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Protein
Submitted name:

Antithrombin-III

Gene

SERPINC1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Antithrombin-IIIImported
Submitted name:
SERPINC1 proteinImported
Gene namesi
Name:SERPINC1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117601.13
HGNCiHGNC:775 SERPINC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000117601

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_501431233035 – 259Sequence analysisAdd BLAST225

Expressioni

Gene expression databases

BgeeiENSG00000117601

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 256SERPINInterPro annotationAdd BLAST165

Sequence similaritiesi

Belongs to the serpin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00900000140788
HOGENOMiHOG000150480
HOVERGENiHBG073386

Family and domain databases

InterProiView protein in InterPro
IPR015555 AT-III
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 2 hits
PTHR11461:SF53 PTHR11461:SF53, 2 hits
PfamiView protein in Pfam
PF00079 Serpin, 2 hits
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 2 hits
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TCE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSNVIGTVT SGKRKVYLLS LLLIGFWDCV TCHGSPVDIC TAKPRDIPMN
60 70 80 90 100
PMCIYRSPEK KATEDEGSEQ KIPEATNRRV WELSKANSRF ATTFYQHLAD
110 120 130 140 150
SKNDNDNIFL SPLSISTAFA MTKLGACNDT LQQLMEVFKF DTISEKTSDQ
160 170 180 190 200
IHFFFAKLNC RLYRKANKSS KLVSANRLFG DKSLTFNDLY VSDAFHKAFL
210 220 230 240 250
EVNEEGSEAA ASTAVVIAGR SLNPNRVTFK ANRPFLVFIR EVPLNTIIFM

GRVANPCVK
Length:259
Mass (Da):29,092
Last modified:June 1, 2002 - v1
Checksum:i8386705A82B8EC8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136170 Genomic DNA No translation available.
BC022309 mRNA Translation: AAH22309.1
UniGeneiHs.75599

Genome annotation databases

EnsembliENST00000617423; ENSP00000478688; ENSG00000117601
UCSCiuc057nks.1 human

Similar proteinsi

Entry informationi

Entry nameiQ8TCE1_HUMAN
AccessioniPrimary (citable) accession number: Q8TCE1
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: April 25, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health