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Protein

AN1-type zinc finger protein 1

Gene

ZFAND1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri7 – 5852AN1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri61 – 11050AN1-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
AN1-type zinc finger protein 1
Gene namesi
Name:ZFAND1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:25858. ZFAND1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670532.

Polymorphism and mutation databases

BioMutaiZFAND1.
DMDMi73622102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268AN1-type zinc finger protein 1PRO_0000066580Add
BLAST

Proteomic databases

EPDiQ8TCF1.
MaxQBiQ8TCF1.
PaxDbiQ8TCF1.
PRIDEiQ8TCF1.

PTM databases

iPTMnetiQ8TCF1.
PhosphoSiteiQ8TCF1.

Expressioni

Gene expression databases

BgeeiQ8TCF1.
CleanExiHS_ZFAND1.
ExpressionAtlasiQ8TCF1. baseline and differential.
GenevisibleiQ8TCF1. HS.

Organism-specific databases

HPAiHPA023383.

Interactioni

Protein-protein interaction databases

BioGridi122863. 1 interaction.
IntActiQ8TCF1. 1 interaction.
STRINGi9606.ENSP00000220669.

Structurei

3D structure databases

ProteinModelPortaliQ8TCF1.
SMRiQ8TCF1. Positions 1-116.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 AN1-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri7 – 5852AN1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri61 – 11050AN1-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG3183. Eukaryota.
ENOG4111JCH. LUCA.
GeneTreeiENSGT00730000111180.
HOGENOMiHOG000007730.
HOVERGENiHBG061273.
InParanoidiQ8TCF1.
KOiK07059.
OMAiGQHCQVE.
OrthoDBiEOG7T1RDX.
PhylomeDBiQ8TCF1.
TreeFamiTF314219.

Family and domain databases

Gene3Di4.10.1110.10. 2 hits.
InterProiIPR000058. Znf_AN1.
[Graphical view]
PfamiPF01428. zf-AN1. 2 hits.
[Graphical view]
SMARTiSM00154. ZnF_AN1. 2 hits.
[Graphical view]
PROSITEiPS51039. ZF_AN1. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TCF1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELDIGQHC QVEHCRQRDF LPFVCDDCSG IFCLEHRSRE SHGCPEVTVI
60 70 80 90 100
NERLKTDQHT SYPCSFKDCA ERELVAVICP YCEKNFCLRH RHQSDHECEK
110 120 130 140 150
LEIPKPRMAA TQKLVKDIID SKTGETASKR WKGAKNSETA AKVALMKLKM
160 170 180 190 200
HADGDKSLPQ TERIYFQVFL PKGSKEKSKP MFFCHRWSIG KAIDFAASLA
210 220 230 240 250
RLKNDNNKFT AKKLRLCHIT SGEALPLDHT LETWIAKEDC PLYNGGNIIL
260
EYLNDEEQFC KNVESYLE
Length:268
Mass (Da):30,787
Last modified:June 1, 2002 - v1
Checksum:iEE554E5D7455F111
GO
Isoform 2 (identifier: Q8TCF1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: Missing.

Note: No experimental confirmation available.
Show »
Length:161
Mass (Da):18,243
Checksum:iFB374DDEB15118D5
GO
Isoform 3 (identifier: Q8TCF1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     160-166: Missing.

Note: No experimental confirmation available.
Show »
Length:261
Mass (Da):29,849
Checksum:i93906DEE249FA675
GO
Isoform 4 (identifier: Q8TCF1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-227: KLRLCHITSGEALPL → VTSHYNNISILIKVL
     228-268: Missing.

Show »
Length:227
Mass (Da):26,018
Checksum:i6AB0837F08561D74
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti182 – 1821F → L in BAB14813 (PubMed:14702039).Curated
Sequence conflicti192 – 1921A → T in CAH56344 (PubMed:17974005).Curated
Sequence conflicti268 – 2681E → D in CAG33604 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 107107Missing in isoform 2. 1 PublicationVSP_014988Add
BLAST
Alternative sequencei160 – 1667Missing in isoform 3. 1 PublicationVSP_046404
Alternative sequencei213 – 22715KLRLC…EALPL → VTSHYNNISILIKVL in isoform 4. CuratedVSP_054080Add
BLAST
Alternative sequencei228 – 26841Missing in isoform 4. CuratedVSP_054081Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024069 mRNA. Translation: BAB14813.1.
CR457323 mRNA. Translation: CAG33604.1.
AK225195 mRNA. No translation available.
AC132219 Genomic DNA. No translation available.
BC022251 mRNA. Translation: AAH22251.1.
BC056877 mRNA. Translation: AAH56877.1.
AL833030 mRNA. Translation: CAH56344.1.
CCDSiCCDS55250.1. [Q8TCF1-4]
CCDS55251.1. [Q8TCF1-3]
CCDS6232.1. [Q8TCF1-1]
RefSeqiNP_001164267.1. NM_001170796.1. [Q8TCF1-3]
NP_001164268.1. NM_001170797.1. [Q8TCF1-4]
NP_078975.2. NM_024699.2. [Q8TCF1-1]
UniGeneiHs.655453.

