ID RM30_HUMAN Reviewed; 161 AA. AC Q8TCC3; A6NIC6; D3DVI0; D3DVI3; Q0D2Q7; Q6ZTP4; Q96Q69; Q9P0N0; DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2002, sequence version 1. DT 27-MAR-2024, entry version 170. DE RecName: Full=Large ribosomal subunit protein uL30m {ECO:0000303|PubMed:25278503}; DE AltName: Full=39S ribosomal protein L28, mitochondrial; DE Short=L28mt; DE Short=MRP-L28; DE AltName: Full=39S ribosomal protein L30, mitochondrial; DE Short=L30mt; DE Short=MRP-L30; DE Flags: Precursor; GN Name=MRPL30; Synonyms=MRPL28, RPML28; ORFNames=HSPC249; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). RC TISSUE=Umbilical cord blood; RX PubMed=11042152; DOI=10.1101/gr.140200; RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.; RT "Cloning and functional analysis of cDNAs with open reading frames for 300 RT previously undefined genes expressed in CD34+ hematopoietic stem/progenitor RT cells."; RL Genome Res. 10:1546-1560(2000). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT THR-130. RC TISSUE=Uterus; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., RA Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 and RT 4."; RL Nature 434:724-731(2005). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT THR-130. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT THR-130. RC TISSUE=Brain, and Kidney; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 94-161. RX PubMed=11543634; DOI=10.1006/geno.2001.6622; RA Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., RA Watanabe K., Tanaka T.; RT "The human mitochondrial ribosomal protein genes: mapping of 54 genes to RT the chromosomes and implications for human disorders."; RL Genomics 77:65-70(2001). RN [7] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D., RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [9] {ECO:0007744|PDB:3J7Y} RP STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS), SUBCELLULAR LOCATION, RP AND SUBUNIT. RX PubMed=25278503; DOI=10.1126/science.1258026; RA Brown A., Amunts A., Bai X.C., Sugimoto Y., Edwards P.C., Murshudov G., RA Scheres S.H., Ramakrishnan V.; RT "Structure of the large ribosomal subunit from human mitochondria."; RL Science 346:718-722(2014). RN [10] {ECO:0007744|PDB:3J9M} RP STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS), SUBCELLULAR LOCATION, RP AND SUBUNIT. RX PubMed=25838379; DOI=10.1126/science.aaa1193; RA Amunts A., Brown A., Toots J., Scheres S.H., Ramakrishnan V.; RT "Ribosome. The structure of the human mitochondrial ribosome."; RL Science 348:95-98(2015). RN [11] {ECO:0007744|PDB:5OOL, ECO:0007744|PDB:5OOM} RP STRUCTURE BY ELECTRON MICROSCOPY (3.03 ANGSTROMS), SUBCELLULAR LOCATION, RP AND SUBUNIT. RX PubMed=28892042; DOI=10.1038/nsmb.3464; RA Brown A., Rathore S., Kimanius D., Aibara S., Bai X.C., Rorbach J., RA Amunts A., Ramakrishnan V.; RT "Structures of the human mitochondrial ribosome in native states of RT assembly."; RL Nat. Struct. Mol. Biol. 24:866-869(2017). CC -!- SUBUNIT: Component of the mitochondrial large ribosomal subunit (mt- CC LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature CC mammalian 55S mitochondrial ribosomes consist of a small (28S) and a CC large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA CC (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains CC a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA CC (mt-tRNA(Val)), which plays an integral structural role, and 52 CC different proteins. {ECO:0000269|PubMed:25278503, CC ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}. CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, CC ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q8TCC3-1; Sequence=Displayed; CC Name=2; CC IsoId=Q8TCC3-2; Sequence=VSP_021746; CC Name=3; CC IsoId=Q8TCC3-3; Sequence=VSP_021747; CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL30 family. CC {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAF36169.1; Type=Frameshift; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF151083; AAF36169.1; ALT_FRAME; mRNA. DR EMBL; AK126402; BAC86542.1; -; mRNA. DR EMBL; AC092587; AAX88929.1; -; Genomic_DNA. DR EMBL; CH471127; EAX01876.1; -; Genomic_DNA. DR EMBL; CH471127; EAX01878.1; -; Genomic_DNA. DR EMBL; CH471127; EAX01880.1; -; Genomic_DNA. DR EMBL; CH471127; EAX01881.1; -; Genomic_DNA. DR EMBL; CH471127; EAX01882.1; -; Genomic_DNA. DR EMBL; CH471127; EAX01883.1; -; Genomic_DNA. DR EMBL; BC000217; AAH00217.1; -; mRNA. DR EMBL; BC022391; AAH22391.1; -; mRNA. DR EMBL; AB051342; BAB54932.1; -; Genomic_DNA. DR CCDS; CCDS2041.1; -. [Q8TCC3-1] DR RefSeq; NP_660213.1; NM_145212.3. [Q8TCC3-1] DR PDB; 3J7Y; EM; 3.40 A; Z=1-161. DR PDB; 3J9M; EM; 3.50 A; Z=1-161. DR PDB; 5OOL; EM; 3.06 A; Z=1-161. DR PDB; 5OOM; EM; 3.03 A; Z=1-161. DR PDB; 6I9R; EM; 3.90 A; Z=1-161. DR PDB; 6NU2; EM; 3.90 A; Z=35-154. DR PDB; 6NU3; EM; 4.40 A; Z=1-161. DR PDB; 6VLZ; EM; 2.97 A; Z=1-161. DR PDB; 6VMI; EM; 2.96 A; Z=1-161. DR PDB; 6ZM5; EM; 2.89 A; Z=1-161. DR PDB; 6ZM6; EM; 2.59 A; Z=1-161. DR PDB; 6ZS9; EM; 4.00 A; XZ=1-161. DR PDB; 6ZSA; EM; 4.00 A; XZ=1-161. DR PDB; 6ZSB; EM; 4.50 A; XZ=1-161. DR PDB; 6ZSC; EM; 3.50 A; XZ=1-161. DR PDB; 6ZSD; EM; 3.70 A; XZ=1-161. DR PDB; 6ZSE; EM; 5.00 A; XZ=1-161. DR PDB; 6ZSG; EM; 4.00 A; XZ=1-161. DR PDB; 7A5F; EM; 4.40 A; Z3=1-161. DR PDB; 7A5G; EM; 4.33 A; Z3=1-161. DR PDB; 7A5H; EM; 3.30 A; Z=1-161. DR PDB; 7A5I; EM; 3.70 A; Z3=1-161. DR PDB; 7A5J; EM; 3.10 A; Z=1-161. DR PDB; 7A5K; EM; 3.70 A; Z3=1-161. DR PDB; 7L08; EM; 3.49 A; Z=1-161. DR PDB; 7L20; EM; 3.15 A; Z=1-161. DR PDB; 7O9K; EM; 3.10 A; Z=1-161. DR PDB; 7O9M; EM; 2.50 A; Z=1-161. DR PDB; 7ODR; EM; 2.90 A; Z=1-161. DR PDB; 