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Q8TCC7

- S22A8_HUMAN

UniProt

Q8TCC7 - S22A8_HUMAN

Protein

Solute carrier family 22 member 8

Gene

SLC22A8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).4 Publications

    GO - Molecular functioni

    1. inorganic anion exchanger activity Source: UniProtKB
    2. organic anion transmembrane transporter activity Source: Ensembl
    3. quaternary ammonium group transmembrane transporter activity Source: Ensembl

    GO - Biological processi

    1. glutathione transport Source: Ensembl
    2. response to methotrexate Source: Ensembl
    3. response to toxic substance Source: UniProtKB-KW
    4. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Detoxification, Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_22310. Organic anion transport.

    Protein family/group databases

    TCDBi2.A.1.19.34. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 22 member 8
    Alternative name(s):
    Organic anion transporter 3
    Short name:
    hOAT3
    Gene namesi
    Name:SLC22A8
    Synonyms:OAT3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:10972. SLC22A8.

    Subcellular locationi

    Basolateral cell membrane Curated; Multi-pass membrane protein Curated
    Note: Localizes on the brush border membrane of the choroid epithelial cells. Localizes to the basolateral membrane of the proximal tubular cells. Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells (BCEC) By similarity.By similarity

    GO - Cellular componenti

    1. basolateral plasma membrane Source: UniProtKB
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA389.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 542542Solute carrier family 22 member 8PRO_0000273439Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8TCC7.
    PRIDEiQ8TCC7.

    Expressioni

    Tissue specificityi

    Expressed in kidney.1 Publication

    Gene expression databases

    ArrayExpressiQ8TCC7.
    BgeeiQ8TCC7.
    CleanExiHS_SLC22A8.
    GenevestigatoriQ8TCC7.

    Organism-specific databases

    HPAiHPA044174.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8TCC7. 1 interaction.
    STRINGi9606.ENSP00000337335.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TCC7.
    SMRiQ8TCC7. Positions 130-279.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 99CytoplasmicSequence Analysis
    Topological domaini31 – 12393ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini145 – 15410CytoplasmicSequence Analysis
    Topological domaini176 – 1761ExtracellularSequence Analysis
    Topological domaini198 – 21215CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini234 – 2363ExtracellularSequence Analysis
    Topological domaini258 – 32770CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini349 – 3546ExtracellularSequence Analysis
    Topological domaini376 – 38611CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini408 – 4114ExtracellularSequence Analysis
    Topological domaini433 – 47139CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini493 – 54250ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei124 – 14421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei155 – 17521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei177 – 19721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei213 – 23321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei237 – 25721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei328 – 34821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei355 – 37521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei387 – 40721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei412 – 43221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei472 – 49221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    HOGENOMiHOG000234569.
    HOVERGENiHBG108433.
    KOiK08205.
    OMAiDGWVYNS.
    OrthoDBiEOG7C8GH9.
    PhylomeDBiQ8TCC7.
    TreeFamiTF315847.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004749. Orgcat_transp.
    IPR005828. Sub_transporter.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00898. 2A0119. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8TCC7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTFSEILDRV GSMGHFQFLH VAILGLPILN MANHNLLQIF TAATPVHHCR    50
    PPHNASTGPW VLPMGPNGKP ERCLRFVHPP NASLPNDTQR AMEPCLDGWV 100
    YNSTKDSIVT EWDLVCNSNK LKEMAQSIFM AGILIGGLVL GDLSDRFGRR 150
    PILTCSYLLL AASGSGAAFS PTFPIYMVFR FLCGFGISGI TLSTVILNVE 200
    WVPTRMRAIM STALGYCYTF GQFILPGLAY AIPQWRWLQL TVSIPFFVFF 250
    LSSWWTPESI RWLVLSGKSS KALKILRRVA VFNGKKEEGE RLSLEELKLN 300
    LQKEISLAKA KYTASDLFRI PMLRRMTFCL SLAWFATGFA YYSLAMGVEE 350
    FGVNLYILQI IFGGVDVPAK FITILSLSYL GRHTTQAAAL LLAGGAILAL 400
    TFVPLDLQTV RTVLAVFGKG CLSSSFSCLF LYTSELYPTV IRQTGMGVSN 450
    LWTRVGSMVS PLVKITGEVQ PFIPNIIYGI TALLGGSAAL FLPETLNQPL 500
    PETIEDLENW SLRAKKPKQE PEVEKASQRI PLQPHGPGLG SS 542
    Length:542
    Mass (Da):59,856
    Last modified:June 1, 2002 - v1
    Checksum:i22799360D91B4CCF
    GO
    Isoform 2 (identifier: Q8TCC7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         510-510: W → WSVTASGPPR

    Note: No experimental confirmation available.

