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Protein

WAP four-disulfide core domain protein 5

Gene

WFDC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative acid-stable proteinase inhibitor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI17.003.

Names & Taxonomyi

Protein namesi
Recommended name:
WAP four-disulfide core domain protein 5
Alternative name(s):
Putative protease inhibitor WAP1
p53-responsive gene 5 protein
Gene namesi
Name:WFDC5
Synonyms:PRG5, WAP1
ORF Names:UNQ3036/PRO9842
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:20477. WFDC5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134885667.

Polymorphism and mutation databases

BioMutaiWFDC5.
DMDMi26401313.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 224200WAP four-disulfide core domain protein 5PRO_0000041382Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 62PROSITE-ProRule annotation
Disulfide bondi41 ↔ 66PROSITE-ProRule annotation
Disulfide bondi49 ↔ 61PROSITE-ProRule annotation
Disulfide bondi55 ↔ 70PROSITE-ProRule annotation
Disulfide bondi81 ↔ 109PROSITE-ProRule annotation
Disulfide bondi88 ↔ 113PROSITE-ProRule annotation
Disulfide bondi96 ↔ 108PROSITE-ProRule annotation
Disulfide bondi102 ↔ 117PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8TCV5.
PRIDEiQ8TCV5.

Expressioni

Inductioni

By p53/TP53.1 Publication

Gene expression databases

BgeeiQ8TCV5.
CleanExiHS_WFDC5.
GenevisibleiQ8TCV5. HS.

Organism-specific databases

HPAiHPA049878.

Interactioni

Protein-protein interaction databases

BioGridi127236. 7 interactions.
STRINGi9606.ENSP00000361875.

Structurei

3D structure databases

ProteinModelPortaliQ8TCV5.
SMRiQ8TCV5. Positions 30-121.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 7347WAP 1PROSITE-ProRule annotationAdd
BLAST
Domaini74 – 12148WAP 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 WAP domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IZEK. Eukaryota.
ENOG4111D8G. LUCA.
GeneTreeiENSGT00730000111369.
HOGENOMiHOG000154853.
InParanoidiQ8TCV5.
OMAiCTTAIRA.
OrthoDBiEOG7S7SG9.
PhylomeDBiQ8TCV5.
TreeFamiTF338375.

Family and domain databases

Gene3Di4.10.75.10. 2 hits.
InterProiIPR008197. WAP_dom.
IPR029714. WFDC5.
[Graphical view]
PANTHERiPTHR19441:SF39. PTHR19441:SF39. 1 hit.
PfamiPF00095. WAP. 2 hits.
[Graphical view]
PRINTSiPR00003. 4DISULPHCORE.
SMARTiSM00217. WAP. 2 hits.
[Graphical view]
SUPFAMiSSF57256. SSF57256. 2 hits.
PROSITEiPS51390. WAP. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TCV5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRTQSLLLLG ALLAVGSQLP AVFGRKKGEK SGGCPPDDGP CLLSVPDQCV
60 70 80 90 100
EDSQCPLTRK CCYRACFRQC VPRVSVKLGS CPEDQLRCLS PMNHLCHKDS
110 120 130 140 150
DCSGKKRCCH SACGRDCRDP ARGTAPGCPG QANSDLGSVA LHLSWGPTER
160 170 180 190 200
VHDGRPGALP AGQHYLYQRW FQPSDNHWPA DTSLQPIHPW FLLLGVKVHS
210 220
LSSEEGLCIT PVLCTTAIRA SHPS
Note: Gene prediction confirmed by EST data.
Length:224
Mass (Da):24,238
Last modified:June 1, 2002 - v1
Checksum:i305CC59024058F15
GO
Isoform 2 (identifier: Q8TCV5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-224: Missing.

Show »
Length:123
Mass (Da):13,313
Checksum:i255B5501B24F54F4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti172 – 1721Q → R in AF147078 (PubMed:10441517).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti97 – 971H → Y.1 Publication
Corresponds to variant rs17422688 [ dbSNP | Ensembl ].
VAR_057474

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei124 – 224101Missing in isoform 2. 3 PublicationsVSP_006756Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY038181 mRNA. Translation: AAK72468.1.
AY358822 mRNA. Translation: AAQ89181.1.
Z93016 Genomic DNA. Translation: CAD27771.1.
Z93016 Genomic DNA. Translation: CAI19816.1.
BC039173 mRNA. Translation: AAH39173.1.
AF147078 mRNA. No translation available.
CCDSiCCDS33475.1. [Q8TCV5-2]
RefSeqiNP_663627.1. NM_145652.3. [Q8TCV5-2]
XP_011526903.1. XM_011528601.1. [Q8TCV5-2]
XP_011526904.1. XM_011528602.1. [Q8TCV5-2]
XP_011526905.1. XM_011528603.1. [Q8TCV5-2]
UniGeneiHs.375031.

