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Q8TCG5

- CPT1C_HUMAN

UniProt

Q8TCG5 - CPT1C_HUMAN

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Protein

Carnitine O-palmitoyltransferase 1, brain isoform

Gene

CPT1C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei470 – 4701Proton acceptorBy similarity
Binding sitei586 – 5861CarnitineBy similarity
Binding sitei588 – 5881CarnitineBy similarity
Binding sitei589 – 5891Coenzyme ABy similarity
Binding sitei599 – 5991CarnitineBy similarity

GO - Molecular functioni

  1. carnitine O-palmitoyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. carnitine metabolic process Source: Ensembl
  2. fatty acid beta-oxidation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:HS09892-MONOMER.
UniPathwayiUPA00659.

Names & Taxonomyi

Protein namesi
Recommended name:
Carnitine O-palmitoyltransferase 1, brain isoform (EC:2.3.1.21)
Short name:
CPT1-B
Alternative name(s):
CPT IC
Carnitine O-palmitoyltransferase I, brain isoform
Short name:
CPTI-B
Carnitine palmitoyltransferase 1C
Gene namesi
Name:CPT1C
Synonyms:CATL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:18540. CPT1C.

Subcellular locationi

Mitochondrion outer membrane By similarity; Multi-pass membrane protein By similarity. Cell junctionsynapse By similarity

GO - Cellular componenti

  1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: Ensembl
  2. cell junction Source: UniProtKB-KW
  3. endoplasmic reticulum membrane Source: Ensembl
  4. mitochondrial outer membrane Source: UniProtKB-KW
  5. synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Membrane, Mitochondrion, Mitochondrion outer membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134922321.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 803803Carnitine O-palmitoyltransferase 1, brain isoformPRO_0000210166Add
BLAST

Proteomic databases

PaxDbiQ8TCG5.
PRIDEiQ8TCG5.

PTM databases

PhosphoSiteiQ8TCG5.

Expressioni

Tissue specificityi

Expressed predominantly in brain and testis.1 Publication

Gene expression databases

BgeeiQ8TCG5.
CleanExiHS_CPT1C.
ExpressionAtlasiQ8TCG5. baseline and differential.
GenevestigatoriQ8TCG5.

Organism-specific databases

HPAiHPA014529.

Interactioni

Subunit structurei

Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including CPT1C. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity).By similarity

Protein-protein interaction databases

BioGridi125958. 1 interaction.
MINTiMINT-6631074.
STRINGi9606.ENSP00000319343.

Structurei

Secondary structure

1
803
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni13 – 153
Helixi25 – 4824

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2M76NMR-A1-50[»]
ProteinModelPortaliQ8TCG5.
SMRiQ8TCG5. Positions 1-50, 180-764.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5252CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini76 – 10328Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Topological domaini127 – 803677CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei53 – 7523HelicalSequence AnalysisAdd
BLAST
Transmembranei104 – 12623HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni552 – 56413Coenzyme A bindingBy similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG272759.
GeneTreeiENSGT00760000119220.
HOGENOMiHOG000233542.
HOVERGENiHBG003458.
InParanoidiQ8TCG5.
KOiK08765.
OMAiIDCHVFP.
OrthoDBiEOG7J17ZQ.
PhylomeDBiQ8TCG5.
TreeFamiTF313836.