7ODS; EM; 3.10 A; Z=1-161. DR PDB; 7ODT; EM; 3.10 A; Z=1-161. DR PDB; 7OF0; EM; 2.20 A; Z=1-161. DR PDB; 7OF2; EM; 2.70 A; Z=1-161. DR PDB; 7OF3; EM; 2.70 A; Z=1-161. DR PDB; 7OF4; EM; 2.70 A; Z=1-161. DR PDB; 7OF5; EM; 2.90 A; Z=1-161. DR PDB; 7OF6; EM; 2.60 A; Z=1-161. DR PDB; 7OF7; EM; 2.50 A; Z=1-161. DR PDB; 7OG4; EM; 3.80 A; XZ=1-161. DR PDB; 7OI6; EM; 5.70 A; Z=1-161. DR PDB; 7OI7; EM; 3.50 A; Z=1-161. DR PDB; 7OI8; EM; 3.50 A; Z=1-161. DR PDB; 7OI9; EM; 3.30 A; Z=1-161. DR PDB; 7OIA; EM; 3.20 A; Z=1-161. DR PDB; 7OIB; EM; 3.30 A; Z=1-161. DR PDB; 7OIC; EM; 3.10 A; Z=1-161. DR PDB; 7OID; EM; 3.70 A; Z=1-161. DR PDB; 7OIE; EM; 3.50 A; Z=1-161. DR PDB; 7PD3; EM; 3.40 A; Z=1-161. DR PDB; 7PO4; EM; 2.56 A; Z=1-161. DR PDB; 7QH6; EM; 3.08 A; Z=1-161. DR PDB; 7QH7; EM; 2.89 A; Z=35-149. DR PDB; 7QI4; EM; 2.21 A; Z=1-161. DR PDB; 7QI5; EM; 2.63 A; Z=1-161. DR PDB; 7QI6; EM; 2.98 A; Z=1-161. DR PDB; 8ANY; EM; 2.85 A; Z=1-161. DR PDB; 8OIR; EM; 3.10 A; BG=1-161. DR PDB; 8OIT; EM; 2.90 A; BG=1-161. DR PDBsum; 3J7Y; -. DR PDBsum; 3J9M; -. DR PDBsum; 5OOL; -. DR PDBsum; 5OOM; -. DR PDBsum; 6I9R; -. DR PDBsum; 6NU2; -. DR PDBsum; 6NU3; -. DR PDBsum; 6VLZ; -. DR PDBsum; 6VMI; -. DR PDBsum; 6ZM5; -. DR PDBsum; 6ZM6; -. DR PDBsum; 6ZS9; -. DR PDBsum; 6ZSA; -. DR PDBsum; 6ZSB; -. DR PDBsum; 6ZSC; -. DR PDBsum; 6ZSD; -. DR PDBsum; 6ZSE; -. DR PDBsum; 6ZSG; -. DR PDBsum; 7A5F; -. DR PDBsum; 7A5G; -. DR PDBsum; 7A5H; -. DR PDBsum; 7A5I; -. DR PDBsum; 7A5J; -. DR PDBsum; 7A5K; -. DR PDBsum; 7L08; -. DR PDBsum; 7L20; -. DR PDBsum; 7O9K; -. DR PDBsum; 7O9M; -. DR PDBsum; 7ODR; -. DR PDBsum; 7ODS; -. DR PDBsum; 7ODT; -. DR PDBsum; 7OF0; -. DR PDBsum; 7OF2; -. DR PDBsum; 7OF3; -. DR PDBsum; 7OF4; -. DR PDBsum; 7OF5; -. DR PDBsum; 7OF6; -. DR PDBsum; 7OF7; -. DR PDBsum; 7OG4; -. DR PDBsum; 7OI6; -. DR PDBsum; 7OI7; -. DR PDBsum; 7OI8; -. DR PDBsum; 7OI9; -. DR PDBsum; 7OIA; -. DR PDBsum; 7OIB; -. DR PDBsum; 7OIC; -. DR PDBsum; 7OID; -. DR PDBsum; 7OIE; -. DR PDBsum; 7PD3; -. DR PDBsum; 7PO4; -. DR PDBsum; 7QH6; -. DR PDBsum; 7QH7; -. DR PDBsum; 7QI4; -. DR PDBsum; 7QI5; -. DR PDBsum; 7QI6; -. DR PDBsum; 8ANY; -. DR PDBsum; 8OIR; -. DR PDBsum; 8OIT; -. DR AlphaFoldDB; Q8TCC3; -. DR EMDB; EMD-0514; -. DR EMDB; EMD-0515; -. DR EMDB; EMD-11278; -. DR EMDB; EMD-11279; -. DR EMDB; EMD-11390; -. DR EMDB; EMD-11391; -. DR EMDB; EMD-11392; -. DR EMDB; EMD-11393; -. DR EMDB; EMD-11394; -. DR EMDB; EMD-11395; -. DR EMDB; EMD-11397; -. DR EMDB; EMD-11641; -. DR EMDB; EMD-11642; -. DR EMDB; EMD-11643; -. DR EMDB; EMD-11644; -. DR EMDB; EMD-11645; -. DR EMDB; EMD-11646; -. DR EMDB; EMD-12763; -. DR EMDB; EMD-12764; -. DR EMDB; EMD-12845; -. DR EMDB; EMD-12846; -. DR EMDB; EMD-12847; -. DR EMDB; EMD-12865; -. DR EMDB; EMD-12867; -. DR EMDB; EMD-12868; -. DR EMDB; EMD-12869; -. DR EMDB; EMD-12870; -. DR