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Protein

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Gene

PREX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • GTPase activator activity Source: UniProtKB
  • phospholipid binding Source: UniProtKB
  • Rho guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124126-MONOMER.
ReactomeiR-HSA-193648. NRAGE signals death through JNK.
R-HSA-194840. Rho GTPase cycle.
R-HSA-416482. G alpha (12/13) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Short name:
P-Rex1
Short name:
PtdIns(3,4,5)-dependent Rac exchanger 1
Gene namesi
Name:PREX1
Synonyms:KIAA1415
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:32594. PREX1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • cytosol Source: UniProtKB
  • dendritic shaft Source: Ensembl
  • growth cone Source: Ensembl
  • intracellular membrane-bounded organelle Source: HPA
  • perinuclear region of cytoplasm Source: Ensembl
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57580.
OpenTargetsiENSG00000124126.
PharmGKBiPA164725018.

Polymorphism and mutation databases

BioMutaiPREX1.
DMDMi148886999.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000809651 – 1659Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 proteinAdd BLAST1659

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei319PhosphoserineCombined sources1
Modified residuei1001PhosphoserineBy similarity1
Modified residuei1195PhosphoserineBy similarity1
Modified residuei1200PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TCU6.
MaxQBiQ8TCU6.
PaxDbiQ8TCU6.
PeptideAtlasiQ8TCU6.
PRIDEiQ8TCU6.

PTM databases

iPTMnetiQ8TCU6.
PhosphoSitePlusiQ8TCU6.

Expressioni

Tissue specificityi

Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues.

Gene expression databases

BgeeiENSG00000124126.
ExpressionAtlasiQ8TCU6. baseline and differential.
GenevisibleiQ8TCU6. HS.

Organism-specific databases

HPAiHPA001927.

Interactioni

Subunit structurei

Interacts preferentially with RAC2 (By similarity). Interacts with RAC1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Akt1P317502EBI-1046542,EBI-298707From a different organism.
MTORP4234511EBI-1046542,EBI-359260
RICTORQ6R3273EBI-1046542,EBI-1387196
RPTORQ8N1222EBI-1046542,EBI-1567928

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi121633. 7 interactors.
DIPiDIP-46975N.
IntActiQ8TCU6. 11 interactors.
MINTiMINT-1649307.
STRINGi9606.ENSP00000361009.

Structurei

Secondary structure

11659
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi36 – 74Combined sources39
Helixi76 – 81Combined sources6
Helixi83 – 88Combined sources6
Helixi93 – 100Combined sources8
Helixi103 – 120Combined sources18
Helixi132 – 138Combined sources7
Helixi139 – 143Combined sources5
Helixi144 – 162Combined sources19
Helixi166 – 178Combined sources13
Beta strandi183 – 185Combined sources3
Helixi188 – 199Combined sources12
Helixi202 – 211Combined sources10
Helixi245 – 254Combined sources10
Beta strandi257 – 259Combined sources3
Helixi265 – 268Combined sources4
Beta strandi272 – 282Combined sources11
Beta strandi285 – 294Combined sources10
Beta strandi297 – 303Combined sources7
Beta strandi320 – 322Combined sources3
Beta strandi325 – 332Combined sources8
Helixi333 – 335Combined sources3
Beta strandi336 – 340Combined sources5
Beta strandi345 – 347Combined sources3
Helixi348 – 350Combined sources3
Beta strandi356 – 363Combined sources8
Turni364 – 367Combined sources4
Beta strandi368 – 373Combined sources6
Helixi377 – 405Combined sources29
Helixi607 – 620Combined sources14
Beta strandi623 – 628Combined sources6
Beta strandi632 – 642Combined sources11
Beta strandi645 – 651Combined sources7
Helixi656 – 660Combined sources5
Beta strandi667 – 671Combined sources5
Beta strandi674 – 676Combined sources3
Helixi681 – 693Combined sources13
Beta strandi698 – 703Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QIKX-ray2.28A607-706[»]
4YONX-ray1.95A1-404[»]
5D27X-ray1.92A245-408[»]
5D3VX-ray1.85A/B245-408[»]
5D3WX-ray1.85A/B245-408[»]
5D3XX-ray1.69A/B245-408[»]
5D3YX-ray1.95A/B245-408[»]
5FI0X-ray3.28A/C/E/G38-408[»]
5FI1X-ray3.20A38-408[»]
ProteinModelPortaliQ8TCU6.
SMRiQ8TCU6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TCU6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 240DHPROSITE-ProRule annotationAdd BLAST192
Domaini271 – 392PHPROSITE-ProRule annotationAdd BLAST122
Domaini421 – 496DEP 1PROSITE-ProRule annotationAdd BLAST76
Domaini523 – 597DEP 2PROSITE-ProRule annotationAdd BLAST75
Domaini625 – 703PDZPROSITE-ProRule annotationAdd BLAST79

Sequence similaritiesi

Contains 2 DEP domains.PROSITE-ProRule annotation
Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410ITRX. Eukaryota.
ENOG410Z6ZS. LUCA.
GeneTreeiENSGT00760000118925.
HOVERGENiHBG053677.
InParanoidiQ8TCU6.
KOiK12365.
OMAiQCILKVN.
OrthoDBiEOG091G00MJ.
PhylomeDBiQ8TCU6.
TreeFamiTF328639.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 2 hits.
InterProiIPR000591. DEP_dom.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR001478. PDZ.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 2 hits.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00049. DEP. 2 hits.
SM00228. PDZ. 2 hits.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 2 hits.
SSF48065. SSF48065. 1 hit.
SSF50156. SSF50156. 2 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50186. DEP. 2 hits.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TCU6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAPSGSEPG GDGAGDCAHP DPRAPGAAAP SSGPGPCAAA RESERQLRLR
60 70 80 90 100
LCVLNEILGT ERDYVGTLRF LQSAFLHRIR QNVADSVEKG LTEENVKVLF
110 120 130 140 150
SNIEDILEVH KDFLAALEYC LHPEPQSQHE LGNVFLKFKD KFCVYEEYCS
160 170 180 190 200
NHEKALRLLV ELNKIPTVRA FLLSCMLLGG RKTTDIPLEG YLLSPIQRIC
210 220 230 240 250
KYPLLLKELA KRTPGKHPDH PAVQSALQAM KTVCSNINET KRQMEKLEAL
260 270 280 290 300
EQLQSHIEGW EGSNLTDICT QLLLQGTLLK ISAGNIQERA FFLFDNLLVY
310 320 330 340 350
CKRKSRVTGS KKSTKRTKSI NGSLYIFRGR INTEVMEVEN VEDGTADYHS
360 370 380 390 400
NGYTVTNGWK IHNTAKNKWF VCMAKTAEEK QKWLDAIIRE REQRESLKLG
410 420 430 440 450
MERDAYVMIA EKGEKLYHMM MNKKVNLIKD RRRKLSTVPK CFLGNEFVAW
460 470 480 490 500
LLEIGEISKT EEGVNLGQAL LENGIIHHVS DKHQFKNEQV MYRFRYDDGT
510 520 530 540 550
YKARSELEDI MSKGVRLYCR LHSLYTPVIK DRDYHLKTYK SVLPGSKLVD
560 570 580 590 600
WLLAQGDCQT REEAVALGVG LCNNGFMHHV LEKSEFRDES QYFRFHADEE
610 620 630 640 650
MEGTSSKNKQ LRNDFKLVEN ILAKRLLILP QEEDYGFDIE EKNKAVVVKS
660 670 680 690 700
VQRGSLAEVA GLQVGRKIYS INEDLVFLRP FSEVESILNQ SFCSRRPLRL
710 720 730 740 750
LVATKAKEII KIPDQPDTLC FQIRGAAPPY VYAVGRGSEA MAAGLCAGQC
760 770 780 790 800
ILKVNGSNVM NDGAPEVLEH FQAFRSRREE ALGLYQWIYH THEDAQEARA
810 820 830 840 850
SQEASTEDPS GEQAQEEDQA DSAFPLLSLG PRLSLCEDSP MVTLTVDNVH
860 870 880 890 900
LEHGVVYEYV STAGVRCHVL EKIVEPRGCF GLTAKILEAF AANDSVFVEN
910 920 930 940 950
CRRLMALSSA IVTMPHFEFR NICDTKLESI GQRIACYQEF AAQLKSRVSP
960 970 980 990 1000
PFKQAPLEPH PLCGLDFCPT NCHINLMEVS YPKTTPSVGR SFSIRFGRKP
1010 1020 1030 1040 1050
SLIGLDPEQG HLNPMSYTQH CITTMAAPSW KCLPAAEGDP QGQGLHDGSF
1060 1070 1080 1090 1100
GPASGTLGQE DRGLSFLLKQ EDREIQDAYL QLFTKLDVAL KEMKQYVTQI
1110 1120 1130 1140 1150
NRLLSTITEP TSGGSCDASL AEEASSLPLV SEESEMDRSD HGGIKKVCFK
1160 1170 1180 1190 1200
VAEEDQEDSG HDTMSYRDSY SECNSNRDSV LSYTSVRSNS SYLGSDEMGS
1210 1220 1230 1240 1250
GDELPCDMRI PSDKQDKLHG CLEHLFNQVD SINALLKGPV MSRAFEETKH
1260 1270 1280 1290 1300
FPMNHSLQEF KQKEECTIRG RSLIQISIQE DPWNLPNSIK TLVDNIQRYV
1310 1320 1330 1340 1350
EDGKNQLLLA LLKCTDTELQ LRRDAIFCQA LVAAVCTFSK QLLAALGYRY
1360 1370 1380 1390 1400
NNNGEYEESS RDASRKWLEQ VAATGVLLHC QSLLSPATVK EERTMLEDIW
1410 1420 1430 1440 1450
VTLSELDNVT FSFKQLDENY VANTNVFYHI EGSRQALKVI FYLDSYHFSK
1460 1470 1480 1490 1500
LPSRLEGGAS LRLHTALFTK VLENVEGLPS PGSQAAEDLQ QDINAQSLEK
1510 1520 1530 1540 1550
VQQYYRKLRA FYLERSNLPT DASTTAVKID QLIRPINALD ELCRLMKSFV
1560 1570 1580 1590 1600
HPKPGAAGSV GAGLIPISSE LCYRLGACQM VMCGTGMQRS TLSVSLEQAA
1610 1620 1630 1640 1650
ILARSHGLLP KCIMQATDIM RKQGPRVEIL AKNLRVKDQM PQGAPRLYRL

