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Protein

Solute carrier family 7 member 13

Gene

SLC7A13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner.By similarity

GO - Molecular functioni

  1. amino acid transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Protein family/group databases

TCDBi2.A.3.8.24. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 7 member 13
Alternative name(s):
Sodium-independent aspartate/glutamate transporter 1
X-amino acid transporter 2
Gene namesi
Name:SLC7A13
Synonyms:AGT1, XAT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:23092. SLC7A13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei12 – 3221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini33 – 4513ExtracellularSequence AnalysisAdd
BLAST
Transmembranei46 – 6621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini67 – 8721CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei88 – 10821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini109 – 12820ExtracellularSequence AnalysisAdd
BLAST
Transmembranei129 – 14921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini150 – 16213CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei163 – 18321Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini184 – 20623ExtracellularSequence AnalysisAdd
BLAST
Transmembranei207 – 22721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini228 – 24013CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei241 – 26121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini262 – 28726ExtracellularSequence AnalysisAdd
BLAST
Transmembranei288 – 30821Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini309 – 33628CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei337 – 35721Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini358 – 3581ExtracellularSequence Analysis
Transmembranei359 – 37921Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini380 – 39314CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei394 – 41421Helical; Name=11Sequence AnalysisAdd
BLAST
Topological domaini415 – 4217ExtracellularSequence Analysis
Transmembranei422 – 44221Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini443 – 47028CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134980828.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470Solute carrier family 7 member 13PRO_0000330725Add
BLAST

Proteomic databases

PaxDbiQ8TCU3.
PRIDEiQ8TCU3.

PTM databases

PhosphoSiteiQ8TCU3.

Expressioni

Tissue specificityi

Expressed in the kidney.1 Publication

Gene expression databases

BgeeiQ8TCU3.
CleanExiHS_SLC7A13.
GenevestigatoriQ8TCU3.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000297524.

Structurei

3D structure databases

ProteinModelPortaliQ8TCU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiQ8TCU3.
KOiK13870.
OMAiKCLALAM.
OrthoDBiEOG7Z3F48.
PhylomeDBiQ8TCU3.
TreeFamiTF313355.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TCU3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDRGEKIQLK RVFGYWWGTS FLLINIIGAG IFVSPKGVLA YSCMNVGVSL
60 70 80 90 100
CVWAGCAILA MTSTLCSAEI SISFPCSGAQ YYFLKRYFGS TVAFLNLWTS
110 120 130 140 150
LFLGSGVVAG QALLLAEYSI QPFFPSCSVP KLPKKCLALA MLWIVGILTS
160 170 180 190 200
RGVKEVTWLQ IASSVLKVSI LSFISLTGVV FLIRGKKENV ERFQNAFDAE
210 220 230 240 250
LPDISHLIQA IFQGYFAYSG GACFTLIAGE LKKPRTTIPK CIFTALPLVT
260 270 280 290 300
VVYLLVNISY LTVLTPREIL SSDAVAITWA DRAFPSLAWI MPFAISTSLF
310 320 330 340 350
SNLLISIFKS SRPIYLASQE GQLPLLFNTL NSHSSPFTAV LLLVTLGSLA
360 370 380 390 400
IILTSLIDLI NYIFFTGSLW SILLMIGILR RRYQEPNLSI PYKVFLSFPL
410 420 430 440 450
ATIVIDVGLV VIPLVKSPNV HYVYVLLLVL SGLLFYIPLI HFKIRLAWFE
460 470
KMTCYLQLLF NICLPDVSEE
Length:470
Mass (Da):52,114
Last modified:June 1, 2002 - v1
Checksum:iF8593B829E2050E7
GO
Isoform 2 (identifier: Q8TCU3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     221-229: Missing.
     394-442: VFLSFPLATI...LLFYIPLIHF → SLILVVQAGE...WDYRCFCHFH
     443-470: Missing.

Show »
Length:433
Mass (Da):48,002
Checksum:i98A7ADEA5CF284E2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti249 – 2491V → M.2 Publications
Corresponds to variant rs2976189 [ dbSNP | Ensembl ].
VAR_042716
Natural varianti380 – 3801R → K.
Corresponds to variant rs4419794 [ dbSNP | Ensembl ].
VAR_042717
Natural varianti452 – 4521M → T.
Corresponds to variant rs9656982 [ dbSNP | Ensembl ].
VAR_042718
Natural varianti470 – 4701E → K.
Corresponds to variant rs9693999 [ dbSNP | Ensembl ].
VAR_042719

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei221 – 2299Missing in isoform 2. 1 PublicationVSP_033067
Alternative sequencei394 – 44249VFLSF…PLIHF → SLILVVQAGEAGVQWHDLGL LQPLLPGFKRFSCLSLPSSW DYRCFCHFH in isoform 2. 1 PublicationVSP_033068Add
BLAST
Alternative sequencei443 – 47028Missing in isoform 2. 1 PublicationVSP_033069Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ417661 mRNA. Translation: CAD10393.1.
AK055815 mRNA. Translation: BAB71021.1.
CH471060 Genomic DNA. Translation: EAW91633.1.
BC125165 mRNA. Translation: AAI25166.1.
BC125166 mRNA. Translation: AAI25167.1.
BC029436 mRNA. Translation: AAH29436.1. Different termination.
CCDSiCCDS34917.1. [Q8TCU3-1]
RefSeqiNP_620172.2. NM_138817.2. [Q8TCU3-1]
XP_005250861.1. XM_005250804.1. [Q8TCU3-2]
UniGeneiHs.149095.

Genome annotation databases

EnsembliENST00000297524; ENSP00000297524; ENSG00000164893. [Q8TCU3-1]
ENST00000419776; ENSP00000410982; ENSG00000164893. [Q8TCU3-2]
GeneIDi157724.
KEGGihsa:157724.
UCSCiuc003ydq.1. human. [Q8TCU3-1]
uc003ydr.1. human. [Q8TCU3-2]

Polymorphism databases

DMDMi74751412.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ417661 mRNA. Translation: CAD10393.1.
AK055815 mRNA. Translation: BAB71021.1.
CH471060 Genomic DNA. Translation: EAW91633.1.
BC125165 mRNA. Translation: AAI25166.1.
BC125166 mRNA. Translation: AAI25167.1.
BC029436 mRNA. Translation: AAH29436.1. Different termination.
CCDSiCCDS34917.1. [Q8TCU3-1]
RefSeqiNP_620172.2. NM_138817.2. [Q8TCU3-1]
XP_005250861.1. XM_005250804.1. [Q8TCU3-2]
UniGeneiHs.149095.

3D structure databases

ProteinModelPortaliQ8TCU3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000297524.

Protein family/group databases

TCDBi2.A.3.8.24. the amino acid-polyamine-organocation (apc) family.

PTM databases

PhosphoSiteiQ8TCU3.

Polymorphism databases

DMDMi74751412.

Proteomic databases

PaxDbiQ8TCU3.
PRIDEiQ8TCU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297524; ENSP00000297524; ENSG00000164893. [Q8TCU3-1]
ENST00000419776; ENSP00000410982; ENSG00000164893. [Q8TCU3-2]
GeneIDi157724.
KEGGihsa:157724.
UCSCiuc003ydq.1. human. [Q8TCU3-1]
uc003ydr.1. human. [Q8TCU3-2]

Organism-specific databases

CTDi157724.
GeneCardsiGC08M087295.
H-InvDBHIX0007630.
HGNCiHGNC:23092. SLC7A13.
neXtProtiNX_Q8TCU3.
PharmGKBiPA134980828.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiQ8TCU3.
KOiK13870.
OMAiKCLALAM.
OrthoDBiEOG7Z3F48.
PhylomeDBiQ8TCU3.
TreeFamiTF313355.

Miscellaneous databases

GenomeRNAii157724.
NextBioi87534.
PROiQ8TCU3.

Gene expression databases

BgeeiQ8TCU3.
CleanExiHS_SLC7A13.
GenevestigatoriQ8TCU3.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Homologues of amino acid permeases: cloning and tissue expression of XAT1 and XAT2."
    Blondeau J.-P.
    Gene 286:241-248(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Kidney.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-249.
    Tissue: Kidney.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT MET-249.
    Tissue: Kidney.

Entry informationi

Entry nameiS7A13_HUMAN
AccessioniPrimary (citable) accession number: Q8TCU3
Secondary accession number(s): Q05C37, Q08AH9, Q96N84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2002
Last modified: January 7, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.