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Protein

Protein CIP2A

Gene

KIAA1524

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation.1 Publication

Miscellaneous

Antibodies against KIAA1524 are present in sera from many patients with gastric or prostate cancer, suggesting that it may act as a marker for such cancers.

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CIP2A
Alternative name(s):
Cancerous inhibitor of PP2A
p90 autoantigen
Gene namesi
Name:KIAA1524
Synonyms:CIP2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163507.13.
HGNCiHGNC:29302. KIAA1524.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57650.
OpenTargetsiENSG00000163507.
PharmGKBiPA134887850.

Chemistry databases

ChEMBLiCHEMBL2146355.

Polymorphism and mutation databases

BioMutaiKIAA1524.
DMDMi147647143.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002871411 – 905Protein CIP2AAdd BLAST905

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei573PhosphoserineCombined sources1
Modified residuei904PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8TCG1.
MaxQBiQ8TCG1.
PaxDbiQ8TCG1.
PeptideAtlasiQ8TCG1.
PRIDEiQ8TCG1.

PTM databases

iPTMnetiQ8TCG1.
PhosphoSitePlusiQ8TCG1.

Expressioni

Tissue specificityi

Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas (HNSCC). Present in liver cancer cells (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000163507.
CleanExiHS_KIAA1524.
ExpressionAtlasiQ8TCG1. baseline and differential.
GenevisibleiQ8TCG1. HS.

Organism-specific databases

HPAiHPA039570.

Interactioni

Subunit structurei

Interacts with MYC.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi121687. 64 interactors.
IntActiQ8TCG1. 13 interactors.
MINTiMINT-4995323.
STRINGi9606.ENSP00000295746.

Structurei

Secondary structure

1905
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 16Combined sources11
Helixi25 – 35Combined sources11
Helixi51 – 62Combined sources12
Helixi70 – 82Combined sources13
Helixi89 – 95Combined sources7
Helixi100 – 108Combined sources9
Helixi116 – 128Combined sources13
Turni137 – 140Combined sources4
Helixi141 – 152Combined sources12
Helixi159 – 170Combined sources12
Helixi174 – 180Combined sources7
Helixi189 – 195Combined sources7
Helixi196 – 198Combined sources3
Helixi202 – 216Combined sources15
Beta strandi217 – 220Combined sources4
Helixi223 – 226Combined sources4
Turni228 – 230Combined sources3
Helixi231 – 244Combined sources14
Helixi249 – 262Combined sources14
Helixi265 – 272Combined sources8
Helixi277 – 286Combined sources10
Helixi287 – 289Combined sources3
Helixi293 – 307Combined sources15
Helixi310 – 320Combined sources11
Helixi336 – 338Combined sources3
Helixi339 – 348Combined sources10
Helixi358 – 374Combined sources17
Helixi379 – 394Combined sources16
Helixi406 – 426Combined sources21
Helixi430 – 439Combined sources10
Helixi442 – 456Combined sources15
Beta strandi461 – 464Combined sources4
Helixi470 – 489Combined sources20
Turni490 – 492Combined sources3
Helixi496 – 504Combined sources9
Helixi507 – 509Combined sources3
Helixi510 – 517Combined sources8
Helixi522 – 535Combined sources14
Helixi543 – 558Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5UFLX-ray3.00A/B1-560[»]
ProteinModelPortaliQ8TCG1.
SMRiQ8TCG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili637 – 883Sequence analysisAdd BLAST247