CQPPVDGDL
Length:1,659
Mass (Da):186,203
Last modified:May 29, 2007 - v3
Checksum:i159419355ED0F00F
GO
Isoform 2 (identifier: Q8TCU6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-703: Missing.
     704-708: TKAKE → MGLEQ

Show »
Length:956
Mass (Da):106,093
Checksum:iE2DCA9099F0CE2C7
GO
Isoform 3 (identifier: Q8TCU6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1471-1561: VLENVEGLPS...PKPGAAGSVG → GELQAWGRED...TCPRMPAPRR
     1562-1659: Missing.

Note: Gene prediction based on EST data. No experimental confirmation available.
Show »
Length:1,561
Mass (Da):175,847
Checksum:iCACDE55657E3A86D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti910A → V in CAB66514 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061798659V → M.1 PublicationCorresponds to variant rs55904123dbSNPEnsembl.1
Natural variantiVAR_057191696R → C.Corresponds to variant rs7271583dbSNPEnsembl.1
Natural variantiVAR_061799786Q → H.1 PublicationCorresponds to variant rs41283558dbSNPEnsembl.1
Natural variantiVAR_0571921118A → T.1 PublicationCorresponds to variant rs6012504dbSNPEnsembl.1
Natural variantiVAR_0232101240V → I.1 PublicationCorresponds to variant rs16993997dbSNPEnsembl.1
Natural variantiVAR_0232111340K → E.5 PublicationsCorresponds to variant rs2664521dbSNPEnsembl.1
Natural variantiVAR_0232121559S → T.Corresponds to variant rs3936192dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0018181 – 703Missing in isoform 2. 1 PublicationAdd BLAST703
Alternative sequenceiVSP_001819704 – 708TKAKE → MGLEQ in isoform 2. 1 Publication5
Alternative sequenceiVSP_0150901471 – 1561VLENV…AGSVG → GELQAWGREDHGGRAKATKH TGSQPPARPRHLPSQCWRTW RGCLLQAARPRRICSRTSTR SPWRKFSSITANSGHFTWSG LTCPRMPAPRR in isoform 3. CuratedAdd BLAST91
Alternative sequenceiVSP_0150911562 – 1659Missing in isoform 3. CuratedAdd BLAST98

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ320261 mRNA. Translation: CAC86401.1.
AL136579 mRNA. Translation: CAB66514.1.
AL133342, AL035106, AL445192 Genomic DNA. Translation: CAI23274.1.
AL445192, AL035106, AL133342 Genomic DNA. Translation: CAI39886.1.
AL035106, AL445192, AL133342 Genomic DNA. Translation: CAI43186.1.
AB037836 mRNA. Translation: BAA92653.2.
CH471077 Genomic DNA. Translation: EAW75684.1.
CH471077 Genomic DNA. Translation: EAW75685.1.
BC053616 mRNA. Translation: AAH53616.1.
AL832913 mRNA. Translation: CAH10614.1.
CCDSiCCDS13410.1. [Q8TCU6-1]
RefSeqiNP_065871.2. NM_020820.3.
UniGeneiHs.153310.

