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Q8TCU5

- NMD3A_HUMAN

UniProt

Q8TCU5 - NMD3A_HUMAN

Protein

Glutamate receptor ionotropic, NMDA 3A

Gene

GRIN3A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (04 Nov 2008)
      Previous versions | rss
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    Functioni

    NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism By similarity.By similarity

    GO - Molecular functioni

    1. calcium channel activity Source: Ensembl
    2. extracellular-glutamate-gated ion channel activity Source: RefGenome
    3. glycine binding Source: UniProtKB
    4. identical protein binding Source: UniProtKB
    5. neurotransmitter binding Source: Ensembl
    6. N-methyl-D-aspartate selective glutamate receptor activity Source: UniProtKB
    7. protein binding Source: UniProtKB
    8. protein phosphatase 2A binding Source: UniProtKB

    GO - Biological processi

    1. calcium ion transport Source: UniProtKB
    2. dendrite development Source: Ensembl
    3. ionotropic glutamate receptor signaling pathway Source: RefGenome
    4. ion transmembrane transport Source: RefGenome
    5. prepulse inhibition Source: Ensembl
    6. response to ethanol Source: UniProtKB
    7. rhythmic process Source: Ensembl
    8. synaptic transmission, glutamatergic Source: RefGenome

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Calcium, Magnesium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate receptor ionotropic, NMDA 3A
    Short name:
    GluN3A
    Alternative name(s):
    N-methyl-D-aspartate receptor subtype 3A
    Short name:
    NMDAR3A
    Short name:
    NR3A
    NMDAR-L
    Gene namesi
    Name:GRIN3A
    Synonyms:KIAA1973
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:16767. GRIN3A.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity
    Note: Enriched in postsynaptic plasma membrane and postsynaptic densities. Requires the presence of GRIN1 to be targeted at the plasma membrane By similarity.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. dendrite Source: RefGenome
    3. integral component of membrane Source: UniProtKB
    4. membrane Source: UniProtKB
    5. neuronal cell body Source: UniProtKB
    6. neuron projection Source: UniProtKB
    7. N-methyl-D-aspartate selective glutamate receptor complex Source: UniProtKB
    8. postsynaptic density Source: UniProtKB-SubCell
    9. postsynaptic membrane Source: RefGenome
    10. synapse Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28983.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 11151092Glutamate receptor ionotropic, NMDA 3APRO_0000011568Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi275 – 2751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi426 – 4261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi439 – 4391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi549 – 5491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi565 – 5651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi886 – 8861N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8TCU5.
    PRIDEiQ8TCU5.

    PTM databases

    PhosphoSiteiQ8TCU5.

    Expressioni

    Developmental stagei

    Expressed in fetal brain.

    Gene expression databases

    BgeeiQ8TCU5.
    CleanExiHS_GRIN3A.
    GenevestigatoriQ8TCU5.

    Interactioni

    Subunit structurei

    Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex with GRIN1, GRIN2A or GRIN2B and PPP2CB. Probably interacts with PPP2CB. No complex with PPP2CB is detected when NMDARs are stimulated by NMDA By similarity.By similarity

    Protein-protein interaction databases

    BioGridi125508. 3 interactions.
    MINTiMINT-6630950.
    STRINGi9606.ENSP00000355155.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TCU5.
    SMRiQ8TCU5. Positions 143-497, 512-952.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 674651ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini696 – 74853CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini770 – 930161ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini952 – 1115164CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei675 – 69521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei749 – 76921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei931 – 95121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni951 – 98737PPP2CB binding siteBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1058 – 110952Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Coiled coil, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320645.
    HOGENOMiHOG000231528.
    HOVERGENiHBG052634.
    InParanoidiQ8TCU5.
    KOiK05213.
    OMAiTQFGVMP.
    OrthoDBiEOG7QK0B4.
    PhylomeDBiQ8TCU5.
    TreeFamiTF314731.

    Family and domain databases

    InterProiIPR019594. Glu_rcpt_Glu/Gly-bd.
    IPR001320. Iontro_glu_rcpt.
    IPR001508. NMDA_rcpt.
    IPR028082. Peripla_BP_I.
    IPR001638. SBP_bac_3.
    [Graphical view]
    PfamiPF00060. Lig_chan. 1 hit.
    PF00497. SBP_bac_3. 1 hit.
    [Graphical view]
    PRINTSiPR00177. NMDARECEPTOR.
    SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
    SM00079. PBPe. 1 hit.
    [Graphical view]
    SUPFAMiSSF53822. SSF53822. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8TCU5-1 [UniParc]FASTAAdd to Basket

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    MRRLSLWWLL SRVCLLLPPP CALVLAGVPS SSSHPQPCQI LKRIGHAVRV     50
    GAVHLQPWTT APRAASRAPD DSRAGAQRDE PEPGTRRSPA PSPGARWLGS 100
    TLHGRGPPGS RKPGEGARAE ALWPRDALLF AVDNLNRVEG LLPYNLSLEV 150
    VMAIEAGLGD LPLLPFSSPS SPWSSDPFSF LQSVCHTVVV QGVSALLAFP 200
    QSQGEMMELD LVSLVLHIPV ISIVRHEFPR ESQNPLHLQL SLENSLSSDA 250
    DVTVSILTMN NWYNFSLLLC QEDWNITDFL LLTQNNSKFH LGSIINITAN 300
    LPSTQDLLSF LQIQLESIKN STPTVVMFGC DMESIRRIFE ITTQFGVMPP 350
    ELRWVLGDSQ NVEELRTEGL PLGLIAHGKT TQSVFEHYVQ DAMELVARAV 400
    ATATMIQPEL ALIPSTMNCM EVETTNLTSG QYLSRFLANT TFRGLSGSIR 450
    VKGSTIVSSE NNFFIWNLQH DPMGKPMWTR LGSWQGGKIV MDYGIWPEQA 500
    QRHKTHFQHP SKLHLRVVTL IEHPFVFTRE VDDEGLCPAG QLCLDPMTND 550
    SSTLDSLFSS LHSSNDTVPI KFKKCCYGYC IDLLEKIAED MNFDFDLYIV 600
    GDGKYGAWKN GHWTGLVGDL LRGTAHMAVT SFSINTARSQ VIDFTSPFFS 650
    TSLGILVRTR DTAAPIGAFM WPLHWTMWLG IFVALHITAV FLTLYEWKSP 700
    FGLTPKGRNR SKVFSFSSAL NICYALLFGR TVAIKPPKCW TGRFLMNLWA 750
    IFCMFCLSTY TANLAAVMVG EKIYEELSGI HDPKLHHPSQ GFRFGTVRES 800
    SAEDYVRQSF PEMHEYMRRY NVPATPDGVE YLKNDPEKLD AFIMDKALLD 850
    YEVSIDADCK LLTVGKPFAI EGYGIGLPPN SPLTANISEL ISQYKSHGFM 900
    DMLHDKWYRV VPCGKRSFAV TETLQMGIKH FSGLFVLLCI GFGLSILTTI 950
    GEHIVYRLLL PRIKNKSKLQ YWLHTSQRLH RAINTSFIEE KQQHFKTKRV 1000
    EKRSNVGPRQ LTVWNTSNLS HDNRRKYIFS DEEGQNQLGI RIHQDIPLPP 1050
    RRRELPALRT TNGKADSLNV SRNSVMQELS ELEKQIQVIR QELQLAVSRK 1100
    TELEEYQRTS RTCES 1115
    Length:1,115
    Mass (Da):125,465
    Last modified:November 4, 2008 - v2
    Checksum:i0FEEC995F6AAF940
    GO

    Sequence cautioni

    The sequence BAB85559.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti559 – 5591S → N in AAL40734. (PubMed:11735224)Curated
    Sequence conflicti977 – 9771Q → R in AAL40734. (PubMed:11735224)Curated
    Sequence conflicti1073 – 10731N → I in AAL40734. (PubMed:11735224)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti362 – 3621V → M.1 Publication
    Corresponds to variant rs10989591 [ dbSNP | Ensembl ].
    VAR_019672
    Natural varianti480 – 4801R → H.
    Corresponds to variant rs34755188 [ dbSNP | Ensembl ].
    VAR_047150
    Natural varianti487 – 4871G → R.2 Publications
    Corresponds to variant rs10989589 [ dbSNP | Ensembl ].
    VAR_019673
    Natural varianti835 – 8351D → N.1 Publication
    Corresponds to variant rs10989563 [ dbSNP | Ensembl ].
    VAR_019674
    Natural varianti1041 – 10411R → Q.2 Publications
    Corresponds to variant rs3739722 [ dbSNP | Ensembl ].
    VAR_019675

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF416558 mRNA. Translation: AAL40734.1.
    AJ416950 mRNA. Translation: CAC95229.2.
    AB075853 mRNA. Translation: BAB85559.1. Different initiation.
    AL591377, AL356516 Genomic DNA. Translation: CAH69962.1.
    AL356516, AL591377 Genomic DNA. Translation: CAI16651.1.
    BC167432 mRNA. Translation: AAI67432.1.
    CCDSiCCDS6758.1.
    RefSeqiNP_597702.2. NM_133445.2.
    UniGeneiHs.654783.

    Genome annotation databases

    EnsembliENST00000361820; ENSP00000355155; ENSG00000198785.
    GeneIDi116443.
    KEGGihsa:116443.
    UCSCiuc004bbp.2. human.

    Polymorphism databases

    DMDMi212276445.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF416558 mRNA. Translation: AAL40734.1 .
    AJ416950 mRNA. Translation: CAC95229.2 .
    AB075853 mRNA. Translation: BAB85559.1 . Different initiation.
    AL591377 , AL356516 Genomic DNA. Translation: CAH69962.1 .
    AL356516 , AL591377 Genomic DNA. Translation: CAI16651.1 .
    BC167432 mRNA. Translation: AAI67432.1 .
    CCDSi CCDS6758.1.
    RefSeqi NP_597702.2. NM_133445.2.
    UniGenei Hs.654783.

    3D structure databases

    ProteinModelPortali Q8TCU5.
    SMRi Q8TCU5. Positions 143-497, 512-952.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125508. 3 interactions.
    MINTi MINT-6630950.
    STRINGi 9606.ENSP00000355155.

    Chemistry

    BindingDBi Q8TCU5.
    ChEMBLi CHEMBL4787.
    DrugBanki DB00659. Acamprosate.
    DB01161. Chloroprocaine.
    DB00514. Dextromethorphan.
    DB00898. Ethanol.
    DB00392. Ethopropazine.
    DB00949. Felbamate.
    DB01221. Ketamine.
    DB00142. L-Glutamic Acid.
    DB01043. Memantine.
    DB00454. Meperidine.
    DB00333. Methadone.
    DB01173. Orphenadrine.
    DB00721. Procaine.
    DB00740. Riluzole.
    GuidetoPHARMACOLOGYi 460.

    PTM databases

    PhosphoSitei Q8TCU5.

    Polymorphism databases

    DMDMi 212276445.

    Proteomic databases

    PaxDbi Q8TCU5.
    PRIDEi Q8TCU5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361820 ; ENSP00000355155 ; ENSG00000198785 .
    GeneIDi 116443.
    KEGGi hsa:116443.
    UCSCi uc004bbp.2. human.

    Organism-specific databases

    CTDi 116443.
    GeneCardsi GC09M104331.
    H-InvDB HIX0008248.
    HIX0125606.
    HGNCi HGNC:16767. GRIN3A.
    MIMi 606650. gene.
    neXtProti NX_Q8TCU5.
    PharmGKBi PA28983.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG320645.
    HOGENOMi HOG000231528.
    HOVERGENi HBG052634.
    InParanoidi Q8TCU5.
    KOi K05213.
    OMAi TQFGVMP.
    OrthoDBi EOG7QK0B4.
    PhylomeDBi Q8TCU5.
    TreeFami TF314731.

    Miscellaneous databases

    GeneWikii GRIN3A.
    GenomeRNAii 116443.
    NextBioi 79919.
    PROi Q8TCU5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8TCU5.
    CleanExi HS_GRIN3A.
    Genevestigatori Q8TCU5.

    Family and domain databases

    InterProi IPR019594. Glu_rcpt_Glu/Gly-bd.
    IPR001320. Iontro_glu_rcpt.
    IPR001508. NMDA_rcpt.
    IPR028082. Peripla_BP_I.
    IPR001638. SBP_bac_3.
    [Graphical view ]
    Pfami PF00060. Lig_chan. 1 hit.
    PF00497. SBP_bac_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00177. NMDARECEPTOR.
    SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
    SM00079. PBPe. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53822. SSF53822. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence, genomic organization, and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B."
      Andersson O., Stenqvist A., Attersand A., von Euler G.
      Genomics 78:178-184(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-487.
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS MET-362; ARG-487 AND ASN-835, TISSUE SPECIFICITY.
      Tissue: Brain.
    3. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
      Nagase T., Kikuno R., Ohara O.
      DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-1041.
      Tissue: Brain.
    4. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-1041.
    6. "Expression of the NR3A subunit of the NMDA receptor in human fetal brain."
      Mueller H.T., Meador-Woodruff J.H.
      Ann. N. Y. Acad. Sci. 1003:448-451(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    7. "An NMDA receptor signaling complex with protein phosphatase 2A."
      Chan S.F., Sucher N.J.
      J. Neurosci. 21:7985-7992(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PPP2CB.

    Entry informationi

    Entry nameiNMD3A_HUMAN
    AccessioniPrimary (citable) accession number: Q8TCU5
    Secondary accession number(s): B3DLF9
    , Q5VTR3, Q8TF29, Q8WXI6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: November 4, 2008
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3