Q8TCC3 (RM30_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
39S ribosomal protein L30, mitochondrial
Short name=L30mt
Short name=MRP-L30

Alternative name(s):
39S ribosomal protein L28, mitochondrial
Short name=L28mt
Short name=MRP-L28

Gene names

Name:	MRPL30
Synonyms:	MRPL28, RPML28
ORF Names:	HSPC249

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	161 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the ribosomal protein L30P family.
Sequence caution	The sequence AAF36169.1 differs from that shown. Reason: Frameshift at positions 1 and 36.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TCC3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TCC3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSSTLGKLSNQVEETLPLLKKPLKRAITTLM

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8TCC3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     119-161: IKPLKLPQGLPAEENMSNTCLKSTGELVVQWHLKPVEQKAHES → FVVSSQLFLKCIA

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 34	34	Mitochondrion By similarity
	Chain	35 – 161	127	39S ribosomal protein L30, mitochondrial		PRO_0000261649
Natural variations
	Alternative sequence	1	1	M → MSSTLGKLSNQVEETLPLLK KPLKRAITTLM in isoform 2.		VSP_021746
	Alternative sequence	119 – 161	43	IKPLK…KAHES → FVVSSQLFLKCIA in isoform 3.		VSP_021747
	Natural variant	130	1	A → T. Ref.2 Ref.4 Ref.5 Corresponds to variant rs1044575 [ dbSNP | Ensembl ].		VAR_034462
Experimental info
	Sequence conflict	45	1	V → A in BAC86542. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: E818AD8B8AA7DD23	FASTA	161	18,546
	10 20 30 40 50 60 MAGILRLVVQ WPPGRLQTVT KGVESLICTD WIRHKFTRSR IPEKVFQASP EDHEKYGGDP 70 80 90 100 110 120 QNPHKLHIVT RIKSTRRRPY WEKDIIKMLG LEKAHTPQVH KNIPSVNAKL KVVKHLIRIK 130 140 150 160 PLKLPQGLPA EENMSNTCLK STGELVVQWH LKPVEQKAHE S
	Isoform 2 [UniParc]. Checksum: 98159061F494ABD5	FASTA	191	21,839
	10 20 30 40 50 60 MSSTLGKLSN QVEETLPLLK KPLKRAITTL MAGILRLVVQ WPPGRLQTVT KGVESLICTD 70 80 90 100 110 120 WIRHKFTRSR IPEKVFQASP EDHEKYGGDP QNPHKLHIVT RIKSTRRRPY WEKDIIKMLG 130 140 150 160 170 180 LEKAHTPQVH KNIPSVNAKL KVVKHLIRIK PLKLPQGLPA EENMSNTCLK STGELVVQWH 190 LKPVEQKAHE S
	Isoform 3 [UniParc]. Checksum: 0CCC141A971552CE	FASTA	131	15,191
	10 20 30 40 50 60 MAGILRLVVQ WPPGRLQTVT KGVESLICTD WIRHKFTRSR IPEKVFQASP EDHEKYGGDP 70 80 90 100 110 120 QNPHKLHIVT RIKSTRRRPY WEKDIIKMLG LEKAHTPQVH KNIPSVNAKL KVVKHLIRFV 130 VSSQLFLKCI A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Umbilical cord blood.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-130. Tissue: Uterus.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-130.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-130. Tissue: Brain and Kidney.
[6]	"The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders." Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T. Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 94-161.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF151083 mRNA. Translation: AAF36169.1. Frameshift. AK126402 mRNA. Translation: BAC86542.1. AC092587 Genomic DNA. Translation: AAX88929.1. CH471127 Genomic DNA. Translation: EAX01876.1. CH471127 Genomic DNA. Translation: EAX01878.1. CH471127 Genomic DNA. Translation: EAX01880.1. CH471127 Genomic DNA. Translation: EAX01881.1. CH471127 Genomic DNA. Translation: EAX01882.1. CH471127 Genomic DNA. Translation: EAX01883.1. BC000217 mRNA. Translation: AAH00217.1. BC022391 mRNA. Translation: AAH22391.1. AB051342 Genomic DNA. Translation: BAB54932.1.
IPI	IPI00465176. IPI00748207. IPI00807606.
RefSeq	NP_660213.1. NM_145212.3.
UniGene	Hs.346736.
3D structure databases
ProteinModelPortal	Q8TCC3.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000311103.
PTM databases
PhosphoSite	Q8TCC3.
Polymorphism databases
DMDM	74730583.
Proteomic databases
PRIDE	Q8TCC3.
Protocols and materials databases
DNASU	51263.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000338148; ENSP00000338057; ENSG00000185414. ENST00000409841; ENSP00000386752; ENSG00000185414. ENST00000410042; ENSP00000387111; ENSG00000185414.
GeneID	51263.
KEGG	hsa:51263.
UCSC	uc002szr.3. human. uc002szu.3. human.
Organism-specific databases
CTD	51263.
GeneCards	GC02P099772.
H-InvDB	HIX0077794.
HGNC	HGNC:14036. MRPL30.
HPA	HPA047255.
MIM	611838. gene.
neXtProt	NX_Q8TCC3.
PharmGKB	PA30961.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG082601.
InParanoid	Q8TCC3.
KO	K02907.
OMA	LVVQWHL.
PhylomeDB	Q8TCC3.
Gene expression databases
ArrayExpress	Q8TCC3.
Bgee	Q8TCC3.
CleanEx	HS_MRPL28. HS_MRPL30.
Genevestigator	Q8TCC3.
GermOnline	ENSG00000185414. Homo sapiens.
Family and domain databases
Gene3D	3.30.1390.20. 1 hit.
InterPro	IPR016082. Ribosomal_L30_ferredoxin-like. [Graphical view]
Pfam	PF00327. Ribosomal_L30. 1 hit. [Graphical view]
SUPFAM	SSF55129. Ribosomal_L30. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	MRPL30. human.
GenomeRNAi	51263.
NextBio	54435.
SOURCE	Search...

Entry information

Entry name

RM30_HUMAN

Accession

Primary (citable) accession number: Q8TCC3
Secondary accession number(s): A6NIC6 , D3DVI0, D3DVI3, Q0D2Q7, Q6ZTP4, Q96Q69, Q9P0N0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.