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ1I. Eukaryota.
ENOG4110856. LUCA.
GeneTreeiENSGT00390000006861.
HOVERGENiHBG107688.
InParanoidiQ8TCG1.
PhylomeDBiQ8TCG1.
TreeFamiTF328534.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TCG1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSTACLKSL LLTVSQYKAV KSEANATQLL RHLEVISGQK LTRLFTSNQI
60 70 80 90 100
LTSECLSCLV ELLEDPNISA SLILSIIGLL SQLAVDIETR DCLQNTYNLN
110 120 130 140 150
SVLAGVVCRS SHTDSVFLQC IQLLQKLTYN VKIFYSGANI DELITFLIDH
160 170 180 190 200
IQSSEDELKM PCLGLLANLC RHNLSVQTHI KTLSNVKSFY RTLITLLAHS
210 220 230 240 250
SLTVVVFALS ILSSLTLNEE VGEKLFHARN IHQTFQLIFN ILINGDGTLT
260 270 280 290 300
RKYSVDLLMD LLKNPKIADY LTRYEHFSSC LHQVLGLLNG KDPDSSSKVL
310 320 330 340 350
ELLLAFCSVT QLRHMLTQMM FEQSPPGSAT LGSHTKCLEP TVALLRWLSQ
360 370 380 390 400
PLDGSENCSV LALELFKEIF EDVIDAANCS SADRFVTLLL PTILDQLQFT
410 420 430 440 450
EQNLDEALTR KKCERIAKAI EVLLTLCGDD TLKMHIAKIL TTVKCTTLIE
460 470 480 490 500
QQFTYGKIDL GFGTKVADSE LCKLAADVIL KTLDLINKLK PLVPGMEVSF
510 520 530 540 550
YKILQDPRLI TPLAFALTSD NREQVQSGLR ILLEAAPLPD FPALVLGESI
560 570 580 590 600
AANNAYRQQE TEHIPRKMPW QSSNHSFPTS IKCLTPHLKD GVPGLNIEEL
610 620 630 640 650
IEKLQSGMVV KDQICDVRIS DIMDVYEMKL STLASKESRL QDLLETKALA
660 670 680 690 700
LAQADRLIAQ HRCQRTQAET EARTLASMLR EVERKNEELS VLLKAQQVES
710 720 730 740 750
ERAQSDIEHL FQHNRKLESV AEEHEILTKS YMELLQRNES TEKKNKDLQI
760 770 780 790 800
TCDSLNKQIE TVKKLNESLK EQNEKSIAQL IEKEEQRKEV QNQLVDREHK
810 820 830 840 850
LANLHQKTKV QEEKIKTLQK EREDKEETID ILRKELSRTE QIRKELSIKA
860 870 880 890 900
SSLEVQKAQL EGRLEEKESL VKLQQEELNK HSHMIAMIHS LSGGKINPET

VNLSI
Length:905
Mass (Da):102,185
Last modified:May 15, 2007 - v2
Checksum:iDAB9CCC03BCEA304
GO
Isoform 2 (identifier: Q8TCG1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: Missing.

Note: No experimental confirmation available.
Show »
Length:746
Mass (Da):84,579
Checksum:i926A1001A55C4248
GO

Sequence cautioni

The sequence AAH63433 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA96048 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14305 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti412 – 415KCER → NVKG in CAD28489 (PubMed:17974005).Curated4
Sequence conflicti419A → S in AAL11632 (PubMed:12118381).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046939126K → R. Corresponds to variant dbSNP:rs7648496Ensembl.1
Natural variantiVAR_046940229R → Q. Corresponds to variant dbSNP:rs2278911Ensembl.1
Natural variantiVAR_046941409T → I. Corresponds to variant dbSNP:rs9856308Ensembl.1
Natural variantiVAR_046942447T → A. Corresponds to variant dbSNP:rs34944683Ensembl.1
Natural variantiVAR_046943494P → L. Corresponds to variant dbSNP:rs13083928Ensembl.1
Natural variantiVAR_046944572S → A. Corresponds to variant dbSNP:rs34172460Ensembl.1
Natural variantiVAR_046945680R → T. Corresponds to variant dbSNP:rs6777766Ensembl.1
Natural variantiVAR_046946759I → V. Corresponds to variant dbSNP:rs13071874Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0253361 – 159Missing in isoform 2. 1 PublicationAdd BLAST159

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334474 mRNA. Translation: AAL11632.1.
AB040957 mRNA. Translation: BAA96048.1. Different initiation.
AL713689 mRNA. Translation: CAD28489.1.
BC017659 mRNA. Translation: AAH17659.1.
BC063433 mRNA. Translation: AAH63433.1. Different initiation.
BC130564 mRNA. Translation: AAI30565.1.
BC136371 mRNA. Translation: AAI36372.1.
AK022912 mRNA. Translation: BAB14305.1. Different initiation.
CCDSiCCDS33812.1. [Q8TCG1-1]
RefSeqiNP_065941.2. NM_020890.2. [Q8TCG1-1]
XP_006713780.1. XM_006713717.2. [Q8TCG1-2]
XP_011511358.1. XM_011513056.1. [Q8TCG1-2]
UniGeneiHs.591308.

Genome annotation databases

EnsembliENST00000295746; ENSP00000295746; ENSG00000163507. [Q8TCG1-1]
ENST00000491772; ENSP00000419487; ENSG00000163507. [Q8TCG1-2]
GeneIDi57650.
KEGGihsa:57650.
UCSCiuc003dxb.5. human. [Q8TCG1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCIP2A_HUMAN
AccessioniPrimary (citable) accession number: Q8TCG1
Secondary accession number(s): A1L4J7
, B9EGC3, Q6P4G6, Q8WVP8, Q96PI2, Q9H9C6, Q9P204
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: November 22, 2017
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references