Reviewed, UniProtKB/Swiss-Prot Q8TCU6 (PREX1_HUMAN)

Names and origin

Protein names

Recommended name:
    Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
      Short name=PtdIns(3,4,5)-dependent Rac exchanger 1
      Short name=P-Rex1

Gene names

Name:	PREX1
Synonyms:	KIAA1415

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1659 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol-3,4,5-triphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Subunit structure	Interacts preferentially with RAC2 By similarity. Interacts with RAC1.
Subcellular location	Cytoplasm › cytosol. Cell membrane. Note: Mainly cytosolic. Some amount is apparently associated to the plasma membrane.
Tissue specificity	Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues.
Sequence similarities	Contains 1 DEP domain. Contains 1 DH (DBL-homology) domain. Contains 1 PDZ (DHR) domain. Contains 2 PH domains.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Molecular function	Guanine-nucleotide releasing factor
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	actin filament polymerization Traceable author statement. Source: UniProtKB apoptosis Inferred from Experiment. Source: Reactome induction of apoptosis by extracellular signals Inferred from Experiment. Source: Reactome intracellular signaling cascade Inferred from electronic annotation. Source: InterPro neutrophil activation Traceable author statement. Source: UniProtKB regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro superoxide metabolic process Traceable author statement. Source: UniProtKB
Cellular component	cytosol Ref.1 Inferred from direct assay. Source: UniProtKB plasma membrane Traceable author statement. Source: UniProtKB
Molecular function	Rho GTPase activator activity Traceable author statement. Source: UniProtKB Rho guanyl-nucleotide exchange factor activity Traceable author statement. Source: UniProtKB enzyme binding Traceable author statement. Source: UniProtKB phospholipid binding Ref.1 Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BZW1	Q7L1Q6	1	EBI-1046542,EBI-1046727
FRAP1	P42345	7	EBI-1046542,EBI-359260

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TCU6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TCU6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-703: Missing.
     704-708: TKAKE → MGLEQ

Isoform 3 (identifier: Q8TCU6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1471-1561: VLENVEGLPS...PKPGAAGSVG → GELQAWGRED...TCPRMPAPRR
     1562-1659: Missing.

Note: Gene prediction based on EST data. No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1659	1659	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein		PRO_0000080965
Regions
	Domain	49 – 240	192	DH
	Domain	271 – 392	122	PH
	Domain	421 – 496	76	DEP 1
	Domain	523 – 597	75	DEP 2
	Domain	625 – 703	79	PDZ
Amino acid modifications
	Modified residue	436	1	Phosphoserine Ref.8
Natural variations
	Alternative sequence	1 – 703	703	Missing in isoform 2.		VSP_001818
	Alternative sequence	704 – 708	5	TKAKE → MGLEQ in isoform 2.		VSP_001819
	Alternative sequence	1471 – 1561	91	VLENV…AGSVG → GELQAWGREDHGGRAKATKH TGSQPPARPRHLPSQCWRTW RGCLLQAARPRRICSRTSTR SPWRKFSSITANSGHFTWSG LTCPRMPAPRR in isoform 3.		VSP_015090
	Alternative sequence	1562 – 1659	98	Missing in isoform 3.		VSP_015091
	Natural variant	659	1	V → M: dbSNP rs55904123. Ref.7		VAR_061798
	Natural variant	696	1	R → C: dbSNP rs7271583.		VAR_057191
	Natural variant	786	1	Q → H: dbSNP rs41283558. Ref.7		VAR_061799
	Natural variant	1118	1	A → T: dbSNP rs6012504. Ref.1		VAR_057192
	Natural variant	1240	1	V → I: dbSNP rs16993997. Ref.7		VAR_023210
	Natural variant	1340	1	K → E: dbSNP rs2664521. Ref.7 Ref.1 Ref.4 Ref.6		VAR_023211
	Natural variant	1559	1	S → T: dbSNP rs3936192.		VAR_023212
Experimental info
	Sequence conflict	910	1	A → V in CAB66514. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 29, 2007. Version 3. Checksum: 159419355ED0F00F	FASTA	1,659	186,203
	10 20 30 40 50 60 MEAPSGSEPG GDGAGDCAHP DPRAPGAAAP SSGPGPCAAA RESERQLRLR LCVLNEILGT 70 80 90 100 110 120 ERDYVGTLRF LQSAFLHRIR QNVADSVEKG LTEENVKVLF SNIEDILEVH KDFLAALEYC 130 140 150 160 170 180 LHPEPQSQHE LGNVFLKFKD KFCVYEEYCS NHEKALRLLV ELNKIPTVRA FLLSCMLLGG 190 200 210 220 230 240 RKTTDIPLEG YLLSPIQRIC KYPLLLKELA KRTPGKHPDH PAVQSALQAM KTVCSNINET 250 260 270 280 290 300 KRQMEKLEAL EQLQSHIEGW EGSNLTDICT QLLLQGTLLK ISAGNIQERA FFLFDNLLVY 310 320 330 340 350 360 CKRKSRVTGS KKSTKRTKSI NGSLYIFRGR INTEVMEVEN VEDGTADYHS NGYTVTNGWK 370 380 390 400 410 420 IHNTAKNKWF VCMAKTAEEK QKWLDAIIRE REQRESLKLG MERDAYVMIA EKGEKLYHMM 430 440 450 460 470 480 MNKKVNLIKD RRRKLSTVPK CFLGNEFVAW LLEIGEISKT EEGVNLGQAL LENGIIHHVS 490 500 510 520 530 540 DKHQFKNEQV MYRFRYDDGT YKARSELEDI MSKGVRLYCR LHSLYTPVIK DRDYHLKTYK 550 560 570 580 590 600 SVLPGSKLVD WLLAQGDCQT REEAVALGVG LCNNGFMHHV LEKSEFRDES QYFRFHADEE 610 620 630 640 650 660 MEGTSSKNKQ LRNDFKLVEN ILAKRLLILP QEEDYGFDIE EKNKAVVVKS VQRGSLAEVA 670 680 690 700 710 720 GLQVGRKIYS INEDLVFLRP FSEVESILNQ SFCSRRPLRL LVATKAKEII KIPDQPDTLC 730 740 750 760 770 780 FQIRGAAPPY VYAVGRGSEA MAAGLCAGQC ILKVNGSNVM NDGAPEVLEH FQAFRSRREE 790 800 810 820 830 840 ALGLYQWIYH THEDAQEARA SQEASTEDPS GEQAQEEDQA DSAFPLLSLG PRLSLCEDSP 850 860 870 880 890 900 MVTLTVDNVH LEHGVVYEYV STAGVRCHVL EKIVEPRGCF GLTAKILEAF AANDSVFVEN 910 920 930 940 950 960 CRRLMALSSA IVTMPHFEFR NICDTKLESI GQRIACYQEF AAQLKSRVSP PFKQAPLEPH 970 980 990 1000 1010 1020 PLCGLDFCPT NCHINLMEVS YPKTTPSVGR SFSIRFGRKP SLIGLDPEQG HLNPMSYTQH 1030 1040 1050 1060 1070 1080 CITTMAAPSW KCLPAAEGDP QGQGLHDGSF GPASGTLGQE DRGLSFLLKQ EDREIQDAYL 1090 1100 1110 1120 1130 1140 QLFTKLDVAL KEMKQYVTQI NRLLSTITEP TSGGSCDASL AEEASSLPLV SEESEMDRSD 1150 1160 1170 1180 1190 1200 HGGIKKVCFK VAEEDQEDSG HDTMSYRDSY SECNSNRDSV LSYTSVRSNS SYLGSDEMGS 1210 1220 1230 1240 1250 1260 GDELPCDMRI PSDKQDKLHG CLEHLFNQVD SINALLKGPV MSRAFEETKH FPMNHSLQEF 1270 1280 1290 1300 1310 1320 KQKEECTIRG RSLIQISIQE DPWNLPNSIK TLVDNIQRYV EDGKNQLLLA LLKCTDTELQ 1330 1340 1350 1360 1370 1380 LRRDAIFCQA LVAAVCTFSK QLLAALGYRY NNNGEYEESS RDASRKWLEQ VAATGVLLHC 1390 1400 1410 1420 1430 1440 QSLLSPATVK EERTMLEDIW VTLSELDNVT FSFKQLDENY VANTNVFYHI EGSRQALKVI 1450 1460 1470 1480 1490 1500 FYLDSYHFSK LPSRLEGGAS LRLHTALFTK VLENVEGLPS PGSQAAEDLQ QDINAQSLEK 1510 1520 1530 1540 1550 1560 VQQYYRKLRA FYLERSNLPT DASTTAVKID QLIRPINALD ELCRLMKSFV HPKPGAAGSV 1570 1580 1590 1600 1610 1620 GAGLIPISSE LCYRLGACQM VMCGTGMQRS TLSVSLEQAA ILARSHGLLP KCIMQATDIM 1630 1640 1650 RKQGPRVEIL AKNLRVKDQM PQGAPRLYRL CQPPVDGDL
	Isoform 2. Checksum: E2DCA9099F0CE2C7	FASTA	956	106,093
	10 20 30 40 50 60 MGLEQIIKIP DQPDTLCFQI RGAAPPYVYA VGRGSEAMAA GLCAGQCILK VNGSNVMNDG 70 80 90 100 110 120 APEVLEHFQA FRSRREEALG LYQWIYHTHE DAQEARASQE ASTEDPSGEQ AQEEDQADSA 130 140 150 160 170 180 FPLLSLGPRL SLCEDSPMVT LTVDNVHLEH GVVYEYVSTA GVRCHVLEKI VEPRGCFGLT 190 200 210 220 230 240 AKILEAFAAN DSVFVENCRR LMALSSAIVT MPHFEFRNIC DTKLESIGQR IACYQEFAAQ 250 260 270 280 290 300 LKSRVSPPFK QAPLEPHPLC GLDFCPTNCH INLMEVSYPK TTPSVGRSFS IRFGRKPSLI 310 320 330 340 350 360 GLDPEQGHLN PMSYTQHCIT TMAAPSWKCL PAAEGDPQGQ GLHDGSFGPA SGTLGQEDRG 370 380 390 400 410 420 LSFLLKQEDR EIQDAYLQLF TKLDVALKEM KQYVTQINRL LSTITEPTSG GSCDASLAEE 430 440 450 460 470 480 ASSLPLVSEE SEMDRSDHGG IKKVCFKVAE EDQEDSGHDT MSYRDSYSEC NSNRDSVLSY 490 500 510 520 530 540 TSVRSNSSYL GSDEMGSGDE LPCDMRIPSD KQDKLHGCLE HLFNQVDSIN ALLKGPVMSR 550 560 570 580 590 600 AFEETKHFPM NHSLQEFKQK EECTIRGRSL IQISIQEDPW NLPNSIKTLV DNIQRYVEDG 610 620 630 640 650 660 KNQLLLALLK CTDTELQLRR DAIFCQALVA AVCTFSKQLL AALGYRYNNN GEYEESSRDA 670 680 690 700 710 720 SRKWLEQVAA TGVLLHCQSL LSPATVKEER TMLEDIWVTL SELDNVTFSF KQLDENYVAN 730 740 750 760 770 780 TNVFYHIEGS RQALKVIFYL DSYHFSKLPS RLEGGASLRL HTALFTKVLE NVEGLPSPGS 790 800 810 820 830 840 QAAEDLQQDI NAQSLEKVQQ YYRKLRAFYL ERSNLPTDAS TTAVKIDQLI RPINALDELC 850 860 870 880 890 900 RLMKSFVHPK PGAAGSVGAG LIPISSELCY RLGACQMVMC GTGMQRSTLS VSLEQAAILA 910 920 930 940 950 RSHGLLPKCI MQATDIMRKQ GPRVEILAKN LRVKDQMPQG APRLYRLCQP PVDGDL
	Isoform 3. Checksum: CACDE55657E3A86D	FASTA	1,561	175,847
	10 20 30 40 50 60 MEAPSGSEPG GDGAGDCAHP DPRAPGAAAP SSGPGPCAAA RESERQLRLR LCVLNEILGT 70 80 90 100 110 120 ERDYVGTLRF LQSAFLHRIR QNVADSVEKG LTEENVKVLF SNIEDILEVH KDFLAALEYC 130 140 150 160 170 180 LHPEPQSQHE LGNVFLKFKD KFCVYEEYCS NHEKALRLLV ELNKIPTVRA FLLSCMLLGG 190 200 210 220 230 240 RKTTDIPLEG YLLSPIQRIC KYPLLLKELA KRTPGKHPDH PAVQSALQAM KTVCSNINET 250 260 270 280 290 300 KRQMEKLEAL EQLQSHIEGW EGSNLTDICT QLLLQGTLLK ISAGNIQERA FFLFDNLLVY 310 320 330 340 350 360 CKRKSRVTGS KKSTKRTKSI NGSLYIFRGR INTEVMEVEN VEDGTADYHS NGYTVTNGWK 370 380 390 400 410 420 IHNTAKNKWF VCMAKTAEEK QKWLDAIIRE REQRESLKLG MERDAYVMIA EKGEKLYHMM 430 440 450 460 470 480 MNKKVNLIKD RRRKLSTVPK CFLGNEFVAW LLEIGEISKT EEGVNLGQAL LENGIIHHVS 490 500 510 520 530 540 DKHQFKNEQV MYRFRYDDGT YKARSELEDI MSKGVRLYCR LHSLYTPVIK DRDYHLKTYK 550 560 570 580 590 600 SVLPGSKLVD WLLAQGDCQT REEAVALGVG LCNNGFMHHV LEKSEFRDES QYFRFHADEE 610 620 630 640 650 660 MEGTSSKNKQ LRNDFKLVEN ILAKRLLILP QEEDYGFDIE EKNKAVVVKS VQRGSLAEVA 670 680 690 700 710 720 GLQVGRKIYS INEDLVFLRP FSEVESILNQ SFCSRRPLRL LVATKAKEII KIPDQPDTLC 730 740 750 760 770 780 FQIRGAAPPY VYAVGRGSEA MAAGLCAGQC ILKVNGSNVM NDGAPEVLEH FQAFRSRREE 790 800 810 820 830 840 ALGLYQWIYH THEDAQEARA SQEASTEDPS GEQAQEEDQA DSAFPLLSLG PRLSLCEDSP 850 860 870 880 890 900 MVTLTVDNVH LEHGVVYEYV STAGVRCHVL EKIVEPRGCF GLTAKILEAF AANDSVFVEN 910 920 930 940 950 960 CRRLMALSSA IVTMPHFEFR NICDTKLESI GQRIACYQEF AAQLKSRVSP PFKQAPLEPH 970 980 990 1000 1010 1020 PLCGLDFCPT NCHINLMEVS YPKTTPSVGR SFSIRFGRKP SLIGLDPEQG HLNPMSYTQH 1030 1040 1050 1060 1070 1080 CITTMAAPSW KCLPAAEGDP QGQGLHDGSF GPASGTLGQE DRGLSFLLKQ EDREIQDAYL 1090 1100 1110 1120 1130 1140 QLFTKLDVAL KEMKQYVTQI NRLLSTITEP TSGGSCDASL AEEASSLPLV SEESEMDRSD 1150 1160 1170 1180 1190 1200 HGGIKKVCFK VAEEDQEDSG HDTMSYRDSY SECNSNRDSV LSYTSVRSNS SYLGSDEMGS 1210 1220 1230 1240 1250 1260 GDELPCDMRI PSDKQDKLHG CLEHLFNQVD SINALLKGPV MSRAFEETKH FPMNHSLQEF 1270 1280 1290 1300 1310 1320 KQKEECTIRG RSLIQISIQE DPWNLPNSIK TLVDNIQRYV EDGKNQLLLA LLKCTDTELQ 1330 1340 1350 1360 1370 1380 LRRDAIFCQA LVAAVCTFSK QLLAALGYRY NNNGEYEESS RDASRKWLEQ VAATGVLLHC 1390 1400 1410 1420 1430 1440 QSLLSPATVK EERTMLEDIW VTLSELDNVT FSFKQLDENY VANTNVFYHI EGSRQALKVI 1450 1460 1470 1480 1490 1500 FYLDSYHFSK LPSRLEGGAS LRLHTALFTK GELQAWGRED HGGRAKATKH TGSQPPARPR 1510 1520 1530 1540 1550 1560 HLPSQCWRTW RGCLLQAARP RRICSRTSTR SPWRKFSSIT ANSGHFTWSG LTCPRMPAPR R

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac." Welch H.C.E., Coadwell W.J., Ellson C.D., Ferguson G.J., Andrews S.R., Erdjument-Bromage H., Tempst P., Hawkins P.T., Stephens L.R. Cell 108:809-821(2002) [PubMed: 11955434] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 182-198; 913-920; 1463-1470; 1501-1506 AND 1590-1604, CHARACTERIZATION, VARIANTS THR-1118 AND GLU-1340.
[2]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Amygdala.
[3]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed: 10718198] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 39-1659 (ISOFORM 1), VARIANT GLU-1340. Tissue: Brain.
[5]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 177-1659 (ISOFORM 1), VARIANT GLU-1340. Tissue: Eye.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 337-1659 (ISOFORM 1), VARIANTS MET-659; HIS-786; ILE-1240 AND GLU-1340. Tissue: Melanoma.
[8]	"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-436, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ320261 mRNA. Translation: CAC86401.1. AL136579 mRNA. Translation: CAB66514.1. AL133342, AL035106, AL445192 Genomic DNA. Translation: CAI23274.1. AL445192, AL035106, AL133342 Genomic DNA. Translation: CAI39886.1. AL035106, AL445192, AL133342 Genomic DNA. Translation: CAI43186.1. AB037836 mRNA. Translation: BAA92653.2. BC053616 mRNA. Translation: AAH53616.1. AL832913 mRNA. Translation: CAH10614.1.
IPI	IPI00218429. IPI00295252. IPI00552692.
RefSeq	NP_065871.2.
UniGene	Hs.153310
3D structure databases
SMR	Q8TCU6. Positions 48-393, 416-494, 528-596, 625-772.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TCU6. 5 interactions.
STRING	Q8TCU6.
PTM databases
PhosphoSite	Q8TCU6.
Proteomic databases
PRIDE	Q8TCU6.
Genome annotation databases
Ensembl	ENST00000371941; ENSP00000361009; ENSG00000124126; Homo sapiens. [Genome view]
GeneID	57580.
KEGG	hsa:57580.
NMPDR	fig|9606.3.peg.20430.
UCSC	uc002xtv.1. human. uc002xtw.1. human.
Organism-specific databases
CTD	57580.
GeneCards	GC20M046674.
H-InvDB	HIX0022544. HIX0027727.
HGNC	HGNC:32594. PREX1.
HPA	HPA001927.
MIM	606905. gene.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19340.
HOVERGEN	Q8TCU6.
InParanoid	Q8TCU6.
OMA	KDRDYHL.
OrthoDB	EOG976NKR.
PhylomeDB	Q8TCU6.
Enzyme and pathway databases
Pathway_Interaction_DB	pi3kcipathway. Class I PI3K signaling events.
Reactome	REACT_11044. Signaling by Rho GTPases. REACT_11061. Signalling by NGF. REACT_14797. Signaling by GPCR.
Gene expression databases
ArrayExpress	Q8TCU6.
Bgee	Q8TCU6.
Genevestigator	Q8TCU6.
GermOnline	ENSG00000124126. Homo sapiens.
Family and domain databases
InterPro	IPR000591. DEP_dom. IPR000219. DH-domain. IPR001331. GDS_CDC24_CS. IPR001478. PDZ/DHR/GLGF. IPR001849. Pleckstrin_homology. IPR011991. WHTH_trsnscrt_rep_DNA-bd. [Graphical view]
Gene3D	G3DSA:1.20.900.10. RhoGEF. 1 hit. G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 2 hits.
Pfam	PF00610. DEP. 2 hits. PF00169. PH. 1 hit. PF00621. RhoGEF. 1 hit. [Graphical view]
SMART	SM00049. DEP. 2 hits. SM00228. PDZ. 2 hits. SM00233. PH. 1 hit. SM00325. RhoGEF. 1 hit. [Graphical view]
PROSITE	PS50186. DEP. 2 hits. PS00741. DH_1. 1 hit. PS50010. DH_2. 1 hit. PS50106. PDZ. 1 hit. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	64135.
SOURCE	Search...

Entry information

Entry name

PREX1_HUMAN

Accession

Primary (citable) accession number: Q8TCU6
Secondary accession number(s): Q5JS95 , Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 17, 2003
Last sequence update:	May 29, 2007
Last modified:	February 9, 2010
This is version 84 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.