Q8TCU6 (PREX1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Short name=P-Rex1
Short name=PtdIns(3,4,5)-dependent Rac exchanger 1

Gene names

Name:	PREX1
Synonyms:	KIAA1415

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1659 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Subunit structure	Interacts preferentially with RAC2 By similarity. Interacts with RAC1.
Subcellular location	Cytoplasm › cytosol. Cell membrane. Note: Mainly cytosolic. Some amount is apparently associated to the plasma membrane.
Tissue specificity	Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues.
Sequence similarities	Contains 2 DEP domains. Contains 1 DH (DBL-homology) domain. Contains 1 PDZ (DHR) domain. Contains 1 PH domain.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Molecular function	Guanine-nucleotide releasing factor
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	actin filament polymerization Traceable author statement PubMed 12123595. Source: UniProtKB apoptotic process Traceable author statement. Source: Reactome nerve growth factor receptor signaling pathway Traceable author statement. Source: Reactome neutrophil activation Traceable author statement PubMed 12123595. Source: UniProtKB regulation of actin filament polymerization Inferred from electronic annotation. Source: Compara regulation of dendrite development Inferred from electronic annotation. Source: Compara small GTPase mediated signal transduction Traceable author statement. Source: Reactome superoxide metabolic process Traceable author statement PubMed 12123595. Source: UniProtKB
Cellular_component	cytosol Inferred from direct assay Ref.1. Source: UniProtKB dendritic shaft Inferred from electronic annotation. Source: Compara growth cone Inferred from electronic annotation. Source: Compara intracellular membrane-bounded organelle Inferred from direct assay. Source: HPA perinuclear region of cytoplasm Inferred from electronic annotation. Source: Compara plasma membrane Traceable author statement PubMed 12123595. Source: UniProtKB
Molecular_function	Rho GTPase activator activity Traceable author statement PubMed 12123595. Source: UniProtKB Rho guanyl-nucleotide exchange factor activity Traceable author statement PubMed 12123595. Source: UniProtKB enzyme binding Traceable author statement PubMed 12123595. Source: UniProtKB phospholipid binding Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Akt1	P31750	2	EBI-1046542,EBI-298707	From a different organism.
MTOR	P42345	11	EBI-1046542,EBI-359260
RICTOR	Q6R327	3	EBI-1046542,EBI-1387196
RPTOR	Q8N122	2	EBI-1046542,EBI-1567928

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TCU6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TCU6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-703: Missing.
     704-708: TKAKE → MGLEQ

Isoform 3 (identifier: Q8TCU6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1471-1561: VLENVEGLPS...PKPGAAGSVG → GELQAWGRED...TCPRMPAPRR
     1562-1659: Missing.

Note: Gene prediction based on EST data. No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1659

1659

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

PRO_0000080965

Regions

Domain

49 – 240

192

DH

Domain

271 – 392

122

PH

Domain

421 – 496

76

DEP 1

Domain

523 – 597

75

DEP 2

Domain

625 – 703

79

PDZ

Natural variations

Alternative sequence

1 – 703

703

Missing in isoform 2.

VSP_001818

Alternative sequence

704 – 708

5

TKAKE → MGLEQ in isoform 2.

VSP_001819

Alternative sequence

1471 – 1561

91

VLENV…AGSVG → GELQAWGREDHGGRAKATKH TGSQPPARPRHLPSQCWRTW RGCLLQAARPRRICSRTSTR SPWRKFSSITANSGHFTWSG LTCPRMPAPRR in isoform 3.

VSP_015090

Alternative sequence

1562 – 1659

98

Missing in isoform 3.

VSP_015091

Natural variant

659

1

V → M. Ref.8
Corresponds to variant rs55904123 [ dbSNP | Ensembl ].

VAR_061798

Natural variant

696

1

R → C.
Corresponds to variant rs7271583 [ dbSNP | Ensembl ].

VAR_057191

Natural variant

786

1

Q → H. Ref.8
Corresponds to variant rs41283558 [ dbSNP | Ensembl ].

VAR_061799

Natural variant

1118

1

A → T. Ref.1
Corresponds to variant rs6012504 [ dbSNP | Ensembl ].

VAR_057192

Natural variant

1240

1

V → I. Ref.8
Corresponds to variant rs16993997 [ dbSNP | Ensembl ].

VAR_023210

Natural variant

1340

1

K → E. Ref.1 Ref.4 Ref.5 Ref.7 Ref.8
Corresponds to variant rs2664521 [ dbSNP | Ensembl ].

