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Q8TCW7

- ZPLD1_HUMAN

UniProt

Q8TCW7 - ZPLD1_HUMAN

Protein

Zona pellucida-like domain-containing protein 1

Gene

ZPLD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 2 (23 Oct 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zona pellucida-like domain-containing protein 1
    Short name:
    ZP domain-containing protein 1
    Gene namesi
    Name:ZPLD1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:27022. ZPLD1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670472.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 415396Zona pellucida-like domain-containing protein 1PRO_0000307284Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi235 ↔ 296By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8TCW7.
    PRIDEiQ8TCW7.

    Expressioni

    Gene expression databases

    BgeeiQ8TCW7.
    CleanExiHS_ZPLD1.
    GenevestigatoriQ8TCW7.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000307801.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TCW7.
    SMRiQ8TCW7. Positions 187-319.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 372353ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini394 – 41522CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei373 – 39321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini43 – 320278ZPPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ZP domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG25201.
    HOGENOMiHOG000136343.
    HOVERGENiHBG108778.
    InParanoidiQ8TCW7.
    OMAiVQATNLD.
    OrthoDBiEOG7SV0VC.
    PhylomeDBiQ8TCW7.
    TreeFamiTF329882.

    Family and domain databases

    InterProiIPR001507. ZP_dom.
    [Graphical view]
    PfamiPF00100. Zona_pellucida. 1 hit.
    [Graphical view]
    SMARTiSM00241. ZP. 1 hit.
    [Graphical view]
    PROSITEiPS51034. ZP_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TCW7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEQIWLLLLL TIRVLPGSAQ FNGYNCDANL HSRFPAERDI SVYCGVQAIT    50
    MKINFCTVLF SGYSETDLAL NGRHGDSHCR GFINNNTFPA VVIFIINLST 100
    LEGCGNNLVV STIPGVSAYG NATSVQVGNI SGYIDTPDPP TIISYLPGLL 150
    YKFSCSYPLE YLVNNTQLAS SSAAISVREN NGTFVSTLNL LLYNDSTYNQ 200
    QLIIPSIGLP LKTKVFAAVQ ATNLDGRWNV LMDYCYTTPS GNPNDDIRYD 250
    LFLSCDKDPQ TTVIENGRSQ RGRFSFEVFR FVKHKNQKMS TVFLHCVTKL 300
    CRADDCPFLM PICSHRERRD AGRRTTWSPQ SSSGSAVLSA GPIITRSDET 350
    PTNNSQLGSP SMPPFQLNAI TSALISGMVI LGVTSFSLLL CSLALLHRKG 400
    PTSLVLNGIR NPVFD 415
    Length:415
    Mass (Da):45,530
    Last modified:October 23, 2007 - v2
    Checksum:i7473CB023438EAB3
    GO
    Isoform 2 (identifier: Q8TCW7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MMLRFSMCRGNDEGFAM

    Show »
    Length:431
    Mass (Da):47,377
    Checksum:iD7B0649DC9BAC073
    GO

    Sequence cautioni

    The sequence EAW79766.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti242 – 2421N → S in AAH31261. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti12 – 121I → F.
    Corresponds to variant rs6784362 [ dbSNP | Ensembl ].
    VAR_035400
    Natural varianti29 – 291N → S.
    Corresponds to variant rs6784389 [ dbSNP | Ensembl ].
    VAR_035401
    Natural varianti197 – 1971T → A.
    Corresponds to variant rs12054046 [ dbSNP | Ensembl ].
    VAR_035402

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MMLRFSMCRGNDEGFAM in isoform 2. 1 PublicationVSP_037072

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY090780 mRNA. Translation: AAM09816.1.
    CH471052 Genomic DNA. Translation: EAW79766.1. Sequence problems.
    BC021279 mRNA. Translation: AAH21279.2.
    BC031261 mRNA. Translation: AAH31261.1.
    CCDSiCCDS2947.1. [Q8TCW7-2]
    RefSeqiNP_778226.1. NM_175056.1. [Q8TCW7-2]
    XP_005247167.1. XM_005247110.1. [Q8TCW7-1]
    UniGeneiHs.352213.

    Genome annotation databases

    EnsembliENST00000306176; ENSP00000307801; ENSG00000170044. [Q8TCW7-2]
    ENST00000466937; ENSP00000418253; ENSG00000170044. [Q8TCW7-1]
    ENST00000491959; ENSP00000420265; ENSG00000170044. [Q8TCW7-1]
    GeneIDi131368.
    KEGGihsa:131368.
    UCSCiuc003dvs.1. human. [Q8TCW7-1]
    uc003dvt.1. human. [Q8TCW7-2]

    Polymorphism databases

    DMDMi160221311.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY090780 mRNA. Translation: AAM09816.1 .
    CH471052 Genomic DNA. Translation: EAW79766.1 . Sequence problems.
    BC021279 mRNA. Translation: AAH21279.2 .
    BC031261 mRNA. Translation: AAH31261.1 .
    CCDSi CCDS2947.1. [Q8TCW7-2 ]
    RefSeqi NP_778226.1. NM_175056.1. [Q8TCW7-2 ]
    XP_005247167.1. XM_005247110.1. [Q8TCW7-1 ]
    UniGenei Hs.352213.

    3D structure databases

    ProteinModelPortali Q8TCW7.
    SMRi Q8TCW7. Positions 187-319.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000307801.

    Polymorphism databases

    DMDMi 160221311.

    Proteomic databases

    PaxDbi Q8TCW7.
    PRIDEi Q8TCW7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306176 ; ENSP00000307801 ; ENSG00000170044 . [Q8TCW7-2 ]
    ENST00000466937 ; ENSP00000418253 ; ENSG00000170044 . [Q8TCW7-1 ]
    ENST00000491959 ; ENSP00000420265 ; ENSG00000170044 . [Q8TCW7-1 ]
    GeneIDi 131368.
    KEGGi hsa:131368.
    UCSCi uc003dvs.1. human. [Q8TCW7-1 ]
    uc003dvt.1. human. [Q8TCW7-2 ]

    Organism-specific databases

    CTDi 131368.
    GeneCardsi GC03P101818.
    HGNCi HGNC:27022. ZPLD1.
    neXtProti NX_Q8TCW7.
    PharmGKBi PA142670472.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG25201.
    HOGENOMi HOG000136343.
    HOVERGENi HBG108778.
    InParanoidi Q8TCW7.
    OMAi VQATNLD.
    OrthoDBi EOG7SV0VC.
    PhylomeDBi Q8TCW7.
    TreeFami TF329882.

    Miscellaneous databases

    GenomeRNAii 131368.
    NextBioi 82892.
    PROi Q8TCW7.

    Gene expression databases

    Bgeei Q8TCW7.
    CleanExi HS_ZPLD1.
    Genevestigatori Q8TCW7.

    Family and domain databases

    InterProi IPR001507. ZP_dom.
    [Graphical view ]
    Pfami PF00100. Zona_pellucida. 1 hit.
    [Graphical view ]
    SMARTi SM00241. ZP. 1 hit.
    [Graphical view ]
    PROSITEi PS51034. ZP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Zhu P.Y., Huang Y.F.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Eye and Testis.

    Entry informationi

    Entry nameiZPLD1_HUMAN
    AccessioniPrimary (citable) accession number: Q8TCW7
    Secondary accession number(s): Q49AS1, Q8WU36
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 74 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3