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Q8TCU6

- PREX1_HUMAN

UniProt

Q8TCU6 - PREX1_HUMAN

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Protein

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Gene

PREX1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.

GO - Molecular functioni

  1. enzyme binding Source: UniProtKB
  2. phospholipid binding Source: UniProtKB
  3. Rho GTPase activator activity Source: UniProtKB
  4. Rho guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

  1. actin filament polymerization Source: UniProtKB
  2. G-protein coupled receptor signaling pathway Source: Ensembl
  3. intracellular signal transduction Source: InterPro
  4. neutrophil activation Source: UniProtKB
  5. neutrophil chemotaxis Source: Ensembl
  6. positive regulation of Rac GTPase activity Source: Ensembl
  7. positive regulation of substrate adhesion-dependent cell spreading Source: Ensembl
  8. regulation of actin filament polymerization Source: Ensembl
  9. regulation of dendrite development Source: Ensembl
  10. superoxide metabolic process Source: UniProtKB
  11. T cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Short name:
P-Rex1
Short name:
PtdIns(3,4,5)-dependent Rac exchanger 1
Gene namesi
Name:PREX1
Synonyms:KIAA1415
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:32594. PREX1.

Subcellular locationi

Cytoplasmcytosol. Cell membrane
Note: Mainly cytosolic. Some amount is apparently associated to the plasma membrane.

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. cytosol Source: UniProtKB
  3. dendritic shaft Source: Ensembl
  4. growth cone Source: Ensembl
  5. intracellular membrane-bounded organelle Source: HPA
  6. perinuclear region of cytoplasm Source: Ensembl
  7. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164725018.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16591659Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 proteinPRO_0000080965Add
BLAST

Proteomic databases

MaxQBiQ8TCU6.
PaxDbiQ8TCU6.
PRIDEiQ8TCU6.

PTM databases

PhosphoSiteiQ8TCU6.

Expressioni

Tissue specificityi

Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues.

Gene expression databases

BgeeiQ8TCU6.
GenevestigatoriQ8TCU6.

Organism-specific databases

HPAiHPA001927.

Interactioni

Subunit structurei

Interacts preferentially with RAC2 (By similarity). Interacts with RAC1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Akt1P317502EBI-1046542,EBI-298707From a different organism.
MTORP4234511EBI-1046542,EBI-359260
RICTORQ6R3273EBI-1046542,EBI-1387196
RPTORQ8N1222EBI-1046542,EBI-1567928

Protein-protein interaction databases

BioGridi121633. 8 interactions.
IntActiQ8TCU6. 11 interactions.
MINTiMINT-1649307.

Structurei

Secondary structure

1
1659
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi607 – 62014Combined sources
Beta strandi623 – 6286Combined sources
Beta strandi632 – 64211Combined sources
Beta strandi645 – 6517Combined sources
Helixi656 – 6605Combined sources
Beta strandi667 – 6715Combined sources
Beta strandi674 – 6763Combined sources
Helixi681 – 69313Combined sources
Beta strandi698 – 7036Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3QIKX-ray2.28A607-706[»]
ProteinModelPortaliQ8TCU6.
SMRiQ8TCU6. Positions 26-393, 409-498, 508-599, 607-706, 712-772.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TCU6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 240192DHPROSITE-ProRule annotationAdd
BLAST
Domaini271 – 392122PHPROSITE-ProRule annotationAdd
BLAST
Domaini421 – 49676DEP 1PROSITE-ProRule annotationAdd
BLAST
Domaini523 – 59775DEP 2PROSITE-ProRule annotationAdd
BLAST
Domaini625 – 70379PDZPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 DEP domains.PROSITE-ProRule annotation
Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5422.
GeneTreeiENSGT00760000118925.
HOVERGENiHBG053677.
InParanoidiQ8TCU6.
KOiK12365.
OMAiFKNEQVM.
PhylomeDBiQ8TCU6.
TreeFamiTF328639.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 2 hits.
InterProiIPR000591. DEP_dom.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR001478. PDZ.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 2 hits.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00049. DEP. 2 hits.
SM00228. PDZ. 2 hits.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50156. SSF50156. 2 hits.
PROSITEiPS50186. DEP. 2 hits.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8TCU6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAPSGSEPG GDGAGDCAHP DPRAPGAAAP SSGPGPCAAA RESERQLRLR
60 70 80 90 100
LCVLNEILGT ERDYVGTLRF LQSAFLHRIR QNVADSVEKG LTEENVKVLF
110 120 130 140 150
SNIEDILEVH KDFLAALEYC LHPEPQSQHE LGNVFLKFKD KFCVYEEYCS
160 170 180 190 200
NHEKALRLLV ELNKIPTVRA FLLSCMLLGG RKTTDIPLEG YLLSPIQRIC
210 220 230 240 250
KYPLLLKELA KRTPGKHPDH PAVQSALQAM KTVCSNINET KRQMEKLEAL
260 270 280 290 300
EQLQSHIEGW EGSNLTDICT QLLLQGTLLK ISAGNIQERA FFLFDNLLVY
310 320 330 340 350
CKRKSRVTGS KKSTKRTKSI NGSLYIFRGR INTEVMEVEN VEDGTADYHS
360 370 380 390 400
NGYTVTNGWK IHNTAKNKWF VCMAKTAEEK QKWLDAIIRE REQRESLKLG
410 420 430 440 450
MERDAYVMIA EKGEKLYHMM MNKKVNLIKD RRRKLSTVPK CFLGNEFVAW
460 470 480 490 500
LLEIGEISKT EEGVNLGQAL LENGIIHHVS DKHQFKNEQV MYRFRYDDGT
510 520 530 540 550
YKARSELEDI MSKGVRLYCR LHSLYTPVIK DRDYHLKTYK SVLPGSKLVD
560 570 580 590 600
WLLAQGDCQT REEAVALGVG LCNNGFMHHV LEKSEFRDES QYFRFHADEE
610 620 630 640 650
MEGTSSKNKQ LRNDFKLVEN ILAKRLLILP QEEDYGFDIE EKNKAVVVKS
660 670 680 690 700
VQRGSLAEVA GLQVGRKIYS INEDLVFLRP FSEVESILNQ SFCSRRPLRL
710 720 730 740 750
LVATKAKEII KIPDQPDTLC FQIRGAAPPY VYAVGRGSEA MAAGLCAGQC
760 770 780 790 800
ILKVNGSNVM NDGAPEVLEH FQAFRSRREE ALGLYQWIYH THEDAQEARA
810 820 830 840 850
SQEASTEDPS GEQAQEEDQA DSAFPLLSLG PRLSLCEDSP MVTLTVDNVH
860 870 880 890 900
LEHGVVYEYV STAGVRCHVL EKIVEPRGCF GLTAKILEAF AANDSVFVEN
910 920 930 940 950
CRRLMALSSA IVTMPHFEFR NICDTKLESI GQRIACYQEF AAQLKSRVSP
960 970 980 990 1000
PFKQAPLEPH PLCGLDFCPT NCHINLMEVS YPKTTPSVGR SFSIRFGRKP
1010 1020 1030 1040 1050
SLIGLDPEQG HLNPMSYTQH CITTMAAPSW KCLPAAEGDP QGQGLHDGSF
1060 1070 1080 1090 1100
GPASGTLGQE DRGLSFLLKQ EDREIQDAYL QLFTKLDVAL KEMKQYVTQI
1110 1120 1130 1140 1150
NRLLSTITEP TSGGSCDASL AEEASSLPLV SEESEMDRSD HGGIKKVCFK
1160 1170 1180 1190 1200
VAEEDQEDSG HDTMSYRDSY SECNSNRDSV LSYTSVRSNS SYLGSDEMGS
1210 1220 1230 1240 1250
GDELPCDMRI PSDKQDKLHG CLEHLFNQVD SINALLKGPV MSRAFEETKH
1260 1270 1280 1290 1300
FPMNHSLQEF KQKEECTIRG RSLIQISIQE DPWNLPNSIK TLVDNIQRYV
1310 1320 1330 1340 1350
EDGKNQLLLA LLKCTDTELQ LRRDAIFCQA LVAAVCTFSK QLLAALGYRY
1360 1370 1380 1390 1400
NNNGEYEESS RDASRKWLEQ VAATGVLLHC QSLLSPATVK EERTMLEDIW
1410 1420 1430 1440 1450
VTLSELDNVT FSFKQLDENY VANTNVFYHI EGSRQALKVI FYLDSYHFSK
1460 1470 1480 1490 1500
LPSRLEGGAS LRLHTALFTK VLENVEGLPS PGSQAAEDLQ QDINAQSLEK
1510 1520 1530 1540 1550
VQQYYRKLRA FYLERSNLPT DASTTAVKID QLIRPINALD ELCRLMKSFV
1560 1570 1580 1590 1600
HPKPGAAGSV GAGLIPISSE LCYRLGACQM VMCGTGMQRS TLSVSLEQAA
1610 1620 1630 1640 1650
ILARSHGLLP KCIMQATDIM RKQGPRVEIL AKNLRVKDQM PQGAPRLYRL

