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Q8TCW7

- ZPLD1_HUMAN

UniProt

Q8TCW7 - ZPLD1_HUMAN

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Protein
Zona pellucida-like domain-containing protein 1
Gene
ZPLD1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Zona pellucida-like domain-containing protein 1
Short name:
ZP domain-containing protein 1
Gene namesi
Name:ZPLD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:27022. ZPLD1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 372353Extracellular Reviewed prediction
Add
BLAST
Transmembranei373 – 39321Helical; Reviewed prediction
Add
BLAST
Topological domaini394 – 41522Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670472.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 415396Zona pellucida-like domain-containing protein 1
PRO_0000307284Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi121 – 1211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi164 – 1641N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi235 ↔ 296 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8TCW7.
PRIDEiQ8TCW7.

Expressioni

Gene expression databases

BgeeiQ8TCW7.
CleanExiHS_ZPLD1.
GenevestigatoriQ8TCW7.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000307801.

Structurei

3D structure databases

ProteinModelPortaliQ8TCW7.
SMRiQ8TCW7. Positions 187-319.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 320278ZP
Add
BLAST

Sequence similaritiesi

Contains 1 ZP domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG25201.
HOGENOMiHOG000136343.
HOVERGENiHBG108778.
InParanoidiQ8TCW7.
OMAiVQATNLD.
OrthoDBiEOG7SV0VC.
PhylomeDBiQ8TCW7.
TreeFamiTF329882.

Family and domain databases

InterProiIPR001507. ZP_dom.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
SMARTiSM00241. ZP. 1 hit.
[Graphical view]
PROSITEiPS51034. ZP_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8TCW7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEQIWLLLLL TIRVLPGSAQ FNGYNCDANL HSRFPAERDI SVYCGVQAIT    50
MKINFCTVLF SGYSETDLAL NGRHGDSHCR GFINNNTFPA VVIFIINLST 100
LEGCGNNLVV STIPGVSAYG NATSVQVGNI SGYIDTPDPP TIISYLPGLL 150
YKFSCSYPLE YLVNNTQLAS SSAAISVREN NGTFVSTLNL LLYNDSTYNQ 200
QLIIPSIGLP LKTKVFAAVQ ATNLDGRWNV LMDYCYTTPS GNPNDDIRYD 250
LFLSCDKDPQ TTVIENGRSQ RGRFSFEVFR FVKHKNQKMS TVFLHCVTKL 300
CRADDCPFLM PICSHRERRD AGRRTTWSPQ SSSGSAVLSA GPIITRSDET 350
PTNNSQLGSP SMPPFQLNAI TSALISGMVI LGVTSFSLLL CSLALLHRKG 400
PTSLVLNGIR NPVFD 415
Length:415
Mass (Da):45,530
Last modified:October 23, 2007 - v2
Checksum:i7473CB023438EAB3
GO
Isoform 2 (identifier: Q8TCW7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MMLRFSMCRGNDEGFAM

Show »
Length:431
Mass (Da):47,377
Checksum:iD7B0649DC9BAC073
GO

Sequence cautioni

The sequence EAW79766.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti12 – 121I → F.
Corresponds to variant rs6784362 [ dbSNP | Ensembl ].
VAR_035400
Natural varianti29 – 291N → S.
Corresponds to variant rs6784389 [ dbSNP | Ensembl ].
VAR_035401
Natural varianti197 – 1971T → A.
Corresponds to variant rs12054046 [ dbSNP | Ensembl ].
VAR_035402

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MMLRFSMCRGNDEGFAM in isoform 2.
VSP_037072

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti242 – 2421N → S in AAH31261. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY090780 mRNA. Translation: AAM09816.1.
CH471052 Genomic DNA. Translation: EAW79766.1. Sequence problems.
BC021279 mRNA. Translation: AAH21279.2.
BC031261 mRNA. Translation: AAH31261.1.
CCDSiCCDS2947.1. [Q8TCW7-2]
RefSeqiNP_778226.1. NM_175056.1. [Q8TCW7-2]
XP_005247167.1. XM_005247110.1. [Q8TCW7-1]
UniGeneiHs.352213.

Genome annotation databases

EnsembliENST00000306176; ENSP00000307801; ENSG00000170044. [Q8TCW7-2]
ENST00000466937; ENSP00000418253; ENSG00000170044. [Q8TCW7-1]
ENST00000491959; ENSP00000420265; ENSG00000170044. [Q8TCW7-1]
GeneIDi131368.
KEGGihsa:131368.
UCSCiuc003dvs.1. human. [Q8TCW7-1]
uc003dvt.1. human. [Q8TCW7-2]

Polymorphism databases

DMDMi160221311.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY090780 mRNA. Translation: AAM09816.1 .
CH471052 Genomic DNA. Translation: EAW79766.1 . Sequence problems.
BC021279 mRNA. Translation: AAH21279.2 .
BC031261 mRNA. Translation: AAH31261.1 .
CCDSi CCDS2947.1. [Q8TCW7-2 ]
RefSeqi NP_778226.1. NM_175056.1. [Q8TCW7-2 ]
XP_005247167.1. XM_005247110.1. [Q8TCW7-1 ]
UniGenei Hs.352213.

3D structure databases

ProteinModelPortali Q8TCW7.
SMRi Q8TCW7. Positions 187-319.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000307801.

Polymorphism databases

DMDMi 160221311.

Proteomic databases

PaxDbi Q8TCW7.
PRIDEi Q8TCW7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000306176 ; ENSP00000307801 ; ENSG00000170044 . [Q8TCW7-2 ]
ENST00000466937 ; ENSP00000418253 ; ENSG00000170044 . [Q8TCW7-1 ]
ENST00000491959 ; ENSP00000420265 ; ENSG00000170044 . [Q8TCW7-1 ]
GeneIDi 131368.
KEGGi hsa:131368.
UCSCi uc003dvs.1. human. [Q8TCW7-1 ]
uc003dvt.1. human. [Q8TCW7-2 ]

Organism-specific databases

CTDi 131368.
GeneCardsi GC03P101818.
HGNCi HGNC:27022. ZPLD1.
neXtProti NX_Q8TCW7.
PharmGKBi PA142670472.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG25201.
HOGENOMi HOG000136343.
HOVERGENi HBG108778.
InParanoidi Q8TCW7.
OMAi VQATNLD.
OrthoDBi EOG7SV0VC.
PhylomeDBi Q8TCW7.
TreeFami TF329882.

Miscellaneous databases

GenomeRNAii 131368.
NextBioi 82892.
PROi Q8TCW7.

Gene expression databases

Bgeei Q8TCW7.
CleanExi HS_ZPLD1.
Genevestigatori Q8TCW7.

Family and domain databases

InterProi IPR001507. ZP_dom.
[Graphical view ]
Pfami PF00100. Zona_pellucida. 1 hit.
[Graphical view ]
SMARTi SM00241. ZP. 1 hit.
[Graphical view ]
PROSITEi PS51034. ZP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Zhu P.Y., Huang Y.F.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye and Testis.

Entry informationi

Entry nameiZPLD1_HUMAN
AccessioniPrimary (citable) accession number: Q8TCW7
Secondary accession number(s): Q49AS1, Q8WU36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: July 9, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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