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Q8TCB6

- O51E1_HUMAN

UniProt

Q8TCB6 - O51E1_HUMAN

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Protein
Olfactory receptor 51E1
Gene
OR51E1, GPR164, OR51E1P, OR52A3P, POGR, PSGR2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 51E1
    Alternative name(s):
    D-GPCR
    G-protein coupled receptor 164
    Olfactory receptor 52A3
    Prostate-overexpressed G protein-coupled receptor
    Prostate-specific G protein-coupled receptor 2
    Gene namesi
    Name:OR51E1
    Synonyms:GPR164, OR51E1P, OR52A3P, POGR, PSGR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15194. OR51E1.

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein 1 Publication

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei28 – 4821Helical; Name=1; Reviewed prediction
    Add
    BLAST
    Topological domaini49 – 568Cytoplasmic Reviewed prediction
    Transmembranei57 – 7721Helical; Name=2; Reviewed prediction
    Add
    BLAST
    Topological domaini78 – 10124Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei102 – 12221Helical; Name=3; Reviewed prediction
    Add
    BLAST
    Topological domaini123 – 14119Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei142 – 16221Helical; Name=4; Reviewed prediction
    Add
    BLAST
    Topological domaini163 – 19836Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei199 – 21921Helical; Name=5; Reviewed prediction
    Add
    BLAST
    Topological domaini220 – 23819Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei239 – 25921Helical; Name=6; Reviewed prediction
    Add
    BLAST
    Topological domaini260 – 27415Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei275 – 29521Helical; Name=7; Reviewed prediction
    Add
    BLAST
    Topological domaini296 – 31722Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32371.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 317317Olfactory receptor 51E1
    PRO_0000150750Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi7 – 71N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi90 – 901N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi99 ↔ 191 By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8TCB6.
    PRIDEiQ8TCB6.

    Expressioni

    Tissue specificityi

    Highly expressed in prostate. Very low levels may be detected in some other tissues, such as placenta, skeletal muscle, heart, ovary and testis. Up-regulated in prostate cancers.2 Publications

    Gene expression databases

    ArrayExpressiQ8TCB6.
    BgeeiQ8TCB6.
    GenevestigatoriQ8TCB6.

    Organism-specific databases

    HPAiCAB019995.
    HPA051439.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000380155.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TCB6.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG122777.
    HOGENOMiHOG000041363.
    HOVERGENiHBG017625.
    InParanoidiQ8TCB6.
    KOiK04257.
    OMAiSSMPKML.
    OrthoDBiEOG754HPV.
    PhylomeDBiQ8TCB6.
    TreeFamiTF342735.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TCB6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVDPNGNESS ATYFILIGLP GLEEAQFWLA FPLCSLYLIA VLGNLTIIYI    50
    VRTEHSLHEP MYIFLCMLSG IDILISTSSM PKMLAIFWFN STTIQFDACL 100
    LQMFAIHSLS GMESTVLLAM AFDRYVAICH PLRHATVLTL PRVTKIGVAA 150
    VVRGAALMAP LPVFIKQLPF CRSNILSHSY CLHQDVMKLA CDDIRVNVVY 200
    GLIVIISAIG LDSLLISFSY LLILKTVLGL TREAQAKAFG TCVSHVCAVF 250
    IFYVPFIGLS MVHRFSKRRD SPLPVILANI YLLVPPVLNP IVYGVKTKEI 300
    RQRILRLFHV ATHASEP 317
    Length:317
    Mass (Da):35,271
    Last modified:June 1, 2002 - v1
    Checksum:i8C7293AA7FBCA95C
    GO

    Sequence cautioni

    The sequence AAU07996.1 differs from that shown. Reason: Erroneous initiation.
    The sequence DAA04767.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti9 – 91S → N.
    Corresponds to variant rs17224476 [ dbSNP | Ensembl ].
    VAR_057577
    Natural varianti10 – 101S → N.
    Corresponds to variant rs17224476 [ dbSNP | Ensembl ].
    VAR_034317

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti305 – 3051L → P in AAU07996. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY698056 mRNA. Translation: AAU07996.1. Different initiation.
    AB065787 Genomic DNA. Translation: BAC06006.1.
    AY775731 mRNA. Translation: AAV54110.1.
    AK293091 mRNA. Translation: BAF85780.1.
    CH471064 Genomic DNA. Translation: EAW68832.1.
    BC022401 mRNA. Translation: AAH22401.1.
    BK004369 Genomic DNA. Translation: DAA04767.1. Different initiation.
    RefSeqiNP_689643.2. NM_152430.3.
    UniGeneiHs.470038.

    Genome annotation databases

    EnsembliENST00000396952; ENSP00000380155; ENSG00000180785.
    GeneIDi143503.
    KEGGihsa:143503.
    UCSCiuc001lzi.4. human.

    Polymorphism databases

    DMDMi38372839.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY698056 mRNA. Translation: AAU07996.1 . Different initiation.
    AB065787 Genomic DNA. Translation: BAC06006.1 .
    AY775731 mRNA. Translation: AAV54110.1 .
    AK293091 mRNA. Translation: BAF85780.1 .
    CH471064 Genomic DNA. Translation: EAW68832.1 .
    BC022401 mRNA. Translation: AAH22401.1 .
    BK004369 Genomic DNA. Translation: DAA04767.1 . Different initiation.
    RefSeqi NP_689643.2. NM_152430.3.
    UniGenei Hs.470038.

    3D structure databases

    ProteinModelPortali Q8TCB6.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000380155.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372839.

    Proteomic databases

    PaxDbi Q8TCB6.
    PRIDEi Q8TCB6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000396952 ; ENSP00000380155 ; ENSG00000180785 .
    GeneIDi 143503.
    KEGGi hsa:143503.
    UCSCi uc001lzi.4. human.

    Organism-specific databases

    CTDi 143503.
    GeneCardsi GC11P004622.
    HGNCi HGNC:15194. OR51E1.
    HPAi CAB019995.
    HPA051439.
    MIMi 611267. gene.
    neXtProti NX_Q8TCB6.
    PharmGKBi PA32371.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG122777.
    HOGENOMi HOG000041363.
    HOVERGENi HBG017625.
    InParanoidi Q8TCB6.
    KOi K04257.
    OMAi SSMPKML.
    OrthoDBi EOG754HPV.
    PhylomeDBi Q8TCB6.
    TreeFami TF342735.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR51E1.
    GenomeRNAii 143503.
    NextBioi 84735.
    PROi Q8TCB6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8TCB6.
    Bgeei Q8TCB6.
    Genevestigatori Q8TCB6.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "D-GPCR: a novel putative G protein-coupled receptor overexpressed in prostate cancer and prostate."
      Weigle B., Fuessel S., Ebner R., Temme A., Schmitz M., Schwind S., Kiessling A., Rieger M.A., Meye A., Bachmann M., Wirth M.P., Rieber E.P.
      Biochem. Biophys. Res. Commun. 322:239-249(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Prostate.
    2. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "PSGR2, a novel G-protein coupled receptor, is overexpressed in human prostate cancer."
      Weng J., Wang J., Hu X., Wang F., Ittmann M., Liu M.
      Int. J. Cancer 118:1471-1480(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    7. Cited for: IDENTIFICATION.
    8. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO51E1_HUMAN
    AccessioniPrimary (citable) accession number: Q8TCB6
    Secondary accession number(s): A8KAM6
    , Q5S4P5, Q66X57, Q6IF93
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: June 1, 2002
    Last modified: September 3, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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