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Protein

Rhophilin-1

Gene

RHPN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-5666185. RHO GTPases Activate Rhotekin and Rhophilins.

Names & Taxonomyi

Protein namesi
Recommended name:
Rhophilin-1
Alternative name(s):
GTP-Rho-binding protein 1
Gene namesi
Name:RHPN1
Synonyms:KIAA1929
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:19973. RHPN1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134987144.

Polymorphism and mutation databases

BioMutaiRHPN1.
DMDMi30173334.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 695695Rhophilin-1PRO_0000218895Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8TCX5.
PeptideAtlasiQ8TCX5.
PRIDEiQ8TCX5.

PTM databases

iPTMnetiQ8TCX5.
PhosphoSiteiQ8TCX5.

Expressioni

Gene expression databases

BgeeiENSG00000158106.
CleanExiHS_RHPN1.
GenevisibleiQ8TCX5. HS.

Organism-specific databases

HPAiHPA024288.
HPA024671.

Interactioni

Subunit structurei

Binds specifically to GTP-Rho. Interacts with ROPN1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MTUS2Q5JR593EBI-746325,EBI-742948
TRIM27P143733EBI-746325,EBI-719493

Protein-protein interaction databases

BioGridi125372. 39 interactions.
IntActiQ8TCX5. 7 interactions.
MINTiMINT-1474759.
STRINGi9606.ENSP00000289013.

Structurei

3D structure databases

ProteinModelPortaliQ8TCX5.
SMRiQ8TCX5. Positions 107-360, 541-602.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati35 – 10773REMAdd
BLAST
Domaini108 – 482375BRO1PROSITE-ProRule annotationAdd
BLAST
Domaini538 – 61780PDZPROSITE-ProRule annotationAdd
BLAST

Domaini

The PDZ domain mediates interaction with ROPN1.By similarity

Sequence similaritiesi

Belongs to the RHPN family.Curated
Contains 1 BRO1 domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 REM (Hr1) repeat.Curated

Phylogenomic databases

eggNOGiKOG2220. Eukaryota.
ENOG410XQX6. LUCA.
GeneTreeiENSGT00780000121909.
HOGENOMiHOG000046725.
HOVERGENiHBG067197.
InParanoidiQ8TCX5.
OMAiFIGNSQE.
OrthoDBiEOG091G04BO.
PhylomeDBiQ8TCX5.
TreeFamiTF323502.

Family and domain databases

Gene3Di1.10.287.160. 1 hit.
1.25.40.280. 2 hits.
2.30.42.10. 1 hit.
InterProiIPR004328. BRO1_dom.
IPR011072. HR1_rho-bd.
IPR001478. PDZ.
[Graphical view]
PfamiPF03097. BRO1. 1 hit.
PF02185. HR1. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM01041. BRO1. 1 hit.
SM00742. Hr1. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF46585. SSF46585. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS51180. BRO1. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TCX5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MILEERPDGA GAGEESPRLQ GCDSLTQIQC GQLQSRRAQI HQQIDKELQM
60 70 80 90 100
RTGAENLYRA TSNNRVRETV ALELSYVNSN LQLLKEELEE LSGGVDPGRH
110 120 130 140 150
GSEAVTVPMI PLGLKETKEL DWSTPLKELI SVHFGEDGAS YEAEIRELEA
160 170 180 190 200
LRQAMRTPSR NESGLELLTA YYNQLCFLDA RFLTPARSLG LFFHWYDSLT
210 220 230 240 250
GVPAQQRALA FEKGSVLFNI GALHTQIGAR QDRSCTEGAR RAMEAFQRAA
260 270 280 290 300
GAFSLLRENF SHAPSPDMSA ASLCALEQLM MAQAQECVFE GLSPPASMAP
310 320 330 340 350
QDCLAQLRLA QEAAQVAAEY RLVHRTMAQP PVHDYVPVSW TALVHVKAEY
360 370 380 390 400
FRSLAHYHVA MALCDGSREC PPHLPMVLPR PPRAGSQPLC PPAATEGELP
410 420 430 440 450
THEQVFLQPP TSSKPRGPVL PQELEERRQL GKAHLKRAIL GQEEALRLHA
460 470 480 490 500
LCRVLREVDL LRAVISQTLQ RSLAKYAELD REDDFCEAAE APDIQPKTHQ
510 520 530 540 550
KPEARMPRLS QGKGPDIFHR LGPLSVFSAK NRWRLVGPVH LTRGEGGFGL
560 570 580 590 600
TLRGDSPVLI AAVIPGSQAA AAGLKEGDYI VSVNGQPCRW WRHAEVVTEL
610 620 630 640 650
KAAGEAGASL QVVSLLPSSR LPSLGDRRPV LLGPRGLLRS QREHGCKTPA
660 670 680 690
STWASPRPLL NWSRKAQQGK TGGCPQPCAP VKPAPPSSLK HPGWP
Note: May be due to intron retention.
Length:695
Mass (Da):76,292
Last modified:June 1, 2002 - v1
Checksum:i89E4DF6806761452
GO
Isoform 2 (identifier: Q8TCX5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-393: RECPPHLPMVLPRPPRAGSQPLCPPA → P

Show »
Length:670
Mass (Da):73,590
Checksum:iCE8C01B716465FF0
GO

Sequence cautioni

The sequence BAB67822 differs from that shown. Reason: Frameshift at position 386. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei368 – 39326RECPP…LCPPA → P in isoform 2. 1 PublicationVSP_014239Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY082588 mRNA. Translation: AAL89809.1.
BC025767 mRNA. Translation: AAH25767.1.
AB067516 mRNA. Translation: BAB67822.1. Frameshift.
CCDSiCCDS47927.1. [Q8TCX5-2]
RefSeqiNP_443156.2. NM_052924.2. [Q8TCX5-2]
UniGeneiHs.521912.

Genome annotation databases

EnsembliENST00000289013; ENSP00000289013; ENSG00000158106. [Q8TCX5-2]
ENST00000620174; ENSP00000484724; ENSG00000158106. [Q8TCX5-1]
GeneIDi114822.
KEGGihsa:114822.
UCSCiuc003yyb.4. human. [Q8TCX5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY082588 mRNA. Translation: AAL89809.1.
BC025767 mRNA. Translation: AAH25767.1.
AB067516 mRNA. Translation: BAB67822.1. Frameshift.
CCDSiCCDS47927.1. [Q8TCX5-2]
RefSeqiNP_443156.2. NM_052924.2. [Q8TCX5-2]
UniGeneiHs.521912.

3D structure databases

ProteinModelPortaliQ8TCX5.
SMRiQ8TCX5. Positions 107-360, 541-602.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125372. 39 interactions.
IntActiQ8TCX5. 7 interactions.
MINTiMINT-1474759.
STRINGi9606.ENSP00000289013.

PTM databases

iPTMnetiQ8TCX5.
PhosphoSiteiQ8TCX5.

Polymorphism and mutation databases

BioMutaiRHPN1.
DMDMi30173334.

Proteomic databases

PaxDbiQ8TCX5.
PeptideAtlasiQ8TCX5.
PRIDEiQ8TCX5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289013; ENSP00000289013; ENSG00000158106. [Q8TCX5-2]
ENST00000620174; ENSP00000484724; ENSG00000158106. [Q8TCX5-1]
GeneIDi114822.
KEGGihsa:114822.
UCSCiuc003yyb.4. human. [Q8TCX5-1]

Organism-specific databases

CTDi114822.
GeneCardsiRHPN1.
HGNCiHGNC:19973. RHPN1.
HPAiHPA024288.
HPA024671.
MIMi601031. gene.
neXtProtiNX_Q8TCX5.
PharmGKBiPA134987144.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2220. Eukaryota.
ENOG410XQX6. LUCA.
GeneTreeiENSGT00780000121909.
HOGENOMiHOG000046725.
HOVERGENiHBG067197.
InParanoidiQ8TCX5.
OMAiFIGNSQE.
OrthoDBiEOG091G04BO.
PhylomeDBiQ8TCX5.
TreeFamiTF323502.

Enzyme and pathway databases

ReactomeiR-HSA-5666185. RHO GTPases Activate Rhotekin and Rhophilins.

Miscellaneous databases

GeneWikiiRHPN1.
GenomeRNAii114822.
PROiQ8TCX5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158106.
CleanExiHS_RHPN1.
GenevisibleiQ8TCX5. HS.

Family and domain databases

Gene3Di1.10.287.160. 1 hit.
1.25.40.280. 2 hits.
2.30.42.10. 1 hit.
InterProiIPR004328. BRO1_dom.
IPR011072. HR1_rho-bd.
IPR001478. PDZ.
[Graphical view]
PfamiPF03097. BRO1. 1 hit.
PF02185. HR1. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM01041. BRO1. 1 hit.
SM00742. Hr1. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF46585. SSF46585. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS51180. BRO1. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHPN1_HUMAN
AccessioniPrimary (citable) accession number: Q8TCX5
Secondary accession number(s): Q8TAV1, Q96PV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: June 1, 2002
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.