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Protein

Glutamate receptor ionotropic, NMDA 3A

Gene

GRIN3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity).By similarity

GO - Molecular functioni

  • calcium channel activity Source: Ensembl
  • extracellular-glutamate-gated ion channel activity Source: InterPro
  • glycine binding Source: UniProtKB
  • identical protein binding Source: UniProtKB
  • NMDA glutamate receptor activity Source: UniProtKB
  • protein phosphatase 2A binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calcium, Magnesium

Enzyme and pathway databases

BioCyciZFISH:G66-33690-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, NMDA 3A
Short name:
GluN3A
Alternative name(s):
N-methyl-D-aspartate receptor subtype 3A
Short name:
NMDAR3A
Short name:
NR3A
NMDAR-L
Gene namesi
Name:GRIN3A
Synonyms:KIAA1973
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:16767. GRIN3A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 674ExtracellularSequence analysisAdd BLAST651
Transmembranei675 – 695HelicalSequence analysisAdd BLAST21
Topological domaini696 – 748CytoplasmicSequence analysisAdd BLAST53
Transmembranei749 – 769HelicalSequence analysisAdd BLAST21
Topological domaini770 – 930ExtracellularSequence analysisAdd BLAST161
Transmembranei931 – 951HelicalSequence analysisAdd BLAST21
Topological domaini952 – 1115CytoplasmicSequence analysisAdd BLAST164

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • integral component of membrane Source: UniProtKB
  • membrane Source: UniProtKB
  • neuronal cell body Source: UniProtKB
  • neuron projection Source: UniProtKB
  • NMDA selective glutamate receptor complex Source: UniProtKB
  • postsynaptic density Source: UniProtKB-SubCell
  • postsynaptic membrane Source: UniProtKB-SubCell
  • synapse Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi116443.
OpenTargetsiENSG00000198785.
PharmGKBiPA28983.

Chemistry databases

ChEMBLiCHEMBL4787.
DrugBankiDB00659. Acamprosate.
DB06151. Acetylcysteine.
DB00915. Amantadine.
DB00289. Atomoxetine.
DB01161. Chloroprocaine.
DB00514. Dextromethorphan.
DB00898. Ethanol.
DB00392. Ethopropazine.
DB00949. Felbamate.
DB00996. Gabapentin.
DB01159. Halothane.
DB01221. Ketamine.
DB06738. Ketobemidone.
DB01043. Memantine.
DB00333. Methadone.
DB04896. Milnacipran.
DB01173. Orphenadrine.
DB00312. Pentobarbital.
DB01174. Phenobarbital.
DB00721. Procaine.
DB00418. Secobarbital.
DB00193. Tramadol.

Polymorphism and mutation databases

BioMutaiGRIN3A.
DMDMi212276445.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001156824 – 1115Glutamate receptor ionotropic, NMDA 3AAdd BLAST1092

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi145N-linked (GlcNAc...)Sequence analysis1
Glycosylationi264N-linked (GlcNAc...)Sequence analysis1
Glycosylationi275N-linked (GlcNAc...)Sequence analysis1
Glycosylationi285N-linked (GlcNAc...)Sequence analysis1
Glycosylationi296N-linked (GlcNAc...)Sequence analysis1
Glycosylationi426N-linked (GlcNAc...)Sequence analysis1
Glycosylationi439N-linked (GlcNAc...)Sequence analysis1
Glycosylationi549N-linked (GlcNAc...)Sequence analysis1
Glycosylationi565N-linked (GlcNAc...)Sequence analysis1
Glycosylationi886N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8TCU5.
PeptideAtlasiQ8TCU5.
PRIDEiQ8TCU5.

PTM databases

iPTMnetiQ8TCU5.
PhosphoSitePlusiQ8TCU5.

Expressioni

Developmental stagei

Expressed in fetal brain.

Gene expression databases

BgeeiENSG00000198785.
CleanExiHS_GRIN3A.
GenevisibleiQ8TCU5. HS.

Interactioni

Subunit structurei

Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex with GRIN1, GRIN2A or GRIN2B and PPP2CB. Probably interacts with PPP2CB. No complex with PPP2CB is detected when NMDARs are stimulated by NMDA (By similarity).By similarity

GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • protein phosphatase 2A binding Source: UniProtKB

Protein-protein interaction databases

BioGridi125508. 2 interactors.
MINTiMINT-6630950.
STRINGi9606.ENSP00000355155.

Structurei

3D structure databases

ProteinModelPortaliQ8TCU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni951 – 987PPP2CB binding siteBy similarityAdd BLAST37

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1058 – 1109Sequence analysisAdd BLAST52

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1053. Eukaryota.
ENOG410XNUR. LUCA.
GeneTreeiENSGT00760000119186.
HOGENOMiHOG000231528.
HOVERGENiHBG052634.
InParanoidiQ8TCU5.
KOiK05213.
OMAiTQFGVMP.
OrthoDBiEOG091G00PT.
PhylomeDBiQ8TCU5.
TreeFamiTF314731.

Family and domain databases

InterProiIPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TCU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRLSLWWLL SRVCLLLPPP CALVLAGVPS SSSHPQPCQI LKRIGHAVRV
60 70 80 90 100
GAVHLQPWTT APRAASRAPD DSRAGAQRDE PEPGTRRSPA PSPGARWLGS
110 120 130 140 150
TLHGRGPPGS RKPGEGARAE ALWPRDALLF AVDNLNRVEG LLPYNLSLEV
160 170 180 190 200
VMAIEAGLGD LPLLPFSSPS SPWSSDPFSF LQSVCHTVVV QGVSALLAFP
210 220 230 240 250
QSQGEMMELD LVSLVLHIPV ISIVRHEFPR ESQNPLHLQL SLENSLSSDA
260 270 280 290 300
DVTVSILTMN NWYNFSLLLC QEDWNITDFL LLTQNNSKFH LGSIINITAN
310 320 330 340 350
LPSTQDLLSF LQIQLESIKN STPTVVMFGC DMESIRRIFE ITTQFGVMPP
360 370 380 390 400
ELRWVLGDSQ NVEELRTEGL PLGLIAHGKT TQSVFEHYVQ DAMELVARAV
410 420 430 440 450
ATATMIQPEL ALIPSTMNCM EVETTNLTSG QYLSRFLANT TFRGLSGSIR
460 470 480 490 500
VKGSTIVSSE NNFFIWNLQH DPMGKPMWTR LGSWQGGKIV MDYGIWPEQA
510 520 530 540 550
QRHKTHFQHP SKLHLRVVTL IEHPFVFTRE VDDEGLCPAG QLCLDPMTND
560 570 580 590 600
SSTLDSLFSS LHSSNDTVPI KFKKCCYGYC IDLLEKIAED MNFDFDLYIV
610 620 630 640 650
GDGKYGAWKN GHWTGLVGDL LRGTAHMAVT SFSINTARSQ VIDFTSPFFS
660 670 680 690 700
TSLGILVRTR DTAAPIGAFM WPLHWTMWLG IFVALHITAV FLTLYEWKSP
710 720 730 740 750
FGLTPKGRNR SKVFSFSSAL NICYALLFGR TVAIKPPKCW TGRFLMNLWA
760 770 780 790 800
IFCMFCLSTY TANLAAVMVG EKIYEELSGI HDPKLHHPSQ GFRFGTVRES
810 820 830 840 850
SAEDYVRQSF PEMHEYMRRY NVPATPDGVE YLKNDPEKLD AFIMDKALLD
860 870 880 890 900
YEVSIDADCK LLTVGKPFAI EGYGIGLPPN SPLTANISEL ISQYKSHGFM
910 920 930 940 950
DMLHDKWYRV VPCGKRSFAV TETLQMGIKH FSGLFVLLCI GFGLSILTTI
960 970 980 990 1000
GEHIVYRLLL PRIKNKSKLQ YWLHTSQRLH RAINTSFIEE KQQHFKTKRV
1010 1020 1030 1040 1050
EKRSNVGPRQ LTVWNTSNLS HDNRRKYIFS DEEGQNQLGI RIHQDIPLPP
1060 1070 1080 1090 1100
RRRELPALRT TNGKADSLNV SRNSVMQELS ELEKQIQVIR QELQLAVSRK
1110
TELEEYQRTS RTCES
Length:1,115
Mass (Da):125,465
Last modified:November 4, 2008 - v2
Checksum:i0FEEC995F6AAF940
GO

Sequence cautioni

The sequence BAB85559 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti559S → N in AAL40734 (PubMed:11735224).Curated1
Sequence conflicti977Q → R in AAL40734 (PubMed:11735224).Curated1
Sequence conflicti1073N → I in AAL40734 (PubMed:11735224).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019672362V → M.1 PublicationCorresponds to variant rs10989591dbSNPEnsembl.1
Natural variantiVAR_047150480R → H.Corresponds to variant rs34755188dbSNPEnsembl.1
Natural variantiVAR_019673487G → R.2 PublicationsCorresponds to variant rs10989589dbSNPEnsembl.1
Natural variantiVAR_019674835D → N.1 PublicationCorresponds to variant rs10989563dbSNPEnsembl.1
Natural variantiVAR_0196751041R → Q.2 PublicationsCorresponds to variant rs3739722dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF416558 mRNA. Translation: AAL40734.1.
AJ416950 mRNA. Translation: CAC95229.2.
AB075853 mRNA. Translation: BAB85559.1. Different initiation.
AL591377, AL356516 Genomic DNA. Translation: CAH69962.1.
AL356516, AL591377 Genomic DNA. Translation: CAI16651.1.
BC167432 mRNA. Translation: AAI67432.1.
CCDSiCCDS6758.1.
RefSeqiNP_597702.2. NM_133445.2.
UniGeneiHs.654783.

Genome annotation databases

EnsembliENST00000361820; ENSP00000355155; ENSG00000198785.
GeneIDi116443.
KEGGihsa:116443.
UCSCiuc004bbp.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF416558 mRNA. Translation: AAL40734.1.
AJ416950 mRNA. Translation: CAC95229.2.
AB075853 mRNA. Translation: BAB85559.1. Different initiation.
AL591377, AL356516 Genomic DNA. Translation: CAH69962.1.
AL356516, AL591377 Genomic DNA. Translation: CAI16651.1.
BC167432 mRNA. Translation: AAI67432.1.
CCDSiCCDS6758.1.
RefSeqiNP_597702.2. NM_133445.2.
UniGeneiHs.654783.

3D structure databases

ProteinModelPortaliQ8TCU5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125508. 2 interactors.
MINTiMINT-6630950.
STRINGi9606.ENSP00000355155.

Chemistry databases

ChEMBLiCHEMBL4787.
DrugBankiDB00659. Acamprosate.
DB06151. Acetylcysteine.
DB00915. Amantadine.
DB00289. Atomoxetine.
DB01161. Chloroprocaine.
DB00514. Dextromethorphan.
DB00898. Ethanol.
DB00392. Ethopropazine.
DB00949. Felbamate.
DB00996. Gabapentin.
DB01159. Halothane.
DB01221. Ketamine.
DB06738. Ketobemidone.
DB01043. Memantine.
DB00333. Methadone.
DB04896. Milnacipran.
DB01173. Orphenadrine.
DB00312. Pentobarbital.
DB01174. Phenobarbital.
DB00721. Procaine.
DB00418. Secobarbital.
DB00193. Tramadol.

PTM databases

iPTMnetiQ8TCU5.
PhosphoSitePlusiQ8TCU5.

Polymorphism and mutation databases

BioMutaiGRIN3A.
DMDMi212276445.

Proteomic databases

PaxDbiQ8TCU5.
PeptideAtlasiQ8TCU5.
PRIDEiQ8TCU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361820; ENSP00000355155; ENSG00000198785.
GeneIDi116443.
KEGGihsa:116443.
UCSCiuc004bbp.3. human.

Organism-specific databases

CTDi116443.
DisGeNETi116443.
GeneCardsiGRIN3A.
H-InvDBHIX0008248.
HIX0125606.
HGNCiHGNC:16767. GRIN3A.
MIMi606650. gene.
neXtProtiNX_Q8TCU5.
OpenTargetsiENSG00000198785.
PharmGKBiPA28983.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1053. Eukaryota.
ENOG410XNUR. LUCA.
GeneTreeiENSGT00760000119186.
HOGENOMiHOG000231528.
HOVERGENiHBG052634.
InParanoidiQ8TCU5.
KOiK05213.
OMAiTQFGVMP.
OrthoDBiEOG091G00PT.
PhylomeDBiQ8TCU5.
TreeFamiTF314731.

Enzyme and pathway databases

BioCyciZFISH:G66-33690-MONOMER.

Miscellaneous databases

GeneWikiiGRIN3A.
GenomeRNAii116443.
PROiQ8TCU5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198785.
CleanExiHS_GRIN3A.
GenevisibleiQ8TCU5. HS.

Family and domain databases

InterProiIPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNMD3A_HUMAN
AccessioniPrimary (citable) accession number: Q8TCU5
Secondary accession number(s): B3DLF9
, Q5VTR3, Q8TF29, Q8WXI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: November 4, 2008
Last modified: November 2, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.