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Protein

UPF0729 protein C18orf32

Gene

C18orf32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May activate the NF-kappa-B signaling pathway.1 Publication

GO - Molecular functioni

  • signal transducer activity Source: UniProtKB

GO - Biological processi

  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177576-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0729 protein C18orf32
Alternative name(s):
Putative NF-kappa-B-activating protein 200
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:31690. C18orf32.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177576.
PharmGKBiPA162378602.

Polymorphism and mutation databases

BioMutaiC18orf32.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003219081 – 76UPF0729 protein C18orf32Add BLAST76

Proteomic databases

EPDiQ8TCD1.
MaxQBiQ8TCD1.
PaxDbiQ8TCD1.
PeptideAtlasiQ8TCD1.
PRIDEiQ8TCD1.

PTM databases

iPTMnetiQ8TCD1.
PhosphoSitePlusiQ8TCD1.

Expressioni

Gene expression databases

BgeeiENSG00000177576.
CleanExiHS_C18orf32.
GenevisibleiQ8TCD1. HS.

Organism-specific databases

HPAiHPA040921.

Interactioni

Protein-protein interaction databases

BioGridi139005. 2 interactors.
IntActiQ8TCD1. 5 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ8TCD1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0729 family.Curated

Phylogenomic databases

eggNOGiENOG410J3GD. Eukaryota.
ENOG410Y1I3. LUCA.
GeneTreeiENSGT00390000018741.
HOGENOMiHOG000111951.
HOVERGENiHBG107759.
InParanoidiQ8TCD1.
OMAiSRMWPRK.
PhylomeDBiQ8TCD1.
TreeFamiTF324662.

Family and domain databases

InterProiIPR026776. UPF0729.
[Graphical view]
PANTHERiPTHR13456. PTHR13456. 1 hit.
PfamiPF14975. DUF4512. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TCD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCIPCIVIP VLLWIYKKFL EPYIYPLVSP FVSRIWPKKA IQESNDTNKG
60 70
KVNFKGADMN GLPTKGPTEI CDKKKD
Length:76
Mass (Da):8,669
Last modified:June 1, 2002 - v1
Checksum:i649F9A02249FAD5E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03937437P → H.Corresponds to variant rs11537626dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097012 mRNA. Translation: BAC77365.1.
AK291882 mRNA. Translation: BAF84571.1.
BC022357 mRNA. Translation: AAH22357.1.
BC093004 mRNA. Translation: AAH93004.1.
CCDSiCCDS32831.1.
RefSeqiNP_001030177.1. NM_001035005.3.
NP_001186275.1. NM_001199346.1.
UniGeneiHs.603040.

Genome annotation databases

EnsembliENST00000318240; ENSP00000323199; ENSG00000177576.
ENST00000582392; ENSP00000462538; ENSG00000177576.
ENST00000613385; ENSP00000480941; ENSG00000177576.
GeneIDi497661.
KEGGihsa:497661.
UCSCiuc002ldk.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097012 mRNA. Translation: BAC77365.1.
AK291882 mRNA. Translation: BAF84571.1.
BC022357 mRNA. Translation: AAH22357.1.
BC093004 mRNA. Translation: AAH93004.1.
CCDSiCCDS32831.1.
RefSeqiNP_001030177.1. NM_001035005.3.
NP_001186275.1. NM_001199346.1.
UniGeneiHs.603040.

3D structure databases

ProteinModelPortaliQ8TCD1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi139005. 2 interactors.
IntActiQ8TCD1. 5 interactors.

PTM databases

iPTMnetiQ8TCD1.
PhosphoSitePlusiQ8TCD1.

Polymorphism and mutation databases

BioMutaiC18orf32.

Proteomic databases

EPDiQ8TCD1.
MaxQBiQ8TCD1.
PaxDbiQ8TCD1.
PeptideAtlasiQ8TCD1.
PRIDEiQ8TCD1.

Protocols and materials databases

DNASUi497661.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318240; ENSP00000323199; ENSG00000177576.
ENST00000582392; ENSP00000462538; ENSG00000177576.
ENST00000613385; ENSP00000480941; ENSG00000177576.
GeneIDi497661.
KEGGihsa:497661.
UCSCiuc002ldk.3. human.

Organism-specific databases

CTDi497661.
GeneCardsiC18orf32.
HGNCiHGNC:31690. C18orf32.
HPAiHPA040921.
neXtProtiNX_Q8TCD1.
OpenTargetsiENSG00000177576.
PharmGKBiPA162378602.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3GD. Eukaryota.
ENOG410Y1I3. LUCA.
GeneTreeiENSGT00390000018741.
HOGENOMiHOG000111951.
HOVERGENiHBG107759.
InParanoidiQ8TCD1.
OMAiSRMWPRK.
PhylomeDBiQ8TCD1.
TreeFamiTF324662.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177576-MONOMER.

Miscellaneous databases

ChiTaRSiC18orf32. human.
GenomeRNAii497661.
PROiQ8TCD1.

Gene expression databases

BgeeiENSG00000177576.
CleanExiHS_C18orf32.
GenevisibleiQ8TCD1. HS.

Family and domain databases

InterProiIPR026776. UPF0729.
[Graphical view]
PANTHERiPTHR13456. PTHR13456. 1 hit.
PfamiPF14975. DUF4512. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCR032_HUMAN
AccessioniPrimary (citable) accession number: Q8TCD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.