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Protein

Protein CIP2A

Gene

KIAA1524

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation.1 Publication

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163507-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CIP2A
Alternative name(s):
Cancerous inhibitor of PP2A
p90 autoantigen
Gene namesi
Name:KIAA1524
Synonyms:CIP2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:29302. KIAA1524.

Subcellular locationi

  • Membrane Curated; Single-pass membrane protein Curated
  • Cytoplasm 1 Publication

  • Note: Slightly concentrates in the perinuclear region.

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57650.
OpenTargetsiENSG00000163507.
PharmGKBiPA134887850.

Chemistry databases

ChEMBLiCHEMBL2146355.

Polymorphism and mutation databases

BioMutaiKIAA1524.
DMDMi147647143.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002871411 – 905Protein CIP2AAdd BLAST905

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei573PhosphoserineCombined sources1
Modified residuei904PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8TCG1.
MaxQBiQ8TCG1.
PaxDbiQ8TCG1.
PeptideAtlasiQ8TCG1.
PRIDEiQ8TCG1.

PTM databases

iPTMnetiQ8TCG1.
PhosphoSitePlusiQ8TCG1.

Expressioni

Tissue specificityi

Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas (HNSCC). Present in liver cancer cells (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000163507.
CleanExiHS_KIAA1524.
ExpressionAtlasiQ8TCG1. baseline and differential.
GenevisibleiQ8TCG1. HS.

Organism-specific databases

HPAiHPA039570.

Interactioni

Subunit structurei

Interacts with MYC.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MYCP011062EBI-1379376,EBI-447544
PPP2R1AP301534EBI-1379376,EBI-302388

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi121687. 39 interactors.
IntActiQ8TCG1. 12 interactors.
MINTiMINT-4995323.
STRINGi9606.ENSP00000295746.

Structurei

3D structure databases

ProteinModelPortaliQ8TCG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili637 – 883Sequence analysisAdd BLAST247

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ1I. Eukaryota.
ENOG4110856. LUCA.
GeneTreeiENSGT00390000006861.
HOVERGENiHBG107688.
InParanoidiQ8TCG1.
PhylomeDBiQ8TCG1.
TreeFamiTF328534.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TCG1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSTACLKSL LLTVSQYKAV KSEANATQLL RHLEVISGQK LTRLFTSNQI
60 70 80 90 100
LTSECLSCLV ELLEDPNISA SLILSIIGLL SQLAVDIETR DCLQNTYNLN
110 120 130 140 150
SVLAGVVCRS SHTDSVFLQC IQLLQKLTYN VKIFYSGANI DELITFLIDH
160 170 180 190 200
IQSSEDELKM PCLGLLANLC RHNLSVQTHI KTLSNVKSFY RTLITLLAHS
210 220 230 240 250
SLTVVVFALS ILSSLTLNEE VGEKLFHARN IHQTFQLIFN ILINGDGTLT
260 270 280 290 300
RKYSVDLLMD LLKNPKIADY LTRYEHFSSC LHQVLGLLNG KDPDSSSKVL
310 320 330 340 350
ELLLAFCSVT QLRHMLTQMM FEQSPPGSAT LGSHTKCLEP TVALLRWLSQ
360 370 380 390 400
PLDGSENCSV LALELFKEIF EDVIDAANCS SADRFVTLLL PTILDQLQFT
410 420 430 440 450
EQNLDEALTR KKCERIAKAI EVLLTLCGDD TLKMHIAKIL TTVKCTTLIE
460 470 480 490 500
QQFTYGKIDL GFGTKVADSE LCKLAADVIL KTLDLINKLK PLVPGMEVSF
510 520 530 540 550
YKILQDPRLI TPLAFALTSD NREQVQSGLR ILLEAAPLPD FPALVLGESI
560 570 580 590 600
AANNAYRQQE TEHIPRKMPW QSSNHSFPTS IKCLTPHLKD GVPGLNIEEL
610 620 630 640 650
IEKLQSGMVV KDQICDVRIS DIMDVYEMKL STLASKESRL QDLLETKALA
660 670 680 690 700
LAQADRLIAQ HRCQRTQAET EARTLASMLR EVERKNEELS VLLKAQQVES
710 720 730 740 750
ERAQSDIEHL FQHNRKLESV AEEHEILTKS YMELLQRNES TEKKNKDLQI
760 770 780 790 800
TCDSLNKQIE TVKKLNESLK EQNEKSIAQL IEKEEQRKEV QNQLVDREHK
810 820 830 840 850
LANLHQKTKV QEEKIKTLQK EREDKEETID ILRKELSRTE QIRKELSIKA
860 870 880 890 900
SSLEVQKAQL EGRLEEKESL VKLQQEELNK HSHMIAMIHS LSGGKINPET

VNLSI
Length:905
Mass (Da):102,185
Last modified:May 15, 2007 - v2
Checksum:iDAB9CCC03BCEA304
GO
Isoform 2 (identifier: Q8TCG1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: Missing.

Note: No experimental confirmation available.
Show »
Length:746
Mass (Da):84,579
Checksum:i926A1001A55C4248
GO

Sequence cautioni

The sequence AAH63433 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA96048 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14305 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti412 – 415KCER → NVKG in CAD28489 (PubMed:17974005).Curated4
Sequence conflicti419A → S in AAL11632 (PubMed:12118381).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046939126K → R.Corresponds to variant rs7648496dbSNPEnsembl.1
Natural variantiVAR_046940229R → Q.Corresponds to variant rs2278911dbSNPEnsembl.1
Natural variantiVAR_046941409T → I.Corresponds to variant rs9856308dbSNPEnsembl.1
Natural variantiVAR_046942447T → A.Corresponds to variant rs34944683dbSNPEnsembl.1
Natural variantiVAR_046943494P → L.Corresponds to variant rs13083928dbSNPEnsembl.1
Natural variantiVAR_046944572S → A.Corresponds to variant rs34172460dbSNPEnsembl.1
Natural variantiVAR_046945680R → T.Corresponds to variant rs6777766dbSNPEnsembl.1
Natural variantiVAR_046946759I → V.Corresponds to variant rs13071874dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0253361 – 159Missing in isoform 2. 1 PublicationAdd BLAST159

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334474 mRNA. Translation: AAL11632.1.
AB040957 mRNA. Translation: BAA96048.1. Different initiation.
AL713689 mRNA. Translation: CAD28489.1.
BC017659 mRNA. Translation: AAH17659.1.
BC063433 mRNA. Translation: AAH63433.1. Different initiation.
BC130564 mRNA. Translation: AAI30565.1.
BC136371 mRNA. Translation: AAI36372.1.
AK022912 mRNA. Translation: BAB14305.1. Different initiation.
CCDSiCCDS33812.1. [Q8TCG1-1]
RefSeqiNP_065941.2. NM_020890.2. [Q8TCG1-1]
XP_006713780.1. XM_006713717.2. [Q8TCG1-2]
XP_011511358.1. XM_011513056.1. [Q8TCG1-2]
UniGeneiHs.591308.

Genome annotation databases

EnsembliENST00000295746; ENSP00000295746; ENSG00000163507. [Q8TCG1-1]
ENST00000491772; ENSP00000419487; ENSG00000163507. [Q8TCG1-2]
GeneIDi57650.
KEGGihsa:57650.
UCSCiuc003dxb.5. human. [Q8TCG1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334474 mRNA. Translation: AAL11632.1.
AB040957 mRNA. Translation: BAA96048.1. Different initiation.
AL713689 mRNA. Translation: CAD28489.1.
BC017659 mRNA. Translation: AAH17659.1.
BC063433 mRNA. Translation: AAH63433.1. Different initiation.
BC130564 mRNA. Translation: AAI30565.1.
BC136371 mRNA. Translation: AAI36372.1.
AK022912 mRNA. Translation: BAB14305.1. Different initiation.
CCDSiCCDS33812.1. [Q8TCG1-1]
RefSeqiNP_065941.2. NM_020890.2. [Q8TCG1-1]
XP_006713780.1. XM_006713717.2. [Q8TCG1-2]
XP_011511358.1. XM_011513056.1. [Q8TCG1-2]
UniGeneiHs.591308.

3D structure databases

ProteinModelPortaliQ8TCG1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121687. 39 interactors.
IntActiQ8TCG1. 12 interactors.
MINTiMINT-4995323.
STRINGi9606.ENSP00000295746.

Chemistry databases

ChEMBLiCHEMBL2146355.

PTM databases

iPTMnetiQ8TCG1.
PhosphoSitePlusiQ8TCG1.

Polymorphism and mutation databases

BioMutaiKIAA1524.
DMDMi147647143.

Proteomic databases

EPDiQ8TCG1.
MaxQBiQ8TCG1.
PaxDbiQ8TCG1.
PeptideAtlasiQ8TCG1.
PRIDEiQ8TCG1.

Protocols and materials databases

DNASUi57650.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295746; ENSP00000295746; ENSG00000163507. [Q8TCG1-1]
ENST00000491772; ENSP00000419487; ENSG00000163507. [Q8TCG1-2]
GeneIDi57650.
KEGGihsa:57650.
UCSCiuc003dxb.5. human. [Q8TCG1-1]

Organism-specific databases

CTDi57650.
DisGeNETi57650.
GeneCardsiKIAA1524.
H-InvDBHIX0003530.
HGNCiHGNC:29302. KIAA1524.
HPAiHPA039570.
MIMi610643. gene.
neXtProtiNX_Q8TCG1.
OpenTargetsiENSG00000163507.
PharmGKBiPA134887850.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ1I. Eukaryota.
ENOG4110856. LUCA.
GeneTreeiENSGT00390000006861.
HOVERGENiHBG107688.
InParanoidiQ8TCG1.
PhylomeDBiQ8TCG1.
TreeFamiTF328534.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163507-MONOMER.

Miscellaneous databases

ChiTaRSiKIAA1524. human.
GeneWikiiKIAA1524.
GenomeRNAii57650.
PROiQ8TCG1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163507.
CleanExiHS_KIAA1524.
ExpressionAtlasiQ8TCG1. baseline and differential.
GenevisibleiQ8TCG1. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCIP2A_HUMAN
AccessioniPrimary (citable) accession number: Q8TCG1
Secondary accession number(s): A1L4J7
, B9EGC3, Q6P4G6, Q8WVP8, Q96PI2, Q9H9C6, Q9P204
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: November 30, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Antibodies against KIAA1524 are present in sera from many patients with gastric or prostate cancer, suggesting that it may act as a marker for such cancers.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.