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Protein

Up-regulator of cell proliferation

Gene

URGCP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Up-regulator of cell proliferation
Alternative name(s):
HBV X protein up-regulated gene 4 protein
HBxAg up-regulated gene 4 protein
Gene namesi
Name:URGCP
Synonyms:KIAA1507Imported, URG4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:30890. URGCP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165618458.

Polymorphism and mutation databases

BioMutaiURGCP.
DMDMi189038114.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 931931Up-regulator of cell proliferationPRO_0000337148Add
BLAST

Proteomic databases

EPDiQ8TCY9.
MaxQBiQ8TCY9.
PaxDbiQ8TCY9.
PRIDEiQ8TCY9.

PTM databases

iPTMnetiQ8TCY9.
PhosphoSiteiQ8TCY9.

Expressioni

Tissue specificityi

Strongly expressed in hepatitis B virus-infected liver and in HCC cells. Also highly expressed in well-differentiated gastric cancer tissues and various gastric cancer cell lines.2 Publications

Inductioni

By HBxAg. Up-regulated in gastric cancer tissues and also in gastric cancer cell lines (at protein level).2 Publications

Gene expression databases

BgeeiQ8TCY9.
ExpressionAtlasiQ8TCY9. baseline and differential.
GenevisibleiQ8TCY9. HS.

Organism-specific databases

HPAiHPA019879.
HPA020134.
HPA029468.

Interactioni

Protein-protein interaction databases

BioGridi120797. 4 interactions.
IntActiQ8TCY9. 1 interaction.
STRINGi9606.ENSP00000396918.

Structurei

3D structure databases

ProteinModelPortaliQ8TCY9.
SMRiQ8TCY9. Positions 259-284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini689 – 929241VLIG-type GAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IG57. Eukaryota.
ENOG410Y9GN. LUCA.
GeneTreeiENSGT00530000063016.
HOVERGENiHBG108652.
InParanoidiQ8TCY9.
OMAiLAFCDPE.
OrthoDBiEOG7TQV06.
PhylomeDBiQ8TCY9.
TreeFamiTF335271.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030383. G_VLIG_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51717. G_VLIG. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TCY9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASPGIEVEL LGKGHSDLGE VAPEIKASER RTAVAIADLE WREMEGDDCE
60 70 80 90 100
FRYGDGTNEA QDNDFPTVER SRLQEMLSLL GLETYQVQKL SLQDSLQISF
110 120 130 140 150
DSMKNWAPQV PKDLPWNFLR KLQALNADAR NTTMVLDVLP DARPVEKESQ
160 170 180 190 200
MEEEIIYWDP ADDLAADIYS FSELPTPDTP VNPLDLLCAL LLSSDSFLQQ
210 220 230 240 250
EIALKMALCQ FALPLVLPDS ENHYHTFLLW AMRGIVRTWW SQPPRGMGSF
260 270 280 290 300
REDSVVLSRA PAFAFVRMDV SSNSKSQLLN AVLSPGHRQW DCFWHRDLNL
310 320 330 340 350
GTNAREISDG LVEISWFFPS GREDLDIFPE PVAFLNLRGD IGSHWLQFKL
360 370 380 390 400
LTEISSAVFI LTDNISKKEY KLLYSMKEST TKYYFILSPY RGKRNTNLRF
410 420 430 440 450
LNKLIPVLKI DHSHVLVKVS STDSDSFVKR IRAIVGNVLR APCRRVSVED
460 470 480 490 500
MAHAARKLGL KVDEDCEECQ KAKDRMERIT RKIKDSDAYR RDELRLQGDP
510 520 530 540 550
WRKAAQVEKE FCQLQWAVDP PEKHRAELRR RLLELRMQQN GHDPSSGVQE
560 570 580 590 600
FISGISSPSL SEKQYFLRWM EWGLARVAQP RLRQPPETLL TLRPKHGGTT
610 620 630 640 650
DVGEPLWPEP LGVEHFLREM GQFYEAESCL VEAGRLPAGQ RRFAHFPGLA
660 670 680 690 700
SELLLTGLPL ELIDGSTLSM PVRWVTGLLK ELHVRLERRS RLVVLSTVGV
710 720 730 740 750
PGTGKSTLLN TMFGLRFATG KSCGPRGAFM QLITVAEGFS QDLGCDHILV
760 770 780 790 800
IDSGGLIGGA LTSAGDRFEL EASLATLLMG LSNVTVISLA ETKDIPAAIL
810 820 830 840 850
HAFLRLEKTG HMPNYQFVYQ NLHDVSVPGP RPRDKRQLLD PPGDLSRAAA
860 870 880 890 900
QMEKQGDGFR ALAGLAFCDP EKQHIWHIPG LWHGAPPMAA VSLAYSEAIF
910 920 930
ELKRCLLENI RNGLSNQNKN IQQLIELVRR L
Length:931
Mass (Da):104,987
Last modified:May 20, 2008 - v2
Checksum:iE0D67A555FD20134
GO
Isoform 22 Publications (identifier: Q8TCY9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     6-14: Missing.

Show »
Length:922
Mass (Da):104,048
Checksum:iB23066996FC078F6
GO
Isoform 3 (identifier: Q8TCY9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.

Note: No experimental confirmation available.
Show »
Length:856
Mass (Da):96,666
Checksum:i612B22D2EE695AF9
GO
Isoform 4 (identifier: Q8TCY9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Note: Gene prediction based on EST data.
Show »
Length:888
Mass (Da):100,373
Checksum:i9BD44C1C803ED5AB
GO

Sequence cautioni

The sequence BAA91312.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA96031.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAE45880.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAH18244.1 differs from that shown. Reason: Frameshift at position 5. Curated
The sequence CAH18244.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61Missing in CAH18244 (PubMed:17974005).Curated
Sequence conflicti290 – 2901W → C in CAE45880 (PubMed:17974005).Curated
Sequence conflicti390 – 3901Y → H in CAH18244 (PubMed:17974005).Curated
Sequence conflicti432 – 4321R → Q in CAH18244 (PubMed:17974005).Curated
Sequence conflicti516 – 5161W → R in CAE45880 (PubMed:17974005).Curated
Sequence conflicti544 – 5441P → S in AAL83710 (PubMed:12082552).Curated
Sequence conflicti601 – 6011D → G in BAA91312 (PubMed:14702039).Curated
Sequence conflicti620 – 6201M → V in BAA96031 (PubMed:10819331).Curated
Sequence conflicti718 – 7181A → V in CAE45880 (PubMed:17974005).Curated
Sequence conflicti760 – 7601A → S in CAH18244 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti697 – 6971T → A.
Corresponds to variant rs2232106 [ dbSNP | Ensembl ].
VAR_051479
Natural varianti756 – 7561L → F.
Corresponds to variant rs2232107 [ dbSNP | Ensembl ].
VAR_051480
Natural varianti779 – 7791M → L.2 Publications
Corresponds to variant rs2232108 [ dbSNP | Ensembl ].
VAR_043668

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7575Missing in isoform 3. 1 PublicationVSP_033942Add
BLAST
Alternative sequencei1 – 4343Missing in isoform 4. CuratedVSP_047068Add
BLAST
Alternative sequencei6 – 149Missing in isoform 2. 2 PublicationsVSP_052799

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY078404 mRNA. Translation: AAL83710.1.
AB040940 mRNA. Translation: BAA96031.1. Different initiation.
AL833744 mRNA. Translation: CAH56246.1.
BX640797 mRNA. Translation: CAE45880.1. Different initiation.
CR749398 mRNA. Translation: CAH18244.1. Sequence problems.
AC004985 mRNA. No translation available.
BC018426 mRNA. Translation: AAH18426.2.
AK000661 mRNA. Translation: BAA91312.1. Different initiation.
CCDSiCCDS43572.1. [Q8TCY9-4]
CCDS47577.1. [Q8TCY9-2]
CCDS47578.1. [Q8TCY9-1]
RefSeqiNP_001071131.1. NM_001077663.2. [Q8TCY9-1]
NP_001071132.1. NM_001077664.2. [Q8TCY9-4]
NP_001277004.1. NM_001290075.1. [Q8TCY9-4]
NP_001277005.1. NM_001290076.1. [Q8TCY9-4]
NP_060390.3. NM_017920.4. [Q8TCY9-2]
UniGeneiHs.663312.

