Q8TCX1 (DC2L1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytoplasmic dynein 2 light intermediate chain 1
Short name=Dynein 2 light intermediate chain

Gene names

Name:	DYNC2LI1
Synonyms:	D2LIC, LIC3
ORF Names:	CGI-60

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis By similarity.
Subunit structure	The cytoplasmic dynein complex 2 is probably composed by a DYNC2H1 homodimer and a number of DYNC2LI1 light intermediate chains By similarity.
Subcellular location	Cytoplasm › cytoskeleton › cilium axoneme By similarity. Cytoplasm By similarity. Note: Localizes to the apical cytoplasm By similarity.
Sequence similarities	Belongs to the dynein light intermediate chain family.
Sequence caution	The sequence AAD34055.1 differs from that shown. Reason: Frameshift at positions 163 and 167.

Ontologies

Keywords
Biological process	Cilium biogenesis/degradation
Cellular component	Cell projection Cilium Cytoplasm Cytoskeleton Dynein Microtubule
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Developmental protein Motor protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II Traceable author statement. Source: Reactome cilium assembly Inferred from electronic annotation. Source: Compara determination of left/right symmetry Inferred from electronic annotation. Source: Compara
Cellular_component	apical part of cell Inferred from sequence or structural similarity. Source: BHF-UCL axonemal dynein complex Inferred from sequence or structural similarity PubMed 12802074. Source: BHF-UCL cilium axoneme Inferred from sequence or structural similarity. Source: BHF-UCL cytosol Traceable author statement. Source: Reactome intraflagellar transport particle Inferred from electronic annotation. Source: Compara microtubule Inferred from electronic annotation. Source: UniProtKB-KW motile primary cilium Inferred from sequence or structural similarity. Source: BHF-UCL
Molecular_function	motor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TCX1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TCX1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     169-169: P → PQ

Isoform 3 (identifier: Q8TCX1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     332-351: ELEQYKRSSSKSWKQIELDS → VLS

Isoform 4 (identifier: Q8TCX1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     170-201: DHELIDPFPVPLVIIGSKYDVFQDFESEKRKV → VSCCLGLLLESLVPFIVNDNITNNFFRFLCMT
     202-351: Missing.

Isoform 5 (identifier: Q8TCX1-5)

