ID   O51E1_HUMAN             Reviewed;         318 AA.
AC   Q8TCB6; A8KAM6; Q5S4P5; Q66X57; Q6IF93;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2024, sequence version 2.
DT   27-MAR-2024, entry version 159.
DE   RecName: Full=Olfactory receptor 51E1;
DE   AltName: Full=D-GPCR;
DE   AltName: Full=G-protein coupled receptor 164;
DE   AltName: Full=Olfactory receptor 52A3;
DE   AltName: Full=Prostate-overexpressed G protein-coupled receptor;
DE   AltName: Full=Prostate-specific G protein-coupled receptor 2;
GN   Name=OR51E1; Synonyms=GPR164, OR51E1P, OR52A3P, POGR, PSGR2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Prostate;
RX   PubMed=15313197; DOI=10.1016/j.bbrc.2004.07.106;
RA   Weigle B., Fuessel S., Ebner R., Temme A., Schmitz M., Schwind S.,
RA   Kiessling A., Rieger M.A., Meye A., Bachmann M., Wirth M.P., Rieber E.P.;
RT   "D-GPCR: a novel putative G protein-coupled receptor overexpressed in
RT   prostate cancer and prostate.";
RL   Biochem. Biophys. Res. Commun. 322:239-249(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=16206286; DOI=10.1002/ijc.21527;
RA   Weng J., Wang J., Hu X., Wang F., Ittmann M., Liu M.;
RT   "PSGR2, a novel G-protein coupled receptor, is overexpressed in human
RT   prostate cancer.";
RL   Int. J. Cancer 118:1471-1480(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Uterus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [8]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- INTERACTION:
CC       Q8TCB6; Q8N5Z5: KCTD17; NbExp=3; IntAct=EBI-12141505, EBI-743960;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15313197};
CC       Multi-pass membrane protein {ECO:0000269|PubMed:15313197}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in prostate. Very low levels may
CC       be detected in some other tissues, such as placenta, skeletal muscle,
CC       heart, ovary and testis. Up-regulated in prostate cancers.
CC       {ECO:0000269|PubMed:15313197, ECO:0000269|PubMed:16206286}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR51E1";
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DR   EMBL; AY698056; AAU07996.1; -; mRNA.
DR   EMBL; AB065787; BAC06006.1; -; Genomic_DNA.
DR   EMBL; AY775731; AAV54110.1; -; mRNA.
DR   EMBL; AK293091; BAF85780.1; -; mRNA.
DR   EMBL; CH471064; EAW68832.1; -; Genomic_DNA.
DR   EMBL; BC022401; AAH22401.1; -; mRNA.
DR   EMBL; BK004369; DAA04767.1; -; Genomic_DNA.
DR   RefSeq; NP_689643.2; NM_152430.3.
DR   AlphaFoldDB; Q8TCB6; -.
DR   SMR; Q8TCB6; -.
DR   BioGRID; 126808; 4.
DR   IntAct; Q8TCB6; 1.
DR   STRING; 9606.ENSP00000380155; -.
DR   GlyCosmos; Q8TCB6; 2 sites, No reported glycans.
DR   GlyGen; Q8TCB6; 2 sites.
DR   BioMuta; OR51E1; -.
DR   DMDM; 38372839; -.
DR   MassIVE; Q8TCB6; -.
DR   PaxDb; 9606-ENSP00000380155; -.
DR   PeptideAtlas; Q8TCB6; -.
DR   Antibodypedia; 23519; 203 antibodies from 27 providers.
DR   DNASU; 143503; -.
DR   Ensembl; ENST00000396952.6; ENSP00000380155.5; ENSG00000180785.10.
DR   GeneID; 143503; -.
DR   KEGG; hsa:143503; -.
DR   MANE-Select; ENST00000396952.6; ENSP00000380155.5; NM_152430.4; NP_689643.2.
DR   UCSC; uc001lzi.5; human.
DR   AGR; HGNC:15194; -.
DR   CTD; 143503; -.
DR   DisGeNET; 143503; -.
DR   GeneCards; OR51E1; -.
DR   HGNC; HGNC:15194; OR51E1.
DR   HPA; ENSG00000180785; Tissue enhanced (adipose tissue, placenta, prostate).
DR   MIM; 611267; gene.
DR   neXtProt; NX_Q8TCB6; -.
DR   OpenTargets; ENSG00000180785; -.
DR   PharmGKB; PA32371; -.
DR   VEuPathDB; HostDB:ENSG00000180785; -.
DR   eggNOG; ENOG502QVRN; Eukaryota.
DR   GeneTree; ENSGT01100000263490; -.
DR   HOGENOM; CLU_012526_0_0_1; -.
DR   InParanoid; Q8TCB6; -.
DR   OMA; RVAKIGM; -.
DR   OrthoDB; 4578140at2759; -.
DR   PhylomeDB; Q8TCB6; -.
DR   TreeFam; TF342735; -.
DR   PathwayCommons; Q8TCB6; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   SignaLink; Q8TCB6; -.
DR   BioGRID-ORCS; 143503; 58 hits in 749 CRISPR screens.
DR   ChiTaRS; OR51E1; human.
DR   GeneWiki; OR51E1; -.
DR   GenomeRNAi; 143503; -.
DR   Pharos; Q8TCB6; Tbio.
DR   PRO; PR:Q8TCB6; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8TCB6; Protein.
DR   Bgee; ENSG00000180785; Expressed in secondary oocyte and 85 other cell types or tissues.
DR   ExpressionAtlas; Q8TCB6; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   CDD; cd15222; 7tmA_OR51-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26450:SF167; OLFACTORY RECEPTOR 51E1; 1.
DR   PANTHER; PTHR26450; OLFACTORY RECEPTOR 56B1-RELATED; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; Q8TCB6; HS.
PE   1: Evidence at protein level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..318
FT                   /note="Olfactory receptor 51E1"
FT                   /id="PRO_0000150750"
FT   TOPO_DOM        1..31
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        53..60
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        82..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        101..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        124..145
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        167..198
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..239
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        261..275
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        297..318
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   CARBOHYD        8
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        91
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        100..182
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         10
FT                   /note="S -> N (in dbSNP:rs17224476)"
FT                   /id="VAR_057577"
FT   VARIANT         11
FT                   /note="S -> N (in dbSNP:rs17224476)"
FT                   /id="VAR_034317"
FT   CONFLICT        306
FT                   /note="L -> P (in Ref. 1; AAU07996)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   318 AA;  35402 MW;  94121253465E4B65 CRC64;
     MMVDPNGNES SATYFILIGL PGLEEAQFWL AFPLCSLYLI AVLGNLTIIY IVRTEHSLHE
     PMYIFLCMLS GIDILISTSS MPKMLAIFWF NSTTIQFDAC LLQMFAIHSL SGMESTVLLA
     MAFDRYVAIC HPLRHATVLT LPRVTKIGVA AVVRGAALMA PLPVFIKQLP FCRSNILSHS
     YCLHQDVMKL ACDDIRVNVV YGLIVIISAI GLDSLLISFS YLLILKTVLG LTREAQAKAF
     GTCVSHVCAV FIFYVPFIGL SMVHRFSKRR DSPLPVILAN IYLLVPPVLN PIVYGVKTKE
     IRQRILRLFH VATHASEP
//