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Q8TCU6

- PREX1_HUMAN

UniProt

Q8TCU6 - PREX1_HUMAN

Protein

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Gene

PREX1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 3 (29 May 2007)
      Previous versions | rss
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    Functioni

    Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.

    GO - Molecular functioni

    1. enzyme binding Source: UniProtKB
    2. phospholipid binding Source: UniProtKB
    3. protein binding Source: IntAct
    4. Rho GTPase activator activity Source: UniProtKB
    5. Rho guanyl-nucleotide exchange factor activity Source: UniProtKB

    GO - Biological processi

    1. actin filament polymerization Source: UniProtKB
    2. intracellular signal transduction Source: InterPro
    3. neutrophil activation Source: UniProtKB
    4. positive regulation of Rho GTPase activity Source: GOC
    5. regulation of actin filament polymerization Source: Ensembl
    6. regulation of dendrite development Source: Ensembl
    7. superoxide metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
    Short name:
    P-Rex1
    Short name:
    PtdIns(3,4,5)-dependent Rac exchanger 1
    Gene namesi
    Name:PREX1
    Synonyms:KIAA1415
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:32594. PREX1.

    Subcellular locationi

    Cytoplasmcytosol. Cell membrane
    Note: Mainly cytosolic. Some amount is apparently associated to the plasma membrane.

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: UniProtKB
    3. dendritic shaft Source: Ensembl
    4. growth cone Source: Ensembl
    5. intracellular membrane-bounded organelle Source: HPA
    6. perinuclear region of cytoplasm Source: Ensembl
    7. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164725018.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16591659Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 proteinPRO_0000080965Add
    BLAST

    Proteomic databases

    MaxQBiQ8TCU6.
    PaxDbiQ8TCU6.
    PRIDEiQ8TCU6.

    PTM databases

    PhosphoSiteiQ8TCU6.

    Expressioni

    Tissue specificityi

    Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues.

    Gene expression databases

    BgeeiQ8TCU6.
    GenevestigatoriQ8TCU6.

    Organism-specific databases

    HPAiHPA001927.

    Interactioni

    Subunit structurei

    Interacts preferentially with RAC2 By similarity. Interacts with RAC1.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Akt1P317502EBI-1046542,EBI-298707From a different organism.
    MTORP4234511EBI-1046542,EBI-359260
    RICTORQ6R3273EBI-1046542,EBI-1387196
    RPTORQ8N1222EBI-1046542,EBI-1567928

    Protein-protein interaction databases

    BioGridi121633. 8 interactions.
    IntActiQ8TCU6. 11 interactions.
    MINTiMINT-1649307.

    Structurei

    Secondary structure

    1
    1659
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi607 – 62014
    Beta strandi623 – 6286
    Beta strandi632 – 64211
    Beta strandi645 – 6517
    Helixi656 – 6605
    Beta strandi667 – 6715
    Beta strandi674 – 6763
    Helixi681 – 69313
    Beta strandi698 – 7036

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3QIKX-ray2.28A607-706[»]
    ProteinModelPortaliQ8TCU6.
    SMRiQ8TCU6. Positions 26-393, 409-498, 508-599, 607-771.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8TCU6.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini49 – 240192DHPROSITE-ProRule annotationAdd
    BLAST
    Domaini271 – 392122PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini421 – 49676DEP 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini523 – 59775DEP 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini625 – 70379PDZPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 DEP domains.PROSITE-ProRule annotation
    Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5422.
    HOVERGENiHBG053677.
    InParanoidiQ8TCU6.
    KOiK12365.
    OMAiFKNEQVM.
    PhylomeDBiQ8TCU6.
    TreeFamiTF328639.

    Family and domain databases

    Gene3Di1.10.10.10. 2 hits.
    1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    2.30.42.10. 2 hits.
    InterProiIPR000591. DEP_dom.
    IPR000219. DH-domain.
    IPR001331. GDS_CDC24_CS.
    IPR001478. PDZ.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00610. DEP. 2 hits.
    PF00169. PH. 1 hit.
    PF00621. RhoGEF. 1 hit.
    [Graphical view]
    SMARTiSM00049. DEP. 2 hits.
    SM00228. PDZ. 2 hits.
    SM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    [Graphical view]
    SUPFAMiSSF48065. SSF48065. 1 hit.
    SSF50156. SSF50156. 2 hits.
    PROSITEiPS50186. DEP. 2 hits.
    PS00741. DH_1. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50106. PDZ. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TCU6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEAPSGSEPG GDGAGDCAHP DPRAPGAAAP SSGPGPCAAA RESERQLRLR     50
    LCVLNEILGT ERDYVGTLRF LQSAFLHRIR QNVADSVEKG LTEENVKVLF 100
    SNIEDILEVH KDFLAALEYC LHPEPQSQHE LGNVFLKFKD KFCVYEEYCS 150
    NHEKALRLLV ELNKIPTVRA FLLSCMLLGG RKTTDIPLEG YLLSPIQRIC 200
    KYPLLLKELA KRTPGKHPDH PAVQSALQAM KTVCSNINET KRQMEKLEAL 250
    EQLQSHIEGW EGSNLTDICT QLLLQGTLLK ISAGNIQERA FFLFDNLLVY 300
    CKRKSRVTGS KKSTKRTKSI NGSLYIFRGR INTEVMEVEN VEDGTADYHS 350
    NGYTVTNGWK IHNTAKNKWF VCMAKTAEEK QKWLDAIIRE REQRESLKLG 400
    MERDAYVMIA EKGEKLYHMM MNKKVNLIKD RRRKLSTVPK CFLGNEFVAW 450
    LLEIGEISKT EEGVNLGQAL LENGIIHHVS DKHQFKNEQV MYRFRYDDGT 500
    YKARSELEDI MSKGVRLYCR LHSLYTPVIK DRDYHLKTYK SVLPGSKLVD 550
    WLLAQGDCQT REEAVALGVG LCNNGFMHHV LEKSEFRDES QYFRFHADEE 600
    MEGTSSKNKQ LRNDFKLVEN ILAKRLLILP QEEDYGFDIE EKNKAVVVKS 650
    VQRGSLAEVA GLQVGRKIYS INEDLVFLRP FSEVESILNQ SFCSRRPLRL 700
    LVATKAKEII KIPDQPDTLC FQIRGAAPPY VYAVGRGSEA MAAGLCAGQC 750
    ILKVNGSNVM NDGAPEVLEH FQAFRSRREE ALGLYQWIYH THEDAQEARA 800
    SQEASTEDPS GEQAQEEDQA DSAFPLLSLG PRLSLCEDSP MVTLTVDNVH 850
    LEHGVVYEYV STAGVRCHVL EKIVEPRGCF GLTAKILEAF AANDSVFVEN 900
    CRRLMALSSA IVTMPHFEFR NICDTKLESI GQRIACYQEF AAQLKSRVSP 950
    PFKQAPLEPH PLCGLDFCPT NCHINLMEVS YPKTTPSVGR SFSIRFGRKP 1000
    SLIGLDPEQG HLNPMSYTQH CITTMAAPSW KCLPAAEGDP QGQGLHDGSF 1050
    GPASGTLGQE DRGLSFLLKQ EDREIQDAYL QLFTKLDVAL KEMKQYVTQI 1100
    NRLLSTITEP TSGGSCDASL AEEASSLPLV SEESEMDRSD HGGIKKVCFK 1150
    VAEEDQEDSG HDTMSYRDSY SECNSNRDSV LSYTSVRSNS SYLGSDEMGS 1200
    GDELPCDMRI PSDKQDKLHG CLEHLFNQVD SINALLKGPV MSRAFEETKH 1250
    FPMNHSLQEF KQKEECTIRG RSLIQISIQE DPWNLPNSIK TLVDNIQRYV 1300
    EDGKNQLLLA LLKCTDTELQ LRRDAIFCQA LVAAVCTFSK QLLAALGYRY 1350
    NNNGEYEESS RDASRKWLEQ VAATGVLLHC QSLLSPATVK EERTMLEDIW 1400
    VTLSELDNVT FSFKQLDENY VANTNVFYHI EGSRQALKVI FYLDSYHFSK 1450
    LPSRLEGGAS LRLHTALFTK VLENVEGLPS PGSQAAEDLQ QDINAQSLEK 1500
    VQQYYRKLRA FYLERSNLPT DASTTAVKID QLIRPINALD ELCRLMKSFV 1550
    HPKPGAAGSV GAGLIPISSE LCYRLGACQM VMCGTGMQRS TLSVSLEQAA 1600
    ILARSHGLLP KCIMQATDIM RKQGPRVEIL AKNLRVKDQM PQGAPRLYRL 1650
    CQPPVDGDL 1659
    Length:1,659
    Mass (Da):186,203
    Last modified:May 29, 2007 - v3
    Checksum:i159419355ED0F00F
    GO
    Isoform 2 (identifier: Q8TCU6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-703: Missing.
         704-708: TKAKE → MGLEQ

    Show »
    Length:956
    Mass (Da):106,093
    Checksum:iE2DCA9099F0CE2C7
    GO
    Isoform 3 (identifier: Q8TCU6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1471-1561: VLENVEGLPS...PKPGAAGSVG → GELQAWGRED...TCPRMPAPRR
         1562-1659: Missing.

    Note: Gene prediction based on EST data. No experimental confirmation available.

    Show »
    Length:1,561
    Mass (Da):175,847
    Checksum:iCACDE55657E3A86D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti910 – 9101A → V in CAB66514. (PubMed:11230166)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti659 – 6591V → M.1 Publication
    Corresponds to variant rs55904123 [ dbSNP | Ensembl ].
    VAR_061798
    Natural varianti696 – 6961R → C.
    Corresponds to variant rs7271583 [ dbSNP | Ensembl ].
    VAR_057191
    Natural varianti786 – 7861Q → H.1 Publication
    Corresponds to variant rs41283558 [ dbSNP | Ensembl ].
    VAR_061799
    Natural varianti1118 – 11181A → T.1 Publication
    Corresponds to variant rs6012504 [ dbSNP | Ensembl ].
    VAR_057192
    Natural varianti1240 – 12401V → I.1 Publication
    Corresponds to variant rs16993997 [ dbSNP | Ensembl ].
    VAR_023210
    Natural varianti1340 – 13401K → E.5 Publications
    Corresponds to variant rs2664521 [ dbSNP | Ensembl ].
    VAR_023211
    Natural varianti1559 – 15591S → T.
    Corresponds to variant rs3936192 [ dbSNP | Ensembl ].
    VAR_023212

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 703703Missing in isoform 2. 1 PublicationVSP_001818Add
    BLAST
    Alternative sequencei704 – 7085TKAKE → MGLEQ in isoform 2. 1 PublicationVSP_001819
    Alternative sequencei1471 – 156191VLENV…AGSVG → GELQAWGREDHGGRAKATKH TGSQPPARPRHLPSQCWRTW RGCLLQAARPRRICSRTSTR SPWRKFSSITANSGHFTWSG LTCPRMPAPRR in isoform 3. CuratedVSP_015090Add
    BLAST
    Alternative sequencei1562 – 165998Missing in isoform 3. CuratedVSP_015091Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ320261 mRNA. Translation: CAC86401.1.
    AL136579 mRNA. Translation: CAB66514.1.
    AL133342, AL035106, AL445192 Genomic DNA. Translation: CAI23274.1.
    AL445192, AL035106, AL133342 Genomic DNA. Translation: CAI39886.1.
    AL035106, AL445192, AL133342 Genomic DNA. Translation: CAI43186.1.
    AB037836 mRNA. Translation: BAA92653.2.
    CH471077 Genomic DNA. Translation: EAW75684.1.
    CH471077 Genomic DNA. Translation: EAW75685.1.
    BC053616 mRNA. Translation: AAH53616.1.
    AL832913 mRNA. Translation: CAH10614.1.
    CCDSiCCDS13410.1. [Q8TCU6-1]
    RefSeqiNP_065871.2. NM_020820.3.
    XP_005260528.1. XM_005260471.1. [Q8TCU6-2]
    UniGeneiHs.153310.

    Genome annotation databases

    EnsembliENST00000371941; ENSP00000361009; ENSG00000124126. [Q8TCU6-1]
    GeneIDi57580.
    KEGGihsa:57580.
    UCSCiuc002xtv.1. human. [Q8TCU6-2]
    uc002xtw.1. human. [Q8TCU6-1]

    Polymorphism databases

    DMDMi148886999.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ320261 mRNA. Translation: CAC86401.1 .
    AL136579 mRNA. Translation: CAB66514.1 .
    AL133342 , AL035106 , AL445192 Genomic DNA. Translation: CAI23274.1 .
    AL445192 , AL035106 , AL133342 Genomic DNA. Translation: CAI39886.1 .
    AL035106 , AL445192 , AL133342 Genomic DNA. Translation: CAI43186.1 .
    AB037836 mRNA. Translation: BAA92653.2 .
    CH471077 Genomic DNA. Translation: EAW75684.1 .
    CH471077 Genomic DNA. Translation: EAW75685.1 .
    BC053616 mRNA. Translation: AAH53616.1 .
    AL832913 mRNA. Translation: CAH10614.1 .
    CCDSi CCDS13410.1. [Q8TCU6-1 ]
    RefSeqi NP_065871.2. NM_020820.3.
    XP_005260528.1. XM_005260471.1. [Q8TCU6-2 ]
    UniGenei Hs.153310.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3QIK X-ray 2.28 A 607-706 [» ]
    ProteinModelPortali Q8TCU6.
    SMRi Q8TCU6. Positions 26-393, 409-498, 508-599, 607-771.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121633. 8 interactions.
    IntActi Q8TCU6. 11 interactions.
    MINTi MINT-1649307.

    PTM databases

    PhosphoSitei Q8TCU6.

    Polymorphism databases

    DMDMi 148886999.

    Proteomic databases

    MaxQBi Q8TCU6.
    PaxDbi Q8TCU6.
    PRIDEi Q8TCU6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000371941 ; ENSP00000361009 ; ENSG00000124126 . [Q8TCU6-1 ]
    GeneIDi 57580.
    KEGGi hsa:57580.
    UCSCi uc002xtv.1. human. [Q8TCU6-2 ]
    uc002xtw.1. human. [Q8TCU6-1 ]

    Organism-specific databases

    CTDi 57580.
    GeneCardsi GC20M047240.
    H-InvDB HIX0138059.
    HGNCi HGNC:32594. PREX1.
    HPAi HPA001927.
    MIMi 606905. gene.
    neXtProti NX_Q8TCU6.
    PharmGKBi PA164725018.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5422.
    HOVERGENi HBG053677.
    InParanoidi Q8TCU6.
    KOi K12365.
    OMAi FKNEQVM.
    PhylomeDBi Q8TCU6.
    TreeFami TF328639.

    Miscellaneous databases

    EvolutionaryTracei Q8TCU6.
    GeneWikii PREX1.
    GenomeRNAii 57580.
    NextBioi 64135.
    PROi Q8TCU6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8TCU6.
    Genevestigatori Q8TCU6.

    Family and domain databases

    Gene3Di 1.10.10.10. 2 hits.
    1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    2.30.42.10. 2 hits.
    InterProi IPR000591. DEP_dom.
    IPR000219. DH-domain.
    IPR001331. GDS_CDC24_CS.
    IPR001478. PDZ.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00610. DEP. 2 hits.
    PF00169. PH. 1 hit.
    PF00621. RhoGEF. 1 hit.
    [Graphical view ]
    SMARTi SM00049. DEP. 2 hits.
    SM00228. PDZ. 2 hits.
    SM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48065. SSF48065. 1 hit.
    SSF50156. SSF50156. 2 hits.
    PROSITEi PS50186. DEP. 2 hits.
    PS00741. DH_1. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50106. PDZ. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac."
      Welch H.C.E., Coadwell W.J., Ellson C.D., Ferguson G.J., Andrews S.R., Erdjument-Bromage H., Tempst P., Hawkins P.T., Stephens L.R.
      Cell 108:809-821(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 182-198; 913-920; 1463-1470; 1501-1506 AND 1590-1604, CHARACTERIZATION, VARIANTS THR-1118 AND GLU-1340.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Amygdala.
    3. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-1340.
    5. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 39-1659 (ISOFORM 1), VARIANT GLU-1340.
      Tissue: Brain.
    6. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 177-1659 (ISOFORM 1), VARIANT GLU-1340.
      Tissue: Eye.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 337-1659 (ISOFORM 1), VARIANTS MET-659; HIS-786; ILE-1240 AND GLU-1340.
      Tissue: Melanoma.
    9. "Crystal structure of the first PDZ domain of PREX1."
      Structural genomics consortium (SGC)
      Submitted (FEB-2011) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.28 ANGSTROMS) OF 607-706.

    Entry informationi

    Entry nameiPREX1_HUMAN
    AccessioniPrimary (citable) accession number: Q8TCU6
    Secondary accession number(s): E1P5X9
    , Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 17, 2003
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 133 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3