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Protein

Protein FAM45A

Gene

FAM45A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM45A
Gene namesi
Name:FAM45A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:31793. FAM45A.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000119979.
PharmGKBiPA134935316.

Polymorphism and mutation databases

BioMutaiFAM45A.
DMDMi51316043.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001870341 – 357Protein FAM45AAdd BLAST357

Proteomic databases

EPDiQ8TCE6.
MaxQBiQ8TCE6.
PaxDbiQ8TCE6.
PeptideAtlasiQ8TCE6.
PRIDEiQ8TCE6.

PTM databases

iPTMnetiQ8TCE6.
PhosphoSitePlusiQ8TCE6.

Expressioni

Gene expression databases

BgeeiENSG00000119979.
CleanExiHS_FAM45A.
GenevisibleiQ8TCE6. HS.

Organism-specific databases

HPAiHPA041159.
HPA041340.

Interactioni

Protein-protein interaction databases

BioGridi135667. 23 interactors.
IntActiQ8TCE6. 9 interactors.
STRINGi9606.ENSP00000354688.

Structurei

3D structure databases

ProteinModelPortaliQ8TCE6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM45 family.Curated

Phylogenomic databases

eggNOGiENOG410IGIW. Eukaryota.
ENOG410Z0E9. LUCA.
GeneTreeiENSGT00390000014431.
HOGENOMiHOG000007594.
HOVERGENiHBG051536.
InParanoidiQ8TCE6.
OMAiHTFVFGQ.
OrthoDBiEOG091G0E6E.
PhylomeDBiQ8TCE6.
TreeFamiTF332501.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TCE6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAEVADTQ LMLGVGLIEK DTNGEVLWVW CYPSTTATLR NLLLRKCCLT
60 70 80 90 100
DENKLLHPFV FGQYRRTWFY ITTIEVPDSS ILKKVTHFSI VLTAKDFNPE
110 120 130 140 150
KYAAFTRILC RMYLKHGSPV KMMESYIAVL TKGICQSEEN GSFLSKDFDA
160 170 180 190 200
RKAYLAGSIK DIVSQFGMET VILHTALMLK KRIVVYHPKI EAVQEFTRTL
210 220 230 240 250
PALVWHRQDW TILHSYVHLN ADELEALQMC TGYVAGFVDL EVSNRPDLYD
260 270 280 290 300
VFVNLAESEI TIAPLAKEAM AMGKLHKEMG QLIVQSAEDP EKSESHVIQD
310 320 330 340 350
IALKTREIFT NLAPFSEVSA DGEKRVLNLE ALKQKRFPPA TENFLYHLAA

AEQMLKI
Length:357
Mass (Da):40,513
Last modified:June 1, 2002 - v1
Checksum:iB4AE072A5D9DB379
GO
Isoform 2 (identifier: Q8TCE6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MAAAEVADTQLMLGVGLI → MLSSDHLSTV

Note: No experimental confirmation available.
Show »
Length:349
Mass (Da):39,799
Checksum:iF9665CCAFB39D52B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti267K → R in BAA90894 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0383011 – 18MAAAE…GVGLI → MLSSDHLSTV in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000031 mRNA. Translation: BAA90894.1.
AK293136 mRNA. Translation: BAG56684.1.
AL355598 Genomic DNA. Translation: CAI14128.1.
CH471066 Genomic DNA. Translation: EAW49406.1.
CH471066 Genomic DNA. Translation: EAW49407.1.
BC022271 mRNA. Translation: AAH22271.1.
CCDSiCCDS7609.1. [Q8TCE6-1]
RefSeqiNP_001290040.1. NM_001303111.1. [Q8TCE6-2]
NP_001290041.1. NM_001303112.1.
NP_001290042.1. NM_001303113.1.
NP_996892.1. NM_207009.3. [Q8TCE6-1]
XP_016871750.1. XM_017016261.1. [Q8TCE6-2]
XP_016871751.1. XM_017016262.1. [Q8TCE6-2]
XP_016871752.1. XM_017016263.1. [Q8TCE6-2]
UniGeneiHs.434241.
Hs.567120.

Genome annotation databases

EnsembliENST00000361432; ENSP00000354688; ENSG00000119979. [Q8TCE6-1]
GeneIDi404636.
KEGGihsa:404636.
UCSCiuc001ldw.5. human. [Q8TCE6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000031 mRNA. Translation: BAA90894.1.
AK293136 mRNA. Translation: BAG56684.1.
AL355598 Genomic DNA. Translation: CAI14128.1.
CH471066 Genomic DNA. Translation: EAW49406.1.
CH471066 Genomic DNA. Translation: EAW49407.1.
BC022271 mRNA. Translation: AAH22271.1.
CCDSiCCDS7609.1. [Q8TCE6-1]
RefSeqiNP_001290040.1. NM_001303111.1. [Q8TCE6-2]
NP_001290041.1. NM_001303112.1.
NP_001290042.1. NM_001303113.1.
NP_996892.1. NM_207009.3. [Q8TCE6-1]
XP_016871750.1. XM_017016261.1. [Q8TCE6-2]
XP_016871751.1. XM_017016262.1. [Q8TCE6-2]
XP_016871752.1. XM_017016263.1. [Q8TCE6-2]
UniGeneiHs.434241.
Hs.567120.

3D structure databases

ProteinModelPortaliQ8TCE6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi135667. 23 interactors.
IntActiQ8TCE6. 9 interactors.
STRINGi9606.ENSP00000354688.

PTM databases

iPTMnetiQ8TCE6.
PhosphoSitePlusiQ8TCE6.

Polymorphism and mutation databases

BioMutaiFAM45A.
DMDMi51316043.

Proteomic databases

EPDiQ8TCE6.
MaxQBiQ8TCE6.
PaxDbiQ8TCE6.
PeptideAtlasiQ8TCE6.
PRIDEiQ8TCE6.

Protocols and materials databases

DNASUi404636.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361432; ENSP00000354688; ENSG00000119979. [Q8TCE6-1]
GeneIDi404636.
KEGGihsa:404636.
UCSCiuc001ldw.5. human. [Q8TCE6-1]

Organism-specific databases

CTDi404636.
GeneCardsiFAM45A.
HGNCiHGNC:31793. FAM45A.
HPAiHPA041159.
HPA041340.
neXtProtiNX_Q8TCE6.
OpenTargetsiENSG00000119979.
PharmGKBiPA134935316.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGIW. Eukaryota.
ENOG410Z0E9. LUCA.
GeneTreeiENSGT00390000014431.
HOGENOMiHOG000007594.
HOVERGENiHBG051536.
InParanoidiQ8TCE6.
OMAiHTFVFGQ.
OrthoDBiEOG091G0E6E.
PhylomeDBiQ8TCE6.
TreeFamiTF332501.

Miscellaneous databases

ChiTaRSiFAM45A. human.
GenomeRNAii404636.
PROiQ8TCE6.

Gene expression databases

BgeeiENSG00000119979.
CleanExiHS_FAM45A.
GenevisibleiQ8TCE6. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiFA45A_HUMAN
AccessioniPrimary (citable) accession number: Q8TCE6
Secondary accession number(s): B1AMV6
, B4DDC3, D3DRC8, Q9NXW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.