The sequence of this isoform differs from the canonical sequence as follows:
     108-144: TFSLVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMK → SWQLSSLLPVSMNLTTPVPHINEIIHYLSFCYLFHLA
     145-351: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	Cytoplasmic dynein 2 light intermediate chain 1		PRO_0000318750
Natural variations
	Alternative sequence	108 – 144	37	TFSLV…KVIMK → SWQLSSLLPVSMNLTTPVPH INEIIHYLSFCYLFHLA in isoform 5.		VSP_031287
	Alternative sequence	145 – 351	207	Missing in isoform 5.		VSP_031288
	Alternative sequence	169	1	P → PQ in isoform 2.		VSP_031289
	Alternative sequence	170 – 201	32	DHELI…EKRKV → VSCCLGLLLESLVPFIVNDN ITNNFFRFLCMT in isoform 4.		VSP_031290
	Alternative sequence	202 – 351	150	Missing in isoform 4.		VSP_031291
	Alternative sequence	332 – 351	20	ELEQY…IELDS → VLS in isoform 3.		VSP_031292
	Natural variant	33	1	F → S. Ref.3 Ref.7 Corresponds to variant rs2288709 [ dbSNP | Ensembl ].		VAR_038874
	Natural variant	58	1	P → S. Ref.6 Corresponds to variant rs17854966 [ dbSNP | Ensembl ].		VAR_038875
	Natural variant	230	1	I → L. Ref.3 Ref.7 Corresponds to variant rs11556157 [ dbSNP | Ensembl ].		VAR_038876
Experimental info
	Sequence conflict	29	1	I → F in CAB43233. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: BB4BB8B528D4A99A	FASTA	351	39,625
	10 20 30 40 50 60 MPSETLWEIA KAEVEKRGIN GSEGDGAEIA EKFVFFIGSK NGGKTTIILR CLDRDEPPKP 70 80 90 100 110 120 TLALEYTYGR RAKGHNTPKD IAHFWELGGG TSLLDLISIP ITGDTLRTFS LVLVLDLSKP 130 140 150 160 170 180 NDLWPTMENL LQATKSHVDK VIMKLGKTNA KAVSEMRQKI WNNMPKDHPD HELIDPFPVP 190 200 210 220 230 240 LVIIGSKYDV FQDFESEKRK VICKTLRFVA HYYGASLMFT SKSEALLLKI RGVINQLAFG 250 260 270 280 290 300 IDKSKSICVD QNKPLFITAG LDSFGQIGSP PVPENDIGKL HAHSPMELWK KVYEKLFPPK 310 320 330 340 350 SINTLKDIKD PARDPQYAEN EVDEMRIQKD LELEQYKRSS SKSWKQIELD S
	Isoform 2 [UniParc]. Checksum: 156B9FAB4FDABAC1	FASTA	352	39,753
	10 20 30 40 50 60 MPSETLWEIA KAEVEKRGIN GSEGDGAEIA EKFVFFIGSK NGGKTTIILR CLDRDEPPKP 70 80 90 100 110 120 TLALEYTYGR RAKGHNTPKD IAHFWELGGG TSLLDLISIP ITGDTLRTFS LVLVLDLSKP 130 140 150 160 170 180 NDLWPTMENL LQATKSHVDK VIMKLGKTNA KAVSEMRQKI WNNMPKDHPQ DHELIDPFPV 190 200 210 220 230 240 PLVIIGSKYD VFQDFESEKR KVICKTLRFV AHYYGASLMF TSKSEALLLK IRGVINQLAF 250 260 270 280 290 300 GIDKSKSICV DQNKPLFITA GLDSFGQIGS PPVPENDIGK LHAHSPMELW KKVYEKLFPP 310 320 330 340 350 KSINTLKDIK DPARDPQYAE NEVDEMRIQK DLELEQYKRS SSKSWKQIEL DS
	Isoform 3 [UniParc]. Checksum: C4D1D8FF4A49656F	FASTA	334	37,500
	10 20 30 40 50 60 MPSETLWEIA KAEVEKRGIN GSEGDGAEIA EKFVFFIGSK NGGKTTIILR CLDRDEPPKP 70 80 90 100 110 120 TLALEYTYGR RAKGHNTPKD IAHFWELGGG TSLLDLISIP ITGDTLRTFS LVLVLDLSKP 130 140 150 160 170 180 NDLWPTMENL LQATKSHVDK VIMKLGKTNA KAVSEMRQKI WNNMPKDHPD HELIDPFPVP 190 200 210 220 230 240 LVIIGSKYDV FQDFESEKRK VICKTLRFVA HYYGASLMFT SKSEALLLKI RGVINQLAFG 250 260 270 280 290 300 IDKSKSICVD QNKPLFITAG LDSFGQIGSP PVPENDIGKL HAHSPMELWK KVYEKLFPPK 310 320 330 SINTLKDIKD PARDPQYAEN EVDEMRIQKD LVLS
	Isoform 4 [UniParc]. Checksum: 88D40AFF3FB35E50	FASTA	201	22,433
