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Q8TCU3

- S7A13_HUMAN

UniProt

Q8TCU3 - S7A13_HUMAN

Protein

Solute carrier family 7 member 13

Gene

SLC7A13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner.By similarity

    GO - Molecular functioni

    1. amino acid transmembrane transporter activity Source: InterPro

    Keywords - Biological processi

    Amino-acid transport, Transport

    Protein family/group databases

    TCDBi2.A.3.8.24. the amino acid-polyamine-organocation (apc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 7 member 13
    Alternative name(s):
    Sodium-independent aspartate/glutamate transporter 1
    X-amino acid transporter 2
    Gene namesi
    Name:SLC7A13
    Synonyms:AGT1, XAT2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:23092. SLC7A13.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134980828.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 470470Solute carrier family 7 member 13PRO_0000330725Add
    BLAST

    Proteomic databases

    PaxDbiQ8TCU3.
    PRIDEiQ8TCU3.

    PTM databases

    PhosphoSiteiQ8TCU3.

    Expressioni

    Tissue specificityi

    Expressed in the kidney.1 Publication

    Gene expression databases

    BgeeiQ8TCU3.
    CleanExiHS_SLC7A13.
    GenevestigatoriQ8TCU3.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000297524.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TCU3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1111CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini33 – 4513ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini67 – 8721CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini109 – 12820ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini150 – 16213CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini184 – 20623ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini228 – 24013CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini262 – 28726ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini309 – 33628CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini358 – 3581ExtracellularSequence Analysis
    Topological domaini380 – 39314CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini415 – 4217ExtracellularSequence Analysis
    Topological domaini443 – 47028CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei46 – 6621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei88 – 10821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei129 – 14921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei163 – 18321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei207 – 22721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei241 – 26121Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei288 – 30821Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei337 – 35721Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei359 – 37921Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei394 – 41421Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei422 – 44221Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0531.
    HOGENOMiHOG000098892.
    HOVERGENiHBG000476.
    InParanoidiQ8TCU3.
    KOiK13870.
    OMAiKCLALAM.
    OrthoDBiEOG7Z3F48.
    PhylomeDBiQ8TCU3.
    TreeFamiTF313355.

    Family and domain databases

    InterProiIPR002293. AA/rel_permease1.
    [Graphical view]
    PANTHERiPTHR11785. PTHR11785. 1 hit.
    PfamiPF13520. AA_permease_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006060. AA_transporter. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TCU3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDRGEKIQLK RVFGYWWGTS FLLINIIGAG IFVSPKGVLA YSCMNVGVSL    50
    CVWAGCAILA MTSTLCSAEI SISFPCSGAQ YYFLKRYFGS TVAFLNLWTS 100
    LFLGSGVVAG QALLLAEYSI QPFFPSCSVP KLPKKCLALA MLWIVGILTS 150
    RGVKEVTWLQ IASSVLKVSI LSFISLTGVV FLIRGKKENV ERFQNAFDAE 200
    LPDISHLIQA IFQGYFAYSG GACFTLIAGE LKKPRTTIPK CIFTALPLVT 250
    VVYLLVNISY LTVLTPREIL SSDAVAITWA DRAFPSLAWI MPFAISTSLF 300
    SNLLISIFKS SRPIYLASQE GQLPLLFNTL NSHSSPFTAV LLLVTLGSLA 350
    IILTSLIDLI NYIFFTGSLW SILLMIGILR RRYQEPNLSI PYKVFLSFPL 400
    ATIVIDVGLV VIPLVKSPNV HYVYVLLLVL SGLLFYIPLI HFKIRLAWFE 450
    KMTCYLQLLF NICLPDVSEE 470
    Length:470
    Mass (Da):52,114
    Last modified:June 1, 2002 - v1
    Checksum:iF8593B829E2050E7
    GO
    Isoform 2 (identifier: Q8TCU3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         221-229: Missing.
         394-442: VFLSFPLATI...LLFYIPLIHF → SLILVVQAGE...WDYRCFCHFH
         443-470: Missing.

    Show »
    Length:433
    Mass (Da):48,002
    Checksum:i98A7ADEA5CF284E2
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti249 – 2491V → M.2 Publications
    Corresponds to variant rs2976189 [ dbSNP | Ensembl ].
    VAR_042716
    Natural varianti380 – 3801R → K.
    Corresponds to variant rs4419794 [ dbSNP | Ensembl ].
    VAR_042717
    Natural varianti452 – 4521M → T.
    Corresponds to variant rs9656982 [ dbSNP | Ensembl ].
    VAR_042718
    Natural varianti470 – 4701E → K.
    Corresponds to variant rs9693999 [ dbSNP | Ensembl ].
    VAR_042719

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei221 – 2299Missing in isoform 2. 1 PublicationVSP_033067
    Alternative sequencei394 – 44249VFLSF…PLIHF → SLILVVQAGEAGVQWHDLGL LQPLLPGFKRFSCLSLPSSW DYRCFCHFH in isoform 2. 1 PublicationVSP_033068Add
    BLAST
    Alternative sequencei443 – 47028Missing in isoform 2. 1 PublicationVSP_033069Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ417661 mRNA. Translation: CAD10393.1.
    AK055815 mRNA. Translation: BAB71021.1.
    CH471060 Genomic DNA. Translation: EAW91633.1.
    BC125165 mRNA. Translation: AAI25166.1.
    BC125166 mRNA. Translation: AAI25167.1.
    BC029436 mRNA. Translation: AAH29436.1. Different termination.
    CCDSiCCDS34917.1. [Q8TCU3-1]
    RefSeqiNP_620172.2. NM_138817.2. [Q8TCU3-1]
    XP_005250861.1. XM_005250804.1. [Q8TCU3-2]
    UniGeneiHs.149095.

    Genome annotation databases

    EnsembliENST00000297524; ENSP00000297524; ENSG00000164893. [Q8TCU3-1]
    ENST00000419776; ENSP00000410982; ENSG00000164893. [Q8TCU3-2]
    GeneIDi157724.
    KEGGihsa:157724.
    UCSCiuc003ydq.1. human. [Q8TCU3-1]
    uc003ydr.1. human. [Q8TCU3-2]

    Polymorphism databases

    DMDMi74751412.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ417661 mRNA. Translation: CAD10393.1 .
    AK055815 mRNA. Translation: BAB71021.1 .
    CH471060 Genomic DNA. Translation: EAW91633.1 .
    BC125165 mRNA. Translation: AAI25166.1 .
    BC125166 mRNA. Translation: AAI25167.1 .
    BC029436 mRNA. Translation: AAH29436.1 . Different termination.
    CCDSi CCDS34917.1. [Q8TCU3-1 ]
    RefSeqi NP_620172.2. NM_138817.2. [Q8TCU3-1 ]
    XP_005250861.1. XM_005250804.1. [Q8TCU3-2 ]
    UniGenei Hs.149095.

    3D structure databases

    ProteinModelPortali Q8TCU3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000297524.

    Protein family/group databases

    TCDBi 2.A.3.8.24. the amino acid-polyamine-organocation (apc) family.

    PTM databases

    PhosphoSitei Q8TCU3.

    Polymorphism databases

    DMDMi 74751412.

    Proteomic databases

    PaxDbi Q8TCU3.
    PRIDEi Q8TCU3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000297524 ; ENSP00000297524 ; ENSG00000164893 . [Q8TCU3-1 ]
    ENST00000419776 ; ENSP00000410982 ; ENSG00000164893 . [Q8TCU3-2 ]
    GeneIDi 157724.
    KEGGi hsa:157724.
    UCSCi uc003ydq.1. human. [Q8TCU3-1 ]
    uc003ydr.1. human. [Q8TCU3-2 ]

    Organism-specific databases

    CTDi 157724.
    GeneCardsi GC08M087295.
    H-InvDB HIX0007630.
    HGNCi HGNC:23092. SLC7A13.
    neXtProti NX_Q8TCU3.
    PharmGKBi PA134980828.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0531.
    HOGENOMi HOG000098892.
    HOVERGENi HBG000476.
    InParanoidi Q8TCU3.
    KOi K13870.
    OMAi KCLALAM.
    OrthoDBi EOG7Z3F48.
    PhylomeDBi Q8TCU3.
    TreeFami TF313355.

    Miscellaneous databases

    GenomeRNAii 157724.
    NextBioi 87534.
    PROi Q8TCU3.

    Gene expression databases

    Bgeei Q8TCU3.
    CleanExi HS_SLC7A13.
    Genevestigatori Q8TCU3.

    Family and domain databases

    InterProi IPR002293. AA/rel_permease1.
    [Graphical view ]
    PANTHERi PTHR11785. PTHR11785. 1 hit.
    Pfami PF13520. AA_permease_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006060. AA_transporter. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Homologues of amino acid permeases: cloning and tissue expression of XAT1 and XAT2."
      Blondeau J.-P.
      Gene 286:241-248(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Kidney.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-249.
      Tissue: Kidney.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT MET-249.
      Tissue: Kidney.

    Entry informationi

    Entry nameiS7A13_HUMAN
    AccessioniPrimary (citable) accession number: Q8TCU3
    Secondary accession number(s): Q05C37, Q08AH9, Q96N84
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3