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Protein

Methyltransferase-like protein 6

Gene

METTL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable methyltransferase.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like protein 6 (EC:2.1.1.-)
Gene namesi
Name:METTL6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:28343. METTL6.

Pathology & Biotechi

Organism-specific databases

DisGeNETi131965.
OpenTargetsiENSG00000206562.
PharmGKBiPA142671462.

Polymorphism and mutation databases

BioMutaiMETTL6.
DMDMi269849620.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002044541 – 284Methyltransferase-like protein 6Add BLAST284

Proteomic databases

EPDiQ8TCB7.
MaxQBiQ8TCB7.
PaxDbiQ8TCB7.
PeptideAtlasiQ8TCB7.
PRIDEiQ8TCB7.

PTM databases

iPTMnetiQ8TCB7.
PhosphoSitePlusiQ8TCB7.

Expressioni

Gene expression databases

BgeeiENSG00000206562.
CleanExiHS_METTL6.
ExpressionAtlasiQ8TCB7. baseline and differential.
GenevisibleiQ8TCB7. HS.

Organism-specific databases

HPAiHPA035166.

Interactioni

Protein-protein interaction databases

BioGridi126301. 9 interactors.
STRINGi9606.ENSP00000373300.

Structurei

3D structure databases

ProteinModelPortaliQ8TCB7.
SMRiQ8TCB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410ITBM. Eukaryota.
ENOG410XSAE. LUCA.
GeneTreeiENSGT00520000055554.
HOGENOMiHOG000182278.
HOVERGENiHBG075344.
InParanoidiQ8TCB7.
KOiK00599.
OMAiCREFADQ.
OrthoDBiEOG091G1235.
PhylomeDBiQ8TCB7.
TreeFamiTF321001.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013217. Methyltransf_12.
IPR026113. MeTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR22809. PTHR22809. 1 hit.
PfamiPF08242. Methyltransf_12. 1 hit.
[Graphical view]
PIRSFiPIRSF037755. Mettl2_prd. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TCB7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASLQRKGLQ ARILTSEEEE KLKRDQTLVS DFKQQKLEQE AQKNWDLFYK
60 70 80 90 100
RNSTNFFKDR HWTTREFEEL RSCREFEDQK LTMLEAGCGV GNCLFPLLEE
110 120 130 140 150
DPNIFAYACD FSPRAIEYVK QNPLYDTERC KVFQCDLTKD DLLDHVPPES
160 170 180 190 200
VDVVMLIFVL SAVHPDKMHL VLQNIYKVLK PGKSVLFRDY GLYDHAMLRF
210 220 230 240 250
KASSKLGENF YVRQDGTRSY FFTDDFLAQL FMDTGYEEVV NEYVFRETVN
260 270 280
KKEGLCVPRV FLQSKFLKPP KNPSPVVLGL DPKS
Length:284
Mass (Da):33,251
Last modified:November 24, 2009 - v2
Checksum:i445CAAE4D669B07F
GO
Isoform 2 (identifier: Q8TCB7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-284: VLKPGKSVLF...PVVLGLDPKS → CHGCSSELRQ...QAVLPPQPLK

Note: No experimental confirmation available.
Show »
Length:240
Mass (Da):27,948
Checksum:iCB9EA08A7C2C71F3
GO

Sequence cautioni

The sequence AAH22400 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67F → L in BAB71574 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008480178 – 284VLKPG…LDPKS → CHGCSSELRQPWDKDDFAVT WDPWSPAIRVLLCHSGWSAV AWTWLTAASTSWAQAVLPPQ PLK in isoform 2. 1 PublicationAdd BLAST107

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057791 mRNA. Translation: BAB71574.1.
AC027125 Genomic DNA. No translation available.
BC022400 mRNA. Translation: AAH22400.1. Sequence problems.
CCDSiCCDS43056.1. [Q8TCB7-1]
RefSeqiNP_001288721.1. NM_001301792.1.
NP_001317591.1. NM_001330662.1.
NP_689609.2. NM_152396.3. [Q8TCB7-1]
XP_005264924.1. XM_005264867.3. [Q8TCB7-1]
XP_005264927.1. XM_005264870.4. [Q8TCB7-2]
XP_006713033.1. XM_006712970.3. [Q8TCB7-1]
XP_016861207.1. XM_017005718.1. [Q8TCB7-1]
UniGeneiHs.149487.
Hs.655765.

Genome annotation databases

EnsembliENST00000383789; ENSP00000373299; ENSG00000206562. [Q8TCB7-2]
ENST00000383790; ENSP00000373300; ENSG00000206562. [Q8TCB7-1]
ENST00000443029; ENSP00000407613; ENSG00000206562. [Q8TCB7-1]
GeneIDi131965.
KEGGihsa:131965.
UCSCiuc003bzs.2. human. [Q8TCB7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057791 mRNA. Translation: BAB71574.1.
AC027125 Genomic DNA. No translation available.
BC022400 mRNA. Translation: AAH22400.1. Sequence problems.
CCDSiCCDS43056.1. [Q8TCB7-1]
RefSeqiNP_001288721.1. NM_001301792.1.
NP_001317591.1. NM_001330662.1.
NP_689609.2. NM_152396.3. [Q8TCB7-1]
XP_005264924.1. XM_005264867.3. [Q8TCB7-1]
XP_005264927.1. XM_005264870.4. [Q8TCB7-2]
XP_006713033.1. XM_006712970.3. [Q8TCB7-1]
XP_016861207.1. XM_017005718.1. [Q8TCB7-1]
UniGeneiHs.149487.
Hs.655765.

3D structure databases

ProteinModelPortaliQ8TCB7.
SMRiQ8TCB7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126301. 9 interactors.
STRINGi9606.ENSP00000373300.

PTM databases

iPTMnetiQ8TCB7.
PhosphoSitePlusiQ8TCB7.

Polymorphism and mutation databases

BioMutaiMETTL6.
DMDMi269849620.

Proteomic databases

EPDiQ8TCB7.
MaxQBiQ8TCB7.
PaxDbiQ8TCB7.
PeptideAtlasiQ8TCB7.
PRIDEiQ8TCB7.

Protocols and materials databases

DNASUi131965.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383789; ENSP00000373299; ENSG00000206562. [Q8TCB7-2]
ENST00000383790; ENSP00000373300; ENSG00000206562. [Q8TCB7-1]
ENST00000443029; ENSP00000407613; ENSG00000206562. [Q8TCB7-1]
GeneIDi131965.
KEGGihsa:131965.
UCSCiuc003bzs.2. human. [Q8TCB7-1]

Organism-specific databases

CTDi131965.
DisGeNETi131965.
GeneCardsiMETTL6.
HGNCiHGNC:28343. METTL6.
HPAiHPA035166.
neXtProtiNX_Q8TCB7.
OpenTargetsiENSG00000206562.
PharmGKBiPA142671462.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITBM. Eukaryota.
ENOG410XSAE. LUCA.
GeneTreeiENSGT00520000055554.
HOGENOMiHOG000182278.
HOVERGENiHBG075344.
InParanoidiQ8TCB7.
KOiK00599.
OMAiCREFADQ.
OrthoDBiEOG091G1235.
PhylomeDBiQ8TCB7.
TreeFamiTF321001.

Miscellaneous databases

GenomeRNAii131965.
PROiQ8TCB7.

Gene expression databases

BgeeiENSG00000206562.
CleanExiHS_METTL6.
ExpressionAtlasiQ8TCB7. baseline and differential.
GenevisibleiQ8TCB7. HS.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013217. Methyltransf_12.
IPR026113. MeTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR22809. PTHR22809. 1 hit.
PfamiPF08242. Methyltransf_12. 1 hit.
[Graphical view]
PIRSFiPIRSF037755. Mettl2_prd. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMETL6_HUMAN
AccessioniPrimary (citable) accession number: Q8TCB7
Secondary accession number(s): Q96LU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 24, 2009
Last modified: November 30, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.