    Show »
    Length:551
    Mass (Da):60,709
    Checksum:i0F202C686929638A
    GO
    Isoform 5 (identifier: Q8TCC7-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-123: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:419
    Mass (Da):46,120
    Checksum:i3BBFC757CEE06790
    GO
    Isoform 3 (identifier: Q8TCC7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-345: Missing.
         406-455: DLQTVRTVLA...MGVSNLWTRV → GERLGLPQNP...SGAQGLSSRK
         456-542: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:110
    Mass (Da):11,502
    Checksum:i0050E6499A6446CB
    GO
    Isoform 4 (identifier: Q8TCC7-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-91: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:451
    Mass (Da):49,821
    Checksum:iB1E5B7631D8BED48
    GO

    Sequence cautioni

    The sequence AAD19357.1 differs from that shown. Reason: Frameshift at several positions.
    The sequence BAD92929.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti150 – 1501Missing in AAD19357. (PubMed:10049739)Curated
    Sequence conflicti151 – 1511P → T in AAD19357. (PubMed:10049739)Curated
    Sequence conflicti271 – 2711K → E in BAB47393. 1 PublicationCurated
    Sequence conflicti286 – 2861Missing in AAD19357. (PubMed:10049739)Curated
    Sequence conflicti411 – 4111R → E in AAD19357. (PubMed:10049739)Curated
    Sequence conflicti478 – 4803YGI → FTGS in AAD19357. (PubMed:10049739)Curated
    Sequence conflicti526 – 5261A → T in BAG60589. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti129 – 1291F → L.
    Corresponds to variant rs11568479 [ dbSNP | Ensembl ].
    VAR_030146
    Natural varianti149 – 1491R → S Complete loss of function. 1 Publication
    Corresponds to variant rs45566039 [ dbSNP | Ensembl ].
    VAR_030147
    Natural varianti260 – 2601I → R Complete loss of function. 1 Publication
    Corresponds to variant rs11568493 [ dbSNP | Ensembl ].
    VAR_030148
    Natural varianti277 – 2771R → W Reduced function. 1 Publication
    Corresponds to variant rs11568492 [ dbSNP | Ensembl ].
    VAR_030149
    Natural varianti281 – 2811V → A in 6% of African-Americans.
    Corresponds to variant rs45438191 [ dbSNP | Ensembl ].
    VAR_030150
    Natural varianti305 – 3051I → F in 3.5% of Asian-American; reduced function. 1 Publication
    Corresponds to variant rs11568482 [ dbSNP | Ensembl ].
    VAR_030151
    Natural varianti389 – 3891A → V.1 Publication
    VAR_030152
    Natural varianti448 – 4481V → I.
    Corresponds to variant rs11568486 [ dbSNP | Ensembl ].
    VAR_030153

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 345345Missing in isoform 3. 1 PublicationVSP_022562Add
    BLAST
    Alternative sequencei1 – 123123Missing in isoform 5. CuratedVSP_045824Add
    BLAST
    Alternative sequencei1 – 9191Missing in isoform 4. 1 PublicationVSP_045272Add
    BLAST
    Alternative sequencei406 – 45550DLQTV…LWTRV → GERLGLPQNPLEEAARLGAR DFTAGSASKSLCYLEQVPAL SGAQGLSSRK in isoform 3. 1 PublicationVSP_022563Add
    BLAST
    Alternative sequencei456 – 54287Missing in isoform 3. 1 PublicationVSP_022564Add
    BLAST
    Alternative sequencei510 – 5101W → WSVTASGPPR in isoform 2. 1 PublicationVSP_022565

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF097491 mRNA. Translation: AAD19357.1. Frameshift.
    AB042505 mRNA. Translation: BAB47393.1.
    AK298341 mRNA. Translation: BAG60589.1.
    AB209692 mRNA. Translation: BAD92929.1. Different initiation.
    AP001858 Genomic DNA. No translation available.
    BC022387 mRNA. Translation: AAH22387.1.
    CCDSiCCDS53643.1. [Q8TCC7-5]
    CCDS53644.1. [Q8TCC7-4]
    CCDS8042.1. [Q8TCC7-1]
    RefSeqiNP_001171661.1. NM_001184732.1. [Q8TCC7-1]
    NP_001171662.1. NM_001184733.1. [Q8TCC7-4]
    NP_001171665.1. NM_001184736.1. [Q8TCC7-5]
    NP_004245.2. NM_004254.3. [Q8TCC7-1]
    UniGeneiHs.266223.

    Genome annotation databases

    EnsembliENST00000336232; ENSP00000337335; ENSG00000149452. [Q8TCC7-1]
    ENST00000430500; ENSP00000398548; ENSG00000149452. [Q8TCC7-1]
    ENST00000535878; ENSP00000443368; ENSG00000149452. [Q8TCC7-5]
    ENST00000545207; ENSP00000441658; ENSG00000149452. [Q8TCC7-4]
    GeneIDi9376.
    KEGGihsa:9376.
    UCSCiuc001nwo.3. human. [Q8TCC7-1]

    Polymorphism databases

    DMDMi74730587.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF097491 mRNA. Translation: AAD19357.1 . Frameshift.
    AB042505 mRNA. Translation: BAB47393.1 .
    AK298341 mRNA. Translation: BAG60589.1 .
    AB209692 mRNA. Translation: BAD92929.1 . Different initiation.
    AP001858 Genomic DNA. No translation available.
    BC022387 mRNA. Translation: AAH22387.1 .
    CCDSi CCDS53643.1. [Q8TCC7-5 ]
    CCDS53644.1. [Q8TCC7-4 ]
    CCDS8042.1. [Q8TCC7-1 ]
    RefSeqi NP_001171661.1. NM_001184732.1. [Q8TCC7-1 ]
    NP_001171662.1. NM_001184733.1. [Q8TCC7-4 ]
    NP_001171665.1. NM_001184736.1. [Q8TCC7-5 ]
    NP_004245.2. NM_004254.3. [Q8TCC7-1 ]
    UniGenei Hs.266223.