CQPPVDGDL
Length:1,659
Mass (Da):186,203
Last modified:May 29, 2007 - v3
Checksum:i159419355ED0F00F
GO
Isoform 2 (identifier: Q8TCU6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-703: Missing.
     704-708: TKAKE → MGLEQ

Show »
Length:956
Mass (Da):106,093
Checksum:iE2DCA9099F0CE2C7
GO
Isoform 3 (identifier: Q8TCU6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1471-1561: VLENVEGLPS...PKPGAAGSVG → GELQAWGRED...TCPRMPAPRR
     1562-1659: Missing.

Note: Gene prediction based on EST data. No experimental confirmation available.

Show »
Length:1,561
Mass (Da):175,847
Checksum:iCACDE55657E3A86D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti910 – 9101A → V in CAB66514. (PubMed:11230166)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti659 – 6591V → M.1 Publication
Corresponds to variant rs55904123 [ dbSNP | Ensembl ].
VAR_061798
Natural varianti696 – 6961R → C.
Corresponds to variant rs7271583 [ dbSNP | Ensembl ].
VAR_057191
Natural varianti786 – 7861Q → H.1 Publication
Corresponds to variant rs41283558 [ dbSNP | Ensembl ].
VAR_061799
Natural varianti1118 – 11181A → T.1 Publication
Corresponds to variant rs6012504 [ dbSNP | Ensembl ].
VAR_057192
Natural varianti1240 – 12401V → I.1 Publication
Corresponds to variant rs16993997 [ dbSNP | Ensembl ].
VAR_023210
Natural varianti1340 – 13401K → E.5 Publications
Corresponds to variant rs2664521 [ dbSNP | Ensembl ].
VAR_023211
Natural varianti1559 – 15591S → T.
Corresponds to variant rs3936192 [ dbSNP | Ensembl ].
VAR_023212

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 703703Missing in isoform 2. 1 PublicationVSP_001818Add
BLAST
Alternative sequencei704 – 7085TKAKE → MGLEQ in isoform 2. 1 PublicationVSP_001819
Alternative sequencei1471 – 156191VLENV…AGSVG → GELQAWGREDHGGRAKATKH TGSQPPARPRHLPSQCWRTW RGCLLQAARPRRICSRTSTR SPWRKFSSITANSGHFTWSG LTCPRMPAPRR in isoform 3. CuratedVSP_015090Add
BLAST
Alternative sequencei1562 – 165998Missing in isoform 3. CuratedVSP_015091Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ320261 mRNA. Translation: CAC86401.1.
AL136579 mRNA. Translation: CAB66514.1.
AL133342, AL035106, AL445192 Genomic DNA. Translation: CAI23274.1.
AL445192, AL035106, AL133342 Genomic DNA. Translation: CAI39886.1.
AL035106, AL445192, AL133342 Genomic DNA. Translation: CAI43186.1.
AB037836 mRNA. Translation: BAA92653.2.
CH471077 Genomic DNA. Translation: EAW75684.1.
CH471077 Genomic DNA. Translation: EAW75685.1.
BC053616 mRNA. Translation: AAH53616.1.
AL832913 mRNA. Translation: CAH10614.1.
CCDSiCCDS13410.1. [Q8TCU6-1]
RefSeqiNP_065871.2. NM_020820.3.
XP_005260528.1. XM_005260471.1. [Q8TCU6-2]
UniGeneiHs.153310.

