Q8TCB6 (O51E1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 51E1

Alternative name(s):
D-GPCR
G-protein coupled receptor 164
Olfactory receptor 52A3
Prostate-overexpressed G protein-coupled receptor
Prostate-specific G protein-coupled receptor 2

Gene names

Name:	OR51E1
Synonyms:	GPR164, OR51E1P, OR52A3P, POGR, PSGR2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein Ref.1.
Tissue specificity	Highly expressed in prostate. Very low levels may be detected in some other tissues, such as placenta, skeletal muscle, heart, ovary and testis. Up-regulated in prostate cancers. Ref.1 Ref.3
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Sequence caution	The sequence AAU07996.1 differs from that shown. Reason: Erroneous initiation. The sequence DAA04767.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 317	317	Olfactory receptor 51E1		PRO_0000150750
Regions
	Topological domain	1 – 27	27	Extracellular Potential
	Transmembrane	28 – 48	21	Helical; Name=1; Potential
	Topological domain	49 – 56	8	Cytoplasmic Potential
	Transmembrane	57 – 77	21	Helical; Name=2; Potential
	Topological domain	78 – 101	24	Extracellular Potential
	Transmembrane	102 – 122	21	Helical; Name=3; Potential
	Topological domain	123 – 141	19	Cytoplasmic Potential
	Transmembrane	142 – 162	21	Helical; Name=4; Potential
	Topological domain	163 – 198	36	Extracellular Potential
	Transmembrane	199 – 219	21	Helical; Name=5; Potential
	Topological domain	220 – 238	19	Cytoplasmic Potential
	Transmembrane	239 – 259	21	Helical; Name=6; Potential
	Topological domain	260 – 274	15	Extracellular Potential
	Transmembrane	275 – 295	21	Helical; Name=7; Potential
	Topological domain	296 – 317	22	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	7	1	N-linked (GlcNAc...) Potential
	Glycosylation	90	1	N-linked (GlcNAc...) Potential
	Disulfide bond	99 ↔ 191		By similarity
Natural variations
	Natural variant	9	1	S → N. Corresponds to variant rs17224476 [ dbSNP | Ensembl ].		VAR_057577
	Natural variant	10	1	S → N. Corresponds to variant rs17224476 [ dbSNP | Ensembl ].		VAR_034317
Experimental info
	Sequence conflict	305	1	L → P in AAU07996. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8TCB6 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 8C7293AA7FBCA95C	FASTA	317	35,271
	10 20 30 40 50 60 MVDPNGNESS ATYFILIGLP GLEEAQFWLA FPLCSLYLIA VLGNLTIIYI VRTEHSLHEP 70 80 90 100 110 120 MYIFLCMLSG IDILISTSSM PKMLAIFWFN STTIQFDACL LQMFAIHSLS GMESTVLLAM 130 140 150 160 170 180 AFDRYVAICH PLRHATVLTL PRVTKIGVAA VVRGAALMAP LPVFIKQLPF CRSNILSHSY 190 200 210 220 230 240 CLHQDVMKLA CDDIRVNVVY GLIVIISAIG LDSLLISFSY LLILKTVLGL TREAQAKAFG 250 260 270 280 290 300 TCVSHVCAVF IFYVPFIGLS MVHRFSKRRD SPLPVILANI YLLVPPVLNP IVYGVKTKEI 310 RQRILRLFHV ATHASEP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"D-GPCR: a novel putative G protein-coupled receptor overexpressed in prostate cancer and prostate." Weigle B., Fuessel S., Ebner R., Temme A., Schmitz M., Schwind S., Kiessling A., Rieger M.A., Meye A., Bachmann M., Wirth M.P., Rieber E.P. Biochem. Biophys. Res. Commun. 322:239-249(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Prostate.
[2]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"PSGR2, a novel G-protein coupled receptor, is overexpressed in human prostate cancer." Weng J., Wang J., Hu X., Wang F., Ittmann M., Liu M. Int. J. Cancer 118:1471-1480(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[7]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[8]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
+	Additional computationally mapped references.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY698056 mRNA. Translation: AAU07996.1. Different initiation. AB065787 Genomic DNA. Translation: BAC06006.1. AY775731 mRNA. Translation: AAV54110.1. AK293091 mRNA. Translation: BAF85780.1. CH471064 Genomic DNA. Translation: EAW68832.1. BC022401 mRNA. Translation: AAH22401.1. BK004369 Genomic DNA. Translation: DAA04767.1. Different initiation.
IPI	IPI00549411.
RefSeq	NP_689643.2. NM_152430.3.
UniGene	Hs.470038.
3D structure databases
ProteinModelPortal	Q8TCB6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000380155.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	38372839.
Proteomic databases
PaxDb	Q8TCB6.
PRIDE	Q8TCB6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000396952; ENSP00000380155; ENSG00000180785.
GeneID	143503.
KEGG	hsa:143503.
UCSC	uc001lzi.4. human.
Organism-specific databases
CTD	143503.
GeneCards	GC11P004622.
HGNC	HGNC:15194. OR51E1.
HPA	CAB019995. HPA051439.
MIM	611267. gene.
neXtProt	NX_Q8TCB6.
PharmGKB	PA32371.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG122777.
HOGENOM	HOG000041363.
HOVERGEN	HBG017625.
InParanoid	Q8TCB6.
KO	K04257.
OMA	SGMESTV.
OrthoDB	EOG4DBTF5.
PhylomeDB	Q8TCB6.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q8TCB6.
Bgee	Q8TCB6.
Genevestigator	Q8TCB6.
GermOnline	ENSG00000180785. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	143503.
NextBio	84735.
SOURCE	Search...

Entry information

Entry name

O51E1_HUMAN

Accession

Primary (citable) accession number: Q8TCB6
Secondary accession number(s): A8KAM6 , Q5S4P5, Q66X57, Q6IF93

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.