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Q8TC94

- ACTL9_HUMAN

UniProt

Q8TC94 - ACTL9_HUMAN

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Protein

Actin-like protein 9

Gene

ACTL9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ8TC94.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-like protein 9
Gene namesi
Name:ACTL9
Synonyms:ACTL7C
ORF Names:HSD21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:28494. ACTL9.

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165392996.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Actin-like protein 9PRO_0000332297Add
BLAST

Proteomic databases

PaxDbiQ8TC94.
PRIDEiQ8TC94.

PTM databases

PhosphoSiteiQ8TC94.

Expressioni

Gene expression databases

BgeeiQ8TC94.
GenevestigatoriQ8TC94.

Organism-specific databases

HPAiHPA019231.
HPA026693.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000316674.

Structurei

3D structure databases

ProteinModelPortaliQ8TC94.
SMRiQ8TC94. Positions 52-415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiCOG5277.
GeneTreeiENSGT00760000119271.
HOGENOMiHOG000233340.
InParanoidiQ8TC94.
OMAiCKESSHF.
OrthoDBiEOG7VTDMX.
PhylomeDBiQ8TC94.
TreeFamiTF354237.

Family and domain databases

InterProiIPR004000. Actin-related.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TC94-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDASRPKSSE SQSSLEAPRP GPNPSPNVVN KPLQRDFPGM VADRLPPKTG
60 70 80 90 100
VVVIDMGTGT CKVGFAGQAS PTYTVATILG CQPKKPATSG QSGLQTFIGE
110 120 130 140 150
AARVLPELTL VQPLRSGIVV DWDAAELIWR HLLEHDLRVA THDHPLLFSD
160 170 180 190 200
PPFSPATNRE KLVEVAFESL RSPAMYVASQ SVLSVYAHGR VSGLVVDTGH
210 220 230 240 250
GVTYTVPVFQ GYNLLHATER LDLAGNHLTA FLAEMLLQAG LPLGQQDLDL
260 270 280 290 300
VENIKHHYCY VASDFQKEQA RPEQEYKRTL KLPDGRTVTL GKELFQCPEL
310 320 330 340 350
LFNPPEVPGL SPVGLSTMAK QSLRKLSLEM RADLAQNVLL CGGSSLFTGF
360 370 380 390 400
EGRFRAELLR ALPAETHVVV AAQPTRNFSV WIGGSILASL RAFQSCWVLR
410
EQYEEQGPYI VYRKCY
Length:416
Mass (Da):45,627
Last modified:October 5, 2010 - v3
Checksum:i7159E4A663798DCF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti148 – 1481F → S in AAP20052. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371F → S.2 Publications
Corresponds to variant rs2340550 [ dbSNP | Ensembl ].
VAR_043000
Natural varianti42 – 421A → D in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_043001
Natural varianti51 – 511V → A.2 Publications
Corresponds to variant rs10410943 [ dbSNP | Ensembl ].
VAR_043002
Natural varianti227 – 2271H → N.1 Publication
Corresponds to variant rs4804079 [ dbSNP | Ensembl ].
VAR_043003
Natural varianti332 – 3321A → T in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_043004

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY248901 mRNA. Translation: AAP20052.1.
AK292258 mRNA. Translation: BAF84947.1.
AC093230 Genomic DNA. No translation available.
BC024028 mRNA. Translation: AAH24028.1.
BC045752 mRNA. Translation: AAH45752.1.
CCDSiCCDS12207.1.
RefSeqiNP_848620.3. NM_178525.4.
UniGeneiHs.209206.

Genome annotation databases

EnsembliENST00000324436; ENSP00000316674; ENSG00000181786.
ENST00000612068; ENSP00000482603; ENSG00000181786.
GeneIDi284382.
KEGGihsa:284382.
UCSCiuc002mkl.2. human.

Polymorphism databases

DMDMi308153636.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY248901 mRNA. Translation: AAP20052.1 .
AK292258 mRNA. Translation: BAF84947.1 .
AC093230 Genomic DNA. No translation available.
BC024028 mRNA. Translation: AAH24028.1 .
BC045752 mRNA. Translation: AAH45752.1 .
CCDSi CCDS12207.1.
RefSeqi NP_848620.3. NM_178525.4.
UniGenei Hs.209206.

3D structure databases

ProteinModelPortali Q8TC94.
SMRi Q8TC94. Positions 52-415.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000316674.

PTM databases

PhosphoSitei Q8TC94.

Polymorphism databases

DMDMi 308153636.

Proteomic databases

PaxDbi Q8TC94.
PRIDEi Q8TC94.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000324436 ; ENSP00000316674 ; ENSG00000181786 .
ENST00000612068 ; ENSP00000482603 ; ENSG00000181786 .
GeneIDi 284382.
KEGGi hsa:284382.
UCSCi uc002mkl.2. human.

Organism-specific databases

CTDi 284382.
GeneCardsi GC19M008807.
H-InvDB HIX0019093.
HGNCi HGNC:28494. ACTL9.
HPAi HPA019231.
HPA026693.
neXtProti NX_Q8TC94.
PharmGKBi PA165392996.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5277.
GeneTreei ENSGT00760000119271.
HOGENOMi HOG000233340.
InParanoidi Q8TC94.
OMAi CKESSHF.
OrthoDBi EOG7VTDMX.
PhylomeDBi Q8TC94.
TreeFami TF354237.

Enzyme and pathway databases

SignaLinki Q8TC94.

Miscellaneous databases

GenomeRNAii 284382.
NextBioi 94810.
PROi Q8TC94.

Gene expression databases

Bgeei Q8TC94.
Genevestigatori Q8TC94.

Family and domain databases

InterProi IPR004000. Actin-related.
[Graphical view ]
PANTHERi PTHR11937. PTHR11937. 1 hit.
Pfami PF00022. Actin. 1 hit.
[Graphical view ]
PRINTSi PR00190. ACTIN.
SMARTi SM00268. ACTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A new spermatogenesis-related gene."
    Yang C.B., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-37 AND ALA-51.
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-37; ALA-51 AND ASN-227.
    Tissue: Testis.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASP-42 AND THR-332.

Entry informationi

Entry nameiACTL9_HUMAN
AccessioniPrimary (citable) accession number: Q8TC94
Secondary accession number(s): A8K893, Q6X960
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 5, 2010
Last modified: October 29, 2014
This is version 87 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3