Genome annotation databases

EnsembliENST00000371941; ENSP00000361009; ENSG00000124126. [Q8TCU6-1]
GeneIDi57580.
KEGGihsa:57580.
UCSCiuc002xtv.1. human. [Q8TCU6-2]
uc002xtw.1. human. [Q8TCU6-1]

Polymorphism databases

DMDMi148886999.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ320261 mRNA. Translation: CAC86401.1 .
AL136579 mRNA. Translation: CAB66514.1 .
AL133342 , AL035106 , AL445192 Genomic DNA. Translation: CAI23274.1 .
AL445192 , AL035106 , AL133342 Genomic DNA. Translation: CAI39886.1 .
AL035106 , AL445192 , AL133342 Genomic DNA. Translation: CAI43186.1 .
AB037836 mRNA. Translation: BAA92653.2 .
CH471077 Genomic DNA. Translation: EAW75684.1 .
CH471077 Genomic DNA. Translation: EAW75685.1 .
BC053616 mRNA. Translation: AAH53616.1 .
AL832913 mRNA. Translation: CAH10614.1 .
CCDSi CCDS13410.1. [Q8TCU6-1 ]
RefSeqi NP_065871.2. NM_020820.3.
XP_005260528.1. XM_005260471.1. [Q8TCU6-2 ]
UniGenei Hs.153310.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3QIK X-ray 2.28 A 607-706 [» ]
ProteinModelPortali Q8TCU6.
SMRi Q8TCU6. Positions 26-393, 409-498, 508-599, 607-706, 712-772.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121633. 8 interactions.
IntActi Q8TCU6. 11 interactions.
MINTi MINT-1649307.

PTM databases

PhosphoSitei Q8TCU6.

Polymorphism databases

DMDMi 148886999.

Proteomic databases

MaxQBi Q8TCU6.
PaxDbi Q8TCU6.
PRIDEi Q8TCU6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371941 ; ENSP00000361009 ; ENSG00000124126 . [Q8TCU6-1 ]
GeneIDi 57580.
KEGGi hsa:57580.
UCSCi uc002xtv.1. human. [Q8TCU6-2 ]
uc002xtw.1. human. [Q8TCU6-1 ]

Organism-specific databases

CTDi 57580.
GeneCardsi GC20M047240.
H-InvDB HIX0138059.
HGNCi HGNC:32594. PREX1.
HPAi HPA001927.
MIMi 606905. gene.
neXtProti NX_Q8TCU6.
PharmGKBi PA164725018.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5422.
GeneTreei ENSGT00760000118925.
HOVERGENi HBG053677.
InParanoidi Q8TCU6.
KOi K12365.
OMAi FKNEQVM.
PhylomeDBi Q8TCU6.
TreeFami TF328639.

Miscellaneous databases

ChiTaRSi PREX1. human.
EvolutionaryTracei Q8TCU6.
GeneWikii PREX1.
GenomeRNAii 57580.
NextBioi 64135.
PROi Q8TCU6.
SOURCEi Search...

Gene expression databases

Bgeei Q8TCU6.
Genevestigatori Q8TCU6.

Family and domain databases

Gene3Di 1.10.10.10. 2 hits.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 2 hits.
InterProi IPR000591. DEP_dom.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR001478. PDZ.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00610. DEP. 2 hits.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view ]
SMARTi SM00049. DEP. 2 hits.
SM00228. PDZ. 2 hits.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view ]
SUPFAMi SSF48065. SSF48065. 1 hit.
SSF50156. SSF50156. 2 hits.
PROSITEi PS50186. DEP. 2 hits.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac."
    Welch H.C.E., Coadwell W.J., Ellson C.D., Ferguson G.J., Andrews S.R., Erdjument-Bromage H., Tempst P., Hawkins P.T., Stephens L.R.
    Cell 108:809-821(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 182-198; 913-920; 1463-1470; 1501-1506 AND 1590-1604, CHARACTERIZATION, VARIANTS THR-1118 AND GLU-1340.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Amygdala.
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-1340.
  5. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 39-1659 (ISOFORM 1), VARIANT GLU-1340.
    Tissue: Brain.
  6. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 177-1659 (ISOFORM 1), VARIANT GLU-1340.
    Tissue: Eye.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 337-1659 (ISOFORM 1), VARIANTS MET-659; HIS-786; ILE-1240 AND GLU-1340.
    Tissue: Melanoma.
  9. "Crystal structure of the first PDZ domain of PREX1."
    Structural genomics consortium (SGC)
    Submitted (FEB-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.28 ANGSTROMS) OF 607-706.

Entry informationi

Entry nameiPREX1_HUMAN
AccessioniPrimary (citable) accession number: Q8TCU6
Secondary accession number(s): E1P5X9
, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: May 29, 2007
Last modified: November 26, 2014
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3