Genome annotation databases

EnsembliENST00000220669; ENSP00000220669; ENSG00000104231. [Q8TCF1-1]
ENST00000519523; ENSP00000429167; ENSG00000104231. [Q8TCF1-4]
ENST00000521287; ENSP00000428139; ENSG00000104231. [Q8TCF1-2]
ENST00000522520; ENSP00000429999; ENSG00000104231. [Q8TCF1-2]
ENST00000523096; ENSP00000430736; ENSG00000104231. [Q8TCF1-3]
GeneIDi79752.
KEGGihsa:79752.
UCSCiuc003ycj.3. human. [Q8TCF1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024069 mRNA. Translation: BAB14813.1.
CR457323 mRNA. Translation: CAG33604.1.
AK225195 mRNA. No translation available.
AC132219 Genomic DNA. No translation available.
BC022251 mRNA. Translation: AAH22251.1.
BC056877 mRNA. Translation: AAH56877.1.
AL833030 mRNA. Translation: CAH56344.1.
CCDSiCCDS55250.1. [Q8TCF1-4]
CCDS55251.1. [Q8TCF1-3]
CCDS6232.1. [Q8TCF1-1]
RefSeqiNP_001164267.1. NM_001170796.1. [Q8TCF1-3]
NP_001164268.1. NM_001170797.1. [Q8TCF1-4]
NP_078975.2. NM_024699.2. [Q8TCF1-1]
UniGeneiHs.655453.

3D structure databases

ProteinModelPortaliQ8TCF1.
SMRiQ8TCF1. Positions 1-116.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122863. 1 interaction.
IntActiQ8TCF1. 1 interaction.
STRINGi9606.ENSP00000220669.

PTM databases

iPTMnetiQ8TCF1.
PhosphoSiteiQ8TCF1.

Polymorphism and mutation databases

BioMutaiZFAND1.
DMDMi73622102.

Proteomic databases

EPDiQ8TCF1.
MaxQBiQ8TCF1.
PaxDbiQ8TCF1.
PRIDEiQ8TCF1.

Protocols and materials databases

DNASUi79752.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000220669; ENSP00000220669; ENSG00000104231. [Q8TCF1-1]
ENST00000519523; ENSP00000429167; ENSG00000104231. [Q8TCF1-4]
ENST00000521287; ENSP00000428139; ENSG00000104231. [Q8TCF1-2]
ENST00000522520; ENSP00000429999; ENSG00000104231. [Q8TCF1-2]
ENST00000523096; ENSP00000430736; ENSG00000104231. [Q8TCF1-3]
GeneIDi79752.
KEGGihsa:79752.
UCSCiuc003ycj.3. human. [Q8TCF1-1]

Organism-specific databases

CTDi79752.
GeneCardsiZFAND1.
HGNCiHGNC:25858. ZFAND1.
HPAiHPA023383.
neXtProtiNX_Q8TCF1.
PharmGKBiPA142670532.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3183. Eukaryota.
ENOG4111JCH. LUCA.
GeneTreeiENSGT00730000111180.
HOGENOMiHOG000007730.
HOVERGENiHBG061273.
InParanoidiQ8TCF1.
KOiK07059.
OMAiGQHCQVE.
OrthoDBiEOG7T1RDX.
PhylomeDBiQ8TCF1.
TreeFamiTF314219.

Miscellaneous databases

GenomeRNAii79752.
PROiQ8TCF1.

Gene expression databases

BgeeiQ8TCF1.
CleanExiHS_ZFAND1.
ExpressionAtlasiQ8TCF1. baseline and differential.
GenevisibleiQ8TCF1. HS.

Family and domain databases

Gene3Di4.10.1110.10. 2 hits.
InterProiIPR000058. Znf_AN1.
[Graphical view]
PfamiPF01428. zf-AN1. 2 hits.
[Graphical view]
SMARTiSM00154. ZnF_AN1. 2 hits.
[Graphical view]
PROSITEiPS51039. ZF_AN1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Colon.
  4. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Eye and Lung.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 72-268 (ISOFORM 1).
    Tissue: Stomach.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZFAN1_HUMAN
AccessioniPrimary (citable) accession number: Q8TCF1
Secondary accession number(s): E5RIG0
, E5RJ99, Q658R7, Q6IA32, Q6PGQ6, Q9H810
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.