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Protein

Protein FAM200A

Gene

FAM200A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM200A
Gene namesi
Name:FAM200A
Synonyms:C7orf38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:25401. FAM200A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 513513ExtracellularSequence analysisAdd
BLAST
Transmembranei514 – 53320HelicalSequence analysisAdd
BLAST
Topological domaini534 – 57340CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165618089.

Polymorphism and mutation databases

BioMutaiFAM200A.
DMDMi74730599.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 573573Protein FAM200APRO_0000279405Add
BLAST

Proteomic databases

EPDiQ8TCP9.
PaxDbiQ8TCP9.
PeptideAtlasiQ8TCP9.
PRIDEiQ8TCP9.

PTM databases

iPTMnetiQ8TCP9.
PhosphoSiteiQ8TCP9.

Expressioni

Gene expression databases

BgeeiENSG00000221909.
CleanExiHS_C7orf38.
ExpressionAtlasiQ8TCP9. baseline and differential.
GenevisibleiQ8TCP9. HS.

Organism-specific databases

HPAiHPA017855.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
G2XKQ03EBI-2799179,EBI-10175576
RBM39Q14498-33EBI-2799179,EBI-6654703

Protein-protein interaction databases

BioGridi128754. 4 interactions.
IntActiQ8TCP9. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8TCP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM200 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVJH. Eukaryota.
ENOG41115RS. LUCA.
GeneTreeiENSGT00760000119070.
HOVERGENiHBG067573.
InParanoidiQ8TCP9.
OMAiTISRRIC.
OrthoDBiEOG091G09O3.
PhylomeDBiQ8TCP9.
TreeFamiTF328297.

Family and domain databases

InterProiIPR025398. DUF4371.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF14291. DUF4371. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TCP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPESRDTTD LSPGGTQEME GIVIVKVEEE DEEDHFQKER NKVESSPQVL
60 70 80 90 100
SRSTTMNERA LLSSYLVAYR VAKEKMAHTA AEKIILPACM DMVRTIFDDK
110 120 130 140 150
SADKLRTIPL SDNTISRRIC TIAKHLEAML ITRLQSGIDF AIQLDESTDI
160 170 180 190 200
ASCPTLLVYV RYVWQDDFVE DLLCCLNLNS HITGLDLFTE LENCLLGQYK
210 220 230 240 250
LNWKHCKGIS SDGTANMTGK HSRLTEKLLE ATHNNAVWNH CFIHREALVS
260 270 280 290 300
KEISPSLMDV LKNAVKTVNF IKGSSLNSRL LEIFCSEIGV NHTHLLFHTE
310 320 330 340 350
VRWLSQGKVL SRVYELRNEI YIFLVEKQSH LANIFEDDIW VTKLAYLSDI
360 370 380 390 400
FGILNELSLK MQGKNNDIFQ YLEHILGFQK TLLLWQARLK SNRPSYYMFP
410 420 430 440 450
TLLQHIEENI INEDCLKEIK LEILLHLTSL SQTFNYYFPE EKFESLKENI
460 470 480 490 500
WMKDPFAFQN PESIIELNLE PEEENELLQL SSSFTLKNYY KILSLSAFWI
510 520 530 540 550
KIKDDFPLLS RKSILLLLPF TTTYLCELGF SILTRLKTKK RNRLNSAPDM
560 570
RVALSSCVPD WKELMNRQAH PSH
Length:573
Mass (Da):66,276
Last modified:June 1, 2002 - v1
Checksum:iC19CC28D9C36FCF0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti125 – 1251H → R in BAF83413 (PubMed:14702039).Curated
Sequence conflicti202 – 2021N → S in BAG37839 (PubMed:14702039).Curated
Sequence conflicti319 – 3191E → G in BAF83413 (PubMed:14702039).Curated
Sequence conflicti330 – 3301H → L in BAC04288 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL713672 mRNA. Translation: CAD28478.1.
AK290724 mRNA. Translation: BAF83413.1.
AK315452 mRNA. Translation: BAG37839.1.
AC005020 Genomic DNA. No translation available.
CH236956 Genomic DNA. Translation: EAL23872.1.
CH471091 Genomic DNA. Translation: EAW76652.1.
CH471091 Genomic DNA. Translation: EAW76653.1.
BC040214 mRNA. Translation: AAH40214.1.
BC126337 mRNA. Translation: AAI26338.1.
BC130371 mRNA. Translation: AAI30372.1.
AK094113 mRNA. Translation: BAC04288.1.
CCDSiCCDS5668.1.
RefSeqiNP_659802.1. NM_145111.3.
XP_011514213.1. XM_011515911.2.
XP_011514215.1. XM_011515913.2.
UniGeneiHs.596587.

Genome annotation databases

EnsembliENST00000449309; ENSP00000411372; ENSG00000221909.
GeneIDi221786.
KEGGihsa:221786.
UCSCiuc003ura.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL713672 mRNA. Translation: CAD28478.1.
AK290724 mRNA. Translation: BAF83413.1.
AK315452 mRNA. Translation: BAG37839.1.
AC005020 Genomic DNA. No translation available.
CH236956 Genomic DNA. Translation: EAL23872.1.
CH471091 Genomic DNA. Translation: EAW76652.1.
CH471091 Genomic DNA. Translation: EAW76653.1.
BC040214 mRNA. Translation: AAH40214.1.
BC126337 mRNA. Translation: AAI26338.1.
BC130371 mRNA. Translation: AAI30372.1.
AK094113 mRNA. Translation: BAC04288.1.
CCDSiCCDS5668.1.
RefSeqiNP_659802.1. NM_145111.3.
XP_011514213.1. XM_011515911.2.
XP_011514215.1. XM_011515913.2.
UniGeneiHs.596587.

3D structure databases

ProteinModelPortaliQ8TCP9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128754. 4 interactions.
IntActiQ8TCP9. 5 interactions.

PTM databases

iPTMnetiQ8TCP9.
PhosphoSiteiQ8TCP9.

Polymorphism and mutation databases

BioMutaiFAM200A.
DMDMi74730599.

Proteomic databases

EPDiQ8TCP9.
PaxDbiQ8TCP9.
PeptideAtlasiQ8TCP9.
PRIDEiQ8TCP9.

Protocols and materials databases

DNASUi221786.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000449309; ENSP00000411372; ENSG00000221909.
GeneIDi221786.
KEGGihsa:221786.
UCSCiuc003ura.4. human.

Organism-specific databases

CTDi221786.
GeneCardsiFAM200A.
H-InvDBHIX0019277.
HGNCiHGNC:25401. FAM200A.
HPAiHPA017855.
neXtProtiNX_Q8TCP9.
PharmGKBiPA165618089.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVJH. Eukaryota.
ENOG41115RS. LUCA.
GeneTreeiENSGT00760000119070.
HOVERGENiHBG067573.
InParanoidiQ8TCP9.
OMAiTISRRIC.
OrthoDBiEOG091G09O3.
PhylomeDBiQ8TCP9.
TreeFamiTF328297.

Miscellaneous databases

GeneWikiiFAM200A.
GenomeRNAii221786.
PROiQ8TCP9.

Gene expression databases

BgeeiENSG00000221909.
CleanExiHS_C7orf38.
ExpressionAtlasiQ8TCP9. baseline and differential.
GenevisibleiQ8TCP9. HS.

Family and domain databases

InterProiIPR025398. DUF4371.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF14291. DUF4371. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiF200A_HUMAN
AccessioniPrimary (citable) accession number: Q8TCP9
Secondary accession number(s): A4D293
, A8K3V9, B2RD92, C9J6A8, D6W5T2, Q8N9P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: June 1, 2002
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.