	10 20 30 40 50 60 MPSETLWEIA KAEVEKRGIN GSEGDGAEIA EKFVFFIGSK NGGKTTIILR CLDRDEPPKP 70 80 90 100 110 120 TLALEYTYGR RAKGHNTPKD IAHFWELGGG TSLLDLISIP ITGDTLRTFS LVLVLDLSKP 130 140 150 160 170 180 NDLWPTMENL LQATKSHVDK VIMKLGKTNA KAVSEMRQKI WNNMPKDHPV SCCLGLLLES 190 200 LVPFIVNDNI TNNFFRFLCM T
	Isoform 5 [UniParc]. Checksum: 4A235A2C5B2D1F15	FASTA	144	15,997
	10 20 30 40 50 60 MPSETLWEIA KAEVEKRGIN GSEGDGAEIA EKFVFFIGSK NGGKTTIILR CLDRDEPPKP 70 80 90 100 110 120 TLALEYTYGR RAKGHNTPKD IAHFWELGGG TSLLDLISIP ITGDTLRSWQ LSSLLPVSMN 130 140 LTTPVPHINE IIHYLSFCYL FHLA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel light intermediate chain (D2LIC) for mammalian cytoplasmic dynein 2." Grissom P.M., Vaisberg E.A., McIntosh J.R. Mol. Biol. Cell 13:817-829(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS SER-33 AND LEU-230. Tissue: Testis.
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 4 AND 5), VARIANT SER-58. Tissue: Brain, Kidney, Testis and Urinary bladder.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-351 (ISOFORM 3), VARIANTS SER-33 AND LEU-230. Tissue: Brain.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY083346 mRNA. Translation: AAL99216.1. AF151818 mRNA. Translation: AAD34055.1. Frameshift. AK223432 mRNA. Translation: BAD97152.1. AC011242 Genomic DNA. Translation: AAY14702.1. CH471053 Genomic DNA. Translation: EAX00289.1. CH471053 Genomic DNA. Translation: EAX00290.1. CH471053 Genomic DNA. Translation: EAX00291.1. BC006969 mRNA. Translation: AAH06969.1. BC016324 mRNA. Translation: AAH16324.1. BC040558 mRNA. Translation: AAH40558.1. BC058823 mRNA. Translation: AAH58823.1. AL050006 mRNA. Translation: CAB43233.1.
IPI	IPI00059632. IPI00217241. IPI00465426. IPI00554555. IPI00885209.
PIR	T08695.
RefSeq	NP_001180393.1. NM_001193464.1. NP_056337.1. NM_015522.3. NP_057092.2. NM_016008.3.
UniGene	Hs.371597.
3D structure databases
ProteinModelPortal	Q8TCX1.
ModBase	Search...
PTM databases
PhosphoSite	Q8TCX1.
Polymorphism databases
DMDM	74715850.
Proteomic databases
PaxDb	Q8TCX1.
PRIDE	Q8TCX1.
Protocols and materials databases
DNASU	51626.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000260605; ENSP00000260605; ENSG00000138036. ENST00000398823; ENSP00000381804; ENSG00000138036. ENST00000406852; ENSP00000385738; ENSG00000138036.
GeneID	51626.
KEGG	hsa:51626.
UCSC	uc002rth.3. human. uc002rti.3. human. uc002rtk.3. human. uc002rtl.3. human. uc021vgq.1. human.
Organism-specific databases
CTD	51626.
GeneCards	GC02P043913.
HGNC	HGNC:24595. DYNC2LI1.
neXtProt	NX_Q8TCX1.
PharmGKB	PA142671919.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG256387.
HOVERGEN	HBG066237.
InParanoid	Q8TCX1.
KO	K10417.
OMA	VICKTLR.
OrthoDB	EOG4W0XDP.
PhylomeDB	Q8TCX1.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
ArrayExpress	Q8TCX1.
Bgee	Q8TCX1.
CleanEx	HS_DYNC2LI1.
Genevestigator	Q8TCX1.
Family and domain databases
InterPro	IPR022780. Dynein_light_int_chain. [Graphical view]
Pfam	PF05783. DLIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	DYNC2LI1. human.
GenomeRNAi	51626.
NextBio	55545.

Entry information

Entry name

DC2L1_HUMAN

Accession

Primary (citable) accession number: Q8TCX1
Secondary accession number(s): A8MVJ5 , Q53F57, Q6PDB2, Q8IWA3, Q96B03, Q96J00, Q9Y370, Q9Y3S9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.