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Q8TCW7 (ZPLD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zona pellucida-like domain-containing protein 1

Short name=ZP domain-containing protein 1
Gene names
Name:ZPLD1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Contains 1 ZP domain.

Sequence caution

The sequence EAW79766.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8TCW7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8TCW7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MMLRFSMCRGNDEGFAM

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 415396Zona pellucida-like domain-containing protein 1
PRO_0000307284

Regions

Topological domain20 – 372353Extracellular Potential
Transmembrane373 – 39321Helical; Potential
Topological domain394 – 41522Cytoplasmic Potential
Domain43 – 320278ZP

Amino acid modifications

Glycosylation1211N-linked (GlcNAc...) Potential
Glycosylation1641N-linked (GlcNAc...) Potential
Disulfide bond235 ↔ 296 By similarity

Natural variations

Alternative sequence11M → MMLRFSMCRGNDEGFAM in isoform 2.
VSP_037072
Natural variant121I → F.
Corresponds to variant rs6784362 [ dbSNP | Ensembl ].
VAR_035400
Natural variant291N → S.
Corresponds to variant rs6784389 [ dbSNP | Ensembl ].
VAR_035401
Natural variant1971T → A.
Corresponds to variant rs12054046 [ dbSNP | Ensembl ].
VAR_035402

Experimental info

Sequence conflict2421N → S in AAH31261. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 23, 2007. Version 2.
Checksum: 7473CB023438EAB3

FASTA41545,530
        10         20         30         40         50         60 
MEQIWLLLLL TIRVLPGSAQ FNGYNCDANL HSRFPAERDI SVYCGVQAIT MKINFCTVLF 

        70         80         90        100        110        120 
SGYSETDLAL NGRHGDSHCR GFINNNTFPA VVIFIINLST LEGCGNNLVV STIPGVSAYG 

       130        140        150        160        170        180 
NATSVQVGNI SGYIDTPDPP TIISYLPGLL YKFSCSYPLE YLVNNTQLAS SSAAISVREN 

       190        200        210        220        230        240 
NGTFVSTLNL LLYNDSTYNQ QLIIPSIGLP LKTKVFAAVQ ATNLDGRWNV LMDYCYTTPS 

       250        260        270        280        290        300 
GNPNDDIRYD LFLSCDKDPQ TTVIENGRSQ RGRFSFEVFR FVKHKNQKMS TVFLHCVTKL 

       310        320        330        340        350        360 
CRADDCPFLM PICSHRERRD AGRRTTWSPQ SSSGSAVLSA GPIITRSDET PTNNSQLGSP 

       370        380        390        400        410 
SMPPFQLNAI TSALISGMVI LGVTSFSLLL CSLALLHRKG PTSLVLNGIR NPVFD 

« Hide

Isoform 2 [UniParc].

Checksum: D7B0649DC9BAC073
Show »

FASTA43147,377

References

« Hide 'large scale' references
[1]Zhu P.Y., Huang Y.F.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Testis.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Eye and Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY090780 mRNA. Translation: AAM09816.1.
CH471052 Genomic DNA. Translation: EAW79766.1. Sequence problems.
BC021279 mRNA. Translation: AAH21279.2.
BC031261 mRNA. Translation: AAH31261.1.
CCDSCCDS2947.1. [Q8TCW7-2]
RefSeqNP_778226.1. NM_175056.1. [Q8TCW7-2]
XP_005247167.1. XM_005247110.1. [Q8TCW7-1]
UniGeneHs.352213.

3D structure databases

ProteinModelPortalQ8TCW7.
SMRQ8TCW7. Positions 187-319.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000307801.

Polymorphism databases

DMDM160221311.

Proteomic databases

PaxDbQ8TCW7.
PRIDEQ8TCW7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000306176; ENSP00000307801; ENSG00000170044. [Q8TCW7-2]
ENST00000466937; ENSP00000418253; ENSG00000170044. [Q8TCW7-1]
ENST00000491959; ENSP00000420265; ENSG00000170044. [Q8TCW7-1]
GeneID131368.
KEGGhsa:131368.
UCSCuc003dvs.1. human. [Q8TCW7-1]
uc003dvt.1. human. [Q8TCW7-2]

Organism-specific databases

CTD131368.
GeneCardsGC03P101818.
HGNCHGNC:27022. ZPLD1.
neXtProtNX_Q8TCW7.
PharmGKBPA142670472.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG25201.
HOGENOMHOG000136343.
HOVERGENHBG108778.
InParanoidQ8TCW7.
OMAVQATNLD.
OrthoDBEOG7SV0VC.
PhylomeDBQ8TCW7.
TreeFamTF329882.

Gene expression databases

BgeeQ8TCW7.
CleanExHS_ZPLD1.
GenevestigatorQ8TCW7.

Family and domain databases

InterProIPR001507. ZP_dom.
[Graphical view]
PfamPF00100. Zona_pellucida. 1 hit.
[Graphical view]
SMARTSM00241. ZP. 1 hit.
[Graphical view]
PROSITEPS51034. ZP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi131368.
NextBio82892.
PROQ8TCW7.

Entry information

Entry nameZPLD1_HUMAN
AccessionPrimary (citable) accession number: Q8TCW7
Secondary accession number(s): Q49AS1, Q8WU36
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: July 9, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM