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Protein

Protein CIP2A

Gene

KIAA1524

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation.1 Publication

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CIP2A
Alternative name(s):
Cancerous inhibitor of PP2A
p90 autoantigen
Gene namesi
Name:KIAA1524
Synonyms:CIP2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:29302. KIAA1524.

Subcellular locationi

  • Membrane Curated; Single-pass membrane protein Curated
  • Cytoplasm 1 Publication

  • Note: Slightly concentrates in the perinuclear region.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei192 – 21221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134887850.

Chemistry

ChEMBLiCHEMBL2146355.

Polymorphism and mutation databases

BioMutaiKIAA1524.
DMDMi147647143.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 905905Protein CIP2APRO_0000287141Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei904 – 9041PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8TCG1.
MaxQBiQ8TCG1.
PaxDbiQ8TCG1.
PRIDEiQ8TCG1.

PTM databases

iPTMnetiQ8TCG1.
PhosphoSiteiQ8TCG1.

Expressioni

Tissue specificityi

Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas (HNSCC). Present in liver cancer cells (at protein level).2 Publications

Gene expression databases

BgeeiQ8TCG1.
CleanExiHS_KIAA1524.
ExpressionAtlasiQ8TCG1. baseline and differential.
GenevisibleiQ8TCG1. HS.

Organism-specific databases

HPAiHPA039570.

Interactioni

Subunit structurei

Interacts with MYC.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MYCP011062EBI-1379376,EBI-447544
PPP2R1AP301534EBI-1379376,EBI-302388

Protein-protein interaction databases

BioGridi121687. 38 interactions.
IntActiQ8TCG1. 11 interactions.
MINTiMINT-4995323.
STRINGi9606.ENSP00000295746.

Structurei

3D structure databases

ProteinModelPortaliQ8TCG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili637 – 883247Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ1I. Eukaryota.
ENOG4110856. LUCA.
GeneTreeiENSGT00390000006861.
HOVERGENiHBG107688.
InParanoidiQ8TCG1.
OrthoDBiEOG79CXXR.
PhylomeDBiQ8TCG1.
TreeFamiTF328534.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TCG1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSTACLKSL LLTVSQYKAV KSEANATQLL RHLEVISGQK LTRLFTSNQI
60 70 80 90 100
LTSECLSCLV ELLEDPNISA SLILSIIGLL SQLAVDIETR DCLQNTYNLN
110 120 130 140 150
SVLAGVVCRS SHTDSVFLQC IQLLQKLTYN VKIFYSGANI DELITFLIDH
160 170 180 190 200
IQSSEDELKM PCLGLLANLC RHNLSVQTHI KTLSNVKSFY RTLITLLAHS
210 220 230 240 250
SLTVVVFALS ILSSLTLNEE VGEKLFHARN IHQTFQLIFN ILINGDGTLT
260 270 280 290 300
RKYSVDLLMD LLKNPKIADY LTRYEHFSSC LHQVLGLLNG KDPDSSSKVL
310 320 330 340 350
ELLLAFCSVT QLRHMLTQMM FEQSPPGSAT LGSHTKCLEP TVALLRWLSQ
360 370 380 390 400
PLDGSENCSV LALELFKEIF EDVIDAANCS SADRFVTLLL PTILDQLQFT
410 420 430 440 450
EQNLDEALTR KKCERIAKAI EVLLTLCGDD TLKMHIAKIL TTVKCTTLIE
460 470 480 490 500
QQFTYGKIDL GFGTKVADSE LCKLAADVIL KTLDLINKLK PLVPGMEVSF
510 520 530 540 550
YKILQDPRLI TPLAFALTSD NREQVQSGLR ILLEAAPLPD FPALVLGESI
560 570 580 590 600
AANNAYRQQE TEHIPRKMPW QSSNHSFPTS IKCLTPHLKD GVPGLNIEEL
610 620 630 640 650
IEKLQSGMVV KDQICDVRIS DIMDVYEMKL STLASKESRL QDLLETKALA
660 670 680 690 700
LAQADRLIAQ HRCQRTQAET EARTLASMLR EVERKNEELS VLLKAQQVES
710 720 730 740 750
ERAQSDIEHL FQHNRKLESV AEEHEILTKS YMELLQRNES TEKKNKDLQI
760 770 780 790 800
TCDSLNKQIE TVKKLNESLK EQNEKSIAQL IEKEEQRKEV QNQLVDREHK
810 820 830 840 850
LANLHQKTKV QEEKIKTLQK EREDKEETID ILRKELSRTE QIRKELSIKA
860 870 880 890 900
SSLEVQKAQL EGRLEEKESL VKLQQEELNK HSHMIAMIHS LSGGKINPET

VNLSI
Length:905
Mass (Da):102,185
Last modified:May 15, 2007 - v2
Checksum:iDAB9CCC03BCEA304
GO
Isoform 2 (identifier: Q8TCG1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: Missing.

Note: No experimental confirmation available.
Show »
Length:746
Mass (Da):84,579
Checksum:i926A1001A55C4248
GO

Sequence cautioni

The sequence AAH63433.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA96048.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB14305.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti412 – 4154KCER → NVKG in CAD28489 (PubMed:17974005).Curated
Sequence conflicti419 – 4191A → S in AAL11632 (PubMed:12118381).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti126 – 1261K → R.
Corresponds to variant rs7648496 [ dbSNP | Ensembl ].
VAR_046939
Natural varianti229 – 2291R → Q.
Corresponds to variant rs2278911 [ dbSNP | Ensembl ].
VAR_046940
Natural varianti409 – 4091T → I.
Corresponds to variant rs9856308 [ dbSNP | Ensembl ].
VAR_046941
Natural varianti447 – 4471T → A.
Corresponds to variant rs34944683 [ dbSNP | Ensembl ].
VAR_046942
Natural varianti494 – 4941P → L.
Corresponds to variant rs13083928 [ dbSNP | Ensembl ].
VAR_046943
Natural varianti572 – 5721S → A.
Corresponds to variant rs34172460 [ dbSNP | Ensembl ].
VAR_046944
Natural varianti680 – 6801R → T.
Corresponds to variant rs6777766 [ dbSNP | Ensembl ].
VAR_046945
Natural varianti759 – 7591I → V.
Corresponds to variant rs13071874 [ dbSNP | Ensembl ].
VAR_046946

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 159159Missing in isoform 2. 1 PublicationVSP_025336Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334474 mRNA. Translation: AAL11632.1.
AB040957 mRNA. Translation: BAA96048.1. Different initiation.
AL713689 mRNA. Translation: CAD28489.1.
BC017659 mRNA. Translation: AAH17659.1.
BC063433 mRNA. Translation: AAH63433.1. Different initiation.
BC130564 mRNA. Translation: AAI30565.1.
BC136371 mRNA. Translation: AAI36372.1.
AK022912 mRNA. Translation: BAB14305.1. Different initiation.
CCDSiCCDS33812.1. [Q8TCG1-1]
RefSeqiNP_065941.2. NM_020890.2. [Q8TCG1-1]
XP_006713780.1. XM_006713717.2. [Q8TCG1-2]
XP_011511358.1. XM_011513056.1. [Q8TCG1-2]
UniGeneiHs.591308.

Genome annotation databases

EnsembliENST00000295746; ENSP00000295746; ENSG00000163507. [Q8TCG1-1]
ENST00000491772; ENSP00000419487; ENSG00000163507. [Q8TCG1-2]
GeneIDi57650.
KEGGihsa:57650.
UCSCiuc003dxb.5. human. [Q8TCG1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334474 mRNA. Translation: AAL11632.1.
AB040957 mRNA. Translation: BAA96048.1. Different initiation.
AL713689 mRNA. Translation: CAD28489.1.
BC017659 mRNA. Translation: AAH17659.1.
BC063433 mRNA. Translation: AAH63433.1. Different initiation.
BC130564 mRNA. Translation: AAI30565.1.
BC136371 mRNA. Translation: AAI36372.1.
AK022912 mRNA. Translation: BAB14305.1. Different initiation.
CCDSiCCDS33812.1. [Q8TCG1-1]
RefSeqiNP_065941.2. NM_020890.2. [Q8TCG1-1]
XP_006713780.1. XM_006713717.2. [Q8TCG1-2]
XP_011511358.1. XM_011513056.1. [Q8TCG1-2]
UniGeneiHs.591308.

3D structure databases

ProteinModelPortaliQ8TCG1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121687. 38 interactions.
IntActiQ8TCG1. 11 interactions.
MINTiMINT-4995323.
STRINGi9606.ENSP00000295746.

Chemistry

ChEMBLiCHEMBL2146355.

PTM databases

iPTMnetiQ8TCG1.
PhosphoSiteiQ8TCG1.

Polymorphism and mutation databases

BioMutaiKIAA1524.
DMDMi147647143.

Proteomic databases

EPDiQ8TCG1.
MaxQBiQ8TCG1.
PaxDbiQ8TCG1.
PRIDEiQ8TCG1.

Protocols and materials databases

DNASUi57650.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295746; ENSP00000295746; ENSG00000163507. [Q8TCG1-1]
ENST00000491772; ENSP00000419487; ENSG00000163507. [Q8TCG1-2]
GeneIDi57650.
KEGGihsa:57650.
UCSCiuc003dxb.5. human. [Q8TCG1-1]

Organism-specific databases

CTDi57650.
GeneCardsiKIAA1524.
H-InvDBHIX0003530.
HGNCiHGNC:29302. KIAA1524.
HPAiHPA039570.
MIMi610643. gene.
neXtProtiNX_Q8TCG1.
PharmGKBiPA134887850.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ1I. Eukaryota.
ENOG4110856. LUCA.
GeneTreeiENSGT00390000006861.
HOVERGENiHBG107688.
InParanoidiQ8TCG1.
OrthoDBiEOG79CXXR.
PhylomeDBiQ8TCG1.
TreeFamiTF328534.

Miscellaneous databases

ChiTaRSiKIAA1524. human.
GeneWikiiKIAA1524.
GenomeRNAii57650.
NextBioi64396.
PROiQ8TCG1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TCG1.
CleanExiHS_KIAA1524.
ExpressionAtlasiQ8TCG1. baseline and differential.
GenevisibleiQ8TCG1. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel 90 kDa 'companion' auto-antigen of p62 overexpressed in cancer."
    Soo Hoo L., Zhang J.Y., Chan E.K.L.
    Oncogene 21:5006-5015(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, PRESENCE OF AUTOANTIBODIES, TISSUE SPECIFICITY.
  2. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain, Mammary gland and Uterus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Melanoma.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 375-905.
    Tissue: Teratocarcinoma.
  6. "Preferential humoral immune response in prostate cancer to cellular proteins p90 and p62 in a panel of tumor-associated antigens."
    Shi F.D., Zhang J.Y., Liu D., Rearden A., Elliot M., Nachtsheim D., Daniels T., Casiano C.A., Heeb M.J., Chan E.K.L., Tan E.M.
    Prostate 63:252-258(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRESENCE OF AUTOANTIBODIES.
  7. Cited for: FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH MYC.
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-904, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-904, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCIP2A_HUMAN
AccessioniPrimary (citable) accession number: Q8TCG1
Secondary accession number(s): A1L4J7
, B9EGC3, Q6P4G6, Q8WVP8, Q96PI2, Q9H9C6, Q9P204
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: May 11, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Antibodies against KIAA1524 are present in sera from many patients with gastric or prostate cancer, suggesting that it may act as a marker for such cancers.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.