VAR_023211

Natural variant

1559

1

S → T.
Corresponds to variant rs3936192 [ dbSNP | Ensembl ].

VAR_023212

Experimental info

Sequence conflict

910

1

A → V in CAB66514. Ref.2

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1659

Helix Strand Turn

Details...

Helix

607 – 620

14

Beta strand

623 – 628

6

Beta strand

632 – 642

11

Beta strand

645 – 651

7

Helix

656 – 660

5

Beta strand

667 – 671

5

Beta strand

674 – 676

3

Helix

681 – 693

13

Beta strand

698 – 703

6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 29, 2007. Version 3. Checksum: 159419355ED0F00F	FASTA	1,659	186,203
	10 20 30 40 50 60 MEAPSGSEPG GDGAGDCAHP DPRAPGAAAP SSGPGPCAAA RESERQLRLR LCVLNEILGT 70 80 90 100 110 120 ERDYVGTLRF LQSAFLHRIR QNVADSVEKG LTEENVKVLF SNIEDILEVH KDFLAALEYC 130 140 150 160 170 180 LHPEPQSQHE LGNVFLKFKD KFCVYEEYCS NHEKALRLLV ELNKIPTVRA FLLSCMLLGG 190 200 210 220 230 240 RKTTDIPLEG YLLSPIQRIC KYPLLLKELA KRTPGKHPDH PAVQSALQAM KTVCSNINET 250 260 270 280 290 300 KRQMEKLEAL EQLQSHIEGW EGSNLTDICT QLLLQGTLLK ISAGNIQERA FFLFDNLLVY 310 320 330 340 350 360 CKRKSRVTGS KKSTKRTKSI NGSLYIFRGR INTEVMEVEN VEDGTADYHS NGYTVTNGWK 370 380 390 400 410 420 IHNTAKNKWF VCMAKTAEEK QKWLDAIIRE REQRESLKLG MERDAYVMIA EKGEKLYHMM 430 440 450 460 470 480 MNKKVNLIKD RRRKLSTVPK CFLGNEFVAW LLEIGEISKT EEGVNLGQAL LENGIIHHVS 490 500 510 520 530 540 DKHQFKNEQV MYRFRYDDGT YKARSELEDI MSKGVRLYCR LHSLYTPVIK DRDYHLKTYK 550 560 570 580 590 600 SVLPGSKLVD WLLAQGDCQT REEAVALGVG LCNNGFMHHV LEKSEFRDES QYFRFHADEE 610 620 630 640 650 660 MEGTSSKNKQ LRNDFKLVEN ILAKRLLILP QEEDYGFDIE EKNKAVVVKS VQRGSLAEVA 670 680 690 700 710 720 GLQVGRKIYS INEDLVFLRP FSEVESILNQ SFCSRRPLRL LVATKAKEII KIPDQPDTLC 730 740 750 760 770 780 FQIRGAAPPY VYAVGRGSEA MAAGLCAGQC ILKVNGSNVM NDGAPEVLEH FQAFRSRREE 790 800 810 820 830 840 ALGLYQWIYH THEDAQEARA SQEASTEDPS GEQAQEEDQA DSAFPLLSLG PRLSLCEDSP 850 860 870 880 890 900 MVTLTVDNVH LEHGVVYEYV STAGVRCHVL EKIVEPRGCF GLTAKILEAF AANDSVFVEN 910 920 930 940 950 960 CRRLMALSSA IVTMPHFEFR NICDTKLESI GQRIACYQEF AAQLKSRVSP PFKQAPLEPH 970 980 990 1000 1010 1020 PLCGLDFCPT NCHINLMEVS YPKTTPSVGR SFSIRFGRKP SLIGLDPEQG HLNPMSYTQH 1030 1040 1050 1060 1070 1080 CITTMAAPSW KCLPAAEGDP QGQGLHDGSF GPASGTLGQE DRGLSFLLKQ EDREIQDAYL 1090 1100 1110 1120 1130 1140 QLFTKLDVAL KEMKQYVTQI NRLLSTITEP TSGGSCDASL AEEASSLPLV SEESEMDRSD 1150 1160 1170 1180 1190 1200 HGGIKKVCFK VAEEDQEDSG HDTMSYRDSY SECNSNRDSV LSYTSVRSNS SYLGSDEMGS 1210 1220 1230 1240 1250 1260 GDELPCDMRI PSDKQDKLHG CLEHLFNQVD SINALLKGPV MSRAFEETKH FPMNHSLQEF 1270 1280 1290 1300 1310 1320 KQKEECTIRG RSLIQISIQE DPWNLPNSIK TLVDNIQRYV EDGKNQLLLA LLKCTDTELQ 1330 1340 1350 1360 1370 1380 LRRDAIFCQA LVAAVCTFSK QLLAALGYRY NNNGEYEESS RDASRKWLEQ VAATGVLLHC 1390 1400 1410 1420 1430 1440 QSLLSPATVK EERTMLEDIW VTLSELDNVT FSFKQLDENY VANTNVFYHI EGSRQALKVI 1450 1460 1470 1480 1490 1500 FYLDSYHFSK LPSRLEGGAS LRLHTALFTK VLENVEGLPS PGSQAAEDLQ QDINAQSLEK 1510 1520 1530 1540 1550 1560 VQQYYRKLRA FYLERSNLPT DASTTAVKID QLIRPINALD ELCRLMKSFV HPKPGAAGSV 1570 1580 1590 1600 1610 1620 GAGLIPISSE LCYRLGACQM VMCGTGMQRS TLSVSLEQAA ILARSHGLLP KCIMQATDIM 1630 1640 1650 RKQGPRVEIL AKNLRVKDQM PQGAPRLYRL CQPPVDGDL
	Isoform 2 [UniParc]. Checksum: E2DCA9099F0CE2C7	FASTA	956	106,093
