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Q8TCB0 (IFI44_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interferon-induced protein 44
Short name=p44
Alternative name(s):
Microtubule-associated protein 44
Gene names
Name:IFI44
Synonyms:MTAP44
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length444 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This protein aggregates to form microtubular structures By similarity.

Subcellular location

Cytoplasm Potential.

Induction

By alpha and beta interferons, but not by gamma interferons. Ref.1

Sequence similarities

Belongs to the IFI44 family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processresponse to virus

Traceable author statement. Source: ProtInc

   Cellular componentcytoplasm

Inferred from direct assay. Source: HPA

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 444444Interferon-induced protein 44
PRO_0000084165

Natural variations

Natural variant91W → R. Ref.4
Corresponds to variant rs2070123 [ dbSNP | Ensembl ].
VAR_054647

Experimental info

Sequence conflict1981G → P in BAA06043. Ref.1
Sequence conflict3311R → Q in BAA06043. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8TCB0 [UniParc].

Last modified March 3, 2009. Version 2.
Checksum: C9B699ECD4523D0F

FASTA44450,491
        10         20         30         40         50         60 
MAVTTRLTWL HEKILQNHFG GKRLSLLYKG SVHGFRNGVL LDRCCNQGPT LTVIYSEDHI 

        70         80         90        100        110        120 
IGAYAEESYQ EGKYASIILF ALQDTKISEW KLGLCTPETL FCCDVTKYNS PTNFQIDGRN 

       130        140        150        160        170        180 
RKVIMDLKTM ENLGLAQNCT ISIQDYEVFR CEDSLDERKI KGVIELRKSL LSALRTYEPY 

       190        200        210        220        230        240 
GSLVQQIRIL LLGPIGAGKS SFFNSVRSVF QGHVTHQALV GTNTTGISEK YRTYSIRDGK 

       250        260        270        280        290        300 
DGKYLPFILC DSLGLSEKEG GLCRDDIFYI LNGNIRDRYQ FNPMESIKLN HHDYIDSPSL 

       310        320        330        340        350        360 
KDRIHCVAFV FDASSIQYFS SQMIVKIKRI RRELVNAGVV HVALLTHVDS MDLITKGDLI 

       370        380        390        400        410        420 
EIERCEPVRS KLEEVQRKLG FALSDISVVS NYSSEWELDP VKDVLILSAL RRMLWAADDF 

       430        440 
LEDLPFEQIG NLREEIINCA QGKK

« Hide

References

« Hide 'large scale' references
[1]"Induction of the human gene for p44, a hepatitis-C-associated microtubular aggregate protein, by interferon-alpha/beta."
Kitamura A., Takahashi K., Okajima A., Kitamura N.
Eur. J. Biochem. 224:877-883(1994) [PubMed: 7925411] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], INDUCTION.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed: 16710414] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-9.
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D28915 Genomic DNA. Translation: BAA06043.1.
AC104837 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX06347.1.
CH471059 Genomic DNA. Translation: EAX06348.1.
BC022870 mRNA. Translation: AAH22870.1.
IPIIPI00291278.
RefSeqNP_006408.3. NM_006417.4.
UniGeneHs.82316.

3D structure databases

ProteinModelPortalQ8TCB0.
SMRQ8TCB0. Positions 166-226.
ModBaseSearch...

Protein-protein interaction databases

IntActQ8TCB0. 1 interaction.
STRINGQ8TCB0.

Polymorphism databases

DMDM224471836.

Proteomic databases

PRIDEQ8TCB0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000370747; ENSP00000359783; ENSG00000137965.
GeneID10561.
KEGGhsa:10561.
UCSCuc001dip.2. human.

Organism-specific databases

CTD10561.
GeneCardsGC01P079115.
H-InvDBHIX0000723.
HGNCHGNC:16938. IFI44.
HPAHPA027148.
MIM610468. gene.
neXtProtNX_Q8TCB0.
PharmGKBPA29647.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG11574.
GeneTreeENSGT00390000017981.
HOGENOMHBG446001.
HOVERGENHBG052085.
InParanoidQ8TCB0.
OMAQMLWAAD.
OrthoDBEOG470TH6.
PhylomeDBQ8TCB0.

Gene expression databases

ArrayExpressQ8TCB0.
BgeeQ8TCB0.
CleanExHS_IFI44.
GenevestigatorQ8TCB0.
GermOnlineENSG00000137965. Homo sapiens.

Family and domain databases

InterProIPR024644. IFI44.
IPR006571. TLDc.
[Graphical view]
PANTHERPTHR14241. PTHR14241. 1 hit.
PfamPF07534. TLD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio40081.
SOURCESearch...

Entry information

Entry nameIFI44_HUMAN
AccessionPrimary (citable) accession number: Q8TCB0
Secondary accession number(s): D3DQ80, Q14496
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: March 3, 2009
Last modified: January 25, 2012
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents