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Q8TCU5

- NMD3A_HUMAN

UniProt

Q8TCU5 - NMD3A_HUMAN

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Protein

Glutamate receptor ionotropic, NMDA 3A

Gene
GRIN3A, KIAA1973
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism By similarity.

GO - Molecular functioni

  1. calcium channel activity Source: Ensembl
  2. extracellular-glutamate-gated ion channel activity Source: RefGenome
  3. glycine binding Source: UniProtKB
  4. identical protein binding Source: UniProtKB
  5. neurotransmitter binding Source: Ensembl
  6. N-methyl-D-aspartate selective glutamate receptor activity Source: UniProtKB
  7. protein binding Source: UniProtKB
  8. protein phosphatase 2A binding Source: UniProtKB

GO - Biological processi

  1. calcium ion transport Source: UniProtKB
  2. dendrite development Source: Ensembl
  3. ionotropic glutamate receptor signaling pathway Source: RefGenome
  4. ion transmembrane transport Source: RefGenome
  5. prepulse inhibition Source: Ensembl
  6. response to ethanol Source: UniProtKB
  7. rhythmic process Source: Ensembl
  8. synaptic transmission, glutamatergic Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calcium, Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, NMDA 3A
Short name:
GluN3A
Alternative name(s):
N-methyl-D-aspartate receptor subtype 3A
Short name:
NMDAR3A
Short name:
NR3A
NMDAR-L
Gene namesi
Name:GRIN3A
Synonyms:KIAA1973
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:16767. GRIN3A.

Subcellular locationi

Cell membrane; Multi-pass membrane protein By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity
Note: Enriched in postsynaptic plasma membrane and postsynaptic densities. Requires the presence of GRIN1 to be targeted at the plasma membrane By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 674651Extracellular Reviewed predictionAdd
BLAST
Transmembranei675 – 69521Helical; Reviewed predictionAdd
BLAST
Topological domaini696 – 74853Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei749 – 76921Helical; Reviewed predictionAdd
BLAST
Topological domaini770 – 930161Extracellular Reviewed predictionAdd
BLAST
Transmembranei931 – 95121Helical; Reviewed predictionAdd
BLAST
Topological domaini952 – 1115164Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. dendrite Source: RefGenome
  3. integral component of membrane Source: UniProtKB
  4. membrane Source: UniProtKB
  5. neuronal cell body Source: UniProtKB
  6. neuron projection Source: UniProtKB
  7. N-methyl-D-aspartate selective glutamate receptor complex Source: UniProtKB
  8. postsynaptic density Source: UniProtKB-SubCell
  9. postsynaptic membrane Source: RefGenome
  10. synapse Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28983.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 11151092Glutamate receptor ionotropic, NMDA 3APRO_0000011568Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi145 – 1451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi264 – 2641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi275 – 2751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi285 – 2851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi296 – 2961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi426 – 4261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi439 – 4391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi549 – 5491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi565 – 5651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi886 – 8861N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated By similarity.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8TCU5.
PRIDEiQ8TCU5.

PTM databases

PhosphoSiteiQ8TCU5.

Expressioni

Developmental stagei

Expressed in fetal brain.

Gene expression databases

BgeeiQ8TCU5.
CleanExiHS_GRIN3A.
GenevestigatoriQ8TCU5.

Interactioni

Subunit structurei

Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex with GRIN1, GRIN2A or GRIN2B and PPP2CB. Probably interacts with PPP2CB. No complex with PPP2CB is detected when NMDARs are stimulated by NMDA By similarity.1 Publication

Protein-protein interaction databases

BioGridi125508. 3 interactions.
MINTiMINT-6630950.
STRINGi9606.ENSP00000355155.

Structurei

3D structure databases

ProteinModelPortaliQ8TCU5.
SMRiQ8TCU5. Positions 143-497, 512-952.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni951 – 98737PPP2CB binding site By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1058 – 110952 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320645.
HOGENOMiHOG000231528.
HOVERGENiHBG052634.
InParanoidiQ8TCU5.
KOiK05213.
OMAiTQFGVMP.
OrthoDBiEOG7QK0B4.
PhylomeDBiQ8TCU5.
TreeFamiTF314731.

Family and domain databases

InterProiIPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
IPR001638. SBP_bac_3.
[Graphical view]
PfamiPF00060. Lig_chan. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TCU5-1 [UniParc]FASTAAdd to Basket

« Hide

MRRLSLWWLL SRVCLLLPPP CALVLAGVPS SSSHPQPCQI LKRIGHAVRV     50
GAVHLQPWTT APRAASRAPD DSRAGAQRDE PEPGTRRSPA PSPGARWLGS 100
TLHGRGPPGS RKPGEGARAE ALWPRDALLF AVDNLNRVEG LLPYNLSLEV 150
VMAIEAGLGD LPLLPFSSPS SPWSSDPFSF LQSVCHTVVV QGVSALLAFP 200
QSQGEMMELD LVSLVLHIPV ISIVRHEFPR ESQNPLHLQL SLENSLSSDA 250
DVTVSILTMN NWYNFSLLLC QEDWNITDFL LLTQNNSKFH LGSIINITAN 300
LPSTQDLLSF LQIQLESIKN STPTVVMFGC DMESIRRIFE ITTQFGVMPP 350
ELRWVLGDSQ NVEELRTEGL PLGLIAHGKT TQSVFEHYVQ DAMELVARAV 400
ATATMIQPEL ALIPSTMNCM EVETTNLTSG QYLSRFLANT TFRGLSGSIR 450
VKGSTIVSSE NNFFIWNLQH DPMGKPMWTR LGSWQGGKIV MDYGIWPEQA 500
QRHKTHFQHP SKLHLRVVTL IEHPFVFTRE VDDEGLCPAG QLCLDPMTND 550
SSTLDSLFSS LHSSNDTVPI KFKKCCYGYC IDLLEKIAED MNFDFDLYIV 600
GDGKYGAWKN GHWTGLVGDL LRGTAHMAVT SFSINTARSQ VIDFTSPFFS 650
TSLGILVRTR DTAAPIGAFM WPLHWTMWLG IFVALHITAV FLTLYEWKSP 700
FGLTPKGRNR SKVFSFSSAL NICYALLFGR TVAIKPPKCW TGRFLMNLWA 750
IFCMFCLSTY TANLAAVMVG EKIYEELSGI HDPKLHHPSQ GFRFGTVRES 800
SAEDYVRQSF PEMHEYMRRY NVPATPDGVE YLKNDPEKLD AFIMDKALLD 850
YEVSIDADCK LLTVGKPFAI EGYGIGLPPN SPLTANISEL ISQYKSHGFM 900
DMLHDKWYRV VPCGKRSFAV TETLQMGIKH FSGLFVLLCI GFGLSILTTI 950
GEHIVYRLLL PRIKNKSKLQ YWLHTSQRLH RAINTSFIEE KQQHFKTKRV 1000
EKRSNVGPRQ LTVWNTSNLS HDNRRKYIFS DEEGQNQLGI RIHQDIPLPP 1050
RRRELPALRT TNGKADSLNV SRNSVMQELS ELEKQIQVIR QELQLAVSRK 1100
TELEEYQRTS RTCES 1115
Length:1,115
Mass (Da):125,465
Last modified:November 4, 2008 - v2
Checksum:i0FEEC995F6AAF940
GO

Sequence cautioni

The sequence BAB85559.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti362 – 3621V → M.1 Publication
Corresponds to variant rs10989591 [ dbSNP | Ensembl ].
VAR_019672
Natural varianti480 – 4801R → H.
Corresponds to variant rs34755188 [ dbSNP | Ensembl ].
VAR_047150
Natural varianti487 – 4871G → R.2 Publications
Corresponds to variant rs10989589 [ dbSNP | Ensembl ].
VAR_019673
Natural varianti835 – 8351D → N.1 Publication
Corresponds to variant rs10989563 [ dbSNP | Ensembl ].
VAR_019674
Natural varianti1041 – 10411R → Q.2 Publications
Corresponds to variant rs3739722 [ dbSNP | Ensembl ].
VAR_019675

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti559 – 5591S → N in AAL40734. 1 Publication
Sequence conflicti977 – 9771Q → R in AAL40734. 1 Publication
Sequence conflicti1073 – 10731N → I in AAL40734. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF416558 mRNA. Translation: AAL40734.1.
AJ416950 mRNA. Translation: CAC95229.2.
AB075853 mRNA. Translation: BAB85559.1. Different initiation.
AL591377, AL356516 Genomic DNA. Translation: CAH69962.1.
AL356516, AL591377 Genomic DNA. Translation: CAI16651.1.
BC167432 mRNA. Translation: AAI67432.1.
CCDSiCCDS6758.1.
RefSeqiNP_597702.2. NM_133445.2.
UniGeneiHs.654783.

Genome annotation databases

EnsembliENST00000361820; ENSP00000355155; ENSG00000198785.
GeneIDi116443.
KEGGihsa:116443.
UCSCiuc004bbp.2. human.

Polymorphism databases

DMDMi212276445.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF416558 mRNA. Translation: AAL40734.1 .
AJ416950 mRNA. Translation: CAC95229.2 .
AB075853 mRNA. Translation: BAB85559.1 . Different initiation.
AL591377 , AL356516 Genomic DNA. Translation: CAH69962.1 .
AL356516 , AL591377 Genomic DNA. Translation: CAI16651.1 .
BC167432 mRNA. Translation: AAI67432.1 .
CCDSi CCDS6758.1.
RefSeqi NP_597702.2. NM_133445.2.
UniGenei Hs.654783.

3D structure databases

ProteinModelPortali Q8TCU5.
SMRi Q8TCU5. Positions 143-497, 512-952.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125508. 3 interactions.
MINTi MINT-6630950.
STRINGi 9606.ENSP00000355155.

Chemistry

BindingDBi Q8TCU5.
ChEMBLi CHEMBL4787.
DrugBanki DB00659. Acamprosate.
DB01161. Chloroprocaine.
DB00514. Dextromethorphan.
DB00898. Ethanol.
DB00392. Ethopropazine.
DB00949. Felbamate.
DB01221. Ketamine.
DB00142. L-Glutamic Acid.
DB01043. Memantine.
DB00454. Meperidine.
DB00333. Methadone.
DB01173. Orphenadrine.
DB00721. Procaine.
DB00740. Riluzole.
GuidetoPHARMACOLOGYi 460.

PTM databases

PhosphoSitei Q8TCU5.

Polymorphism databases

DMDMi 212276445.

Proteomic databases

PaxDbi Q8TCU5.
PRIDEi Q8TCU5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361820 ; ENSP00000355155 ; ENSG00000198785 .
GeneIDi 116443.
KEGGi hsa:116443.
UCSCi uc004bbp.2. human.

Organism-specific databases

CTDi 116443.
GeneCardsi GC09M104331.
H-InvDB HIX0008248.
HIX0125606.
HGNCi HGNC:16767. GRIN3A.
MIMi 606650. gene.
neXtProti NX_Q8TCU5.
PharmGKBi PA28983.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG320645.
HOGENOMi HOG000231528.
HOVERGENi HBG052634.
InParanoidi Q8TCU5.
KOi K05213.
OMAi TQFGVMP.
OrthoDBi EOG7QK0B4.
PhylomeDBi Q8TCU5.
TreeFami TF314731.

Miscellaneous databases

GeneWikii GRIN3A.
GenomeRNAii 116443.
NextBioi 79919.
PROi Q8TCU5.
SOURCEi Search...

Gene expression databases

Bgeei Q8TCU5.
CleanExi HS_GRIN3A.
Genevestigatori Q8TCU5.

Family and domain databases

InterProi IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
IPR001638. SBP_bac_3.
[Graphical view ]
Pfami PF00060. Lig_chan. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view ]
PRINTSi PR00177. NMDARECEPTOR.
SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view ]
SUPFAMi SSF53822. SSF53822. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence, genomic organization, and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B."
    Andersson O., Stenqvist A., Attersand A., von Euler G.
    Genomics 78:178-184(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-487.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS MET-362; ARG-487 AND ASN-835, TISSUE SPECIFICITY.
    Tissue: Brain.
  3. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-1041.
    Tissue: Brain.
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-1041.
  6. "Expression of the NR3A subunit of the NMDA receptor in human fetal brain."
    Mueller H.T., Meador-Woodruff J.H.
    Ann. N. Y. Acad. Sci. 1003:448-451(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "An NMDA receptor signaling complex with protein phosphatase 2A."
    Chan S.F., Sucher N.J.
    J. Neurosci. 21:7985-7992(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PPP2CB.

Entry informationi

Entry nameiNMD3A_HUMAN
AccessioniPrimary (citable) accession number: Q8TCU5
Secondary accession number(s): B3DLF9
, Q5VTR3, Q8TF29, Q8WXI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: November 4, 2008
Last modified: July 9, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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