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Q8TCC7

- S22A8_HUMAN

UniProt

Q8TCC7 - S22A8_HUMAN

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Protein

Solute carrier family 22 member 8

Gene
SLC22A8, OAT3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).4 Publications

GO - Molecular functioni

  1. inorganic anion exchanger activity Source: UniProtKB
  2. organic anion transmembrane transporter activity Source: Ensembl
  3. quaternary ammonium group transmembrane transporter activity Source: Ensembl

GO - Biological processi

  1. glutathione transport Source: Ensembl
  2. response to methotrexate Source: Ensembl
  3. response to toxic substance Source: UniProtKB-KW
  4. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Detoxification, Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_22310. Organic anion transport.

Protein family/group databases

TCDBi2.A.1.19.34. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 8
Alternative name(s):
Organic anion transporter 3
Short name:
hOAT3
Gene namesi
Name:SLC22A8
Synonyms:OAT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:10972. SLC22A8.

Subcellular locationi

Basolateral cell membrane; Multi-pass membrane protein Reviewed prediction
Note: Localizes on the brush border membrane of the choroid epithelial cells. Localizes to the basolateral membrane of the proximal tubular cells. Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells (BCEC) By similarity.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99Cytoplasmic Reviewed prediction
Transmembranei10 – 3021Helical; Reviewed predictionAdd
BLAST
Topological domaini31 – 12393Extracellular Reviewed predictionAdd
BLAST
Transmembranei124 – 14421Helical; Reviewed predictionAdd
BLAST
Topological domaini145 – 15410Cytoplasmic Reviewed prediction
Transmembranei155 – 17521Helical; Reviewed predictionAdd
BLAST
Topological domaini176 – 1761Extracellular Reviewed prediction
Transmembranei177 – 19721Helical; Reviewed predictionAdd
BLAST
Topological domaini198 – 21215Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei213 – 23321Helical; Reviewed predictionAdd
BLAST
Topological domaini234 – 2363Extracellular Reviewed prediction
Transmembranei237 – 25721Helical; Reviewed predictionAdd
BLAST
Topological domaini258 – 32770Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei328 – 34821Helical; Reviewed predictionAdd
BLAST
Topological domaini349 – 3546Extracellular Reviewed prediction
Transmembranei355 – 37521Helical; Reviewed predictionAdd
BLAST
Topological domaini376 – 38611Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei387 – 40721Helical; Reviewed predictionAdd
BLAST
Topological domaini408 – 4114Extracellular Reviewed prediction
Transmembranei412 – 43221Helical; Reviewed predictionAdd
BLAST
Topological domaini433 – 47139Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei472 – 49221Helical; Reviewed predictionAdd
BLAST
Topological domaini493 – 54250Extracellular Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: UniProtKB
  2. extracellular vesicular exosome Source: UniProt
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA389.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 542542Solute carrier family 22 member 8PRO_0000273439Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi86 – 861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi102 – 1021N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8TCC7.
PRIDEiQ8TCC7.

Expressioni

Tissue specificityi

Expressed in kidney.1 Publication

Gene expression databases

ArrayExpressiQ8TCC7.
BgeeiQ8TCC7.
CleanExiHS_SLC22A8.
GenevestigatoriQ8TCC7.

Organism-specific databases

HPAiHPA044174.

Interactioni

Protein-protein interaction databases

IntActiQ8TCC7. 1 interaction.
STRINGi9606.ENSP00000337335.

