Reviewed,
UniProtKB/Swiss-Prot Q8TCJ0 (FBX25_HUMAN)
Last modified
November 25, 2008.
Version 53.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: F-box only protein 25 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 367 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. |
| Subunit structure | Directly interacts with SKP1A and CUL1. |
| Subcellular location | |
| Tissue specificity | Expressed in all brain tissue observed. |
| Involvement in disease | A chromosomal aberration involving FBXO25 is a cause of X-linked mental retardation (XLMR). Translocation t(X;8)(p11.22;p23.3) with SHROOM4. |
| Sequence similarities | Contains 1 F-box domain. |
Ontologies
Keywords | |
|---|---|
| Biological process | Ubl conjugation pathway |
| Cellular component | Nucleus |
| Coding sequence diversity | Alternative splicing Chromosomal rearrangement |
Gene Ontology (GO) | |
| Biological process | protein ubiquitination Ref.4 Non-traceable author statement. Source: UniProtKB ubiquitin-dependent protein catabolic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin ligase complex Ref.4Non-traceable author statement. Source: UniProtKB |
| Molecular function | ubiquitin-protein ligase activity Ref.4 Non-traceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Alternative products
| This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q8TCJ0-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Notes: No experimental confirmation available. | ||||||
| Isoform 2 (identifier: Q8TCJ0-2) The sequence of this isoform differs from the canonical sequence as follows: 331-339: Missing. | ||||||
| Isoform 3 (identifier: Q8TCJ0-3) The sequence of this isoform differs from the canonical sequence as follows: 1-67: Missing. 68-96: KKDHFRNDTNTQSFYREKWIYVHKESTKE → MEKYSIMKSMNMHRKKGKRTILEMTQILK 331-339: Missing. | ||||||
| Notes: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 367 | 367 | F-box only protein 25 | PRO_0000119911 | |||||
Regions | |||||||||
| Domain | 226 – 274 | 49 | F-box | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 67 | 67 | Missing in isoform 3. | VSP_013060 | |||||
| Alternative sequence | 68 – 96 | 29 | KKDHF…ESTKE → MEKYSIMKSMNMHRKKGKRT ILEMTQILK in isoform 3. | VSP_013061 | |||||
| Alternative sequence | 331 – 339 | 9 | Missing in isoform 2 and isoform 3. | VSP_007374 | |||||
Experimental info | |||||||||
| Mutagenesis | 244 | 1 | S → L: Loss of SKP1 binding | ||||||
| Sequence conflict | 38 | 1 | R → H in AAH50393. Ref.3 | ||||||
| Sequence conflict | 87 – 96 | 10 | IYVHKESTKE → LILTSVLLFQ Ref.4 | ||||||
| Sequence conflict | 121 | 1 | R → T in AAF04526. Ref.4 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Guo J.H., She X.Y., Yu L. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). |
| [2] | "Expression of Fbx25-containing protein in prostate cancer tissues." Tsujiawa K., Mitsui E., Ono Y., Sakamoto K., Konishi N., Yamamoto H. Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Prostatic carcinoma. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Brain and Placenta. |
| [4] | "Identification of a family of human F-box proteins." Cenciarelli C., Chiaur D.S., Guardavaccaro D., Parks W., Vidal M., Pagano M. Curr. Biol. 9:1177-1179(1999) [PubMed: 10531035] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 87-367 (ISOFORM 2). |
| [5] | "Characterization of FBX25, encoding a novel brain-expressed F-box protein." Hagens O., Minina E., Schweiger S., Ropers H.-H., Kalscheuer V. Biochim. Biophys. Acta 1760:110-118(2006) [PubMed: 16278047] [Abstract] Cited for: INTERACTION WITH SKP1A AND CUL1, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF SER-244. |
| [6] | "Disruptions of the novel KIAA1202 gene are associated with X-linked mental retardation." Hagens O., Dubos A., Abidi F., Barbi G., Van Zutven L., Hoeltzenbein M., Tommerup N., Moraine C., Fryns J.-P., Chelly J., van Bokhoven H., Gecz J., Dollfus H., Ropers H.-H., Schwartz C.E., de Cassia Stocco Dos Santos R., Kalscheuer V., Hanauer A. Hum. Genet. 118:578-590(2006) [PubMed: 16249884] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH SHROOM4. |
Cross-references
Sequence databases | |
|---|---|
| AF419858 mRNA. Translation: AAP97293.1. AB070270 mRNA. Translation: BAB85128.1. BC020249 mRNA. Translation: AAH20249.1. BC050393 mRNA. Translation: AAH50393.1. AF174605 mRNA. Translation: AAF04526.1. | |
| RefSeq | NP_036305.2. NP_904356.1. NP_904357.1. |
| UniGene | Hs.438454 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q8TCJ0. |
Genome annotation databases | |
| Ensembl | ENSG00000147364. Homo sapiens. [Contig view] |
| GeneID | 26260. |
| KEGG | hsa:26260. |
Organism-specific databases | |
| HGNC | HGNC:13596. FBXO25. |
| HPA | HPA002553. |
| MIM | 609098. gene. |
| PharmGKB | PA28038. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | Q8TCJ0. |
| HOVERGEN | Q8TCJ0. |
Gene expression databases | |
| ArrayExpress | Q8TCJ0. |
| CleanEx | HS_FBXO25. |
| GermOnline | ENSG00000147364. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001810. F-box. [Graphical view] |
| Pfam | PF00646. F-box. 1 hit. [Graphical view] |
| PROSITE | PS50181. FBOX. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| LinkHub | Q8TCJ0. |
| NextBio | 48509. |
| SOURCE | Search... |
Entry information
| Entry name | FBX25_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8TCJ0 Secondary accession number(s): Q6PJ83, Q7Z4V4, Q9UKB8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 8 Human chromosome 8: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


