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Protein

Solute carrier family 7 member 13

Gene

SLC7A13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164893-MONOMER.

Protein family/group databases

TCDBi2.A.3.8.24. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 7 member 13
Alternative name(s):
Sodium-independent aspartate/glutamate transporter 1
X-amino acid transporter 2
Gene namesi
Name:SLC7A13
Synonyms:AGT1, XAT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:23092. SLC7A13.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini33 – 45ExtracellularSequence analysisAdd BLAST13
Transmembranei46 – 66Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini67 – 87CytoplasmicSequence analysisAdd BLAST21
Transmembranei88 – 108Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini109 – 128ExtracellularSequence analysisAdd BLAST20
Transmembranei129 – 149Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini150 – 162CytoplasmicSequence analysisAdd BLAST13
Transmembranei163 – 183Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini184 – 206ExtracellularSequence analysisAdd BLAST23
Transmembranei207 – 227Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini228 – 240CytoplasmicSequence analysisAdd BLAST13
Transmembranei241 – 261Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini262 – 287ExtracellularSequence analysisAdd BLAST26
Transmembranei288 – 308Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini309 – 336CytoplasmicSequence analysisAdd BLAST28
Transmembranei337 – 357Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini358ExtracellularSequence analysis1
Transmembranei359 – 379Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini380 – 393CytoplasmicSequence analysisAdd BLAST14
Transmembranei394 – 414Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini415 – 421ExtracellularSequence analysis7
Transmembranei422 – 442Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini443 – 470CytoplasmicSequence analysisAdd BLAST28

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi157724.
OpenTargetsiENSG00000164893.
PharmGKBiPA134980828.

Polymorphism and mutation databases

BioMutaiSLC7A13.
DMDMi74751412.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003307251 – 470Solute carrier family 7 member 13Add BLAST470

Proteomic databases

PaxDbiQ8TCU3.
PRIDEiQ8TCU3.

PTM databases

iPTMnetiQ8TCU3.
PhosphoSitePlusiQ8TCU3.

Expressioni

Tissue specificityi

Expressed in the kidney.1 Publication

Gene expression databases

BgeeiENSG00000164893.
CleanExiHS_SLC7A13.
GenevisibleiQ8TCU3. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000297524.

Structurei

3D structure databases

ProteinModelPortaliQ8TCU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1287. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiQ8TCU3.
KOiK13870.
OMAiCSAEISI.
OrthoDBiEOG091G05K3.
PhylomeDBiQ8TCU3.
TreeFamiTF313355.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TCU3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDRGEKIQLK RVFGYWWGTS FLLINIIGAG IFVSPKGVLA YSCMNVGVSL
60 70 80 90 100
CVWAGCAILA MTSTLCSAEI SISFPCSGAQ YYFLKRYFGS TVAFLNLWTS
110 120 130 140 150
LFLGSGVVAG QALLLAEYSI QPFFPSCSVP KLPKKCLALA MLWIVGILTS
160 170 180 190 200
RGVKEVTWLQ IASSVLKVSI LSFISLTGVV FLIRGKKENV ERFQNAFDAE
210 220 230 240 250
LPDISHLIQA IFQGYFAYSG GACFTLIAGE LKKPRTTIPK CIFTALPLVT
260 270 280 290 300
VVYLLVNISY LTVLTPREIL SSDAVAITWA DRAFPSLAWI MPFAISTSLF
310 320 330 340 350
SNLLISIFKS SRPIYLASQE GQLPLLFNTL NSHSSPFTAV LLLVTLGSLA
360 370 380 390 400
IILTSLIDLI NYIFFTGSLW SILLMIGILR RRYQEPNLSI PYKVFLSFPL
410 420 430 440 450
ATIVIDVGLV VIPLVKSPNV HYVYVLLLVL SGLLFYIPLI HFKIRLAWFE
460 470
KMTCYLQLLF NICLPDVSEE
Length:470
Mass (Da):52,114
Last modified:June 1, 2002 - v1
Checksum:iF8593B829E2050E7
GO
Isoform 2 (identifier: Q8TCU3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     221-229: Missing.
     394-442: VFLSFPLATI...LLFYIPLIHF → SLILVVQAGE...WDYRCFCHFH
     443-470: Missing.

Show »
Length:433
Mass (Da):48,002
Checksum:i98A7ADEA5CF284E2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042716249V → M.2 PublicationsCorresponds to variant rs2976189dbSNPEnsembl.1
Natural variantiVAR_042717380R → K.Corresponds to variant rs4419794dbSNPEnsembl.1
Natural variantiVAR_042718452M → T.Corresponds to variant rs9656982dbSNPEnsembl.1
Natural variantiVAR_042719470E → K.Corresponds to variant rs9693999dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033067221 – 229Missing in isoform 2. 1 Publication9
Alternative sequenceiVSP_033068394 – 442VFLSF…PLIHF → SLILVVQAGEAGVQWHDLGL LQPLLPGFKRFSCLSLPSSW DYRCFCHFH in isoform 2. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_033069443 – 470Missing in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ417661 mRNA. Translation: CAD10393.1.
AK055815 mRNA. Translation: BAB71021.1.
CH471060 Genomic DNA. Translation: EAW91633.1.
BC125165 mRNA. Translation: AAI25166.1.
BC125166 mRNA. Translation: AAI25167.1.
BC029436 mRNA. Translation: AAH29436.1. Different termination.
CCDSiCCDS34917.1. [Q8TCU3-1]
RefSeqiNP_620172.2. NM_138817.2. [Q8TCU3-1]
UniGeneiHs.149095.

Genome annotation databases

EnsembliENST00000297524; ENSP00000297524; ENSG00000164893. [Q8TCU3-1]
ENST00000419776; ENSP00000410982; ENSG00000164893. [Q8TCU3-2]
GeneIDi157724.
KEGGihsa:157724.
UCSCiuc003ydq.2. human. [Q8TCU3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ417661 mRNA. Translation: CAD10393.1.
AK055815 mRNA. Translation: BAB71021.1.
CH471060 Genomic DNA. Translation: EAW91633.1.
BC125165 mRNA. Translation: AAI25166.1.
BC125166 mRNA. Translation: AAI25167.1.
BC029436 mRNA. Translation: AAH29436.1. Different termination.
CCDSiCCDS34917.1. [Q8TCU3-1]
RefSeqiNP_620172.2. NM_138817.2. [Q8TCU3-1]
UniGeneiHs.149095.

3D structure databases

ProteinModelPortaliQ8TCU3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000297524.

Protein family/group databases

TCDBi2.A.3.8.24. the amino acid-polyamine-organocation (apc) family.

PTM databases

iPTMnetiQ8TCU3.
PhosphoSitePlusiQ8TCU3.

Polymorphism and mutation databases

BioMutaiSLC7A13.
DMDMi74751412.

Proteomic databases

PaxDbiQ8TCU3.
PRIDEiQ8TCU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297524; ENSP00000297524; ENSG00000164893. [Q8TCU3-1]
ENST00000419776; ENSP00000410982; ENSG00000164893. [Q8TCU3-2]
GeneIDi157724.
KEGGihsa:157724.
UCSCiuc003ydq.2. human. [Q8TCU3-1]

Organism-specific databases

CTDi157724.
DisGeNETi157724.
GeneCardsiSLC7A13.
H-InvDBHIX0007630.
HGNCiHGNC:23092. SLC7A13.
neXtProtiNX_Q8TCU3.
OpenTargetsiENSG00000164893.
PharmGKBiPA134980828.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1287. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiQ8TCU3.
KOiK13870.
OMAiCSAEISI.
OrthoDBiEOG091G05K3.
PhylomeDBiQ8TCU3.
TreeFamiTF313355.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164893-MONOMER.

Miscellaneous databases

GenomeRNAii157724.
PROiQ8TCU3.

Gene expression databases

BgeeiENSG00000164893.
CleanExiHS_SLC7A13.
GenevisibleiQ8TCU3. HS.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS7A13_HUMAN
AccessioniPrimary (citable) accession number: Q8TCU3
Secondary accession number(s): Q05C37, Q08AH9, Q96N84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.