Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

V-type proton ATPase subunit a

Gene

TCIRG1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transportUniRule annotation, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit aUniRule annotation
Gene namesi
Name:TCIRG1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:11647. TCIRG1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ8TCH1.

Expressioni

Gene expression databases

ExpressionAtlasiQ8TCH1. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000265686.

Structurei

3D structure databases

ProteinModelPortaliQ8TCH1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase 116 kDa subunit family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2189. Eukaryota.
COG1269. LUCA.
GeneTreeiENSGT00390000004941.

Family and domain databases

InterProiIPR002490. V-ATPase_116kDa_su.
[Graphical view]
PANTHERiPTHR11629. PTHR11629. 1 hit.
PfamiPF01496. V_ATPase_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8TCH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DDEEEAELVP SEVLMHQAIH TIEFCLGCVS NTASYLRLWA LSLAHARWNS
60
RTSSTQARAT S
Length:61
Mass (Da):6,805
Last modified:June 1, 2002 - v1
Checksum:iB5F91060BEFB3D01
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002807 Genomic DNA. No translation available.
AF497545 mRNA. Translation: AAM18704.1.
UniGeneiHs.495985.

Genome annotation databases

EnsembliENST00000530063; ENSP00000432957; ENSG00000110719.
UCSCiuc058elu.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002807 Genomic DNA. No translation available.
AF497545 mRNA. Translation: AAM18704.1.
UniGeneiHs.495985.

3D structure databases

ProteinModelPortaliQ8TCH1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000265686.

Proteomic databases

PaxDbiQ8TCH1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000530063; ENSP00000432957; ENSG00000110719.
UCSCiuc058elu.1. human.

Organism-specific databases

HGNCiHGNC:11647. TCIRG1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2189. Eukaryota.
COG1269. LUCA.
GeneTreeiENSGT00390000004941.

Miscellaneous databases

ChiTaRSiTCIRG1. human.

Gene expression databases

ExpressionAtlasiQ8TCH1. baseline and differential.

Family and domain databases

InterProiIPR002490. V-ATPase_116kDa_su.
[Graphical view]
PANTHERiPTHR11629. PTHR11629. 1 hit.
PfamiPF01496. V_ATPase_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Specificity of alternative splice form detection using RT-PCR with a primer spanning the exon junction."
    Shulzhenko N., Smirnova A.S., Morgun A., Gerbase-DeLima M.
    BioTechniques 34:1244-1249(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Uterine cervixImported.
  2. "Identification of new alternative splice events in the TCIRG1 gene in different human tissues."
    Smirnova A.S., Morgun A., Shulzhenko N., Silva I.D., Gerbase-DeLima M.
    Biochem. Biophys. Res. Commun. 330:943-949(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Uterine cervixImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ8TCH1_HUMAN
AccessioniPrimary (citable) accession number: Q8TCH1
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.