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Protein

Interferon-induced protein 44

Gene

IFI44

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This protein aggregates to form microtubular structures.By similarity

GO - Biological processi

  • response to virus Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced protein 44
Short name:
p44
Alternative name(s):
Microtubule-associated protein 44
Gene namesi
Name:IFI44
Synonyms:MTAP44
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:16938. IFI44.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29647.

Polymorphism and mutation databases

BioMutaiIFI44.
DMDMi224471836.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444Interferon-induced protein 44PRO_0000084165Add
BLAST

Proteomic databases

MaxQBiQ8TCB0.
PaxDbiQ8TCB0.
PRIDEiQ8TCB0.

PTM databases

iPTMnetiQ8TCB0.
PhosphoSiteiQ8TCB0.

Expressioni

Inductioni

By alpha and beta interferons, but not by gamma interferons.1 Publication

Gene expression databases

BgeeiQ8TCB0.
CleanExiHS_IFI44.
ExpressionAtlasiQ8TCB0. baseline and differential.
GenevisibleiQ8TCB0. HS.

Organism-specific databases

HPAiHPA027148.
HPA043858.

Interactioni

Protein-protein interaction databases

BioGridi115812. 1 interaction.
IntActiQ8TCB0. 1 interaction.
STRINGi9606.ENSP00000359783.

Structurei

3D structure databases

ProteinModelPortaliQ8TCB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IFI44 family.Curated

Phylogenomic databases

eggNOGiENOG410IDX3. Eukaryota.
ENOG410XP4J. LUCA.
GeneTreeiENSGT00390000017981.
HOGENOMiHOG000035123.
HOVERGENiHBG052085.
InParanoidiQ8TCB0.
OMAiSEKYRTY.
OrthoDBiEOG7TQV0X.
PhylomeDBiQ8TCB0.
TreeFamiTF328728.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR024644. IFI44_fam.
IPR027417. P-loop_NTPase.
IPR006571. TLDc_dom.
[Graphical view]
PANTHERiPTHR14241:SF3. PTHR14241:SF3. 1 hit.
PfamiPF07534. TLD. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TCB0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVTTRLTWL HEKILQNHFG GKRLSLLYKG SVHGFRNGVL LDRCCNQGPT
60 70 80 90 100
LTVIYSEDHI IGAYAEESYQ EGKYASIILF ALQDTKISEW KLGLCTPETL
110 120 130 140 150
FCCDVTKYNS PTNFQIDGRN RKVIMDLKTM ENLGLAQNCT ISIQDYEVFR
160 170 180 190 200
CEDSLDERKI KGVIELRKSL LSALRTYEPY GSLVQQIRIL LLGPIGAGKS
210 220 230 240 250
SFFNSVRSVF QGHVTHQALV GTNTTGISEK YRTYSIRDGK DGKYLPFILC
260 270 280 290 300
DSLGLSEKEG GLCRDDIFYI LNGNIRDRYQ FNPMESIKLN HHDYIDSPSL
310 320 330 340 350
KDRIHCVAFV FDASSIQYFS SQMIVKIKRI RRELVNAGVV HVALLTHVDS
360 370 380 390 400
MDLITKGDLI EIERCEPVRS KLEEVQRKLG FALSDISVVS NYSSEWELDP
410 420 430 440
VKDVLILSAL RRMLWAADDF LEDLPFEQIG NLREEIINCA QGKK
Length:444
Mass (Da):50,491
Last modified:March 3, 2009 - v2
Checksum:iC9B699ECD4523D0F
GO
Isoform 2 (identifier: Q8TCB0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-283: Missing.
     372-443: LEEVQRKLGF...EEIINCAQGK → VMNDALRKHI...LGLRRITKLL

Note: No experimental confirmation available.
Show »
Length:129
Mass (Da):14,984
Checksum:iE216B49D8F9341D2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti198 – 1981G → P in BAA06043 (PubMed:7925411).Curated
Sequence conflicti331 – 3311R → Q in BAA06043 (PubMed:7925411).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91W → R.1 Publication
Corresponds to variant rs2070123 [ dbSNP | Ensembl ].
VAR_054647

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 283283Missing in isoform 2. 1 PublicationVSP_057031Add
BLAST
Alternative sequencei372 – 44372LEEVQ…CAQGK → VMNDALRKHIFWGMLLQSHT SVYKNKNKQLLGLRRITKLL in isoform 2. 1 PublicationVSP_057032Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28915 Genomic DNA. Translation: BAA06043.1.
AK316278 mRNA. Translation: BAH14649.1.
AC104837 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX06347.1.
CH471059 Genomic DNA. Translation: EAX06348.1.
BC022870 mRNA. Translation: AAH22870.1.
CCDSiCCDS688.1. [Q8TCB0-1]
RefSeqiNP_006408.3. NM_006417.4. [Q8TCB0-1]
UniGeneiHs.82316.

Genome annotation databases

EnsembliENST00000370747; ENSP00000359783; ENSG00000137965. [Q8TCB0-1]
GeneIDi10561.
KEGGihsa:10561.
UCSCiuc001dip.5. human. [Q8TCB0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28915 Genomic DNA. Translation: BAA06043.1.
AK316278 mRNA. Translation: BAH14649.1.
AC104837 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX06347.1.
CH471059 Genomic DNA. Translation: EAX06348.1.
BC022870 mRNA. Translation: AAH22870.1.
CCDSiCCDS688.1. [Q8TCB0-1]
RefSeqiNP_006408.3. NM_006417.4. [Q8TCB0-1]
UniGeneiHs.82316.

3D structure databases

ProteinModelPortaliQ8TCB0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115812. 1 interaction.
IntActiQ8TCB0. 1 interaction.
STRINGi9606.ENSP00000359783.

PTM databases

iPTMnetiQ8TCB0.
PhosphoSiteiQ8TCB0.

Polymorphism and mutation databases

BioMutaiIFI44.
DMDMi224471836.

Proteomic databases

MaxQBiQ8TCB0.
PaxDbiQ8TCB0.
PRIDEiQ8TCB0.

Protocols and materials databases

DNASUi10561.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370747; ENSP00000359783; ENSG00000137965. [Q8TCB0-1]
GeneIDi10561.
KEGGihsa:10561.
UCSCiuc001dip.5. human. [Q8TCB0-1]

Organism-specific databases

CTDi10561.
GeneCardsiIFI44.
H-InvDBHIX0000723.
HGNCiHGNC:16938. IFI44.
HPAiHPA027148.
HPA043858.
MIMi610468. gene.
neXtProtiNX_Q8TCB0.
PharmGKBiPA29647.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IDX3. Eukaryota.
ENOG410XP4J. LUCA.
GeneTreeiENSGT00390000017981.
HOGENOMiHOG000035123.
HOVERGENiHBG052085.
InParanoidiQ8TCB0.
OMAiSEKYRTY.
OrthoDBiEOG7TQV0X.
PhylomeDBiQ8TCB0.
TreeFamiTF328728.

Miscellaneous databases

GenomeRNAii10561.
PROiQ8TCB0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TCB0.
CleanExiHS_IFI44.
ExpressionAtlasiQ8TCB0. baseline and differential.
GenevisibleiQ8TCB0. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR024644. IFI44_fam.
IPR027417. P-loop_NTPase.
IPR006571. TLDc_dom.
[Graphical view]
PANTHERiPTHR14241:SF3. PTHR14241:SF3. 1 hit.
PfamiPF07534. TLD. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Induction of the human gene for p44, a hepatitis-C-associated microtubular aggregate protein, by interferon-alpha/beta."
    Kitamura A., Takahashi K., Okajima A., Kitamura N.
    Eur. J. Biochem. 224:877-883(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), INDUCTION.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-9.
    Tissue: Lung.

Entry informationi

Entry nameiIFI44_HUMAN
AccessioniPrimary (citable) accession number: Q8TCB0
Secondary accession number(s): B7ZAG3, D3DQ80, Q14496
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: March 3, 2009
Last modified: June 8, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.