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Protein

Fibronectin type III domain-containing protein 8

Gene

FNDC8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Fibronectin type III domain-containing protein 8
Gene namesi
Name:FNDC8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000073598.5.
HGNCiHGNC:25286. FNDC8.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000073598.
PharmGKBiPA142671757.

Polymorphism and mutation databases

BioMutaiFNDC8.
DMDMi145558918.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002845301 – 324Fibronectin type III domain-containing protein 8Add BLAST324

Proteomic databases

PaxDbiQ8TC99.
PeptideAtlasiQ8TC99.
PRIDEiQ8TC99.

PTM databases

iPTMnetiQ8TC99.
PhosphoSitePlusiQ8TC99.

Expressioni

Gene expression databases

BgeeiENSG00000073598.
CleanExiHS_FNDC8.
GenevisibleiQ8TC99. HS.

Organism-specific databases

HPAiHPA026521.

Interactioni

Protein-protein interaction databases

IntActiQ8TC99. 3 interactors.
STRINGi9606.ENSP00000158009.

Structurei

3D structure databases

ProteinModelPortaliQ8TC99.
SMRiQ8TC99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini179 – 280Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST102

Phylogenomic databases

eggNOGiENOG410IF7Q. Eukaryota.
ENOG41115T3. LUCA.
GeneTreeiENSGT00390000006458.
HOGENOMiHOG000060110.
HOVERGENiHBG096624.
InParanoidiQ8TC99.
OMAiAVISWTY.
OrthoDBiEOG091G0D7C.
PhylomeDBiQ8TC99.
TreeFamiTF338149.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
PfamiView protein in Pfam
PF00041. fn3. 1 hit.
SMARTiView protein in SMART
SM00060. FN3. 1 hit.
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiView protein in PROSITE
PS50853. FN3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TC99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEALHQVG DGEEAVLKKE NFNMMNALDQ LPKPFSNPKS MNRTVTTKGL
60 70 80 90 100
PLASKGNLVN FLEDDTINLL KPLPVEDSDC SSDETSISAF SSTLLNPIKL
110 120 130 140 150
AVTQPNSSFF AGMLEGELNK LSFSPMAKNA ENEDLALGPC PCPSKSQMAT
160 170 180 190 200
RGLLDLDNPE LETETSSTHS ESSVVVDLPD TPFIFEHTVN NSTAVISWTY
210 220 230 240 250
ALGKQPVSFY QLLLQEVAKT QENELPEAKN RPWIFNKILG TTVKLMELKP
260 270 280 290 300
NTCYCLSVRA ANTAGVGKWC KPYKFATLAT DFSSFPENYP IQITVRRKEP
310 320
RQKIVSIGPE EMRRLEDLEY LFPC
Length:324
Mass (Da):35,921
Last modified:April 17, 2007 - v2
Checksum:iFB08649C5CADE086
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03177036S → P1 PublicationCorresponds to variant dbSNP:rs1871892Ensembl.1
Natural variantiVAR_050999127A → T. Corresponds to variant dbSNP:rs12952106Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313775 mRNA. Translation: BAG36513.1.
AL133054 mRNA. Translation: CAB61380.1.
BC024002 mRNA. Translation: AAH24002.1.
CCDSiCCDS11290.1.
PIRiT42656.
RefSeqiNP_060029.1. NM_017559.2.
UniGeneiHs.120369.

Genome annotation databases

EnsembliENST00000158009; ENSP00000158009; ENSG00000073598.
GeneIDi54752.
KEGGihsa:54752.
UCSCiuc002hix.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFNDC8_HUMAN
AccessioniPrimary (citable) accession number: Q8TC99
Secondary accession number(s): B2R9G6, Q9UFC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: September 27, 2017
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations