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Protein

Rhophilin-1

Gene

RHPN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules (By similarity).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-5666185 RHO GTPases Activate Rhotekin and Rhophilins

Names & Taxonomyi

Protein namesi
Recommended name:
Rhophilin-1
Alternative name(s):
GTP-Rho-binding protein 1
Gene namesi
Name:RHPN1
Synonyms:KIAA1929
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000158106.12
HGNCiHGNC:19973 RHPN1
MIMi601031 gene
neXtProtiNX_Q8TCX5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi114822
OpenTargetsiENSG00000158106
PharmGKBiPA134987144

Polymorphism and mutation databases

BioMutaiRHPN1
DMDMi30173334

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002188951 – 695Rhophilin-1Add BLAST695

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8TCX5
PeptideAtlasiQ8TCX5
PRIDEiQ8TCX5

PTM databases

iPTMnetiQ8TCX5
PhosphoSitePlusiQ8TCX5

Expressioni

Gene expression databases

BgeeiENSG00000158106
CleanExiHS_RHPN1
GenevisibleiQ8TCX5 HS

Organism-specific databases

HPAiHPA024288
HPA024671

Interactioni

Subunit structurei

Binds specifically to GTP-Rho. Interacts with ROPN1 (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi125372, 41 interactors
IntActiQ8TCX5, 13 interactors
STRINGi9606.ENSP00000289013

Structurei

3D structure databases

ProteinModelPortaliQ8TCX5
SMRiQ8TCX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 97REM-1PROSITE-ProRule annotationAdd BLAST75
Domaini108 – 482BRO1PROSITE-ProRule annotationAdd BLAST375
Domaini538 – 617PDZPROSITE-ProRule annotationAdd BLAST80

Domaini

The PDZ domain mediates interaction with ROPN1.By similarity

Sequence similaritiesi

Belongs to the RHPN family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2220 Eukaryota
ENOG410XQX6 LUCA
GeneTreeiENSGT00780000121909
HOGENOMiHOG000046725
HOVERGENiHBG067197
InParanoidiQ8TCX5
OMAiWNPFRRT
OrthoDBiEOG091G04BO
PhylomeDBiQ8TCX5
TreeFamiTF323502

Family and domain databases

Gene3Di1.25.40.280, 1 hit
InterProiView protein in InterPro
IPR004328 BRO1_dom
IPR038499 BRO1_sf
IPR011072 HR1_rho-bd
IPR036274 HR1_rpt_sf
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF03097 BRO1, 1 hit
PF02185 HR1, 1 hit
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM01041 BRO1, 1 hit
SM00742 Hr1, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF46585 SSF46585, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51180 BRO1, 1 hit
PS50106 PDZ, 1 hit
PS51860 REM_1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TCX5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MILEERPDGA GAGEESPRLQ GCDSLTQIQC GQLQSRRAQI HQQIDKELQM
60 70 80 90 100
RTGAENLYRA TSNNRVRETV ALELSYVNSN LQLLKEELEE LSGGVDPGRH
110 120 130 140 150
GSEAVTVPMI PLGLKETKEL DWSTPLKELI SVHFGEDGAS YEAEIRELEA
160 170 180 190 200
LRQAMRTPSR NESGLELLTA YYNQLCFLDA RFLTPARSLG LFFHWYDSLT
210 220 230 240 250
GVPAQQRALA FEKGSVLFNI GALHTQIGAR QDRSCTEGAR RAMEAFQRAA
260 270 280 290 300
GAFSLLRENF SHAPSPDMSA ASLCALEQLM MAQAQECVFE GLSPPASMAP
310 320 330 340 350
QDCLAQLRLA QEAAQVAAEY RLVHRTMAQP PVHDYVPVSW TALVHVKAEY
360 370 380 390 400
FRSLAHYHVA MALCDGSREC PPHLPMVLPR PPRAGSQPLC PPAATEGELP
410 420 430 440 450
THEQVFLQPP TSSKPRGPVL PQELEERRQL GKAHLKRAIL GQEEALRLHA
460 470 480 490 500
LCRVLREVDL LRAVISQTLQ RSLAKYAELD REDDFCEAAE APDIQPKTHQ
510 520 530 540 550
KPEARMPRLS QGKGPDIFHR LGPLSVFSAK NRWRLVGPVH LTRGEGGFGL
560 570 580 590 600
TLRGDSPVLI AAVIPGSQAA AAGLKEGDYI VSVNGQPCRW WRHAEVVTEL
610 620 630 640 650
KAAGEAGASL QVVSLLPSSR LPSLGDRRPV LLGPRGLLRS QREHGCKTPA
660 670 680 690
STWASPRPLL NWSRKAQQGK TGGCPQPCAP VKPAPPSSLK HPGWP
Note: May be due to intron retention.
Length:695
Mass (Da):76,292
Last modified:June 1, 2002 - v1
Checksum:i89E4DF6806761452
GO
Isoform 2 (identifier: Q8TCX5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-393: RECPPHLPMVLPRPPRAGSQPLCPPA → P

Show »
Length:670
Mass (Da):73,590
Checksum:iCE8C01B716465FF0
GO

Sequence cautioni

The sequence BAB67822 differs from that shown. Reason: Frameshift at position 386.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014239368 – 393RECPP…LCPPA → P in isoform 2. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY082588 mRNA Translation: AAL89809.1
BC025767 mRNA Translation: AAH25767.1
AB067516 mRNA Translation: BAB67822.1 Frameshift.
CCDSiCCDS47927.1 [Q8TCX5-2]
RefSeqiNP_443156.2, NM_052924.2 [Q8TCX5-2]
UniGeneiHs.521912

Genome annotation databases

EnsembliENST00000289013; ENSP00000289013; ENSG00000158106 [Q8TCX5-2]
GeneIDi114822
KEGGihsa:114822
UCSCiuc003yyb.4 human [Q8TCX5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRHPN1_HUMAN
AccessioniPrimary (citable) accession number: Q8TCX5
Secondary accession number(s): Q8TAV1, Q96PV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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