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Protein

Fibronectin type III domain-containing protein 8

Gene

FNDC8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Fibronectin type III domain-containing protein 8
Gene namesi
Name:FNDC8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:25286. FNDC8.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671757.

Polymorphism and mutation databases

BioMutaiFNDC8.
DMDMi145558918.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Fibronectin type III domain-containing protein 8PRO_0000284530Add
BLAST

Proteomic databases

PaxDbiQ8TC99.
PRIDEiQ8TC99.

PTM databases

iPTMnetiQ8TC99.
PhosphoSiteiQ8TC99.

Expressioni

Gene expression databases

BgeeiQ8TC99.
CleanExiHS_FNDC8.
GenevisibleiQ8TC99. HS.

Organism-specific databases

HPAiHPA026521.

Structurei

3D structure databases

ProteinModelPortaliQ8TC99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini179 – 280102Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IF7Q. Eukaryota.
ENOG41115T3. LUCA.
GeneTreeiENSGT00390000006458.
HOGENOMiHOG000060110.
HOVERGENiHBG096624.
InParanoidiQ8TC99.
OMAiQPNSSFF.
OrthoDBiEOG74N5H9.
PhylomeDBiQ8TC99.
TreeFamiTF338149.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TC99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEALHQVG DGEEAVLKKE NFNMMNALDQ LPKPFSNPKS MNRTVTTKGL
60 70 80 90 100
PLASKGNLVN FLEDDTINLL KPLPVEDSDC SSDETSISAF SSTLLNPIKL
110 120 130 140 150
AVTQPNSSFF AGMLEGELNK LSFSPMAKNA ENEDLALGPC PCPSKSQMAT
160 170 180 190 200
RGLLDLDNPE LETETSSTHS ESSVVVDLPD TPFIFEHTVN NSTAVISWTY
210 220 230 240 250
ALGKQPVSFY QLLLQEVAKT QENELPEAKN RPWIFNKILG TTVKLMELKP
260 270 280 290 300
NTCYCLSVRA ANTAGVGKWC KPYKFATLAT DFSSFPENYP IQITVRRKEP
310 320
RQKIVSIGPE EMRRLEDLEY LFPC
Length:324
Mass (Da):35,921
Last modified:April 17, 2007 - v2
Checksum:iFB08649C5CADE086
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti36 – 361S → P.1 Publication
Corresponds to variant rs1871892 [ dbSNP | Ensembl ].
VAR_031770
Natural varianti127 – 1271A → T.
Corresponds to variant rs12952106 [ dbSNP | Ensembl ].
VAR_050999

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313775 mRNA. Translation: BAG36513.1.
AL133054 mRNA. Translation: CAB61380.1.
BC024002 mRNA. Translation: AAH24002.1.
CCDSiCCDS11290.1.
PIRiT42656.
RefSeqiNP_060029.1. NM_017559.2.
UniGeneiHs.120369.

Genome annotation databases

EnsembliENST00000158009; ENSP00000158009; ENSG00000073598.
GeneIDi54752.
KEGGihsa:54752.
UCSCiuc002hix.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313775 mRNA. Translation: BAG36513.1.
AL133054 mRNA. Translation: CAB61380.1.
BC024002 mRNA. Translation: AAH24002.1.
CCDSiCCDS11290.1.
PIRiT42656.
RefSeqiNP_060029.1. NM_017559.2.
UniGeneiHs.120369.

3D structure databases

ProteinModelPortaliQ8TC99.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ8TC99.
PhosphoSiteiQ8TC99.

Polymorphism and mutation databases

BioMutaiFNDC8.
DMDMi145558918.

Proteomic databases

PaxDbiQ8TC99.
PRIDEiQ8TC99.

Protocols and materials databases

DNASUi54752.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000158009; ENSP00000158009; ENSG00000073598.
GeneIDi54752.
KEGGihsa:54752.
UCSCiuc002hix.4. human.

Organism-specific databases

CTDi54752.
GeneCardsiFNDC8.
HGNCiHGNC:25286. FNDC8.
HPAiHPA026521.
neXtProtiNX_Q8TC99.
PharmGKBiPA142671757.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF7Q. Eukaryota.
ENOG41115T3. LUCA.
GeneTreeiENSGT00390000006458.
HOGENOMiHOG000060110.
HOVERGENiHBG096624.
InParanoidiQ8TC99.
OMAiQPNSSFF.
OrthoDBiEOG74N5H9.
PhylomeDBiQ8TC99.
TreeFamiTF338149.

Miscellaneous databases

GenomeRNAii54752.
PROiQ8TC99.

Gene expression databases

BgeeiQ8TC99.
CleanExiHS_FNDC8.
GenevisibleiQ8TC99. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-36.
    Tissue: Testis.

Entry informationi

Entry nameiFNDC8_HUMAN
AccessioniPrimary (citable) accession number: Q8TC99
Secondary accession number(s): B2R9G6, Q9UFC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: June 8, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.