Reviewed, UniProtKB/Swiss-Prot Q8TCD1 (CR032_HUMAN)

Names and origin

Protein names

Recommended name:
    UPF0729 protein C18orf32
Alternative name(s):
    Putative NF-kappa-B-activating protein 200

Gene names

Name:

C18orf32

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	76 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May activate the NF-kappa-B signaling pathway. Ref.1
Sequence similarities	Belongs to the UPF0729 family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	positive regulation of I-kappaB kinase/NF-kappaB cascade Ref.1 Inferred from mutant phenotype. Source: UniProtKB
Molecular function	signal transducer activity Ref.1 Inferred from mutant phenotype. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 76	76	UPF0729 protein C18orf32		PRO_0000321908
Natural variations
	Natural variant	37	1	P → H: dbSNP rs11537626.		VAR_039374

Sequences

	Sequence		Length	Mass (Da)
	Q8TCD1-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 649F9A02249FAD5E	FASTA	76	8,669
	10 20 30 40 50 60 MVCIPCIVIP VLLWIYKKFL EPYIYPLVSP FVSRIWPKKA IQESNDTNKG KVNFKGADMN 70 GLPTKGPTEI CDKKKD

References

[1]	"Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways." Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S. Oncogene 22:3307-3318(2003) [PubMed: 12761501] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], FUNCTION. Tissue: Lung.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skeletal muscle.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate and Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB097012 mRNA. Translation: BAC77365.1. AK291882 mRNA. Translation: BAF84571.1. BC022357 mRNA. Translation: AAH22357.1. BC093004 mRNA. Translation: AAH93004.1.
IPI	IPI00152342.
RefSeq	NP_001030177.1.
UniGene	Hs.293653 Hs.374588 Hs.485090 Hs.654638
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENST00000318240; ENSP00000323199; ENSG00000177576; Homo sapiens. [Genome view]
GeneID	497661.
KEGG	hsa:497661.
UCSC	uc002ldk.1. human.
Organism-specific databases
CTD	497661.
GeneCards	GC18M045264.
HGNC	HGNC:31690. C18orf32.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8TCD1.
OMA	RMWPRKA
OrthoDB	EOG9KPWWT
Enzyme and pathway databases
BioCyc	CATTLE:ENSBTAG00000031651-MON.
Gene expression databases
ArrayExpress	Q8TCD1.
Bgee	Q8TCD1.
CleanEx	HS_C18orf32.
Genevestigator	Q8TCD1.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	111936.

Entry information

Entry name

CR032_HUMAN

Accession

Primary (citable) accession number: Q8TCD1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	June 1, 2002
Last modified:	November 24, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.