EMDB; EMD-12871; -. DR EMDB; EMD-12872; -. DR EMDB; EMD-12877; -. DR EMDB; EMD-12919; -. DR EMDB; EMD-12920; -. DR EMDB; EMD-12921; -. DR EMDB; EMD-12922; -. DR EMDB; EMD-12923; -. DR EMDB; EMD-12924; -. DR EMDB; EMD-12925; -. DR EMDB; EMD-12926; -. DR EMDB; EMD-12927; -. DR EMDB; EMD-13329; -. DR EMDB; EMD-13562; -. DR EMDB; EMD-13965; -. DR EMDB; EMD-13967; -. DR EMDB; EMD-13980; -. DR EMDB; EMD-13981; -. DR EMDB; EMD-13982; -. DR EMDB; EMD-15544; -. DR EMDB; EMD-16897; -. DR EMDB; EMD-16899; -. DR EMDB; EMD-21233; -. DR EMDB; EMD-21242; -. DR EMDB; EMD-23096; -. DR EMDB; EMD-23121; -. DR EMDB; EMD-3842; -. DR EMDB; EMD-3843; -. DR EMDB; EMD-4434; -. DR SMR; Q8TCC3; -. DR BioGRID; 119417; 167. DR ComplexPortal; CPX-5226; 39S mitochondrial large ribosomal subunit. DR CORUM; Q8TCC3; -. DR IntAct; Q8TCC3; 27. DR MINT; Q8TCC3; -. DR STRING; 9606.ENSP00000338057; -. DR GlyGen; Q8TCC3; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; Q8TCC3; -. DR PhosphoSitePlus; Q8TCC3; -. DR BioMuta; MRPL30; -. DR DMDM; 74730583; -. DR EPD; Q8TCC3; -. DR jPOST; Q8TCC3; -. DR MassIVE; Q8TCC3; -. DR MaxQB; Q8TCC3; -. DR PaxDb; 9606-ENSP00000338057; -. DR PeptideAtlas; Q8TCC3; -. DR Pumba; Q8TCC3; -. DR TopDownProteomics; Q8TCC3-1; -. [Q8TCC3-1] DR TopDownProteomics; Q8TCC3-2; -. [Q8TCC3-2] DR TopDownProteomics; Q8TCC3-3; -. [Q8TCC3-3] DR Antibodypedia; 65219; 75 antibodies from 17 providers. DR DNASU; 51263; -. DR Ensembl; ENST00000338148.8; ENSP00000338057.3; ENSG00000185414.20. [Q8TCC3-1] DR Ensembl; ENST00000409841.1; ENSP00000386752.1; ENSG00000185414.20. [Q8TCC3-1] DR GeneID; 51263; -. DR KEGG; hsa:51263; -. DR MANE-Select; ENST00000338148.8; ENSP00000338057.3; NM_145212.4; NP_660213.1. DR UCSC; uc002szv.4; human. [Q8TCC3-1] DR AGR; HGNC:14036; -. DR CTD; 51263; -. DR DisGeNET; 51263; -. DR GeneCards; MRPL30; -. DR HGNC; HGNC:14036; MRPL30. DR HPA; ENSG00000185414; Low tissue specificity. DR MIM; 611838; gene. DR neXtProt; NX_Q8TCC3; -. DR OpenTargets; ENSG00000185414; -. DR PharmGKB; PA30961; -. DR VEuPathDB; HostDB:ENSG00000185414; -. DR eggNOG; KOG4799; Eukaryota. DR GeneTree; ENSGT00390000016769; -. DR HOGENOM; CLU_139849_0_0_1; -. DR InParanoid; Q8TCC3; -. DR OMA; VESFICT; -. DR OrthoDB; 2872634at2759; -. DR PhylomeDB; Q8TCC3; -. DR TreeFam; TF314611; -. DR PathwayCommons; Q8TCC3; -. DR Reactome; R-HSA-5368286; Mitochondrial translation initiation. DR Reactome; R-HSA-5389840; Mitochondrial translation elongation. DR Reactome; R-HSA-5419276; Mitochondrial translation termination. DR SignaLink; Q8TCC3; -. DR SIGNOR; Q8TCC3; -. DR BioGRID-ORCS; 51263; 145 hits in 1124 CRISPR screens. DR ChiTaRS; MRPL30; human. DR GeneWiki; MRPL30; -. DR GenomeRNAi; 51263; -. DR Pharos; Q8TCC3; Tdark. DR PRO; PR:Q8TCC3; -. DR Proteomes; UP000005640; Chromosome 2. DR RNAct; Q8TCC3; Protein. DR