	10 20 30 40 50 60 MGLEQIIKIP DQPDTLCFQI RGAAPPYVYA VGRGSEAMAA GLCAGQCILK VNGSNVMNDG 70 80 90 100 110 120 APEVLEHFQA FRSRREEALG LYQWIYHTHE DAQEARASQE ASTEDPSGEQ AQEEDQADSA 130 140 150 160 170 180 FPLLSLGPRL SLCEDSPMVT LTVDNVHLEH GVVYEYVSTA GVRCHVLEKI VEPRGCFGLT 190 200 210 220 230 240 AKILEAFAAN DSVFVENCRR LMALSSAIVT MPHFEFRNIC DTKLESIGQR IACYQEFAAQ 250 260 270 280 290 300 LKSRVSPPFK QAPLEPHPLC GLDFCPTNCH INLMEVSYPK TTPSVGRSFS IRFGRKPSLI 310 320 330 340 350 360 GLDPEQGHLN PMSYTQHCIT TMAAPSWKCL PAAEGDPQGQ GLHDGSFGPA SGTLGQEDRG 370 380 390 400 410 420 LSFLLKQEDR EIQDAYLQLF TKLDVALKEM KQYVTQINRL LSTITEPTSG GSCDASLAEE 430 440 450 460 470 480 ASSLPLVSEE SEMDRSDHGG IKKVCFKVAE EDQEDSGHDT MSYRDSYSEC NSNRDSVLSY 490 500 510 520 530 540 TSVRSNSSYL GSDEMGSGDE LPCDMRIPSD KQDKLHGCLE HLFNQVDSIN ALLKGPVMSR 550 560 570 580 590 600 AFEETKHFPM NHSLQEFKQK EECTIRGRSL IQISIQEDPW NLPNSIKTLV DNIQRYVEDG 610 620 630 640 650 660 KNQLLLALLK CTDTELQLRR DAIFCQALVA AVCTFSKQLL AALGYRYNNN GEYEESSRDA 670 680 690 700 710 720 SRKWLEQVAA TGVLLHCQSL LSPATVKEER TMLEDIWVTL SELDNVTFSF KQLDENYVAN 730 740 750 760 770 780 TNVFYHIEGS RQALKVIFYL DSYHFSKLPS RLEGGASLRL HTALFTKVLE NVEGLPSPGS 790 800 810 820 830 840 QAAEDLQQDI NAQSLEKVQQ YYRKLRAFYL ERSNLPTDAS TTAVKIDQLI RPINALDELC 850 860 870 880 890 900 RLMKSFVHPK PGAAGSVGAG LIPISSELCY RLGACQMVMC GTGMQRSTLS VSLEQAAILA 910 920 930 940 950 RSHGLLPKCI MQATDIMRKQ GPRVEILAKN LRVKDQMPQG APRLYRLCQP PVDGDL
	Isoform 3 [UniParc]. Checksum: CACDE55657E3A86D	FASTA	1,561	175,847
	10 20 30 40 50 60 MEAPSGSEPG GDGAGDCAHP DPRAPGAAAP SSGPGPCAAA RESERQLRLR LCVLNEILGT 70 80 90 100 110 120 ERDYVGTLRF LQSAFLHRIR QNVADSVEKG LTEENVKVLF SNIEDILEVH KDFLAALEYC 130 140 150 160 170 180 LHPEPQSQHE LGNVFLKFKD KFCVYEEYCS NHEKALRLLV ELNKIPTVRA FLLSCMLLGG 190 200 210 220 230 240 RKTTDIPLEG YLLSPIQRIC KYPLLLKELA KRTPGKHPDH PAVQSALQAM KTVCSNINET 250 260 270 280 290 300 KRQMEKLEAL EQLQSHIEGW EGSNLTDICT QLLLQGTLLK ISAGNIQERA FFLFDNLLVY 310 320 330 340 350 360 CKRKSRVTGS KKSTKRTKSI NGSLYIFRGR INTEVMEVEN VEDGTADYHS NGYTVTNGWK 370 380 390 400 410 420 IHNTAKNKWF VCMAKTAEEK QKWLDAIIRE REQRESLKLG MERDAYVMIA EKGEKLYHMM 430 440 450 460 470 480 MNKKVNLIKD RRRKLSTVPK CFLGNEFVAW LLEIGEISKT EEGVNLGQAL LENGIIHHVS 490 500 510 520 530 540 DKHQFKNEQV MYRFRYDDGT YKARSELEDI MSKGVRLYCR LHSLYTPVIK DRDYHLKTYK 550 560 570 580 590 600 SVLPGSKLVD WLLAQGDCQT REEAVALGVG LCNNGFMHHV LEKSEFRDES QYFRFHADEE 610 620 630 640 650 660 MEGTSSKNKQ LRNDFKLVEN ILAKRLLILP QEEDYGFDIE EKNKAVVVKS VQRGSLAEVA 670 680 690 700 710 720 GLQVGRKIYS INEDLVFLRP FSEVESILNQ SFCSRRPLRL LVATKAKEII KIPDQPDTLC 730 740 750 760 770 780 FQIRGAAPPY VYAVGRGSEA MAAGLCAGQC ILKVNGSNVM NDGAPEVLEH FQAFRSRREE 790 800 810 820 830 840 ALGLYQWIYH THEDAQEARA SQEASTEDPS GEQAQEEDQA DSAFPLLSLG PRLSLCEDSP 850 860 870 880 890 900 MVTLTVDNVH LEHGVVYEYV STAGVRCHVL EKIVEPRGCF GLTAKILEAF AANDSVFVEN 910 920 930 940 950 960 CRRLMALSSA IVTMPHFEFR NICDTKLESI GQRIACYQEF AAQLKSRVSP PFKQAPLEPH 970 980 990 1000 1010 1020 PLCGLDFCPT NCHINLMEVS YPKTTPSVGR SFSIRFGRKP SLIGLDPEQG HLNPMSYTQH 1030 1040 1050 1060 1070 1080 CITTMAAPSW KCLPAAEGDP QGQGLHDGSF GPASGTLGQE DRGLSFLLKQ EDREIQDAYL 1090 1100 1110 1120 1130 1140 QLFTKLDVAL KEMKQYVTQI NRLLSTITEP TSGGSCDASL AEEASSLPLV SEESEMDRSD 1150 1160 1170 1180 1190 1200 HGGIKKVCFK VAEEDQEDSG HDTMSYRDSY SECNSNRDSV LSYTSVRSNS SYLGSDEMGS 1210 1220 1230 1240 1250 1260 GDELPCDMRI PSDKQDKLHG CLEHLFNQVD SINALLKGPV MSRAFEETKH FPMNHSLQEF 1270 1280 1290 1300 1310 1320 KQKEECTIRG RSLIQISIQE DPWNLPNSIK TLVDNIQRYV EDGKNQLLLA LLKCTDTELQ 1330 1340 1350 1360 1370 1380 LRRDAIFCQA LVAAVCTFSK QLLAALGYRY NNNGEYEESS RDASRKWLEQ VAATGVLLHC 1390 1400 1410 1420 1430 1440 QSLLSPATVK EERTMLEDIW VTLSELDNVT FSFKQLDENY VANTNVFYHI EGSRQALKVI 1450 1460 1470 1480 1490 1500 FYLDSYHFSK LPSRLEGGAS LRLHTALFTK GELQAWGRED HGGRAKATKH TGSQPPARPR 1510 1520 1530 1540 1550 1560 HLPSQCWRTW RGCLLQAARP RRICSRTSTR SPWRKFSSIT ANSGHFTWSG LTCPRMPAPR R

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac." Welch H.C.E., Coadwell W.J., Ellson C.D., Ferguson G.J., Andrews S.R., Erdjument-Bromage H., Tempst P., Hawkins P.T., Stephens L.R. Cell 108:809-821(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 182-198; 913-920; 1463-1470; 1501-1506 AND 1590-1604, CHARACTERIZATION, VARIANTS THR-1118 AND GLU-1340.
[2]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Amygdala.
[3]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-1340.
[5]	"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 39-1659 (ISOFORM 1), VARIANT GLU-1340. Tissue: Brain.
[6]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 177-1659 (ISOFORM 1), VARIANT GLU-1340. Tissue: Eye.
[8]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 337-1659 (ISOFORM 1), VARIANTS MET-659; HIS-786; ILE-1240 AND GLU-1340. Tissue: Melanoma.
[9]	"Crystal structure of the first PDZ domain of PREX1." Structural genomics consortium (SGC) Submitted (FEB-2011) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.28 ANGSTROMS) OF 607-706.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AJ320261 mRNA. Translation: CAC86401.1.
AL136579 mRNA. Translation: CAB66514.1.
AL133342, AL035106, AL445192 Genomic DNA. Translation: CAI23274.1.
AL445192, AL035106, AL133342 Genomic DNA. Translation: CAI39886.1.
AL035106, AL445192, AL133342 Genomic DNA. Translation: CAI43186.1.
AB037836 mRNA. Translation: BAA92653.2.
CH471077 Genomic DNA. Translation: EAW75684.1.
CH471077 Genomic DNA. Translation: EAW75685.1.
BC053616 mRNA. Translation: AAH53616.1.
AL832913 mRNA. Translation: CAH10614.1.

IPI

IPI00218429.
IPI00295252.
IPI00552692.

RefSeq

NP_065871.2. NM_020820.3.

UniGene

Hs.153310.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3QIK	X-ray	2.28	A	607-706	[»]

ProteinModelPortal

Q8TCU6.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q8TCU6. 11 interactions.

PTM databases

PhosphoSite

Q8TCU6.

Polymorphism databases

DMDM

148886999.

Proteomic databases

PaxDb

Q8TCU6.

PRIDE

Q8TCU6.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000371941; ENSP00000361009; ENSG00000124126.
ENST00000396220; ENSP00000379522; ENSG00000124126.

GeneID

57580.

KEGG

hsa:57580.

UCSC

uc002xtv.1. human.
uc002xtw.1. human.

Organism-specific databases

CTD

57580.

GeneCards

GC20M047240.

H-InvDB

HIX0138059.

HGNC

HGNC:32594. PREX1.

HPA

HPA001927.

MIM

606905. gene.

neXtProt

NX_Q8TCU6.

PharmGKB

PA164725018.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5422.

HOVERGEN

HBG053677.

InParanoid

Q8TCU6.

KO

K12365.

OMA

FKNEQVM.

OrthoDB

EOG479F66.

PhylomeDB

Q8TCU6.

Enzyme and pathway databases

Pathway_Interaction_DB

pi3kcipathway. Class I PI3K signaling events.

Reactome

REACT_111102. Signal Transduction.

Gene expression databases

Bgee

Q8TCU6.

Genevestigator

Q8TCU6.

GermOnline

ENSG00000124126. Homo sapiens.

Family and domain databases

Gene3D

1.10.10.10. 2 hits.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.

InterPro

IPR000591. DEP_dom.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR001478. PDZ.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]

Pfam

PF00610. DEP. 2 hits.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]

SMART

SM00049. DEP. 2 hits.
SM00228. PDZ. 2 hits.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]

SUPFAM

SSF48065. DH-domain. 1 hit.
SSF50156. PDZ. 2 hits.

PROSITE

PS50186. DEP. 2 hits.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q8TCU6.

GenomeRNAi

57580.

NextBio

64135.

SOURCE

Search...

Entry information

Entry name

PREX1_HUMAN

Accession

Primary (citable) accession number: Q8TCU6
Secondary accession number(s): E1P5X9 , Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 17, 2003
Last sequence update:	May 29, 2007
Last modified:	May 1, 2013
This is version 119 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.