    3D structure databases

    ProteinModelPortali Q8TCC7.
    SMRi Q8TCC7. Positions 130-279.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8TCC7. 1 interaction.
    STRINGi 9606.ENSP00000337335.

    Chemistry

    ChEMBLi CHEMBL1641348.

    Protein family/group databases

    TCDBi 2.A.1.19.34. the major facilitator superfamily (mfs).

    Polymorphism databases

    DMDMi 74730587.

    Proteomic databases

    PaxDbi Q8TCC7.
    PRIDEi Q8TCC7.

    Protocols and materials databases

    DNASUi 9376.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000336232 ; ENSP00000337335 ; ENSG00000149452 . [Q8TCC7-1 ]
    ENST00000430500 ; ENSP00000398548 ; ENSG00000149452 . [Q8TCC7-1 ]
    ENST00000535878 ; ENSP00000443368 ; ENSG00000149452 . [Q8TCC7-5 ]
    ENST00000545207 ; ENSP00000441658 ; ENSG00000149452 . [Q8TCC7-4 ]
    GeneIDi 9376.
    KEGGi hsa:9376.
    UCSCi uc001nwo.3. human. [Q8TCC7-1 ]

    Organism-specific databases

    CTDi 9376.
    GeneCardsi GC11M062760.
    HGNCi HGNC:10972. SLC22A8.
    HPAi HPA044174.
    MIMi 607581. gene.
    neXtProti NX_Q8TCC7.
    PharmGKBi PA389.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0477.
    HOGENOMi HOG000234569.
    HOVERGENi HBG108433.
    KOi K08205.
    OMAi DGWVYNS.
    OrthoDBi EOG7C8GH9.
    PhylomeDBi Q8TCC7.
    TreeFami TF315847.

    Enzyme and pathway databases

    Reactomei REACT_22310. Organic anion transport.

    Miscellaneous databases

    GeneWikii SLC22A8.
    GenomeRNAii 9376.
    NextBioi 35126.
    PROi Q8TCC7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8TCC7.
    Bgeei Q8TCC7.
    CleanExi HS_SLC22A8.
    Genevestigatori Q8TCC7.

    Family and domain databases

    InterProi IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004749. Orgcat_transp.
    IPR005828. Sub_transporter.
    IPR005829. Sugar_transporter_CS.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    TIGRFAMsi TIGR00898. 2A0119. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3)."
      Race J.E., Grassl S.M., Williams W.J., Holtzman E.J.
      Biochem. Biophys. Res. Commun. 255:508-514(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Kidney.
    2. "Molecular cloning and characterization of human organic anion transporter 3."
      Cha S., Sekine T., Kanai Y., Endou H.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Kidney.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Kidney.
    4. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney.
    7. "Gene expression levels and immunolocalization of organic ion transporters in the human kidney."
      Motohashi H., Sakurai Y., Saito H., Masuda S., Urakami Y., Goto M., Fukatsu A., Ogawa O., Inui K.
      J. Am. Soc. Nephrol. 13:866-874(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    8. "Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux."
      Bakhiya A., Bahn A., Burckhardt G., Wolff N.
      Cell. Physiol. Biochem. 13:249-256(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8)."
      Srimaroeng C., Chatsudthipong V., Aslamkhan A.G., Pritchard J.B.
      J. Pharmacol. Exp. Ther. 313:621-628(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney."
      Tahara H., Shono M., Kusuhara H., Kinoshita H., Fuse E., Takadate A., Otagiri M., Sugiyama Y.
      Pharm. Res. 22:647-660(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. "Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid."
      Tahara H., Kusuhara H., Maeda K., Koepsell H., Fuse E., Sugiyama Y.
      Drug Metab. Dispos. 34:743-747(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics."
      Nishizato Y., Ieiri I., Suzuki H., Kimura M., Kawabata K., Hirota T., Takane H., Irie S., Kusuhara H., Urasaki Y., Urae A., Higuchi S., Otsubo K., Sugiyama Y.
      Clin. Pharmacol. Ther. 73:554-565(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT VAL-389.
    13. Cited for: VARIANTS SER-149; ARG-260; TRP-277 AND PHE-305, CHARACTERIZATION OF VARIANTS SER-149; ARG-260; TRP-277 AND PHE-305.

    Entry informationi

    Entry nameiS22A8_HUMAN
    AccessioniPrimary (citable) accession number: Q8TCC7
    Secondary accession number(s): B4DPH7
    , F5GWA8, F5H5J1, O95820, Q59EW9, Q96TC1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3