Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8TCW9 (PKR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prokineticin receptor 1

Short name=PK-R1
Alternative name(s):
G-protein coupled receptor 73
G-protein coupled receptor ZAQ
GPR73a
Gene names
Name:PROKR1
Synonyms:GPR73, PKR1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length393 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy. Ref.7

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Localizes to glandular epithelium, stroma and vascular endothelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the stomach, throughout the small intestine, colon, rectum, thyroid gland, pituitary gland, salivary gland, adrenal gland, testis, ovary, brain, spleen, prostate and pancreas. Ref.7

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 393393Prokineticin receptor 1
PRO_0000070079

Regions

Topological domain1 – 6262Extracellular Potential
Transmembrane63 – 8321Helical; Name=1; Potential
Topological domain84 – 9815Cytoplasmic Potential
Transmembrane99 – 11921Helical; Name=2; Potential
Topological domain120 – 14627Extracellular Potential
Transmembrane147 – 16721Helical; Name=3; Potential
Topological domain168 – 18013Cytoplasmic Potential
Transmembrane181 – 20121Helical; Name=4; Potential
Topological domain202 – 23231Extracellular Potential
Transmembrane233 – 25321Helical; Name=5; Potential
Topological domain254 – 28229Cytoplasmic Potential
Transmembrane283 – 30321Helical; Name=6; Potential
Topological domain304 – 32219Extracellular Potential
Transmembrane323 – 34321Helical; Name=7; Potential
Topological domain344 – 39350Cytoplasmic Potential

Amino acid modifications

Glycosylation111N-linked (GlcNAc...) Potential
Glycosylation141N-linked (GlcNAc...) Potential
Glycosylation361N-linked (GlcNAc...) Potential
Disulfide bond137 ↔ 217 By similarity

Natural variations

Natural variant401S → G.
Corresponds to variant rs7570797 [ dbSNP | Ensembl ].
VAR_024261

Experimental info

Sequence conflict255 – 2562IS → MT in AAM48127. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q8TCW9 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 0D36461CA99CAEC1

FASTA39344,770
        10         20         30         40         50         60 
METTMGFMDD NATNTSTSFL SVLNPHGAHA TSFPFNFSYS DYDMPLDEDE DVTNSRTFFA 

        70         80         90        100        110        120 
AKIVIGMALV GIMLVCGIGN FIFIAALVRY KKLRNLTNLL IANLAISDFL VAIVCCPFEM 

       130        140        150        160        170        180 
DYYVVRQLSW EHGHVLCTSV NYLRTVSLYV STNALLAIAI DRYLAIVHPL RPRMKCQTAT 

       190        200        210        220        230        240 
GLIALVWTVS ILIAIPSAYF TTETVLVIVK SQEKIFCGQI WPVDQQLYYK SYFLFIFGIE 

       250        260        270        280        290        300 
FVGPVVTMTL CYARISRELW FKAVPGFQTE QIRKRLRCRR KTVLVLMCIL TAYVLCWAPF 

       310        320        330        340        350        360 
YGFTIVRDFF PTVFVKEKHY LTAFYIVECI AMSNSMINTL CFVTVKNDTV KYFKKIMLLH 

       370        380        390 
WKASYNGGKS SADLDLKTIG MPATEEVDCI RLK 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors."
Masuda Y., Takatsu Y., Terao Y., Kumano S., Ishibashi Y., Suenaga M., Abe M., Fukusumi S., Watanabe T., Shintani Y., Yamada T., Hinuma S., Inatomi N., Ohtaki T., Onda H., Fujino M.
Biochem. Biophys. Res. Commun. 293:396-402(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Molecular cloning and characterization of prokineticin receptors."
Soga T., Matsumoto S., Oda T., Saito T., Hiyama H., Takasaki J., Kamohara M., Ohishi T., Matsushime H., Furuichi K.
Biochim. Biophys. Acta 1579:173-179(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor."
Lin D.C.-H., Bullock C.M., Ehlert F.J., Chen J.-L., Tian H., Zhou Q.-Y.
J. Biol. Chem. 277:19276-19280(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Martin A.L., Kaighin V.A., Aronstam R.S.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]"Prokineticin 1 signaling and gene regulation in early human pregnancy."
Evans J., Catalano R.D., Morgan K., Critchley H.O.D., Millar R.P., Jabbour H.N.
Endocrinology 149:2877-2887(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY089976 mRNA. Translation: AAM11892.1.
AB084080 mRNA. Translation: BAC24021.1.
AF506287 mRNA. Translation: AAM48127.1.
AC105054 Genomic DNA. Translation: AAY24114.1.
EF577399 mRNA. Translation: ABQ52419.1.
BC100960 mRNA. Translation: AAI00961.1.
RefSeqNP_620414.1. NM_138964.2.
UniGeneHs.683430.

3D structure databases

ProteinModelPortalQ8TCW9.
SMRQ8TCW9. Positions 67-357.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000303775.

Chemistry

BindingDBQ8TCW9.
ChEMBLCHEMBL5649.
GuidetoPHARMACOLOGY335.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8TCW9.

Polymorphism databases

DMDM33112428.

Proteomic databases

PaxDbQ8TCW9.
PRIDEQ8TCW9.

Protocols and materials databases

DNASU10887.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000303786; ENSP00000303775; ENSG00000169618.
ENST00000394342; ENSP00000377874; ENSG00000169618.
GeneID10887.
KEGGhsa:10887.
UCSCuc010yqj.2. human.

Organism-specific databases

CTD10887.
GeneCardsGC02P068870.
HGNCHGNC:4524. PROKR1.
HPAHPA029396.
MIM607122. gene.
neXtProtNX_Q8TCW9.
PharmGKBPA28916.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG319668.
HOGENOMHOG000231664.
HOVERGENHBG039631.
InParanoidQ8TCW9.
KOK08379.
OMALIIVKSQ.
OrthoDBEOG73NG3D.
PhylomeDBQ8TCW9.
TreeFamTF315303.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ8TCW9.
CleanExHS_PROKR1.
GenevestigatorQ8TCW9.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000611. NPY_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01012. NRPEPTIDEYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiProkineticin_receptor_1.
GenomeRNAi10887.
NextBio41341.
PROQ8TCW9.
SOURCESearch...

Entry information

Entry namePKR1_HUMAN
AccessionPrimary (citable) accession number: Q8TCW9
Secondary accession number(s): A5JUU2, Q53QT9, Q8NFJ7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries