Q8TCC7 (S22A8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 22 member 8

Alternative name(s):
Organic anion transporter 3
Short name=hOAT3

Gene names

Name:	SLC22A8
Synonyms:	OAT3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	542 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA). Ref.8 Ref.9 Ref.10 Ref.11
Subcellular location	Basolateral cell membrane; Multi-pass membrane protein Potential. Note: Localizes on the brush border membrane of the choroid epithelial cells. Localizes to the basolateral membrane of the proximal tubular cells. Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells (BCEC) By similarity. Ref.7
Tissue specificity	Expressed in kidney. Ref.7
Sequence similarities	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. [View classification]
Sequence caution	The sequence AAD19357.1 differs from that shown. Reason: Frameshift at several positions. The sequence BAD92929.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Detoxification Ion transport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glutathione transport Inferred from electronic annotation. Source: Compara response to methotrexate Inferred from electronic annotation. Source: Compara response to toxic substance Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	basolateral plasma membrane Inferred from direct assay PubMed 15037815. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	inorganic anion exchanger activity Inferred from direct assay PubMed 15037815. Source: UniProtKB organic anion transmembrane transporter activity Inferred from electronic annotation. Source: Compara quaternary ammonium group transmembrane transporter activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TCC7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TCC7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     510-510: W → WSVTASGPPR

Note: No experimental confirmation available.

Isoform 5 (identifier: Q8TCC7-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8TCC7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-345: Missing.
     406-455: DLQTVRTVLA...MGVSNLWTRV → GERLGLPQNP...SGAQGLSSRK
     456-542: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q8TCC7-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 542	542	Solute carrier family 22 member 8		PRO_0000273439
Regions
	Topological domain	1 – 9	9	Cytoplasmic Potential
	Transmembrane	10 – 30	21	Helical; Potential
	Topological domain	31 – 123	93	Extracellular Potential
	Transmembrane	124 – 144	21	Helical; Potential
	Topological domain	145 – 154	10	Cytoplasmic Potential
	Transmembrane	155 – 175	21	Helical; Potential
	Topological domain	176	1	Extracellular Potential
	Transmembrane	177 – 197	21	Helical; Potential
	Topological domain	198 – 212	15	Cytoplasmic Potential
	Transmembrane	213 – 233	21	Helical; Potential
	Topological domain	234 – 236	3	Extracellular Potential
	Transmembrane	237 – 257	21	Helical; Potential
	Topological domain	258 – 327	70	Cytoplasmic Potential
	Transmembrane	328 – 348	21	Helical; Potential
	Topological domain	349 – 354	6	Extracellular Potential
	Transmembrane	355 – 375	21	Helical; Potential
	Topological domain	376 – 386	11	Cytoplasmic Potential
	Transmembrane	387 – 407	21	Helical; Potential
	Topological domain	408 – 411	4	Extracellular Potential
	Transmembrane	412 – 432	21	Helical; Potential
	Topological domain	433 – 471	39	Cytoplasmic Potential
	Transmembrane	472 – 492	21	Helical; Potential
	Topological domain	493 – 542	50	Extracellular Potential
Amino acid modifications
	Glycosylation	86	1	N-linked (GlcNAc...) Potential
	Glycosylation	102	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 345	345	Missing in isoform 3.		VSP_022562
	Alternative sequence	1 – 123	123	Missing in isoform 5.		VSP_045824
	Alternative sequence	1 – 91	91	Missing in isoform 4.		VSP_045272
	Alternative sequence	406 – 455	50	DLQTV…LWTRV → GERLGLPQNPLEEAARLGAR DFTAGSASKSLCYLEQVPAL SGAQGLSSRK in isoform 3.		VSP_022563
	Alternative sequence	456 – 542	87	Missing in isoform 3.		VSP_022564
	Alternative sequence	510	1	W → WSVTASGPPR in isoform 2.		VSP_022565
	Natural variant	129	1	F → L. Corresponds to variant rs11568479 [ dbSNP | Ensembl ].		VAR_030146
	Natural variant	149	1	R → S Complete loss of function. Ref.13 Corresponds to variant rs45566039 [ dbSNP | Ensembl ].		VAR_030147
	Natural variant	260	1	I → R Complete loss of function. Ref.13 Corresponds to variant rs11568493 [ dbSNP | Ensembl ].		VAR_030148
	Natural variant	277	1	R → W Reduced function. Ref.13 Corresponds to variant rs11568492 [ dbSNP | Ensembl ].		VAR_030149
	Natural variant	281	1	V → A in 6% of African-Americans. Corresponds to variant rs45438191 [ dbSNP | Ensembl ].		VAR_030150
	Natural variant	305	1	I → F in 3.5% of Asian-American; reduced function. Ref.13 Corresponds to variant rs11568482 [ dbSNP | Ensembl ].		VAR_030151
	Natural variant	389	1	A → V. Ref.12		VAR_030152
	Natural variant	448	1	V → I. Corresponds to variant rs11568486 [ dbSNP | Ensembl ].		VAR_030153
Experimental info
	Sequence conflict	150	1	Missing in AAD19357. Ref.1
	Sequence conflict	151	1	P → T in AAD19357. Ref.1
	Sequence conflict	271	1	K → E in BAB47393. Ref.2
	Sequence conflict	286	1	Missing in AAD19357. Ref.1
	Sequence conflict	411	1	R → E in AAD19357. Ref.1
	Sequence conflict	478 – 480	3	YGI → FTGS in AAD19357. Ref.1
	Sequence conflict	526	1	A → T in BAG60589. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 22799360D91B4CCF	FASTA	542	59,856
	10 20 30 40 50 60 MTFSEILDRV GSMGHFQFLH VAILGLPILN MANHNLLQIF TAATPVHHCR PPHNASTGPW 70 80 90 100 110 120 VLPMGPNGKP ERCLRFVHPP NASLPNDTQR AMEPCLDGWV YNSTKDSIVT EWDLVCNSNK 130 140 150 160 170 180 LKEMAQSIFM AGILIGGLVL GDLSDRFGRR PILTCSYLLL AASGSGAAFS PTFPIYMVFR 190 200 210 220 230 240 FLCGFGISGI TLSTVILNVE WVPTRMRAIM STALGYCYTF GQFILPGLAY AIPQWRWLQL 250 260 270 280 290 300 TVSIPFFVFF LSSWWTPESI RWLVLSGKSS KALKILRRVA VFNGKKEEGE RLSLEELKLN 310 320 330 340 350 360 LQKEISLAKA KYTASDLFRI PMLRRMTFCL SLAWFATGFA YYSLAMGVEE FGVNLYILQI 370 380 390 400 410 420 IFGGVDVPAK FITILSLSYL GRHTTQAAAL LLAGGAILAL TFVPLDLQTV RTVLAVFGKG 430 440 450 460 470 480 CLSSSFSCLF LYTSELYPTV IRQTGMGVSN LWTRVGSMVS PLVKITGEVQ PFIPNIIYGI 490 500 510 520 530 540 TALLGGSAAL FLPETLNQPL PETIEDLENW SLRAKKPKQE PEVEKASQRI PLQPHGPGLG SS
	Isoform 2 [UniParc]. Checksum: 0F202C686929638A	FASTA	551	60,709
	10 20 30 40 50 60 MTFSEILDRV GSMGHFQFLH VAILGLPILN MANHNLLQIF TAATPVHHCR PPHNASTGPW 70 80 90 100 110 120 VLPMGPNGKP ERCLRFVHPP NASLPNDTQR AMEPCLDGWV YNSTKDSIVT EWDLVCNSNK 130 140 150 160 170 180 LKEMAQSIFM AGILIGGLVL GDLSDRFGRR PILTCSYLLL AASGSGAAFS PTFPIYMVFR 190 200 210 220 230 240 FLCGFGISGI TLSTVILNVE WVPTRMRAIM STALGYCYTF GQFILPGLAY AIPQWRWLQL 250 260 270 280 290 300 TVSIPFFVFF LSSWWTPESI RWLVLSGKSS KALKILRRVA VFNGKKEEGE RLSLEELKLN 310 320 330 340 350 360 LQKEISLAKA KYTASDLFRI PMLRRMTFCL SLAWFATGFA YYSLAMGVEE FGVNLYILQI 370 380 390 400 410 420 IFGGVDVPAK FITILSLSYL GRHTTQAAAL LLAGGAILAL TFVPLDLQTV RTVLAVFGKG 430 440 450 460 470 480 CLSSSFSCLF LYTSELYPTV IRQTGMGVSN LWTRVGSMVS PLVKITGEVQ PFIPNIIYGI 490 500 510 520 530 540 TALLGGSAAL FLPETLNQPL PETIEDLENW SVTASGPPRS LRAKKPKQEP EVEKASQRIP 550 LQPHGPGLGS S
	Isoform 5 [UniParc]. Checksum: 3BBFC757CEE06790	FASTA	419	46,120
	10 20 30 40 50 60 MAQSIFMAGI LIGGLVLGDL SDRFGRRPIL TCSYLLLAAS GSGAAFSPTF PIYMVFRFLC 70 80 90 100 110 120 GFGISGITLS TVILNVEWVP TRMRAIMSTA LGYCYTFGQF ILPGLAYAIP QWRWLQLTVS 130 140 150 160 170 180 IPFFVFFLSS WWTPESIRWL VLSGKSSKAL KILRRVAVFN GKKEEGERLS LEELKLNLQK 190 200 210 220 230 240 EISLAKAKYT ASDLFRIPML RRMTFCLSLA WFATGFAYYS LAMGVEEFGV NLYILQIIFG 250 260 270 280 290 300 GVDVPAKFIT ILSLSYLGRH TTQAAALLLA GGAILALTFV PLDLQTVRTV LAVFGKGCLS 310 320 330 340 350 360 SSFSCLFLYT SELYPTVIRQ TGMGVSNLWT RVGSMVSPLV KITGEVQPFI PNIIYGITAL 370 380 390 400 410 LGGSAALFLP ETLNQPLPET IEDLENWSLR AKKPKQEPEV EKASQRIPLQ PHGPGLGSS
	Isoform 3 [UniParc]. Checksum: 0050E6499A6446CB	FASTA	110	11,502
	10 20 30 40 50 60 MGVEEFGVNL YILQIIFGGV DVPAKFITIL SLSYLGRHTT QAAALLLAGG AILALTFVPL 70 80 90 100 110 GERLGLPQNP LEEAARLGAR DFTAGSASKS LCYLEQVPAL SGAQGLSSRK
	Isoform 4 [UniParc]. Checksum: B1E5B7631D8BED48	FASTA	451	49,821
	10 20 30 40 50 60 MEPCLDGWVY NSTKDSIVTE WDLVCNSNKL KEMAQSIFMA GILIGGLVLG DLSDRFGRRP 70 80 90 100 110 120 ILTCSYLLLA ASGSGAAFSP TFPIYMVFRF LCGFGISGIT LSTVILNVEW VPTRMRAIMS 130 140 150 160 170 180 TALGYCYTFG QFILPGLAYA IPQWRWLQLT VSIPFFVFFL SSWWTPESIR WLVLSGKSSK 190 200 210 220 230 240 ALKILRRVAV FNGKKEEGER LSLEELKLNL QKEISLAKAK YTASDLFRIP MLRRMTFCLS 250 260 270 280 290 300 LAWFATGFAY YSLAMGVEEF GVNLYILQII FGGVDVPAKF ITILSLSYLG RHTTQAAALL 310 320 330 340 350 360 LAGGAILALT FVPLDLQTVR TVLAVFGKGC LSSSFSCLFL YTSELYPTVI RQTGMGVSNL 370 380 390 400 410 420 WTRVGSMVSP LVKITGEVQP FIPNIIYGIT ALLGGSAALF LPETLNQPLP ETIEDLENWS 430 440 450 LRAKKPKQEP EVEKASQRIP LQPHGPGLGS S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3)." Race J.E., Grassl S.M., Williams W.J., Holtzman E.J. Biochem. Biophys. Res. Commun. 255:508-514(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Kidney.
[2]	"Molecular cloning and characterization of human organic anion transporter 3." Cha S., Sekine T., Kanai Y., Endou H. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Kidney.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Kidney.
[4]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[5]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Kidney.
[7]	"Gene expression levels and immunolocalization of organic ion transporters in the human kidney." Motohashi H., Sakurai Y., Saito H., Masuda S., Urakami Y., Goto M., Fukatsu A., Ogawa O., Inui K. J. Am. Soc. Nephrol. 13:866-874(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[8]	"Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux." Bakhiya A., Bahn A., Burckhardt G., Wolff N. Cell. Physiol. Biochem. 13:249-256(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[9]	"Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8)." Srimaroeng C., Chatsudthipong V., Aslamkhan A.G., Pritchard J.B. J. Pharmacol. Exp. Ther. 313:621-628(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[10]	"Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney." Tahara H., Shono M., Kusuhara H., Kinoshita H., Fuse E., Takadate A., Otagiri M., Sugiyama Y. Pharm. Res. 22:647-660(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[11]	"Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid." Tahara H., Kusuhara H., Maeda K., Koepsell H., Fuse E., Sugiyama Y. Drug Metab. Dispos. 34:743-747(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[12]	"Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics." Nishizato Y., Ieiri I., Suzuki H., Kimura M., Kawabata K., Hirota T., Takane H., Irie S., Kusuhara H., Urasaki Y., Urae A., Higuchi S., Otsubo K., Sugiyama Y. Clin. Pharmacol. Ther. 73:554-565(2003) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT VAL-389.
[13]	"The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics." Erdman A.R., Mangravite L.M., Urban T.J., Lagpacan L.L., Castro R.A., de la Cruz M., Chan W., Huang C.C., Johns S.J., Kawamoto M., Stryke D., Taylor T.R., Carlson E.J., Ferrin T.E., Brett C.M., Burchard E.G., Giacomini K.M. Am. J. Physiol. 290:F905-F912(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS SER-149; ARG-260; TRP-277 AND PHE-305, CHARACTERIZATION OF VARIANTS SER-149; ARG-260; TRP-277 AND PHE-305.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF097491 mRNA. Translation: AAD19357.1. Frameshift. AB042505 mRNA. Translation: BAB47393.1. AK298341 mRNA. Translation: BAG60589.1. AB209692 mRNA. Translation: BAD92929.1. Different initiation. AP001858 Genomic DNA. No translation available. BC022387 mRNA. Translation: AAH22387.1.
IPI	IPI00163456. IPI00827526. IPI00827863. IPI00975555. IPI00982691.
RefSeq	NP_001171661.1. NM_001184732.1. NP_001171662.1. NM_001184733.1. NP_001171665.1. NM_001184736.1. NP_004245.2. NM_004254.3.
UniGene	Hs.266223.
3D structure databases
ProteinModelPortal	Q8TCC7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TCC7. 1 interaction.
STRING	9606.ENSP00000337335.
Polymorphism databases
DMDM	74730587.
Proteomic databases
PaxDb	Q8TCC7.
PRIDE	Q8TCC7.
Protocols and materials databases
DNASU	9376.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000336232; ENSP00000337335; ENSG00000149452. ENST00000430500; ENSP00000398548; ENSG00000149452. ENST00000535878; ENSP00000443368; ENSG00000149452. ENST00000545207; ENSP00000441658; ENSG00000149452.
GeneID	9376.
KEGG	hsa:9376.
UCSC	uc001nwo.3. human. uc001nwp.2. human.
Organism-specific databases
CTD	9376.
GeneCards	GC11M062760.
HGNC	HGNC:10972. SLC22A8.
HPA	HPA044174.
MIM	607581. gene.
neXtProt	NX_Q8TCC7.
PharmGKB	PA389.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0477.
HOGENOM	HOG000234569.
HOVERGEN	HBG108433.
KO	K08205.
OMA	MANHNLL.
OrthoDB	EOG418BPG.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	Q8TCC7.
Bgee	Q8TCC7.
CleanEx	HS_SLC22A8.
Genevestigator	Q8TCC7.
Family and domain databases
InterPro	IPR020846. MFS_dom. IPR016196. MFS_dom_general_subst_transpt. IPR004749. Orgcat_transp. IPR005828. Sub_transporter. IPR005829. Sugar_transporter_CS. [Graphical view]
Pfam	PF00083. Sugar_tr. 1 hit. [Graphical view]
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMs	TIGR00898. 2A0119. 1 hit.
PROSITE	PS50850. MFS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL1641348.
GenomeRNAi	9376.
NextBio	35126.
SOURCE	Search...

Entry information

Entry name

S22A8_HUMAN

Accession

Primary (citable) accession number: Q8TCC7
Secondary accession number(s): B4DPH7 , F5GWA8, F5H5J1, O95820, Q59EW9, Q96TC1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	June 1, 2002
Last modified:	May 29, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.