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Protein

Leucine-rich repeat-containing protein 20

Gene

LRRC20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 20
Gene namesi
Name:LRRC20
ORF Names:UNQ2429/PRO4989
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000172731.13
HGNCiHGNC:23421 LRRC20
neXtProtiNX_Q8TCA0

Pathology & Biotechi

Organism-specific databases

DisGeNETi55222
OpenTargetsiENSG00000172731
PharmGKBiPA134935389

Polymorphism and mutation databases

DMDMi74762612

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000844751 – 184Leucine-rich repeat-containing protein 20Add BLAST184

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei175PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TCA0
MaxQBiQ8TCA0
PaxDbiQ8TCA0
PeptideAtlasiQ8TCA0
PRIDEiQ8TCA0
ProteomicsDBi74105
74106 [Q8TCA0-2]
74107 [Q8TCA0-3]

PTM databases

iPTMnetiQ8TCA0
PhosphoSitePlusiQ8TCA0

Expressioni

Gene expression databases

BgeeiENSG00000172731
CleanExiHS_LRRC20
ExpressionAtlasiQ8TCA0 baseline and differential
GenevisibleiQ8TCA0 HS

Organism-specific databases

HPAiHPA039630

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120517, 6 interactors
IntActiQ8TCA0, 2 interactors
STRINGi9606.ENSP00000348043

Structurei

3D structure databases

ProteinModelPortaliQ8TCA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati51 – 72LRR 1Add BLAST22
Repeati75 – 96LRR 2Add BLAST22
Repeati98 – 120LRR 3Add BLAST23
Repeati121 – 141LRR 4Add BLAST21
Repeati145 – 167LRR 5Add BLAST23

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG4579 Eukaryota
ENOG4111NSQ LUCA
GeneTreeiENSGT00730000111199
HOGENOMiHOG000294062
HOVERGENiHBG058383
InParanoidiQ8TCA0
OMAiNVSDQIH
OrthoDBiEOG091G0NYY
PhylomeDBiQ8TCA0
TreeFamiTF319816

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR037384 LRRC20
PANTHERiPTHR16083 PTHR16083, 1 hit
PfamiView protein in Pfam
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 3 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TCA0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLKKMGEAVA RVARKVNETV ESGSDTLDLA ECKLVSFPIG IYKVLRNVSG
60 70 80 90 100
QIHLITLANN ELKSLTSKFM TTFSQLRELH LEGNFLHRLP SEVSALQHLK
110 120 130 140 150
AIDLSRNQFQ DFPEQLTALP ALETINLEEN EIVDVPVEKL AAMPALRSIN
160 170 180
LRFNPLNAEV RVIAPPLIKF DMLMSPEGAR APLP
Length:184
Mass (Da):20,509
Last modified:June 1, 2002 - v1
Checksum:i1E0443D40FE672EC
GO
Isoform 2 (identifier: Q8TCA0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-77: Missing.

Show »
Length:134
Mass (Da):14,887
Checksum:i16A5E552F6343379
GO
Isoform 3 (identifier: Q8TCA0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-133: Missing.

Show »
Length:128
Mass (Da):14,105
Checksum:iDE63D1111E714C36
GO

Sequence cautioni

The sequence BAA91849 differs from that shown. Reason: Erroneous termination at position 185. Translated as stop.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01593328 – 77Missing in isoform 2. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_01593478 – 133Missing in isoform 3. 1 PublicationAdd BLAST56

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358318 mRNA Translation: AAQ88684.1
AK001613 mRNA Translation: BAA91789.1
AK001706 mRNA Translation: BAA91849.1 Sequence problems.
AK094734 mRNA Translation: BAC04409.1
AC022532 Genomic DNA No translation available.
AL355138 Genomic DNA No translation available.
BC024001 mRNA Translation: AAH24001.1
CCDSiCCDS7300.1 [Q8TCA0-3]
CCDS7301.1 [Q8TCA0-2]
CCDS7302.1 [Q8TCA0-1]
RefSeqiNP_001265140.1, NM_001278211.1 [Q8TCA0-1]
NP_001265141.1, NM_001278212.1 [Q8TCA0-1]
NP_001265142.1, NM_001278213.1 [Q8TCA0-2]
NP_001265143.1, NM_001278214.1
NP_060675.1, NM_018205.3 [Q8TCA0-3]
NP_060709.2, NM_018239.3 [Q8TCA0-2]
NP_997002.1, NM_207119.2 [Q8TCA0-1]
XP_016871863.1, XM_017016374.1 [Q8TCA0-1]
XP_016871864.1, XM_017016375.1 [Q8TCA0-1]
UniGeneiHs.7778

Genome annotation databases

EnsembliENST00000355790; ENSP00000348043; ENSG00000172731 [Q8TCA0-1]
ENST00000357631; ENSP00000350255; ENSG00000172731 [Q8TCA0-3]
ENST00000358141; ENSP00000350860; ENSG00000172731 [Q8TCA0-2]
ENST00000373224; ENSP00000362321; ENSG00000172731 [Q8TCA0-1]
ENST00000395011; ENSP00000378458; ENSG00000172731 [Q8TCA0-2]
GeneIDi55222
KEGGihsa:55222
UCSCiuc001jqx.3 human [Q8TCA0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLRC20_HUMAN
AccessioniPrimary (citable) accession number: Q8TCA0
Secondary accession number(s): Q5T6D4
, Q5T6D6, Q9NVA6, Q9NVG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: June 1, 2002
Last modified: June 20, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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