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Protein

WAP four-disulfide core domain protein 5

Gene

WFDC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative acid-stable proteinase inhibitor.

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI17.003.

Names & Taxonomyi

Protein namesi
Recommended name:
WAP four-disulfide core domain protein 5
Alternative name(s):
Putative protease inhibitor WAP1
p53-responsive gene 5 protein
Gene namesi
Name:WFDC5
Synonyms:PRG5, WAP1
ORF Names:UNQ3036/PRO9842
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000175121.11.
HGNCiHGNC:20477. WFDC5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi149708.
OpenTargetsiENSG00000175121.
PharmGKBiPA134885667.

Polymorphism and mutation databases

BioMutaiWFDC5.
DMDMi26401313.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000004138225 – 224WAP four-disulfide core domain protein 5Add BLAST200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 62PROSITE-ProRule annotation
Disulfide bondi41 ↔ 66PROSITE-ProRule annotation
Disulfide bondi49 ↔ 61PROSITE-ProRule annotation
Disulfide bondi55 ↔ 70PROSITE-ProRule annotation
Disulfide bondi81 ↔ 109PROSITE-ProRule annotation
Disulfide bondi88 ↔ 113PROSITE-ProRule annotation
Disulfide bondi96 ↔ 108PROSITE-ProRule annotation
Disulfide bondi102 ↔ 117PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8TCV5.
PeptideAtlasiQ8TCV5.
PRIDEiQ8TCV5.

Expressioni

Inductioni

By p53/TP53.1 Publication

Gene expression databases

BgeeiENSG00000175121.
CleanExiHS_WFDC5.
GenevisibleiQ8TCV5. HS.

Interactioni

Protein-protein interaction databases

BioGridi127236. 7 interactors.
IntActiQ8TCV5. 1 interactor.
STRINGi9606.ENSP00000361875.

Structurei

3D structure databases

ProteinModelPortaliQ8TCV5.
SMRiQ8TCV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 73WAP 1PROSITE-ProRule annotationAdd BLAST47
Domaini74 – 121WAP 2PROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IZEK. Eukaryota.
ENOG4111D8G. LUCA.
GeneTreeiENSGT00730000111369.
HOGENOMiHOG000154853.
InParanoidiQ8TCV5.
OMAiLQPIHPW.
OrthoDBiEOG091G0XEE.
PhylomeDBiQ8TCV5.
TreeFamiTF338375.

Family and domain databases

InterProiView protein in InterPro
IPR008197. WAP_dom.
IPR029714. WFDC5.
PANTHERiPTHR19441:SF59. PTHR19441:SF59. 1 hit.
PfamiView protein in Pfam
PF00095. WAP. 2 hits.
PRINTSiPR00003. 4DISULPHCORE.
SMARTiView protein in SMART
SM00217. WAP. 2 hits.
SUPFAMiSSF57256. SSF57256. 2 hits.
PROSITEiView protein in PROSITE
PS51390. WAP. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TCV5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRTQSLLLLG ALLAVGSQLP AVFGRKKGEK SGGCPPDDGP CLLSVPDQCV
60 70 80 90 100
EDSQCPLTRK CCYRACFRQC VPRVSVKLGS CPEDQLRCLS PMNHLCHKDS
110 120 130 140 150
DCSGKKRCCH SACGRDCRDP ARGTAPGCPG QANSDLGSVA LHLSWGPTER
160 170 180 190 200
VHDGRPGALP AGQHYLYQRW FQPSDNHWPA DTSLQPIHPW FLLLGVKVHS
210 220
LSSEEGLCIT PVLCTTAIRA SHPS
Note: Gene prediction confirmed by EST data.
Length:224
Mass (Da):24,238
Last modified:June 1, 2002 - v1
Checksum:i305CC59024058F15
GO
Isoform 2 (identifier: Q8TCV5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-224: Missing.

Show »
Length:123
Mass (Da):13,313
Checksum:i255B5501B24F54F4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti172Q → R in AF147078 (PubMed:10441517).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05747497H → Y1 PublicationCorresponds to variant dbSNP:rs17422688Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006756124 – 224Missing in isoform 2. 3 PublicationsAdd BLAST101

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY038181 mRNA. Translation: AAK72468.1.
AY358822 mRNA. Translation: AAQ89181.1.
Z93016 Genomic DNA. Translation: CAD27771.1.
Z93016 Genomic DNA. Translation: CAI19816.1.
BC039173 mRNA. Translation: AAH39173.1.
AF147078 mRNA. No translation available.
CCDSiCCDS33475.1. [Q8TCV5-2]
RefSeqiNP_663627.1. NM_145652.3. [Q8TCV5-2]
XP_011526903.1. XM_011528601.1. [Q8TCV5-2]
XP_011526904.1. XM_011528602.1. [Q8TCV5-2]
UniGeneiHs.375031.

Genome annotation databases

EnsembliENST00000307971; ENSP00000312381; ENSG00000175121. [Q8TCV5-1]
ENST00000372789; ENSP00000361875; ENSG00000175121. [Q8TCV5-2]
GeneIDi149708.
KEGGihsa:149708.
UCSCiuc002xne.2. human. [Q8TCV5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiWFDC5_HUMAN
AccessioniPrimary (citable) accession number: Q8TCV5
Secondary accession number(s): Q5H981, Q6UWE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: June 1, 2002
Last modified: September 27, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot