##gff-version 3 Q8TCS8 UniProtKB Transit peptide 1 45 . . . Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8TCS8 UniProtKB Chain 46 783 . . . ID=PRO_0000024751;Note=Polyribonucleotide nucleotidyltransferase 1%2C mitochondrial Q8TCS8 UniProtKB Domain 605 664 . . . Note=KH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117 Q8TCS8 UniProtKB Domain 679 750 . . . Note=S1 motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00180 Q8TCS8 UniProtKB Modified residue 250 250 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8K1R3 Q8TCS8 UniProtKB Modified residue 264 264 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 Q8TCS8 UniProtKB Modified residue 285 285 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 Q8TCS8 UniProtKB Modified residue 289 289 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 Q8TCS8 UniProtKB Modified residue 552 552 . . . Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8K1R3 Q8TCS8 UniProtKB Modified residue 754 754 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q8TCS8 UniProtKB Modified residue 782 782 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21406692;Dbxref=PMID:21406692 Q8TCS8 UniProtKB Natural variant 121 121 . . . ID=VAR_027787;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12419256,ECO:0000269|PubMed:12473748,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs782572,PMID:12419256,PMID:12473748,PMID:15489334 Q8TCS8 UniProtKB Natural variant 230 230 . . . ID=VAR_050610;Note=E->Q;Dbxref=dbSNP:rs34928857 Q8TCS8 UniProtKB Natural variant 387 387 . . . ID=VAR_069248;Note=In COXPD13%3B the mutation alters multimerization of the protein. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23084291;Dbxref=dbSNP:rs397514598,PMID:23084291 Q8TCS8 UniProtKB Natural variant 475 475 . . . ID=VAR_069249;Note=In DFNB70%3B results in a hypofunctional protein leading to disturbed enzyme trimerization and impaired mitochondrial RNA import. E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23084290;Dbxref=dbSNP:rs397514599,PMID:23084290 Q8TCS8 UniProtKB Natural variant 590 590 . . . ID=VAR_027788;Note=N->D;Dbxref=dbSNP:rs7594497 Q8TCS8 UniProtKB Mutagenesis 135 135 . . . Note=Inhibits poly(A) polymerase and RNA degradation activities. Inhibits the import or stabilization of RNase PRNA into the mitochondrial matrix. Does not inhibit homotrimerization activity. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20691904;Dbxref=PMID:20691904 Q8TCS8 UniProtKB Mutagenesis 445 446 . . . Note=Stimulates in vitro poly(A) polymerase activity. Inhibits RNA degradation activity. Does not inhibit the import or stabilization of RNase PRNA into the mitochondrial matrix. Does not inhibit homotrimerization activity. RR->EE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20691904;Dbxref=PMID:20691904 Q8TCS8 UniProtKB Mutagenesis 484 484 . . . Note=Inhibits poly(A) polymerase and RNA degradation activities. Does not inhibit the import or stabilization of RNase PRNA into the mitochondrial matrix. Does not inhibit homotrimerization activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20691904;Dbxref=PMID:20691904 Q8TCS8 UniProtKB Mutagenesis 544 544 . . . Note=Stimulates in vitro poly(A) polymerase activity. Inhibits RNA degradation activity. Inhibits the import or stabilization of RNase PRNA into the mitochondrial matrix. Does not inhibit homotrimerization activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20691904;Dbxref=PMID:20691904 Q8TCS8 UniProtKB Sequence conflict 656 656 . . . Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8TCS8 UniProtKB Beta strand 46 50 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Beta strand 52 63 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Beta strand 67 75 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Beta strand 78 86 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Beta strand 92 95 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Beta strand 98 103 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Beta strand 105 107 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Turn 108 111 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Helix 125 138 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Helix 139 141 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Beta strand 150 158 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Beta strand 161 163 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Helix 165 179 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Beta strand 180 182 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Beta strand 189 196 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Beta strand 199 203 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Helix 206 210 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Beta strand 212 221 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Turn 222 224 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Beta strand 225 236 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Helix 238 266 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Helix 281 299 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Helix 306 327 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Helix 333 355 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Beta strand 370 374 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Beta strand 380 388 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Beta strand 391 400 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Helix 402 405 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Helix 410 416 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Helix 420 422 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Beta strand 423 428 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Helix 431 434 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Helix 445 458 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Helix 459 461 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Beta strand 467 478 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Helix 483 497 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Beta strand 507 517 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Beta strand 519 522 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Beta strand 524 532 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Helix 535 539 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Beta strand 541 549 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Beta strand 554 561 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Helix 568 592 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Beta strand 606 611 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Helix 614 621 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Helix 623 625 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Helix 626 635 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Beta strand 638 641 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Beta strand 643 653 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K Q8TCS8 UniProtKB Helix 654 663 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U1K