Genome annotation databases

EnsembliENST00000371941; ENSP00000361009; ENSG00000124126. [Q8TCU6-1]
GeneIDi57580.
KEGGihsa:57580.
UCSCiuc002xtw.2. human. [Q8TCU6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ320261 mRNA. Translation: CAC86401.1.
AL136579 mRNA. Translation: CAB66514.1.
AL133342, AL035106, AL445192 Genomic DNA. Translation: CAI23274.1.
AL445192, AL035106, AL133342 Genomic DNA. Translation: CAI39886.1.
AL035106, AL445192, AL133342 Genomic DNA. Translation: CAI43186.1.
AB037836 mRNA. Translation: BAA92653.2.
CH471077 Genomic DNA. Translation: EAW75684.1.
CH471077 Genomic DNA. Translation: EAW75685.1.
BC053616 mRNA. Translation: AAH53616.1.
AL832913 mRNA. Translation: CAH10614.1.
CCDSiCCDS13410.1. [Q8TCU6-1]
RefSeqiNP_065871.2. NM_020820.3.
UniGeneiHs.153310.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QIKX-ray2.28A607-706[»]
4YONX-ray1.95A1-404[»]
5D27X-ray1.92A245-408[»]
5D3VX-ray1.85A/B245-408[»]
5D3WX-ray1.85A/B245-408[»]
5D3XX-ray1.69A/B245-408[»]
5D3YX-ray1.95A/B245-408[»]
5FI0X-ray3.28A/C/E/G38-408[»]
5FI1X-ray3.20A38-408[»]
ProteinModelPortaliQ8TCU6.
SMRiQ8TCU6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121633. 7 interactors.
DIPiDIP-46975N.
IntActiQ8TCU6. 11 interactors.
MINTiMINT-1649307.
STRINGi9606.ENSP00000361009.

PTM databases

iPTMnetiQ8TCU6.
PhosphoSitePlusiQ8TCU6.

Polymorphism and mutation databases

BioMutaiPREX1.
DMDMi148886999.

Proteomic databases

EPDiQ8TCU6.
MaxQBiQ8TCU6.
PaxDbiQ8TCU6.
PeptideAtlasiQ8TCU6.
PRIDEiQ8TCU6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371941; ENSP00000361009; ENSG00000124126. [Q8TCU6-1]
GeneIDi57580.
KEGGihsa:57580.
UCSCiuc002xtw.2. human. [Q8TCU6-1]

Organism-specific databases

CTDi57580.
DisGeNETi57580.
GeneCardsiPREX1.
H-InvDBHIX0138059.
HGNCiHGNC:32594. PREX1.
HPAiHPA001927.
MIMi606905. gene.
neXtProtiNX_Q8TCU6.
OpenTargetsiENSG00000124126.
PharmGKBiPA164725018.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITRX. Eukaryota.
ENOG410Z6ZS. LUCA.
GeneTreeiENSGT00760000118925.
HOVERGENiHBG053677.
InParanoidiQ8TCU6.
KOiK12365.
OMAiQCILKVN.
OrthoDBiEOG091G00MJ.
PhylomeDBiQ8TCU6.
TreeFamiTF328639.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124126-MONOMER.
ReactomeiR-HSA-193648. NRAGE signals death through JNK.
R-HSA-194840. Rho GTPase cycle.
R-HSA-416482. G alpha (12/13) signalling events.

Miscellaneous databases

ChiTaRSiPREX1. human.
EvolutionaryTraceiQ8TCU6.
GeneWikiiPREX1.
GenomeRNAii57580.
PROiQ8TCU6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124126.
ExpressionAtlasiQ8TCU6. baseline and differential.
GenevisibleiQ8TCU6. HS.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 2 hits.
InterProiIPR000591. DEP_dom.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR001478. PDZ.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 2 hits.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00049. DEP. 2 hits.
SM00228. PDZ. 2 hits.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 2 hits.
SSF48065. SSF48065. 1 hit.
SSF50156. SSF50156. 2 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50186. DEP. 2 hits.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPREX1_HUMAN
AccessioniPrimary (citable) accession number: Q8TCU6
Secondary accession number(s): E1P5X9
, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: May 29, 2007
Last modified: November 2, 2016
This is version 155 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.