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Protein

Prokineticin receptor 1

Gene

PROKR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy.1 Publication

GO - Molecular functioni

  1. neuropeptide Y receptor activity Source: InterPro

GO - Biological processi

  1. negative regulation of apoptotic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Prokineticin receptor 1
Short name:
PK-R1
Alternative name(s):
G-protein coupled receptor 73
G-protein coupled receptor ZAQ
GPR73a
Gene namesi
Name:PROKR1
Synonyms:GPR73, PKR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:4524. PROKR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6262ExtracellularSequence AnalysisAdd
BLAST
Transmembranei63 – 8321Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini84 – 9815CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei99 – 11921Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini120 – 14627ExtracellularSequence AnalysisAdd
BLAST
Transmembranei147 – 16721Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini168 – 18013CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei181 – 20121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini202 – 23231ExtracellularSequence AnalysisAdd
BLAST
Transmembranei233 – 25321Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini254 – 28229CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei283 – 30321Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini304 – 32219ExtracellularSequence AnalysisAdd
BLAST
Transmembranei323 – 34321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini344 – 39350CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28916.

Polymorphism and mutation databases

BioMutaiPROKR1.
DMDMi33112428.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Prokineticin receptor 1PRO_0000070079Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi137 ↔ 217PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8TCW9.
PRIDEiQ8TCW9.

PTM databases

PhosphoSiteiQ8TCW9.

Expressioni

Tissue specificityi

Localizes to glandular epithelium, stroma and vascular endothelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the stomach, throughout the small intestine, colon, rectum, thyroid gland, pituitary gland, salivary gland, adrenal gland, testis, ovary, brain, spleen, prostate and pancreas.1 Publication

Gene expression databases

BgeeiQ8TCW9.
CleanExiHS_PROKR1.
ExpressionAtlasiQ8TCW9. baseline and differential.
GenevestigatoriQ8TCW9.

Organism-specific databases

HPAiHPA029396.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303775.

Structurei

3D structure databases

SMRiQ8TCW9. Positions 67-357.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG319668.
GeneTreeiENSGT00390000010591.
ENSGT00770000120614.
HOGENOMiHOG000231664.
HOVERGENiHBG039631.
InParanoidiQ8TCW9.
KOiK08379.
OMAiLIIVKSQ.
OrthoDBiEOG73NG3D.
PhylomeDBiQ8TCW9.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TCW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METTMGFMDD NATNTSTSFL SVLNPHGAHA TSFPFNFSYS DYDMPLDEDE
60 70 80 90 100
DVTNSRTFFA AKIVIGMALV GIMLVCGIGN FIFIAALVRY KKLRNLTNLL
110 120 130 140 150
IANLAISDFL VAIVCCPFEM DYYVVRQLSW EHGHVLCTSV NYLRTVSLYV
160 170 180 190 200
STNALLAIAI DRYLAIVHPL RPRMKCQTAT GLIALVWTVS ILIAIPSAYF
210 220 230 240 250
TTETVLVIVK SQEKIFCGQI WPVDQQLYYK SYFLFIFGIE FVGPVVTMTL
260 270 280 290 300
CYARISRELW FKAVPGFQTE QIRKRLRCRR KTVLVLMCIL TAYVLCWAPF
310 320 330 340 350
YGFTIVRDFF PTVFVKEKHY LTAFYIVECI AMSNSMINTL CFVTVKNDTV
360 370 380 390
KYFKKIMLLH WKASYNGGKS SADLDLKTIG MPATEEVDCI RLK
Length:393
Mass (Da):44,770
Last modified:June 1, 2002 - v1
Checksum:i0D36461CA99CAEC1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti255 – 2562IS → MT in AAM48127 (PubMed:11886876).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 401S → G.
Corresponds to variant rs7570797 [ dbSNP | Ensembl ].
VAR_024261

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY089976 mRNA. Translation: AAM11892.1.
AB084080 mRNA. Translation: BAC24021.1.
AF506287 mRNA. Translation: AAM48127.1.
AC105054 Genomic DNA. Translation: AAY24114.1.
EF577399 mRNA. Translation: ABQ52419.1.
BC100960 mRNA. Translation: AAI00961.1.
CCDSiCCDS1889.1.
RefSeqiNP_620414.1. NM_138964.2.
UniGeneiHs.683430.

Genome annotation databases

EnsembliENST00000303786; ENSP00000303775; ENSG00000169618.
GeneIDi10887.
KEGGihsa:10887.
UCSCiuc010yqj.2. human.

Polymorphism and mutation databases

BioMutaiPROKR1.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY089976 mRNA. Translation: AAM11892.1.
AB084080 mRNA. Translation: BAC24021.1.
AF506287 mRNA. Translation: AAM48127.1.
AC105054 Genomic DNA. Translation: AAY24114.1.
EF577399 mRNA. Translation: ABQ52419.1.
BC100960 mRNA. Translation: AAI00961.1.
CCDSiCCDS1889.1.
RefSeqiNP_620414.1. NM_138964.2.
UniGeneiHs.683430.

3D structure databases

SMRiQ8TCW9. Positions 67-357.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000303775.

Chemistry

BindingDBiQ8TCW9.
ChEMBLiCHEMBL5649.
GuidetoPHARMACOLOGYi335.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8TCW9.

Polymorphism and mutation databases

BioMutaiPROKR1.
DMDMi33112428.

Proteomic databases

PaxDbiQ8TCW9.
PRIDEiQ8TCW9.

Protocols and materials databases

DNASUi10887.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303786; ENSP00000303775; ENSG00000169618.
GeneIDi10887.
KEGGihsa:10887.
UCSCiuc010yqj.2. human.

Organism-specific databases

CTDi10887.
GeneCardsiGC02P068870.
HGNCiHGNC:4524. PROKR1.
HPAiHPA029396.
MIMi607122. gene.
neXtProtiNX_Q8TCW9.
PharmGKBiPA28916.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG319668.
GeneTreeiENSGT00390000010591.
ENSGT00770000120614.
HOGENOMiHOG000231664.
HOVERGENiHBG039631.
InParanoidiQ8TCW9.
KOiK08379.
OMAiLIIVKSQ.
OrthoDBiEOG73NG3D.
PhylomeDBiQ8TCW9.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

ChiTaRSiPROKR1. human.
GeneWikiiProkineticin_receptor_1.
GenomeRNAii10887.
NextBioi41341.
PROiQ8TCW9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TCW9.
CleanExiHS_PROKR1.
ExpressionAtlasiQ8TCW9. baseline and differential.
GenevestigatoriQ8TCW9.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors."
    Masuda Y., Takatsu Y., Terao Y., Kumano S., Ishibashi Y., Suenaga M., Abe M., Fukusumi S., Watanabe T., Shintani Y., Yamada T., Hinuma S., Inatomi N., Ohtaki T., Onda H., Fujino M.
    Biochem. Biophys. Res. Commun. 293:396-402(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor."
    Lin D.C.-H., Bullock C.M., Ehlert F.J., Chen J.-L., Tian H., Zhou Q.-Y.
    J. Biol. Chem. 277:19276-19280(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Martin A.L., Kaighin V.A., Aronstam R.S.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Prokineticin 1 signaling and gene regulation in early human pregnancy."
    Evans J., Catalano R.D., Morgan K., Critchley H.O.D., Millar R.P., Jabbour H.N.
    Endocrinology 149:2877-2887(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiPKR1_HUMAN
AccessioniPrimary (citable) accession number: Q8TCW9
Secondary accession number(s): A5JUU2, Q53QT9, Q8NFJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2002
Last modified: April 29, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.