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Protein

Protein FAM200A

Gene

FAM200A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM200A
Gene namesi
Name:FAM200A
Synonyms:C7orf38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000221909.2
HGNCiHGNC:25401 FAM200A
neXtProtiNX_Q8TCP9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 513ExtracellularSequence analysisAdd BLAST513
Transmembranei514 – 533HelicalSequence analysisAdd BLAST20
Topological domaini534 – 573CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000221909
PharmGKBiPA165618089

Polymorphism and mutation databases

BioMutaiFAM200A
DMDMi74730599

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002794051 – 573Protein FAM200AAdd BLAST573

Proteomic databases

PaxDbiQ8TCP9
PeptideAtlasiQ8TCP9
PRIDEiQ8TCP9
ProteomicsDBi74149

PTM databases

iPTMnetiQ8TCP9
PhosphoSitePlusiQ8TCP9

Expressioni

Gene expression databases

BgeeiENSG00000221909
CleanExiHS_C7orf38
ExpressionAtlasiQ8TCP9 baseline and differential
GenevisibleiQ8TCP9 HS

Organism-specific databases

HPAiHPA017855

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi128754, 7 interactors
IntActiQ8TCP9, 6 interactors
MINTiQ8TCP9

Structurei

3D structure databases

ProteinModelPortaliQ8TCP9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM200 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVJH Eukaryota
ENOG41115RS LUCA
GeneTreeiENSGT00860000133692
HOVERGENiHBG067573
InParanoidiQ8TCP9
OMAiTISRRIC
OrthoDBiEOG091G09O3
PhylomeDBiQ8TCP9
TreeFamiTF328297

Family and domain databases

InterProiView protein in InterPro
IPR012337 RNaseH-like_sf
SUPFAMiSSF53098 SSF53098, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TCP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPESRDTTD LSPGGTQEME GIVIVKVEEE DEEDHFQKER NKVESSPQVL
60 70 80 90 100
SRSTTMNERA LLSSYLVAYR VAKEKMAHTA AEKIILPACM DMVRTIFDDK
110 120 130 140 150
SADKLRTIPL SDNTISRRIC TIAKHLEAML ITRLQSGIDF AIQLDESTDI
160 170 180 190 200
ASCPTLLVYV RYVWQDDFVE DLLCCLNLNS HITGLDLFTE LENCLLGQYK
210 220 230 240 250
LNWKHCKGIS SDGTANMTGK HSRLTEKLLE ATHNNAVWNH CFIHREALVS
260 270 280 290 300
KEISPSLMDV LKNAVKTVNF IKGSSLNSRL LEIFCSEIGV NHTHLLFHTE
310 320 330 340 350
VRWLSQGKVL SRVYELRNEI YIFLVEKQSH LANIFEDDIW VTKLAYLSDI
360 370 380 390 400
FGILNELSLK MQGKNNDIFQ YLEHILGFQK TLLLWQARLK SNRPSYYMFP
410 420 430 440 450
TLLQHIEENI INEDCLKEIK LEILLHLTSL SQTFNYYFPE EKFESLKENI
460 470 480 490 500
WMKDPFAFQN PESIIELNLE PEEENELLQL SSSFTLKNYY KILSLSAFWI
510 520 530 540 550
KIKDDFPLLS RKSILLLLPF TTTYLCELGF SILTRLKTKK RNRLNSAPDM
560 570
RVALSSCVPD WKELMNRQAH PSH
Length:573
Mass (Da):66,276
Last modified:June 1, 2002 - v1
Checksum:iC19CC28D9C36FCF0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti125H → R in BAF83413 (PubMed:14702039).Curated1
Sequence conflicti202N → S in BAG37839 (PubMed:14702039).Curated1
Sequence conflicti319E → G in BAF83413 (PubMed:14702039).Curated1
Sequence conflicti330H → L in BAC04288 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL713672 mRNA Translation: CAD28478.1
AK290724 mRNA Translation: BAF83413.1
AK315452 mRNA Translation: BAG37839.1
AC005020 Genomic DNA No translation available.
CH236956 Genomic DNA Translation: EAL23872.1
CH471091 Genomic DNA Translation: EAW76652.1
CH471091 Genomic DNA Translation: EAW76653.1
BC040214 mRNA Translation: AAH40214.1
BC126337 mRNA Translation: AAI26338.1
BC130371 mRNA Translation: AAI30372.1
AK094113 mRNA Translation: BAC04288.1
CCDSiCCDS5668.1
RefSeqiNP_659802.1, NM_145111.3
XP_011514213.1, XM_011515911.2
XP_011514215.1, XM_011515913.2
UniGeneiHs.596587

Genome annotation databases

EnsembliENST00000449309; ENSP00000411372; ENSG00000221909
GeneIDi221786
KEGGihsa:221786
UCSCiuc003ura.4 human

Similar proteinsi

Entry informationi

Entry nameiF200A_HUMAN
AccessioniPrimary (citable) accession number: Q8TCP9
Secondary accession number(s): A4D293
, A8K3V9, B2RD92, C9J6A8, D6W5T2, Q8N9P3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: June 1, 2002
Last modified: June 20, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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