Bgee; ENSG00000185414; Expressed in tibialis anterior and 193 other cell types or tissues. DR ExpressionAtlas; Q8TCC3; baseline and differential. DR GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome. DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; IDA:UniProtKB. DR GO; GO:0005739; C:mitochondrion; IDA:UniProtKB. DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro. DR GO; GO:0032543; P:mitochondrial translation; NAS:ComplexPortal. DR CDD; cd01658; Ribosomal_L30; 1. DR Gene3D; 3.30.1390.20; Ribosomal protein L30, ferredoxin-like fold domain; 1. DR InterPro; IPR036919; Ribo_uL30_ferredoxin-like_sf. DR InterPro; IPR005996; Ribosomal_uL30_bac-type. DR InterPro; IPR016082; Ribosomal_uL30_ferredoxin-like. DR PANTHER; PTHR15892:SF2; 39S RIBOSOMAL PROTEIN L30, MITOCHONDRIAL; 1. DR PANTHER; PTHR15892; MITOCHONDRIAL RIBOSOMAL PROTEIN L30; 1. DR Pfam; PF00327; Ribosomal_L30; 1. DR SUPFAM; SSF55129; Ribosomal protein L30p/L7e; 1. DR Genevisible; Q8TCC3; HS. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; Mitochondrion; Reference proteome; KW Ribonucleoprotein; Ribosomal protein; Transit peptide. FT TRANSIT 1..34 FT /note="Mitochondrion" FT /evidence="ECO:0000250" FT CHAIN 35..161 FT /note="Large ribosomal subunit protein uL30m" FT /id="PRO_0000261649" FT VAR_SEQ 1 FT /note="M -> MSSTLGKLSNQVEETLPLLKKPLKRAITTLM (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_021746" FT VAR_SEQ 119..161 FT /note="IKPLKLPQGLPAEENMSNTCLKSTGELVVQWHLKPVEQKAHES -> FVVSS FT QLFLKCIA (in isoform 3)" FT /evidence="ECO:0000303|PubMed:11042152" FT /id="VSP_021747" FT VARIANT 130 FT /note="A -> T (in dbSNP:rs1044575)" FT /evidence="ECO:0000269|PubMed:14702039, FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.4" FT /id="VAR_034462" FT CONFLICT 45 FT /note="V -> A (in Ref. 2; BAC86542)" FT /evidence="ECO:0000305" FT HELIX 43..46 FT /evidence="ECO:0007829|PDB:7OF0" FT HELIX 50..56 FT /evidence="ECO:0007829|PDB:7OF0" FT STRAND 60..62 FT /evidence="ECO:0007829|PDB:7OF0" FT STRAND 65..71 FT /evidence="ECO:0007829|PDB:7OF0" FT STRAND 75..78 FT /evidence="ECO:0007829|PDB:7OI9" FT HELIX 80..89 FT /evidence="ECO:0007829|PDB:7OF0" FT STRAND 93..95 FT /evidence="ECO:0007829|PDB:7QH7" FT STRAND 98..101 FT /evidence="ECO:0007829|PDB:7OF0" FT HELIX 104..112 FT /evidence="ECO:0007829|PDB:7OF0" FT TURN 113..115 FT /evidence="ECO:0007829|PDB:7OF0" FT STRAND 116..121 FT /evidence="ECO:0007829|PDB:7OF0" FT TURN 132..135 FT /evidence="ECO:0007829|PDB:7OF0" FT STRAND 143..147 FT /evidence="ECO:0007829|PDB:7OF0" FT STRAND 151..153 FT /evidence="ECO:0007829|PDB:7OIA" SQ SEQUENCE 161 AA; 18546 MW; E818AD8B8AA7DD23 CRC64; MAGILRLVVQ WPPGRLQTVT KGVESLICTD WIRHKFTRSR IPEKVFQASP EDHEKYGGDP QNPHKLHIVT RIKSTRRRPY WEKDIIKMLG LEKAHTPQVH KNIPSVNAKL KVVKHLIRIK PLKLPQGLPA EENMSNTCLK STGELVVQWH LKPVEQKAHE S //