Family and domain databases

InterProiIPR000542. Carn_acyl_trans.
[Graphical view]
PANTHERiPTHR22589. PTHR22589. 1 hit.
PfamiPF00755. Carn_acyltransf. 1 hit.
[Graphical view]
PROSITEiPS00439. ACYLTRANSF_C_1. 1 hit.
PS00440. ACYLTRANSF_C_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8TCG5) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAHQAVGF RPSLTSDGAE VELSAPVLQE IYLSGLRSWK RHLSRFWNDF
60 70 80 90 100
LTGVFPASPL SWLFLFSAIQ LAWFLQLDPS LGLMEKIKEL LPDWGGQHHG
110 120 130 140 150
LRGVLAAALF ASCLWGALIF TLHVALRLLL SYHGWLLEPH GAMSSPTKTW
160 170 180 190 200
LALVRIFSGR HPMLFSYQRS LPRQPVPSVQ DTVRKYLESV RPILSDEDFD
210 220 230 240 250
WTAVLAQEFL RLQASLLQWY LRLKSWWASN YVSDWWEEFV YLRSRNPLMV
260 270 280 290 300
NSNYYMMDFL YVTPTPLQAA RAGNAVHALL LYRHRLNRQE IPPTLLMGMR
310 320 330 340 350
PLCSAQYEKI FNTTRIPGVQ KDYIRHLHDS QHVAVFHRGR FFRMGTHSRN
360 370 380 390 400
SLLSPRALEQ QFQRILDDPS PACPHEEHLA ALTAAPRGTW AQVRTSLKTQ
410 420 430 440 450
AAEALEAVEG AAFFVSLDAE PAGLTREDPA ASLDAYAHAL LAGRGHDRWF
460 470 480 490 500
DKSFTLIVFS NGKLGLSVEH SWADCPISGH MWEFTLATEC FQLGYSTDGH
510 520 530 540 550
CKGHPDPTLP QPQRLQWDLP DQIHSSISLA LRGAKILSEN VDCHVVPFSL
560 570 580 590 600
FGKSFIRRCH LSSDSFIQIA LQLAHFRDRG QFCLTYESAM TRLFLEGRTE
610 620 630 640 650
TVRSCTREAC NFVRAMEDKE KTDPQCLALF RVAVDKHQAL LKAAMSGQGV
660 670 680 690 700
DRHLFALYIV SRFLHLQSPF LTQVHSEQWQ LSTSQIPVQQ MHLFDVHNYP
710 720 730 740 750
DYVSSGGGFG PADDHGYGVS YIFMGDGMIT FHISSKKSST KTDSHRLGQH
760 770 780 790 800
IEDALLDVAS LFQAGQHFKR RFRGSGKENS RHRCGFLSRQ TGASKASMTS

TDF
Length:803
Mass (Da):90,989
Last modified:June 1, 2002 - v1
Checksum:i96C2AE6ED0DEC705
GO
Isoform 2 (identifier: Q8TCG5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-268: Missing.

Note: No experimental confirmation available.

Show »
Length:792
Mass (Da):89,713
Checksum:i3420B3FE0457E895
GO
Isoform 3 (identifier: Q8TCG5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     623-711: Missing.

Note: No experimental confirmation available.

Show »
Length:714
Mass (Da):81,000
Checksum:i4435ECAA8502D6BA
GO

Sequence cautioni

The sequence BAB85068.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAD38561.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581S → G in BAF82402. (PubMed:14702039)Curated
Sequence conflicti375 – 3784HEEH → RTRG in CAD38561. (PubMed:17974005)Curated
Sequence conflicti542 – 5421D → G in BAB85068. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei258 – 26811Missing in isoform 2. 1 PublicationVSP_010677Add
BLAST
Alternative sequencei623 – 71189Missing in isoform 3. 1 PublicationVSP_012457Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF357970 mRNA. Translation: AAL99615.1.
AF331918 Genomic DNA. Translation: AAQ14875.1.
AK074389 mRNA. Translation: BAB85068.1. Different initiation.
AK289713 mRNA. Translation: BAF82402.1.
AK290092 mRNA. Translation: BAF82781.1.
CH471177 Genomic DNA. Translation: EAW52524.1.
BC029104 mRNA. Translation: AAH29104.1.
AL831876 mRNA. Translation: CAD38561.2. Different initiation.
CCDSiCCDS12779.1. [Q8TCG5-1]
CCDS46147.1. [Q8TCG5-2]
RefSeqiNP_001129524.1. NM_001136052.2. [Q8TCG5-2]
NP_001186681.1. NM_001199752.2. [Q8TCG5-1]
NP_001186682.1. NM_001199753.1. [Q8TCG5-1]
NP_689572.1. NM_152359.2. [Q8TCG5-1]
XP_005258562.1. XM_005258505.2. [Q8TCG5-1]
XP_005258563.1. XM_005258506.2. [Q8TCG5-1]
UniGeneiHs.112195.

Genome annotation databases

EnsembliENST00000323446; ENSP00000319343; ENSG00000169169. [Q8TCG5-1]
ENST00000392518; ENSP00000376303; ENSG00000169169. [Q8TCG5-1]
ENST00000405931; ENSP00000384465; ENSG00000169169. [Q8TCG5-2]
ENST00000598293; ENSP00000473028; ENSG00000169169. [Q8TCG5-1]
GeneIDi126129.
KEGGihsa:126129.
UCSCiuc002ppi.3. human. [Q8TCG5-1]
uc002ppk.3. human. [Q8TCG5-2]
uc010eni.1. human. [Q8TCG5-3]

Polymorphism databases

DMDMi57013809.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF357970 mRNA. Translation: AAL99615.1 .
AF331918 Genomic DNA. Translation: AAQ14875.1 .
AK074389 mRNA. Translation: BAB85068.1 . Different initiation.
AK289713 mRNA. Translation: BAF82402.1 .
AK290092 mRNA. Translation: BAF82781.1 .
CH471177 Genomic DNA. Translation: EAW52524.1 .
BC029104 mRNA. Translation: AAH29104.1 .
AL831876 mRNA. Translation: CAD38561.2 . Different initiation.
CCDSi CCDS12779.1. [Q8TCG5-1 ]
CCDS46147.1. [Q8TCG5-2 ]
RefSeqi NP_001129524.1. NM_001136052.2. [Q8TCG5-2 ]
NP_001186681.1. NM_001199752.2. [Q8TCG5-1 ]
NP_001186682.1. NM_001199753.1. [Q8TCG5-1 ]
NP_689572.1. NM_152359.2. [Q8TCG5-1 ]
XP_005258562.1. XM_005258505.2. [Q8TCG5-1 ]
XP_005258563.1. XM_005258506.2. [Q8TCG5-1 ]
UniGenei Hs.112195.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2M76 NMR - A 1-50 [» ]
ProteinModelPortali Q8TCG5.
SMRi Q8TCG5. Positions 1-50, 180-764.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125958. 1 interaction.
MINTi MINT-6631074.
STRINGi 9606.ENSP00000319343.

PTM databases

PhosphoSitei Q8TCG5.

Polymorphism databases

DMDMi 57013809.

Proteomic databases

PaxDbi Q8TCG5.
PRIDEi Q8TCG5.

Protocols and materials databases

DNASUi 126129.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000323446 ; ENSP00000319343 ; ENSG00000169169 . [Q8TCG5-1 ]
ENST00000392518 ; ENSP00000376303 ; ENSG00000169169 . [Q8TCG5-1 ]
ENST00000405931 ; ENSP00000384465 ; ENSG00000169169 . [Q8TCG5-2 ]
ENST00000598293 ; ENSP00000473028 ; ENSG00000169169 . [Q8TCG5-1 ]
GeneIDi 126129.
KEGGi hsa:126129.
UCSCi uc002ppi.3. human. [Q8TCG5-1 ]
uc002ppk.3. human. [Q8TCG5-2 ]
uc010eni.1. human. [Q8TCG5-3 ]

Organism-specific databases

CTDi 126129.
GeneCardsi GC19P050207.
HGNCi HGNC:18540. CPT1C.
HPAi HPA014529.
MIMi 608846. gene.
neXtProti NX_Q8TCG5.
PharmGKBi PA134922321.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG272759.
GeneTreei ENSGT00760000119220.
HOGENOMi HOG000233542.
HOVERGENi HBG003458.
InParanoidi Q8TCG5.
KOi K08765.
OMAi IDCHVFP.
OrthoDBi EOG7J17ZQ.
PhylomeDBi Q8TCG5.
TreeFami TF313836.

Enzyme and pathway databases

UniPathwayi UPA00659 .
BioCyci MetaCyc:HS09892-MONOMER.

Miscellaneous databases

GenomeRNAii 126129.
NextBioi 81696.
PROi Q8TCG5.
SOURCEi Search...

Gene expression databases

Bgeei Q8TCG5.
CleanExi HS_CPT1C.
ExpressionAtlasi Q8TCG5. baseline and differential.
Genevestigatori Q8TCG5.

Family and domain databases

InterProi IPR000542. Carn_acyl_trans.
[Graphical view ]
PANTHERi PTHR22589. PTHR22589. 1 hit.
Pfami PF00755. Carn_acyltransf. 1 hit.
[Graphical view ]
PROSITEi PS00439. ACYLTRANSF_C_1. 1 hit.
PS00440. ACYLTRANSF_C_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel brain-expressed protein related to carnitine palmitoyltransferase I."
    Price N., van der Leij F.R., Jackson V., Corstorphine C., Thomson R., Sorensen A., Zammit V.
    Genomics 80:433-442(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Eye.
  2. "Molecular characterization, chromosomal localization and expression analysis of a gene, CATL1, encoding for a new member of the human carnitine acyltransferase family."
    Scorilas A., Katsaros N.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain, Kidney epithelium and Subthalamic nucleus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Eye.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 375-803 (ISOFORM 3).
    Tissue: Brain.

Entry informationi

Entry nameiCPT1C_HUMAN
AccessioniPrimary (citable) accession number: Q8TCG5
Secondary accession number(s): A8K0Z8
, Q5K6N5, Q8N6Q9, Q8NDS6, Q8TE84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3