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Protein

Leucine-rich repeat-containing protein 20

Gene

LRRC20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 20
Gene namesi
Name:LRRC20
ORF Names:UNQ2429/PRO4989
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000172731.13.
HGNCiHGNC:23421. LRRC20.

Pathology & Biotechi

Organism-specific databases

DisGeNETi55222.
OpenTargetsiENSG00000172731.
PharmGKBiPA134935389.

Polymorphism and mutation databases

DMDMi74762612.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000844751 – 184Leucine-rich repeat-containing protein 20Add BLAST184

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei175PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TCA0.
MaxQBiQ8TCA0.
PaxDbiQ8TCA0.
PeptideAtlasiQ8TCA0.
PRIDEiQ8TCA0.

PTM databases

iPTMnetiQ8TCA0.
PhosphoSitePlusiQ8TCA0.

Expressioni

Gene expression databases

BgeeiENSG00000172731.
CleanExiHS_LRRC20.
ExpressionAtlasiQ8TCA0. baseline and differential.
GenevisibleiQ8TCA0. HS.

Organism-specific databases

HPAiHPA039630.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120517. 6 interactors.
IntActiQ8TCA0. 2 interactors.
STRINGi9606.ENSP00000348043.

Structurei

3D structure databases

ProteinModelPortaliQ8TCA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati51 – 72LRR 1Add BLAST22
Repeati75 – 96LRR 2Add BLAST22
Repeati98 – 120LRR 3Add BLAST23
Repeati121 – 141LRR 4Add BLAST21
Repeati145 – 167LRR 5Add BLAST23

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG4579. Eukaryota.
ENOG4111NSQ. LUCA.
GeneTreeiENSGT00730000111199.
HOGENOMiHOG000294062.
HOVERGENiHBG058383.
InParanoidiQ8TCA0.
OMAiNVSDQIH.
OrthoDBiEOG091G0NYY.
PhylomeDBiQ8TCA0.
TreeFamiTF319816.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiView protein in InterPro
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR032675. LRR_dom_sf.
PfamiView protein in Pfam
PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
SMARTiView protein in SMART
SM00369. LRR_TYP. 3 hits.
SUPFAMiSSF52058. SSF52058. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TCA0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLKKMGEAVA RVARKVNETV ESGSDTLDLA ECKLVSFPIG IYKVLRNVSG
60 70 80 90 100
QIHLITLANN ELKSLTSKFM TTFSQLRELH LEGNFLHRLP SEVSALQHLK
110 120 130 140 150
AIDLSRNQFQ DFPEQLTALP ALETINLEEN EIVDVPVEKL AAMPALRSIN
160 170 180
LRFNPLNAEV RVIAPPLIKF DMLMSPEGAR APLP
Length:184
Mass (Da):20,509
Last modified:June 1, 2002 - v1
Checksum:i1E0443D40FE672EC
GO
Isoform 2 (identifier: Q8TCA0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-77: Missing.

Show »
Length:134
Mass (Da):14,887
Checksum:i16A5E552F6343379
GO
Isoform 3 (identifier: Q8TCA0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-133: Missing.

Show »
Length:128
Mass (Da):14,105
Checksum:iDE63D1111E714C36
GO

Sequence cautioni

The sequence BAA91849 differs from that shown. Reason: Erroneous termination at position 185. Translated as stop.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01593328 – 77Missing in isoform 2. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_01593478 – 133Missing in isoform 3. 1 PublicationAdd BLAST56

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358318 mRNA. Translation: AAQ88684.1.
AK001613 mRNA. Translation: BAA91789.1.
AK001706 mRNA. Translation: BAA91849.1. Sequence problems.
AK094734 mRNA. Translation: BAC04409.1.
AL355138, AC022532 Genomic DNA. Translation: CAI12600.1.
AL355138, AC022532 Genomic DNA. Translation: CAI12601.1.
AL355138, AC022532 Genomic DNA. Translation: CAI12602.1.
AL355138, AC022532 Genomic DNA. Translation: CAI12603.1.
BC024001 mRNA. Translation: AAH24001.1.
CCDSiCCDS7300.1. [Q8TCA0-3]
CCDS7301.1. [Q8TCA0-2]
CCDS7302.1. [Q8TCA0-1]
RefSeqiNP_001265140.1. NM_001278211.1. [Q8TCA0-1]
NP_001265141.1. NM_001278212.1. [Q8TCA0-1]
NP_001265142.1. NM_001278213.1. [Q8TCA0-2]
NP_001265143.1. NM_001278214.1.
NP_060675.1. NM_018205.3. [Q8TCA0-3]
NP_060709.2. NM_018239.3. [Q8TCA0-2]
NP_997002.1. NM_207119.2. [Q8TCA0-1]
XP_016871863.1. XM_017016374.1. [Q8TCA0-1]
XP_016871864.1. XM_017016375.1. [Q8TCA0-1]
UniGeneiHs.7778.

Genome annotation databases

EnsembliENST00000355790; ENSP00000348043; ENSG00000172731. [Q8TCA0-1]
ENST00000357631; ENSP00000350255; ENSG00000172731. [Q8TCA0-3]
ENST00000358141; ENSP00000350860; ENSG00000172731. [Q8TCA0-2]
ENST00000373224; ENSP00000362321; ENSG00000172731. [Q8TCA0-1]
ENST00000395011; ENSP00000378458; ENSG00000172731. [Q8TCA0-2]
GeneIDi55222.
KEGGihsa:55222.
UCSCiuc001jqx.3. human. [Q8TCA0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLRC20_HUMAN
AccessioniPrimary (citable) accession number: Q8TCA0
Secondary accession number(s): Q5T6D4
, Q5T6D6, Q9NVA6, Q9NVG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: June 1, 2002
Last modified: November 22, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM