Q8TCU3 (S7A13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 7 member 13

Alternative name(s):
Sodium-independent aspartate/glutamate transporter 1
X-amino acid transporter 2

Gene names

Name:	SLC7A13
Synonyms:	AGT1, XAT2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	470 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Expressed in the kidney. Ref.1
Sequence similarities	Belongs to the amino acid-polyamine-organocation (APC) superfamily.

Ontologies

Keywords
Biological process	Amino-acid transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	amino acid transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TCU3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TCU3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     221-229: Missing.
     394-442: VFLSFPLATI...LLFYIPLIHF → SLILVVQAGE...WDYRCFCHFH
     443-470: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 470	470	Solute carrier family 7 member 13		PRO_0000330725
Regions
	Topological domain	1 – 11	11	Cytoplasmic Potential
	Transmembrane	12 – 32	21	Helical; Name=1; Potential
	Topological domain	33 – 45	13	Extracellular Potential
	Transmembrane	46 – 66	21	Helical; Name=2; Potential
	Topological domain	67 – 87	21	Cytoplasmic Potential
	Transmembrane	88 – 108	21	Helical; Name=3; Potential
	Topological domain	109 – 128	20	Extracellular Potential
	Transmembrane	129 – 149	21	Helical; Name=4; Potential
	Topological domain	150 – 162	13	Cytoplasmic Potential
	Transmembrane	163 – 183	21	Helical; Name=5; Potential
	Topological domain	184 – 206	23	Extracellular Potential
	Transmembrane	207 – 227	21	Helical; Name=6; Potential
	Topological domain	228 – 240	13	Cytoplasmic Potential
	Transmembrane	241 – 261	21	Helical; Name=7; Potential
	Topological domain	262 – 287	26	Extracellular Potential
	Transmembrane	288 – 308	21	Helical; Name=8; Potential
	Topological domain	309 – 336	28	Cytoplasmic Potential
	Transmembrane	337 – 357	21	Helical; Name=9; Potential
	Topological domain	358	1	Extracellular Potential
	Transmembrane	359 – 379	21	Helical; Name=10; Potential
	Topological domain	380 – 393	14	Cytoplasmic Potential
	Transmembrane	394 – 414	21	Helical; Name=11; Potential
	Topological domain	415 – 421	7	Extracellular Potential
	Transmembrane	422 – 442	21	Helical; Name=12; Potential
	Topological domain	443 – 470	28	Cytoplasmic Potential
Natural variations
	Alternative sequence	221 – 229	9	Missing in isoform 2.		VSP_033067
	Alternative sequence	394 – 442	49	VFLSF…PLIHF → SLILVVQAGEAGVQWHDLGL LQPLLPGFKRFSCLSLPSSW DYRCFCHFH in isoform 2.		VSP_033068
	Alternative sequence	443 – 470	28	Missing in isoform 2.		VSP_033069
	Natural variant	249	1	V → M. Ref.2 Ref.4 Corresponds to variant rs2976189 [ dbSNP | Ensembl ].		VAR_042716
	Natural variant	380	1	R → K. Corresponds to variant rs4419794 [ dbSNP | Ensembl ].		VAR_042717
	Natural variant	452	1	M → T. Corresponds to variant rs9656982 [ dbSNP | Ensembl ].		VAR_042718
	Natural variant	470	1	E → K. Corresponds to variant rs9693999 [ dbSNP | Ensembl ].		VAR_042719

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: F8593B829E2050E7	FASTA	470	52,114
	10 20 30 40 50 60 MDRGEKIQLK RVFGYWWGTS FLLINIIGAG IFVSPKGVLA YSCMNVGVSL CVWAGCAILA 70 80 90 100 110 120 MTSTLCSAEI SISFPCSGAQ YYFLKRYFGS TVAFLNLWTS LFLGSGVVAG QALLLAEYSI 130 140 150 160 170 180 QPFFPSCSVP KLPKKCLALA MLWIVGILTS RGVKEVTWLQ IASSVLKVSI LSFISLTGVV 190 200 210 220 230 240 FLIRGKKENV ERFQNAFDAE LPDISHLIQA IFQGYFAYSG GACFTLIAGE LKKPRTTIPK 250 260 270 280 290 300 CIFTALPLVT VVYLLVNISY LTVLTPREIL SSDAVAITWA DRAFPSLAWI MPFAISTSLF 310 320 330 340 350 360 SNLLISIFKS SRPIYLASQE GQLPLLFNTL NSHSSPFTAV LLLVTLGSLA IILTSLIDLI 370 380 390 400 410 420 NYIFFTGSLW SILLMIGILR RRYQEPNLSI PYKVFLSFPL ATIVIDVGLV VIPLVKSPNV 430 440 450 460 470 HYVYVLLLVL SGLLFYIPLI HFKIRLAWFE KMTCYLQLLF NICLPDVSEE
	Isoform 2 [UniParc]. Checksum: 98A7ADEA5CF284E2	FASTA	433	48,002
	10 20 30 40 50 60 MDRGEKIQLK RVFGYWWGTS FLLINIIGAG IFVSPKGVLA YSCMNVGVSL CVWAGCAILA 70 80 90 100 110 120 MTSTLCSAEI SISFPCSGAQ YYFLKRYFGS TVAFLNLWTS LFLGSGVVAG QALLLAEYSI 130 140 150 160 170 180 QPFFPSCSVP KLPKKCLALA MLWIVGILTS RGVKEVTWLQ IASSVLKVSI LSFISLTGVV 190 200 210 220 230 240 FLIRGKKENV ERFQNAFDAE LPDISHLIQA IFQGYFAYSG ELKKPRTTIP KCIFTALPLV 250 260 270 280 290 300 TVVYLLVNIS YLTVLTPREI LSSDAVAITW ADRAFPSLAW IMPFAISTSL FSNLLISIFK 310 320 330 340 350 360 SSRPIYLASQ EGQLPLLFNT LNSHSSPFTA VLLLVTLGSL AIILTSLIDL INYIFFTGSL 370 380 390 400 410 420 WSILLMIGIL RRRYQEPNLS IPYKSLILVV QAGEAGVQWH DLGLLQPLLP GFKRFSCLSL 430 PSSWDYRCFC HFH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Homologues of amino acid permeases: cloning and tissue expression of XAT1 and XAT2." Blondeau J.-P. Gene 286:241-248(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Kidney.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-249. Tissue: Kidney.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT MET-249. Tissue: Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ417661 mRNA. Translation: CAD10393.1. AK055815 mRNA. Translation: BAB71021.1. CH471060 Genomic DNA. Translation: EAW91633.1. BC125165 mRNA. Translation: AAI25166.1. BC125166 mRNA. Translation: AAI25167.1. BC029436 mRNA. Translation: AAH29436.1. Different termination.
IPI	IPI00291186. IPI00890695.
RefSeq	NP_620172.2. NM_138817.2.
UniGene	Hs.149095.
3D structure databases
ProteinModelPortal	Q8TCU3.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000297524.
PTM databases
PhosphoSite	Q8TCU3.
Polymorphism databases
DMDM	74751412.
Proteomic databases
PaxDb	Q8TCU3.
PRIDE	Q8TCU3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000297524; ENSP00000297524; ENSG00000164893. ENST00000419776; ENSP00000410982; ENSG00000164893.
GeneID	157724.
KEGG	hsa:157724.
UCSC	uc003ydq.1. human. uc003ydr.1. human.
Organism-specific databases
CTD	157724.
GeneCards	GC08M087295.
H-InvDB	HIX0007630.
HGNC	HGNC:23092. SLC7A13.
neXtProt	NX_Q8TCU3.
PharmGKB	PA134980828.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0531.
HOGENOM	HOG000098892.
HOVERGEN	HBG000476.
InParanoid	Q8TCU3.
KO	K13870.
OMA	ELPDISH.
OrthoDB	EOG4K9BC9.
PhylomeDB	Q8TCU3.
Gene expression databases
Bgee	Q8TCU3.
CleanEx	HS_SLC7A13.
Genevestigator	Q8TCU3.
Family and domain databases
InterPro	IPR002293. AA/rel_permease1. [Graphical view]
PANTHER	PTHR11785. PTHR11785. 1 hit.
PIRSF	PIRSF006060. AA_transporter. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	157724.
NextBio	87534.

Entry information

Entry name

S7A13_HUMAN

Accession

Primary (citable) accession number: Q8TCU3
Secondary accession number(s): Q05C37, Q08AH9, Q96N84

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	June 1, 2002
Last modified:	April 3, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.