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Q8TCB6

- O51E1_HUMAN

UniProt

Q8TCB6 - O51E1_HUMAN

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Protein

Olfactory receptor 51E1

Gene

OR51E1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51E1
Alternative name(s):
D-GPCR
G-protein coupled receptor 164
Olfactory receptor 52A3
Prostate-overexpressed G protein-coupled receptor
Prostate-specific G protein-coupled receptor 2
Gene namesi
Name:OR51E1
Synonyms:GPR164, OR51E1P, OR52A3P, POGR, PSGR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15194. OR51E1.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32371.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Olfactory receptor 51E1PRO_0000150750Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8TCB6.
PRIDEiQ8TCB6.

Expressioni

Tissue specificityi

Highly expressed in prostate. Very low levels may be detected in some other tissues, such as placenta, skeletal muscle, heart, ovary and testis. Up-regulated in prostate cancers.2 Publications

Gene expression databases

BgeeiQ8TCB6.
ExpressionAtlasiQ8TCB6. baseline and differential.
GenevestigatoriQ8TCB6.

Organism-specific databases

HPAiCAB019995.
HPA051439.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000380155.

Structurei

3D structure databases

ProteinModelPortaliQ8TCB6.
SMRiQ8TCB6. Positions 111-142.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence Analysis
Topological domaini78 – 10124ExtracellularSequence AnalysisAdd
BLAST
Topological domaini123 – 14119CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini163 – 19836ExtracellularSequence AnalysisAdd
BLAST
Topological domaini220 – 23819CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini260 – 27415ExtracellularSequence AnalysisAdd
BLAST
Topological domaini296 – 31722CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei28 – 4821Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei199 – 21921Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei275 – 29521Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG122777.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8TCB6.
KOiK04257.
OMAiSSMPKML.
OrthoDBiEOG754HPV.
PhylomeDBiQ8TCB6.
TreeFamiTF342735.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TCB6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVDPNGNESS ATYFILIGLP GLEEAQFWLA FPLCSLYLIA VLGNLTIIYI
60 70 80 90 100
VRTEHSLHEP MYIFLCMLSG IDILISTSSM PKMLAIFWFN STTIQFDACL
110 120 130 140 150
LQMFAIHSLS GMESTVLLAM AFDRYVAICH PLRHATVLTL PRVTKIGVAA
160 170 180 190 200
VVRGAALMAP LPVFIKQLPF CRSNILSHSY CLHQDVMKLA CDDIRVNVVY
210 220 230 240 250
GLIVIISAIG LDSLLISFSY LLILKTVLGL TREAQAKAFG TCVSHVCAVF
260 270 280 290 300
IFYVPFIGLS MVHRFSKRRD SPLPVILANI YLLVPPVLNP IVYGVKTKEI
310
RQRILRLFHV ATHASEP
Length:317
Mass (Da):35,271
Last modified:June 1, 2002 - v1
Checksum:i8C7293AA7FBCA95C
GO

Sequence cautioni

The sequence AAU07996.1 differs from that shown. Reason: Erroneous initiation.
The sequence DAA04767.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti305 – 3051L → P in AAU07996. (PubMed:15313197)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91S → N.
Corresponds to variant rs17224476 [ dbSNP | Ensembl ].
VAR_057577
Natural varianti10 – 101S → N.
Corresponds to variant rs17224476 [ dbSNP | Ensembl ].
VAR_034317

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY698056 mRNA. Translation: AAU07996.1. Different initiation.
AB065787 Genomic DNA. Translation: BAC06006.1.
AY775731 mRNA. Translation: AAV54110.1.
AK293091 mRNA. Translation: BAF85780.1.
CH471064 Genomic DNA. Translation: EAW68832.1.
BC022401 mRNA. Translation: AAH22401.1.
BK004369 Genomic DNA. Translation: DAA04767.1. Different initiation.
RefSeqiNP_689643.2. NM_152430.3.
UniGeneiHs.470038.

Genome annotation databases

EnsembliENST00000396952; ENSP00000380155; ENSG00000180785.
GeneIDi143503.
KEGGihsa:143503.
UCSCiuc001lzi.4. human.

Polymorphism databases

DMDMi38372839.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY698056 mRNA. Translation: AAU07996.1 . Different initiation.
AB065787 Genomic DNA. Translation: BAC06006.1 .
AY775731 mRNA. Translation: AAV54110.1 .
AK293091 mRNA. Translation: BAF85780.1 .
CH471064 Genomic DNA. Translation: EAW68832.1 .
BC022401 mRNA. Translation: AAH22401.1 .
BK004369 Genomic DNA. Translation: DAA04767.1 . Different initiation.
RefSeqi NP_689643.2. NM_152430.3.
UniGenei Hs.470038.

3D structure databases

ProteinModelPortali Q8TCB6.
SMRi Q8TCB6. Positions 111-142.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000380155.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 38372839.

Proteomic databases

PaxDbi Q8TCB6.
PRIDEi Q8TCB6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000396952 ; ENSP00000380155 ; ENSG00000180785 .
GeneIDi 143503.
KEGGi hsa:143503.
UCSCi uc001lzi.4. human.

Organism-specific databases

CTDi 143503.
GeneCardsi GC11P004622.
HGNCi HGNC:15194. OR51E1.
HPAi CAB019995.
HPA051439.
MIMi 611267. gene.
neXtProti NX_Q8TCB6.
PharmGKBi PA32371.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG122777.
HOGENOMi HOG000041363.
HOVERGENi HBG017625.
InParanoidi Q8TCB6.
KOi K04257.
OMAi SSMPKML.
OrthoDBi EOG754HPV.
PhylomeDBi Q8TCB6.
TreeFami TF342735.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR51E1.
GenomeRNAii 143503.
NextBioi 84735.
PROi Q8TCB6.
SOURCEi Search...

Gene expression databases

Bgeei Q8TCB6.
ExpressionAtlasi Q8TCB6. baseline and differential.
Genevestigatori Q8TCB6.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "D-GPCR: a novel putative G protein-coupled receptor overexpressed in prostate cancer and prostate."
    Weigle B., Fuessel S., Ebner R., Temme A., Schmitz M., Schwind S., Kiessling A., Rieger M.A., Meye A., Bachmann M., Wirth M.P., Rieber E.P.
    Biochem. Biophys. Res. Commun. 322:239-249(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Prostate.
  2. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "PSGR2, a novel G-protein coupled receptor, is overexpressed in human prostate cancer."
    Weng J., Wang J., Hu X., Wang F., Ittmann M., Liu M.
    Int. J. Cancer 118:1471-1480(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  7. Cited for: IDENTIFICATION.
  8. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO51E1_HUMAN
AccessioniPrimary (citable) accession number: Q8TCB6
Secondary accession number(s): A8KAM6
, Q5S4P5, Q66X57, Q6IF93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3