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Q8TCW9

- PKR1_HUMAN

UniProt

Q8TCW9 - PKR1_HUMAN

Protein

Prokineticin receptor 1

Gene

PROKR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy.1 Publication

    GO - Molecular functioni

    1. neuropeptide Y receptor activity Source: InterPro

    GO - Biological processi

    1. negative regulation of apoptotic process Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prokineticin receptor 1
    Short name:
    PK-R1
    Alternative name(s):
    G-protein coupled receptor 73
    G-protein coupled receptor ZAQ
    GPR73a
    Gene namesi
    Name:PROKR1
    Synonyms:GPR73, PKR1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:4524. PROKR1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28916.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 393393Prokineticin receptor 1PRO_0000070079Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi137 ↔ 217PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8TCW9.
    PRIDEiQ8TCW9.

    PTM databases

    PhosphoSiteiQ8TCW9.

    Expressioni

    Tissue specificityi

    Localizes to glandular epithelium, stroma and vascular endothelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the stomach, throughout the small intestine, colon, rectum, thyroid gland, pituitary gland, salivary gland, adrenal gland, testis, ovary, brain, spleen, prostate and pancreas.1 Publication

    Gene expression databases

    BgeeiQ8TCW9.
    CleanExiHS_PROKR1.
    GenevestigatoriQ8TCW9.

    Organism-specific databases

    HPAiHPA029396.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000303775.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TCW9.
    SMRiQ8TCW9. Positions 67-357.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6262ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini84 – 9815CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini120 – 14627ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini168 – 18013CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini202 – 23231ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini254 – 28229CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini304 – 32219ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini344 – 39350CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei63 – 8321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei99 – 11921Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei147 – 16721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei181 – 20121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei233 – 25321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei283 – 30321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei323 – 34321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG319668.
    HOGENOMiHOG000231664.
    HOVERGENiHBG039631.
    InParanoidiQ8TCW9.
    KOiK08379.
    OMAiLIIVKSQ.
    OrthoDBiEOG73NG3D.
    PhylomeDBiQ8TCW9.
    TreeFamiTF315303.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000611. NPY_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01012. NRPEPTIDEYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TCW9-1 [UniParc]FASTAAdd to Basket

    « Hide

    METTMGFMDD NATNTSTSFL SVLNPHGAHA TSFPFNFSYS DYDMPLDEDE    50
    DVTNSRTFFA AKIVIGMALV GIMLVCGIGN FIFIAALVRY KKLRNLTNLL 100
    IANLAISDFL VAIVCCPFEM DYYVVRQLSW EHGHVLCTSV NYLRTVSLYV 150
    STNALLAIAI DRYLAIVHPL RPRMKCQTAT GLIALVWTVS ILIAIPSAYF 200
    TTETVLVIVK SQEKIFCGQI WPVDQQLYYK SYFLFIFGIE FVGPVVTMTL 250
    CYARISRELW FKAVPGFQTE QIRKRLRCRR KTVLVLMCIL TAYVLCWAPF 300
    YGFTIVRDFF PTVFVKEKHY LTAFYIVECI AMSNSMINTL CFVTVKNDTV 350
    KYFKKIMLLH WKASYNGGKS SADLDLKTIG MPATEEVDCI RLK 393
    Length:393
    Mass (Da):44,770
    Last modified:June 1, 2002 - v1
    Checksum:i0D36461CA99CAEC1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti255 – 2562IS → MT in AAM48127. (PubMed:11886876)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti40 – 401S → G.
    Corresponds to variant rs7570797 [ dbSNP | Ensembl ].
    VAR_024261

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY089976 mRNA. Translation: AAM11892.1.
    AB084080 mRNA. Translation: BAC24021.1.
    AF506287 mRNA. Translation: AAM48127.1.
    AC105054 Genomic DNA. Translation: AAY24114.1.
    EF577399 mRNA. Translation: ABQ52419.1.
    BC100960 mRNA. Translation: AAI00961.1.
    CCDSiCCDS1889.1.
    RefSeqiNP_620414.1. NM_138964.2.
    UniGeneiHs.683430.

    Genome annotation databases

    EnsembliENST00000303786; ENSP00000303775; ENSG00000169618.
    ENST00000394342; ENSP00000377874; ENSG00000169618.
    GeneIDi10887.
    KEGGihsa:10887.
    UCSCiuc010yqj.2. human.

    Polymorphism databases

    DMDMi33112428.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY089976 mRNA. Translation: AAM11892.1 .
    AB084080 mRNA. Translation: BAC24021.1 .
    AF506287 mRNA. Translation: AAM48127.1 .
    AC105054 Genomic DNA. Translation: AAY24114.1 .
    EF577399 mRNA. Translation: ABQ52419.1 .
    BC100960 mRNA. Translation: AAI00961.1 .
    CCDSi CCDS1889.1.
    RefSeqi NP_620414.1. NM_138964.2.
    UniGenei Hs.683430.

    3D structure databases

    ProteinModelPortali Q8TCW9.
    SMRi Q8TCW9. Positions 67-357.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000303775.

    Chemistry

    BindingDBi Q8TCW9.
    ChEMBLi CHEMBL5649.
    GuidetoPHARMACOLOGYi 335.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8TCW9.

    Polymorphism databases

    DMDMi 33112428.

    Proteomic databases

    PaxDbi Q8TCW9.
    PRIDEi Q8TCW9.

    Protocols and materials databases

    DNASUi 10887.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000303786 ; ENSP00000303775 ; ENSG00000169618 .
    ENST00000394342 ; ENSP00000377874 ; ENSG00000169618 .
    GeneIDi 10887.
    KEGGi hsa:10887.
    UCSCi uc010yqj.2. human.

    Organism-specific databases

    CTDi 10887.
    GeneCardsi GC02P068870.
    HGNCi HGNC:4524. PROKR1.
    HPAi HPA029396.
    MIMi 607122. gene.
    neXtProti NX_Q8TCW9.
    PharmGKBi PA28916.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG319668.
    HOGENOMi HOG000231664.
    HOVERGENi HBG039631.
    InParanoidi Q8TCW9.
    KOi K08379.
    OMAi LIIVKSQ.
    OrthoDBi EOG73NG3D.
    PhylomeDBi Q8TCW9.
    TreeFami TF315303.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    GeneWikii Prokineticin_receptor_1.
    GenomeRNAii 10887.
    NextBioi 41341.
    PROi Q8TCW9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8TCW9.
    CleanExi HS_PROKR1.
    Genevestigatori Q8TCW9.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000611. NPY_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01012. NRPEPTIDEYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors."
      Masuda Y., Takatsu Y., Terao Y., Kumano S., Ishibashi Y., Suenaga M., Abe M., Fukusumi S., Watanabe T., Shintani Y., Yamada T., Hinuma S., Inatomi N., Ohtaki T., Onda H., Fujino M.
      Biochem. Biophys. Res. Commun. 293:396-402(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor."
      Lin D.C.-H., Bullock C.M., Ehlert F.J., Chen J.-L., Tian H., Zhou Q.-Y.
      J. Biol. Chem. 277:19276-19280(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Martin A.L., Kaighin V.A., Aronstam R.S.
      Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "Prokineticin 1 signaling and gene regulation in early human pregnancy."
      Evans J., Catalano R.D., Morgan K., Critchley H.O.D., Millar R.P., Jabbour H.N.
      Endocrinology 149:2877-2887(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiPKR1_HUMAN
    AccessioniPrimary (citable) accession number: Q8TCW9
    Secondary accession number(s): A5JUU2, Q53QT9, Q8NFJ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2003
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3