Genome annotation databases

EnsembliENST00000307971; ENSP00000312381; ENSG00000175121. [Q8TCV5-1]
ENST00000372789; ENSP00000361875; ENSG00000175121. [Q8TCV5-2]
GeneIDi149708.
KEGGihsa:149708.
UCSCiuc002xne.2. human. [Q8TCV5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY038181 mRNA. Translation: AAK72468.1.
AY358822 mRNA. Translation: AAQ89181.1.
Z93016 Genomic DNA. Translation: CAD27771.1.
Z93016 Genomic DNA. Translation: CAI19816.1.
BC039173 mRNA. Translation: AAH39173.1.
AF147078 mRNA. No translation available.
CCDSiCCDS33475.1. [Q8TCV5-2]
RefSeqiNP_663627.1. NM_145652.3. [Q8TCV5-2]
XP_011526903.1. XM_011528601.1. [Q8TCV5-2]
XP_011526904.1. XM_011528602.1. [Q8TCV5-2]
XP_011526905.1. XM_011528603.1. [Q8TCV5-2]
UniGeneiHs.375031.

3D structure databases

ProteinModelPortaliQ8TCV5.
SMRiQ8TCV5. Positions 30-121.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127236. 7 interactions.
STRINGi9606.ENSP00000361875.

Protein family/group databases

MEROPSiI17.003.

Polymorphism and mutation databases

BioMutaiWFDC5.
DMDMi26401313.

Proteomic databases

PaxDbiQ8TCV5.
PRIDEiQ8TCV5.

Protocols and materials databases

DNASUi149708.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307971; ENSP00000312381; ENSG00000175121. [Q8TCV5-1]
ENST00000372789; ENSP00000361875; ENSG00000175121. [Q8TCV5-2]
GeneIDi149708.
KEGGihsa:149708.
UCSCiuc002xne.2. human. [Q8TCV5-1]

Organism-specific databases

CTDi149708.
GeneCardsiWFDC5.
HGNCiHGNC:20477. WFDC5.
HPAiHPA049878.
MIMi605161. gene.
neXtProtiNX_Q8TCV5.
PharmGKBiPA134885667.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZEK. Eukaryota.
ENOG4111D8G. LUCA.
GeneTreeiENSGT00730000111369.
HOGENOMiHOG000154853.
InParanoidiQ8TCV5.
OMAiCTTAIRA.
OrthoDBiEOG7S7SG9.
PhylomeDBiQ8TCV5.
TreeFamiTF338375.

Miscellaneous databases

GeneWikiiWFDC5.
GenomeRNAii149708.
NextBioi86241.
PROiQ8TCV5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TCV5.
CleanExiHS_WFDC5.
GenevisibleiQ8TCV5. HS.

Family and domain databases

Gene3Di4.10.75.10. 2 hits.
InterProiIPR008197. WAP_dom.
IPR029714. WFDC5.
[Graphical view]
PANTHERiPTHR19441:SF39. PTHR19441:SF39. 1 hit.
PfamiPF00095. WAP. 2 hits.
[Graphical view]
PRINTSiPR00003. 4DISULPHCORE.
SMARTiSM00217. WAP. 2 hits.
[Graphical view]
SUPFAMiSSF57256. SSF57256. 2 hits.
PROSITEiPS51390. WAP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein."
    Clauss A., Lilja H., Lundwall A.
    Biochem. J. 368:233-242(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT TYR-97.
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Skin.
  5. "Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene."
    Horikoshi N., Cong J., Kley N., Shenk T.
    Biochem. Biophys. Res. Commun. 261:864-869(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 145-224 (ISOFORM 1), INDUCTION.

Entry informationi

Entry nameiWFDC5_HUMAN
AccessioniPrimary (citable) accession number: Q8TCV5
Secondary accession number(s): Q5H981, Q6UWE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: June 1, 2002
Last modified: November 11, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.