.
PROiQ8TD06.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173467.
CleanExiHS_AGR3.
ExpressionAtlasiQ8TD06. baseline and differential.
GenevisibleiQ8TD06. HS.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAGR3_HUMAN
AccessioniPrimary (citable) accession number: Q8TD06
Secondary accession number(s): A4D120
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: June 1, 2002
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.