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Protein

Zona pellucida-like domain-containing protein 1

Gene

ZPLD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170044-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zona pellucida-like domain-containing protein 1
Short name:
ZP domain-containing protein 1
Gene namesi
Name:ZPLD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:27022. ZPLD1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 372ExtracellularSequence analysisAdd BLAST353
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 415CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi131368.
OpenTargetsiENSG00000170044.
PharmGKBiPA142670472.

Polymorphism and mutation databases

BioMutaiZPLD1.
DMDMi160221311.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000030728420 – 415Zona pellucida-like domain-containing protein 1Add BLAST396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi121N-linked (GlcNAc...)Sequence analysis1
Glycosylationi164N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi235 ↔ 296By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8TCW7.
PeptideAtlasiQ8TCW7.
PRIDEiQ8TCW7.

PTM databases

PhosphoSitePlusiQ8TCW7.

Expressioni

Tissue specificityi

Detected in placenta, kidney, lung, pancreas and at very low level in other tissues.1 Publication

Gene expression databases

BgeeiENSG00000170044.
CleanExiHS_ZPLD1.
GenevisibleiQ8TCW7. HS.

Interactioni

Protein-protein interaction databases

BioGridi126276. 10 interactors.
STRINGi9606.ENSP00000307801.

Structurei

3D structure databases

ProteinModelPortaliQ8TCW7.
SMRiQ8TCW7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 320ZPPROSITE-ProRule annotationAdd BLAST278

Sequence similaritiesi

Contains 1 ZP domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGW3. Eukaryota.
ENOG411153Y. LUCA.
GeneTreeiENSGT00530000063315.
HOGENOMiHOG000136343.
HOVERGENiHBG108778.
InParanoidiQ8TCW7.
OMAiMPICGHR.
OrthoDBiEOG091G06ZH.
PhylomeDBiQ8TCW7.
TreeFamiTF329882.

Family and domain databases

InterProiIPR001507. ZP_dom.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
SMARTiSM00241. ZP. 1 hit.
[Graphical view]
PROSITEiPS51034. ZP_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TCW7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEQIWLLLLL TIRVLPGSAQ FNGYNCDANL HSRFPAERDI SVYCGVQAIT
60 70 80 90 100
MKINFCTVLF SGYSETDLAL NGRHGDSHCR GFINNNTFPA VVIFIINLST
110 120 130 140 150
LEGCGNNLVV STIPGVSAYG NATSVQVGNI SGYIDTPDPP TIISYLPGLL
160 170 180 190 200
YKFSCSYPLE YLVNNTQLAS SSAAISVREN NGTFVSTLNL LLYNDSTYNQ
210 220 230 240 250
QLIIPSIGLP LKTKVFAAVQ ATNLDGRWNV LMDYCYTTPS GNPNDDIRYD
260 270 280 290 300
LFLSCDKDPQ TTVIENGRSQ RGRFSFEVFR FVKHKNQKMS TVFLHCVTKL
310 320 330 340 350
CRADDCPFLM PICSHRERRD AGRRTTWSPQ SSSGSAVLSA GPIITRSDET
360 370 380 390 400
PTNNSQLGSP SMPPFQLNAI TSALISGMVI LGVTSFSLLL CSLALLHRKG
410
PTSLVLNGIR NPVFD
Length:415
Mass (Da):45,530
Last modified:October 23, 2007 - v2
Checksum:i7473CB023438EAB3
GO
Isoform 2 (identifier: Q8TCW7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MMLRFSMCRGNDEGFAM

Show »
Length:431
Mass (Da):47,377
Checksum:iD7B0649DC9BAC073
GO

Sequence cautioni

The sequence EAW79766 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242N → S in AAH31261 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03540012I → F.Corresponds to variant rs6784362dbSNPEnsembl.1
Natural variantiVAR_03540129N → S.Corresponds to variant rs6784389dbSNPEnsembl.1
Natural variantiVAR_035402197T → A.Corresponds to variant rs12054046dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0370721M → MMLRFSMCRGNDEGFAM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY090780 mRNA. Translation: AAM09816.1.
CH471052 Genomic DNA. Translation: EAW79766.1. Sequence problems.
BC021279 mRNA. Translation: AAH21279.2.
BC031261 mRNA. Translation: AAH31261.1.
CCDSiCCDS2947.1. [Q8TCW7-2]
RefSeqiNP_001316717.1. NM_001329788.1. [Q8TCW7-1]
NP_778226.1. NM_175056.1. [Q8TCW7-2]
XP_016861192.1. XM_017005703.1. [Q8TCW7-1]
XP_016861193.1. XM_017005704.1. [Q8TCW7-1]
UniGeneiHs.352213.

Genome annotation databases

EnsembliENST00000306176; ENSP00000307801; ENSG00000170044. [Q8TCW7-2]
ENST00000466937; ENSP00000418253; ENSG00000170044. [Q8TCW7-1]
ENST00000491959; ENSP00000420265; ENSG00000170044. [Q8TCW7-1]
GeneIDi131368.
KEGGihsa:131368.
UCSCiuc003dvs.2. human. [Q8TCW7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY090780 mRNA. Translation: AAM09816.1.
CH471052 Genomic DNA. Translation: EAW79766.1. Sequence problems.
BC021279 mRNA. Translation: AAH21279.2.
BC031261 mRNA. Translation: AAH31261.1.
CCDSiCCDS2947.1. [Q8TCW7-2]
RefSeqiNP_001316717.1. NM_001329788.1. [Q8TCW7-1]
NP_778226.1. NM_175056.1. [Q8TCW7-2]
XP_016861192.1. XM_017005703.1. [Q8TCW7-1]
XP_016861193.1. XM_017005704.1. [Q8TCW7-1]
UniGeneiHs.352213.

3D structure databases

ProteinModelPortaliQ8TCW7.
SMRiQ8TCW7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126276. 10 interactors.
STRINGi9606.ENSP00000307801.

PTM databases

PhosphoSitePlusiQ8TCW7.

Polymorphism and mutation databases

BioMutaiZPLD1.
DMDMi160221311.

Proteomic databases

PaxDbiQ8TCW7.
PeptideAtlasiQ8TCW7.
PRIDEiQ8TCW7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306176; ENSP00000307801; ENSG00000170044. [Q8TCW7-2]
ENST00000466937; ENSP00000418253; ENSG00000170044. [Q8TCW7-1]
ENST00000491959; ENSP00000420265; ENSG00000170044. [Q8TCW7-1]
GeneIDi131368.
KEGGihsa:131368.
UCSCiuc003dvs.2. human. [Q8TCW7-1]

Organism-specific databases

CTDi131368.
DisGeNETi131368.
GeneCardsiZPLD1.
HGNCiHGNC:27022. ZPLD1.
MIMi615915. gene.
neXtProtiNX_Q8TCW7.
OpenTargetsiENSG00000170044.
PharmGKBiPA142670472.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGW3. Eukaryota.
ENOG411153Y. LUCA.
GeneTreeiENSGT00530000063315.
HOGENOMiHOG000136343.
HOVERGENiHBG108778.
InParanoidiQ8TCW7.
OMAiMPICGHR.
OrthoDBiEOG091G06ZH.
PhylomeDBiQ8TCW7.
TreeFamiTF329882.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170044-MONOMER.

Miscellaneous databases

GenomeRNAii131368.
PROiQ8TCW7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170044.
CleanExiHS_ZPLD1.
GenevisibleiQ8TCW7. HS.

Family and domain databases

InterProiIPR001507. ZP_dom.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
SMARTiSM00241. ZP. 1 hit.
[Graphical view]
PROSITEiPS51034. ZP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZPLD1_HUMAN
AccessioniPrimary (citable) accession number: Q8TCW7
Secondary accession number(s): Q49AS1, Q8WU36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: November 30, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.