Genome annotation databases

EnsembliENST00000336086; ENSP00000336872; ENSG00000106608. [Q8TCY9-4]
ENST00000402306; ENSP00000384955; ENSG00000106608. [Q8TCY9-2]
ENST00000443736; ENSP00000392136; ENSG00000106608. [Q8TCY9-4]
ENST00000453200; ENSP00000396918; ENSG00000106608. [Q8TCY9-1]
GeneIDi55665.
KEGGihsa:55665.
UCSCiuc003tiu.4. human. [Q8TCY9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY078404 mRNA. Translation: AAL83710.1.
AB040940 mRNA. Translation: BAA96031.1. Different initiation.
AL833744 mRNA. Translation: CAH56246.1.
BX640797 mRNA. Translation: CAE45880.1. Different initiation.
CR749398 mRNA. Translation: CAH18244.1. Sequence problems.
AC004985 mRNA. No translation available.
BC018426 mRNA. Translation: AAH18426.2.
AK000661 mRNA. Translation: BAA91312.1. Different initiation.
CCDSiCCDS43572.1. [Q8TCY9-4]
CCDS47577.1. [Q8TCY9-2]
CCDS47578.1. [Q8TCY9-1]
RefSeqiNP_001071131.1. NM_001077663.2. [Q8TCY9-1]
NP_001071132.1. NM_001077664.2. [Q8TCY9-4]
NP_001277004.1. NM_001290075.1. [Q8TCY9-4]
NP_001277005.1. NM_001290076.1. [Q8TCY9-4]
NP_060390.3. NM_017920.4. [Q8TCY9-2]
UniGeneiHs.663312.

3D structure databases

ProteinModelPortaliQ8TCY9.
SMRiQ8TCY9. Positions 259-284.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120797. 4 interactions.
IntActiQ8TCY9. 1 interaction.
STRINGi9606.ENSP00000396918.

PTM databases

iPTMnetiQ8TCY9.
PhosphoSiteiQ8TCY9.

Polymorphism and mutation databases

BioMutaiURGCP.
DMDMi189038114.

Proteomic databases

EPDiQ8TCY9.
MaxQBiQ8TCY9.
PaxDbiQ8TCY9.
PRIDEiQ8TCY9.

Protocols and materials databases

DNASUi55665.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336086; ENSP00000336872; ENSG00000106608. [Q8TCY9-4]
ENST00000402306; ENSP00000384955; ENSG00000106608. [Q8TCY9-2]
ENST00000443736; ENSP00000392136; ENSG00000106608. [Q8TCY9-4]
ENST00000453200; ENSP00000396918; ENSG00000106608. [Q8TCY9-1]
GeneIDi55665.
KEGGihsa:55665.
UCSCiuc003tiu.4. human. [Q8TCY9-1]

Organism-specific databases

CTDi55665.
GeneCardsiURGCP.
HGNCiHGNC:30890. URGCP.
HPAiHPA019879.
HPA020134.
HPA029468.
MIMi610337. gene.
neXtProtiNX_Q8TCY9.
PharmGKBiPA165618458.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG57. Eukaryota.
ENOG410Y9GN. LUCA.
GeneTreeiENSGT00530000063016.
HOVERGENiHBG108652.
InParanoidiQ8TCY9.
OMAiLAFCDPE.
OrthoDBiEOG7TQV06.
PhylomeDBiQ8TCY9.
TreeFamiTF335271.

Miscellaneous databases

GeneWikiiURG4.
GenomeRNAii55665.
NextBioi60415.
PROiQ8TCY9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TCY9.
ExpressionAtlasiQ8TCY9. baseline and differential.
GenevisibleiQ8TCY9. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030383. G_VLIG_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51717. G_VLIG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Hepatitis Bx antigen stimulates expression of a novel cellular gene, URG4, that promotes hepatocellular growth and survival."
    Tufan N.L.S., Lian Z., Liu J., Pan J., Arbuthnot P., Kew M., Clayton M.M., Zhu M., Feitelson M.A.
    Neoplasia 4:355-368(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION BY HBXAG.
  2. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain1 Publication.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 470-931 (ISOFORMS 1/2), VARIANT LEU-779.
    Tissue: Endometrial adenocarcinoma, Endometrium and Stomach.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT LEU-779.
    Tissue: GlioblastomaImported.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 601-931.
    Tissue: Signet-ring cell carcinoma1 Publication.
  7. "Enhanced cell survival of gastric cancer cells by a novel gene URG4."
    Song J., Xie H., Lian Z., Yang G., Du R., Du Y., Zou X., Jin H., Gao J., Liu J., Fan D.
    Neoplasia 8:995-1002(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiURGCP_HUMAN
AccessioniPrimary (citable) accession number: Q8TCY9
Secondary accession number(s): E9PFF6
, Q658M4, Q68DH6, Q6MZZ5, Q8WV98, Q9NWR7, Q9P221
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: April 13, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.