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Q8TCU5

- NMD3A_HUMAN

UniProt

Q8TCU5 - NMD3A_HUMAN

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Protein

Glutamate receptor ionotropic, NMDA 3A

Gene

GRIN3A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity).By similarity

GO - Molecular functioni

  1. calcium channel activity Source: Ensembl
  2. extracellular-glutamate-gated ion channel activity Source: RefGenome
  3. glycine binding Source: UniProtKB
  4. identical protein binding Source: UniProtKB
  5. neurotransmitter binding Source: Ensembl
  6. N-methyl-D-aspartate selective glutamate receptor activity Source: UniProtKB
  7. protein phosphatase 2A binding Source: UniProtKB

GO - Biological processi

  1. calcium ion transport Source: UniProtKB
  2. dendrite development Source: Ensembl
  3. ionotropic glutamate receptor signaling pathway Source: RefGenome
  4. ion transmembrane transport Source: RefGenome
  5. prepulse inhibition Source: Ensembl
  6. response to ethanol Source: UniProtKB
  7. rhythmic process Source: Ensembl
  8. synaptic transmission, glutamatergic Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calcium, Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, NMDA 3A
Short name:
GluN3A
Alternative name(s):
N-methyl-D-aspartate receptor subtype 3A
Short name:
NMDAR3A
Short name:
NR3A
NMDAR-L
Gene namesi
Name:GRIN3A
Synonyms:KIAA1973
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:16767. GRIN3A.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity
Note: Enriched in postsynaptic plasma membrane and postsynaptic densities. Requires the presence of GRIN1 to be targeted at the plasma membrane (By similarity).By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. dendrite Source: RefGenome
  3. integral component of membrane Source: UniProtKB
  4. membrane Source: UniProtKB
  5. neuronal cell body Source: UniProtKB
  6. neuron projection Source: UniProtKB
  7. N-methyl-D-aspartate selective glutamate receptor complex Source: UniProtKB
  8. postsynaptic membrane Source: RefGenome
  9. synapse Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28983.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 11151092Glutamate receptor ionotropic, NMDA 3APRO_0000011568Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi275 – 2751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi426 – 4261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi439 – 4391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi549 – 5491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi565 – 5651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi886 – 8861N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8TCU5.
PRIDEiQ8TCU5.

PTM databases

PhosphoSiteiQ8TCU5.

Expressioni

Developmental stagei

Expressed in fetal brain.

Gene expression databases

BgeeiQ8TCU5.
CleanExiHS_GRIN3A.
GenevestigatoriQ8TCU5.

Interactioni

Subunit structurei

Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex with GRIN1, GRIN2A or GRIN2B and PPP2CB. Probably interacts with PPP2CB. No complex with PPP2CB is detected when NMDARs are stimulated by NMDA (By similarity).By similarity

Protein-protein interaction databases

BioGridi125508. 3 interactions.
MINTiMINT-6630950.
STRINGi9606.ENSP00000355155.

Structurei

3D structure databases

ProteinModelPortaliQ8TCU5.
SMRiQ8TCU5. Positions 116-957.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 674651ExtracellularSequence AnalysisAdd
BLAST
Topological domaini696 – 74853CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini770 – 930161ExtracellularSequence AnalysisAdd
BLAST
Topological domaini952 – 1115164CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei675 – 69521HelicalSequence AnalysisAdd
BLAST
Transmembranei749 – 76921HelicalSequence AnalysisAdd
BLAST
Transmembranei931 – 95121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni951 – 98737PPP2CB binding siteBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1058 – 110952Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320645.
GeneTreeiENSGT00760000119186.
HOGENOMiHOG000231528.
HOVERGENiHBG052634.
InParanoidiQ8TCU5.
KOiK05213.
OMAiTQFGVMP.
OrthoDBiEOG7QK0B4.
PhylomeDBiQ8TCU5.
TreeFamiTF314731.

Family and domain databases

InterProiIPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
IPR001638. SBP_bac_3.
[Graphical view]
PfamiPF00060. Lig_chan. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TCU5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRRLSLWWLL SRVCLLLPPP CALVLAGVPS SSSHPQPCQI LKRIGHAVRV
60 70 80 90 100
GAVHLQPWTT APRAASRAPD DSRAGAQRDE PEPGTRRSPA PSPGARWLGS
110 120 130 140 150
TLHGRGPPGS RKPGEGARAE ALWPRDALLF AVDNLNRVEG LLPYNLSLEV
160 170 180 190 200
VMAIEAGLGD LPLLPFSSPS SPWSSDPFSF LQSVCHTVVV QGVSALLAFP
210 220 230 240 250
QSQGEMMELD LVSLVLHIPV ISIVRHEFPR ESQNPLHLQL SLENSLSSDA
260 270 280 290 300
DVTVSILTMN NWYNFSLLLC QEDWNITDFL LLTQNNSKFH LGSIINITAN
310 320 330 340 350
LPSTQDLLSF LQIQLESIKN STPTVVMFGC DMESIRRIFE ITTQFGVMPP
360 370 380 390 400
ELRWVLGDSQ NVEELRTEGL PLGLIAHGKT TQSVFEHYVQ DAMELVARAV
410 420 430 440 450
ATATMIQPEL ALIPSTMNCM EVETTNLTSG QYLSRFLANT TFRGLSGSIR
460 470 480 490 500
VKGSTIVSSE NNFFIWNLQH DPMGKPMWTR LGSWQGGKIV MDYGIWPEQA
510 520 530 540 550
QRHKTHFQHP SKLHLRVVTL IEHPFVFTRE VDDEGLCPAG QLCLDPMTND
560 570 580 590 600
SSTLDSLFSS LHSSNDTVPI KFKKCCYGYC IDLLEKIAED MNFDFDLYIV
610 620 630 640 650
GDGKYGAWKN GHWTGLVGDL LRGTAHMAVT SFSINTARSQ VIDFTSPFFS
660 670 680 690 700
TSLGILVRTR DTAAPIGAFM WPLHWTMWLG IFVALHITAV FLTLYEWKSP
710 720 730 740 750
FGLTPKGRNR SKVFSFSSAL NICYALLFGR TVAIKPPKCW TGRFLMNLWA
760 770 780 790 800
IFCMFCLSTY TANLAAVMVG EKIYEELSGI HDPKLHHPSQ GFRFGTVRES
810 820 830 840 850
SAEDYVRQSF PEMHEYMRRY NVPATPDGVE YLKNDPEKLD AFIMDKALLD
860 870 880 890 900
YEVSIDADCK LLTVGKPFAI EGYGIGLPPN SPLTANISEL ISQYKSHGFM
910 920 930 940 950
DMLHDKWYRV VPCGKRSFAV TETLQMGIKH FSGLFVLLCI GFGLSILTTI
960 970 980 990 1000
GEHIVYRLLL PRIKNKSKLQ YWLHTSQRLH RAINTSFIEE KQQHFKTKRV
1010 1020 1030 1040 1050
EKRSNVGPRQ LTVWNTSNLS HDNRRKYIFS DEEGQNQLGI RIHQDIPLPP
1060 1070 1080 1090 1100
RRRELPALRT TNGKADSLNV SRNSVMQELS ELEKQIQVIR QELQLAVSRK
1110
TELEEYQRTS RTCES
Length:1,115
Mass (Da):125,465
Last modified:November 4, 2008 - v2
Checksum:i0FEEC995F6AAF940
GO

Sequence cautioni

The sequence BAB85559.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti559 – 5591S → N in AAL40734. (PubMed:11735224)Curated
Sequence conflicti977 – 9771Q → R in AAL40734. (PubMed:11735224)Curated
Sequence conflicti1073 – 10731N → I in AAL40734. (PubMed:11735224)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti362 – 3621V → M.1 Publication
Corresponds to variant rs10989591 [ dbSNP | Ensembl ].
VAR_019672
Natural varianti480 – 4801R → H.
Corresponds to variant rs34755188 [ dbSNP | Ensembl ].
VAR_047150
Natural varianti487 – 4871G → R.2 Publications
Corresponds to variant rs10989589 [ dbSNP | Ensembl ].
VAR_019673
Natural varianti835 – 8351D → N.1 Publication
Corresponds to variant rs10989563 [ dbSNP | Ensembl ].
VAR_019674
Natural varianti1041 – 10411R → Q.2 Publications
Corresponds to variant rs3739722 [ dbSNP | Ensembl ].
VAR_019675

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF416558 mRNA. Translation: AAL40734.1.
AJ416950 mRNA. Translation: CAC95229.2.
AB075853 mRNA. Translation: BAB85559.1. Different initiation.
AL591377, AL356516 Genomic DNA. Translation: CAH69962.1.
AL356516, AL591377 Genomic DNA. Translation: CAI16651.1.
BC167432 mRNA. Translation: AAI67432.1.
CCDSiCCDS6758.1.
RefSeqiNP_597702.2. NM_133445.2.
UniGeneiHs.654783.

Genome annotation databases

EnsembliENST00000361820; ENSP00000355155; ENSG00000198785.
GeneIDi116443.
KEGGihsa:116443.
UCSCiuc004bbp.2. human.

Polymorphism databases

DMDMi212276445.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF416558 mRNA. Translation: AAL40734.1 .
AJ416950 mRNA. Translation: CAC95229.2 .
AB075853 mRNA. Translation: BAB85559.1 . Different initiation.
AL591377 , AL356516 Genomic DNA. Translation: CAH69962.1 .
AL356516 , AL591377 Genomic DNA. Translation: CAI16651.1 .
BC167432 mRNA. Translation: AAI67432.1 .
CCDSi CCDS6758.1.
RefSeqi NP_597702.2. NM_133445.2.
UniGenei Hs.654783.

3D structure databases

ProteinModelPortali Q8TCU5.
SMRi Q8TCU5. Positions 116-957.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125508. 3 interactions.
MINTi MINT-6630950.
STRINGi 9606.ENSP00000355155.

Chemistry

BindingDBi Q8TCU5.
ChEMBLi CHEMBL2094124.
DrugBanki DB00659. Acamprosate.
DB06151. Acetylcysteine.
DB00915. Amantadine.
DB00289. Atomoxetine.
DB01161. Chloroprocaine.
DB00514. Dextromethorphan.
DB00898. Ethanol.
DB00392. Ethopropazine.
DB00949. Felbamate.
DB00996. Gabapentin.
DB01159. Halothane.
DB01221. Ketamine.
DB06738. Ketobemidone.
DB01043. Memantine.
DB00333. Methadone.
DB04896. Milnacipran.
DB01173. Orphenadrine.
DB00312. Pentobarbital.
DB01174. Phenobarbital.
DB00721. Procaine.
DB00418. Secobarbital.
DB00193. Tramadol.
GuidetoPHARMACOLOGYi 460.

PTM databases

PhosphoSitei Q8TCU5.

Polymorphism databases

DMDMi 212276445.

Proteomic databases

PaxDbi Q8TCU5.
PRIDEi Q8TCU5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361820 ; ENSP00000355155 ; ENSG00000198785 .
GeneIDi 116443.
KEGGi hsa:116443.
UCSCi uc004bbp.2. human.

Organism-specific databases

CTDi 116443.
GeneCardsi GC09M104331.
H-InvDB HIX0008248.
HIX0125606.
HGNCi HGNC:16767. GRIN3A.
MIMi 606650. gene.
neXtProti NX_Q8TCU5.
PharmGKBi PA28983.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG320645.
GeneTreei ENSGT00760000119186.
HOGENOMi HOG000231528.
HOVERGENi HBG052634.
InParanoidi Q8TCU5.
KOi K05213.
OMAi TQFGVMP.
OrthoDBi EOG7QK0B4.
PhylomeDBi Q8TCU5.
TreeFami TF314731.

Miscellaneous databases

GeneWikii GRIN3A.
GenomeRNAii 116443.
NextBioi 79919.
PROi Q8TCU5.
SOURCEi Search...

Gene expression databases

Bgeei Q8TCU5.
CleanExi HS_GRIN3A.
Genevestigatori Q8TCU5.

Family and domain databases

InterProi IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
IPR001638. SBP_bac_3.
[Graphical view ]
Pfami PF00060. Lig_chan. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view ]
PRINTSi PR00177. NMDARECEPTOR.
SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view ]
SUPFAMi SSF53822. SSF53822. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence, genomic organization, and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B."
    Andersson O., Stenqvist A., Attersand A., von Euler G.
    Genomics 78:178-184(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-487.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS MET-362; ARG-487 AND ASN-835, TISSUE SPECIFICITY.
    Tissue: Brain.
  3. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-1041.
    Tissue: Brain.
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-1041.
  6. "Expression of the NR3A subunit of the NMDA receptor in human fetal brain."
    Mueller H.T., Meador-Woodruff J.H.
    Ann. N. Y. Acad. Sci. 1003:448-451(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "An NMDA receptor signaling complex with protein phosphatase 2A."
    Chan S.F., Sucher N.J.
    J. Neurosci. 21:7985-7992(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PPP2CB.

Entry informationi

Entry nameiNMD3A_HUMAN
AccessioniPrimary (citable) accession number: Q8TCU5
Secondary accession number(s): B3DLF9
, Q5VTR3, Q8TF29, Q8WXI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: November 4, 2008
Last modified: October 29, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3