Structurei

3D structure databases

ProteinModelPortaliQ8TCC7.
SMRiQ8TCC7. Positions 130-279.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
KOiK08205.
OMAiDGWVYNS.
OrthoDBiEOG7C8GH9.
PhylomeDBiQ8TCC7.
TreeFamiTF315847.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004749. Orgcat_transp.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8TCC7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTFSEILDRV GSMGHFQFLH VAILGLPILN MANHNLLQIF TAATPVHHCR    50
PPHNASTGPW VLPMGPNGKP ERCLRFVHPP NASLPNDTQR AMEPCLDGWV 100
YNSTKDSIVT EWDLVCNSNK LKEMAQSIFM AGILIGGLVL GDLSDRFGRR 150
PILTCSYLLL AASGSGAAFS PTFPIYMVFR FLCGFGISGI TLSTVILNVE 200
WVPTRMRAIM STALGYCYTF GQFILPGLAY AIPQWRWLQL TVSIPFFVFF 250
LSSWWTPESI RWLVLSGKSS KALKILRRVA VFNGKKEEGE RLSLEELKLN 300
LQKEISLAKA KYTASDLFRI PMLRRMTFCL SLAWFATGFA YYSLAMGVEE 350
FGVNLYILQI IFGGVDVPAK FITILSLSYL GRHTTQAAAL LLAGGAILAL 400
TFVPLDLQTV RTVLAVFGKG CLSSSFSCLF LYTSELYPTV IRQTGMGVSN 450
LWTRVGSMVS PLVKITGEVQ PFIPNIIYGI TALLGGSAAL FLPETLNQPL 500
PETIEDLENW SLRAKKPKQE PEVEKASQRI PLQPHGPGLG SS 542
Length:542
Mass (Da):59,856
Last modified:June 1, 2002 - v1
Checksum:i22799360D91B4CCF
GO
Isoform 2 (identifier: Q8TCC7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     510-510: W → WSVTASGPPR

Note: No experimental confirmation available.

Show »
Length:551
Mass (Da):60,709
Checksum:i0F202C686929638A
GO
Isoform 5 (identifier: Q8TCC7-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Note: No experimental confirmation available.

Show »
Length:419
Mass (Da):46,120
Checksum:i3BBFC757CEE06790
GO
Isoform 3 (identifier: Q8TCC7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-345: Missing.
     406-455: DLQTVRTVLA...MGVSNLWTRV → GERLGLPQNP...SGAQGLSSRK
     456-542: Missing.

Note: No experimental confirmation available.

Show »
Length:110
Mass (Da):11,502
Checksum:i0050E6499A6446CB
GO
Isoform 4 (identifier: Q8TCC7-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: Missing.

Note: No experimental confirmation available.

Show »
Length:451
Mass (Da):49,821
Checksum:iB1E5B7631D8BED48
GO

Sequence cautioni

The sequence AAD19357.1 differs from that shown. Reason: Frameshift at several positions.
The sequence BAD92929.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti129 – 1291F → L.
Corresponds to variant rs11568479 [ dbSNP | Ensembl ].
VAR_030146
Natural varianti149 – 1491R → S Complete loss of function. 1 Publication
Corresponds to variant rs45566039 [ dbSNP | Ensembl ].
VAR_030147
Natural varianti260 – 2601I → R Complete loss of function. 1 Publication
Corresponds to variant rs11568493 [ dbSNP | Ensembl ].
VAR_030148
Natural varianti277 – 2771R → W Reduced function. 1 Publication
Corresponds to variant rs11568492 [ dbSNP | Ensembl ].
VAR_030149
Natural varianti281 – 2811V → A in 6% of African-Americans.
Corresponds to variant rs45438191 [ dbSNP | Ensembl ].
VAR_030150
Natural varianti305 – 3051I → F in 3.5% of Asian-American; reduced function. 1 Publication
Corresponds to variant rs11568482 [ dbSNP | Ensembl ].
VAR_030151
Natural varianti389 – 3891A → V.1 Publication
VAR_030152
Natural varianti448 – 4481V → I.
Corresponds to variant rs11568486 [ dbSNP | Ensembl ].
VAR_030153

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 345345Missing in isoform 3. VSP_022562Add
BLAST
Alternative sequencei1 – 123123Missing in isoform 5. VSP_045824Add
BLAST
Alternative sequencei1 – 9191Missing in isoform 4. VSP_045272Add
BLAST
Alternative sequencei406 – 45550DLQTV…LWTRV → GERLGLPQNPLEEAARLGAR DFTAGSASKSLCYLEQVPAL SGAQGLSSRK in isoform 3. VSP_022563Add
BLAST
Alternative sequencei456 – 54287Missing in isoform 3. VSP_022564Add
BLAST
Alternative sequencei510 – 5101W → WSVTASGPPR in isoform 2. VSP_022565

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti150 – 1501Missing in AAD19357. 1 Publication
Sequence conflicti151 – 1511P → T in AAD19357. 1 Publication
Sequence conflicti271 – 2711K → E in BAB47393. 1 Publication
Sequence conflicti286 – 2861Missing in AAD19357. 1 Publication
Sequence conflicti411 – 4111R → E in AAD19357. 1 Publication
Sequence conflicti478 – 4803YGI → FTGS in AAD19357. 1 Publication
Sequence conflicti526 – 5261A → T in BAG60589. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF097491 mRNA. Translation: AAD19357.1. Frameshift.
AB042505 mRNA. Translation: BAB47393.1.
AK298341 mRNA. Translation: BAG60589.1.
AB209692 mRNA. Translation: BAD92929.1. Different initiation.
AP001858 Genomic DNA. No translation available.
BC022387 mRNA. Translation: AAH22387.1.
CCDSiCCDS53643.1. [Q8TCC7-5]
CCDS53644.1. [Q8TCC7-4]
CCDS8042.1. [Q8TCC7-1]
RefSeqiNP_001171661.1. NM_001184732.1. [Q8TCC7-1]
NP_001171662.1. NM_001184733.1. [Q8TCC7-4]
NP_001171665.1. NM_001184736.1. [Q8TCC7-5]
NP_004245.2. NM_004254.3. [Q8TCC7-1]
UniGeneiHs.266223.

Genome annotation databases

EnsembliENST00000336232; ENSP00000337335; ENSG00000149452. [Q8TCC7-1]
ENST00000430500; ENSP00000398548; ENSG00000149452. [Q8TCC7-1]
ENST00000535878; ENSP00000443368; ENSG00000149452. [Q8TCC7-5]
ENST00000545207; ENSP00000441658; ENSG00000149452. [Q8TCC7-4]
GeneIDi9376.
KEGGihsa:9376.
UCSCiuc001nwo.3. human. [Q8TCC7-1]

Polymorphism databases

DMDMi74730587.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF097491 mRNA. Translation: AAD19357.1 . Frameshift.
AB042505 mRNA. Translation: BAB47393.1 .
AK298341 mRNA. Translation: BAG60589.1 .
AB209692 mRNA. Translation: BAD92929.1 . Different initiation.
AP001858 Genomic DNA. No translation available.
BC022387 mRNA. Translation: AAH22387.1 .
CCDSi CCDS53643.1. [Q8TCC7-5 ]
CCDS53644.1. [Q8TCC7-4 ]
CCDS8042.1. [Q8TCC7-1 ]
RefSeqi NP_001171661.1. NM_001184732.1. [Q8TCC7-1 ]
NP_001171662.1. NM_001184733.1. [Q8TCC7-4 ]
NP_001171665.1. NM_001184736.1. [Q8TCC7-5 ]
NP_004245.2. NM_004254.3. [Q8TCC7-1 ]
UniGenei Hs.266223.

3D structure databases

ProteinModelPortali Q8TCC7.
SMRi Q8TCC7. Positions 130-279.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8TCC7. 1 interaction.
STRINGi 9606.ENSP00000337335.

Chemistry

ChEMBLi CHEMBL1641348.

Protein family/group databases

TCDBi 2.A.1.19.34. the major facilitator superfamily (mfs).

Polymorphism databases

DMDMi 74730587.

Proteomic databases

PaxDbi Q8TCC7.
PRIDEi Q8TCC7.

Protocols and materials databases

DNASUi 9376.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000336232 ; ENSP00000337335 ; ENSG00000149452 . [Q8TCC7-1 ]
ENST00000430500 ; ENSP00000398548 ; ENSG00000149452 . [Q8TCC7-1 ]
ENST00000535878 ; ENSP00000443368 ; ENSG00000149452 . [Q8TCC7-5 ]
ENST00000545207 ; ENSP00000441658 ; ENSG00000149452 . [Q8TCC7-4 ]
GeneIDi 9376.
KEGGi hsa:9376.
UCSCi uc001nwo.3. human. [Q8TCC7-1 ]

Organism-specific databases

CTDi 9376.
GeneCardsi GC11M062760.
HGNCi HGNC:10972. SLC22A8.
HPAi HPA044174.
MIMi 607581. gene.
neXtProti NX_Q8TCC7.
PharmGKBi PA389.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0477.
HOGENOMi HOG000234569.
HOVERGENi HBG108433.
KOi K08205.
OMAi DGWVYNS.
OrthoDBi EOG7C8GH9.
PhylomeDBi Q8TCC7.
TreeFami TF315847.

Enzyme and pathway databases

Reactomei REACT_22310. Organic anion transport.

Miscellaneous databases

GeneWikii SLC22A8.
GenomeRNAii 9376.
NextBioi 35126.
PROi Q8TCC7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8TCC7.
Bgeei Q8TCC7.
CleanExi HS_SLC22A8.
Genevestigatori Q8TCC7.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004749. Orgcat_transp.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
TIGRFAMsi TIGR00898. 2A0119. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3)."
    Race J.E., Grassl S.M., Williams W.J., Holtzman E.J.
    Biochem. Biophys. Res. Commun. 255:508-514(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Kidney.
  2. "Molecular cloning and characterization of human organic anion transporter 3."
    Cha S., Sekine T., Kanai Y., Endou H.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Kidney.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Kidney.
  4. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  7. "Gene expression levels and immunolocalization of organic ion transporters in the human kidney."
    Motohashi H., Sakurai Y., Saito H., Masuda S., Urakami Y., Goto M., Fukatsu A., Ogawa O., Inui K.
    J. Am. Soc. Nephrol. 13:866-874(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  8. "Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux."
    Bakhiya A., Bahn A., Burckhardt G., Wolff N.
    Cell. Physiol. Biochem. 13:249-256(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8)."
    Srimaroeng C., Chatsudthipong V., Aslamkhan A.G., Pritchard J.B.
    J. Pharmacol. Exp. Ther. 313:621-628(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney."
    Tahara H., Shono M., Kusuhara H., Kinoshita H., Fuse E., Takadate A., Otagiri M., Sugiyama Y.
    Pharm. Res. 22:647-660(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid."
    Tahara H., Kusuhara H., Maeda K., Koepsell H., Fuse E., Sugiyama Y.
    Drug Metab. Dispos. 34:743-747(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics."
    Nishizato Y., Ieiri I., Suzuki H., Kimura M., Kawabata K., Hirota T., Takane H., Irie S., Kusuhara H., Urasaki Y., Urae A., Higuchi S., Otsubo K., Sugiyama Y.
    Clin. Pharmacol. Ther. 73:554-565(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT VAL-389.
  13. Cited for: VARIANTS SER-149; ARG-260; TRP-277 AND PHE-305, CHARACTERIZATION OF VARIANTS SER-149; ARG-260; TRP-277 AND PHE-305.

Entry informationi

Entry nameiS22A8_HUMAN
AccessioniPrimary (citable) accession number: Q8TCC7
Secondary accession number(s): B4DPH7
, F5GWA8, F5H5J1, O95820, Q59EW9, Q96TC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: June 1, 2002
Last modified: September 3, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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