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Q8TCU3 (S7A13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 7 member 13
Alternative name(s):
Sodium-independent aspartate/glutamate transporter 1
X-amino acid transporter 2
Gene names
Name:SLC7A13
Synonyms:AGT1, XAT2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Expressed in the kidney. Ref.1

Sequence similarities

Belongs to the amino acid-polyamine-organocation (APC) superfamily.

Ontologies

Keywords
   Biological processAmino-acid transport
Transport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionamino acid transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8TCU3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8TCU3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     221-229: Missing.
     394-442: VFLSFPLATI...LLFYIPLIHF → SLILVVQAGE...WDYRCFCHFH
     443-470: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 470470Solute carrier family 7 member 13
PRO_0000330725

Regions

Topological domain1 – 1111Cytoplasmic Potential
Transmembrane12 – 3221Helical; Name=1; Potential
Topological domain33 – 4513Extracellular Potential
Transmembrane46 – 6621Helical; Name=2; Potential
Topological domain67 – 8721Cytoplasmic Potential
Transmembrane88 – 10821Helical; Name=3; Potential
Topological domain109 – 12820Extracellular Potential
Transmembrane129 – 14921Helical; Name=4; Potential
Topological domain150 – 16213Cytoplasmic Potential
Transmembrane163 – 18321Helical; Name=5; Potential
Topological domain184 – 20623Extracellular Potential
Transmembrane207 – 22721Helical; Name=6; Potential
Topological domain228 – 24013Cytoplasmic Potential
Transmembrane241 – 26121Helical; Name=7; Potential
Topological domain262 – 28726Extracellular Potential
Transmembrane288 – 30821Helical; Name=8; Potential
Topological domain309 – 33628Cytoplasmic Potential
Transmembrane337 – 35721Helical; Name=9; Potential
Topological domain3581Extracellular Potential
Transmembrane359 – 37921Helical; Name=10; Potential
Topological domain380 – 39314Cytoplasmic Potential
Transmembrane394 – 41421Helical; Name=11; Potential
Topological domain415 – 4217Extracellular Potential
Transmembrane422 – 44221Helical; Name=12; Potential
Topological domain443 – 47028Cytoplasmic Potential

Natural variations

Alternative sequence221 – 2299Missing in isoform 2.
VSP_033067
Alternative sequence394 – 44249VFLSF…PLIHF → SLILVVQAGEAGVQWHDLGL LQPLLPGFKRFSCLSLPSSW DYRCFCHFH in isoform 2.
VSP_033068
Alternative sequence443 – 47028Missing in isoform 2.
VSP_033069
Natural variant2491V → M. Ref.2 Ref.4
Corresponds to variant rs2976189 [ dbSNP | Ensembl ].
VAR_042716
Natural variant3801R → K.
Corresponds to variant rs4419794 [ dbSNP | Ensembl ].
VAR_042717
Natural variant4521M → T.
Corresponds to variant rs9656982 [ dbSNP | Ensembl ].
VAR_042718
Natural variant4701E → K.
Corresponds to variant rs9693999 [ dbSNP | Ensembl ].
VAR_042719

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: F8593B829E2050E7

FASTA47052,114
        10         20         30         40         50         60 
MDRGEKIQLK RVFGYWWGTS FLLINIIGAG IFVSPKGVLA YSCMNVGVSL CVWAGCAILA 

        70         80         90        100        110        120 
MTSTLCSAEI SISFPCSGAQ YYFLKRYFGS TVAFLNLWTS LFLGSGVVAG QALLLAEYSI 

       130        140        150        160        170        180 
QPFFPSCSVP KLPKKCLALA MLWIVGILTS RGVKEVTWLQ IASSVLKVSI LSFISLTGVV 

       190        200        210        220        230        240 
FLIRGKKENV ERFQNAFDAE LPDISHLIQA IFQGYFAYSG GACFTLIAGE LKKPRTTIPK 

       250        260        270        280        290        300 
CIFTALPLVT VVYLLVNISY LTVLTPREIL SSDAVAITWA DRAFPSLAWI MPFAISTSLF 

       310        320        330        340        350        360 
SNLLISIFKS SRPIYLASQE GQLPLLFNTL NSHSSPFTAV LLLVTLGSLA IILTSLIDLI 

       370        380        390        400        410        420 
NYIFFTGSLW SILLMIGILR RRYQEPNLSI PYKVFLSFPL ATIVIDVGLV VIPLVKSPNV 

       430        440        450        460        470 
HYVYVLLLVL SGLLFYIPLI HFKIRLAWFE KMTCYLQLLF NICLPDVSEE 

« Hide

Isoform 2 [UniParc].

Checksum: 98A7ADEA5CF284E2
Show »

FASTA43348,002

References

« Hide 'large scale' references
[1]"Homologues of amino acid permeases: cloning and tissue expression of XAT1 and XAT2."
Blondeau J.-P.
Gene 286:241-248(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
Tissue: Kidney.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-249.
Tissue: Kidney.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT MET-249.
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ417661 mRNA. Translation: CAD10393.1.
AK055815 mRNA. Translation: BAB71021.1.
CH471060 Genomic DNA. Translation: EAW91633.1.
BC125165 mRNA. Translation: AAI25166.1.
BC125166 mRNA. Translation: AAI25167.1.
BC029436 mRNA. Translation: AAH29436.1. Different termination.
CCDSCCDS34917.1. [Q8TCU3-1]
RefSeqNP_620172.2. NM_138817.2. [Q8TCU3-1]
XP_005250861.1. XM_005250804.1. [Q8TCU3-2]
UniGeneHs.149095.

3D structure databases

ProteinModelPortalQ8TCU3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000297524.

Protein family/group databases

TCDB2.A.3.8.24. the amino acid-polyamine-organocation (apc) family.

PTM databases

PhosphoSiteQ8TCU3.

Polymorphism databases

DMDM74751412.

Proteomic databases

PaxDbQ8TCU3.
PRIDEQ8TCU3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000297524; ENSP00000297524; ENSG00000164893. [Q8TCU3-1]
ENST00000419776; ENSP00000410982; ENSG00000164893. [Q8TCU3-2]
GeneID157724.
KEGGhsa:157724.
UCSCuc003ydq.1. human. [Q8TCU3-1]
uc003ydr.1. human. [Q8TCU3-2]

Organism-specific databases

CTD157724.
GeneCardsGC08M087295.
H-InvDBHIX0007630.
HGNCHGNC:23092. SLC7A13.
neXtProtNX_Q8TCU3.
PharmGKBPA134980828.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0531.
HOGENOMHOG000098892.
HOVERGENHBG000476.
InParanoidQ8TCU3.
KOK13870.
OMAKCLALAM.
OrthoDBEOG7Z3F48.
PhylomeDBQ8TCU3.
TreeFamTF313355.

Gene expression databases

BgeeQ8TCU3.
CleanExHS_SLC7A13.
GenevestigatorQ8TCU3.

Family and domain databases

InterProIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERPTHR11785. PTHR11785. 1 hit.
PfamPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFPIRSF006060. AA_transporter. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi157724.
NextBio87534.
PROQ8TCU3.

Entry information

Entry nameS7A13_HUMAN
AccessionPrimary (citable) accession number: Q8TCU3
Secondary accession number(s): Q05C37, Q08AH9, Q96N84
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM