Reviewed, UniProtKB/Swiss-Prot Q8TC94 (ACTL9_HUMAN)

Names and origin

Protein names

Recommended name:
    Actin-like protein 9

Gene names

Name:	ACTL9
Synonyms:	ACTL7C
ORF Names:	HSD21

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Cytoplasm › cytoskeleton By similarity.
Sequence similarities	Belongs to the actin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Polymorphism
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 416	416	Actin-like protein 9		PRO_0000332297
Natural variations
	Natural variant	37	1	S → F: dbSNP rs2340550. Ref.2		VAR_043000
	Natural variant	42	1	A → D in a colorectal cancer sample; somatic mutation. Ref.4		VAR_043001
	Natural variant	51	1	V → A: dbSNP rs10410943. Ref.1 Ref.3		VAR_043002
	Natural variant	227	1	H → N: dbSNP rs4804079. Ref.3		VAR_043003
	Natural variant	332	1	A → T in a colorectal cancer sample; somatic mutation. Ref.4		VAR_043004
Experimental info
	Sequence conflict	148	1	F → S in AAP20052. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8TC94-1 [UniParc]. Last modified April 29, 2008. Version 2. Checksum: 70E2E41413C0FDCA	FASTA	416	45,567
	10 20 30 40 50 60 MDASRPKSSE SQSSLEAPRP GPNPSPNVVN KPLQRDSPGM VADRLPPKTG VVVIDMGTGT 70 80 90 100 110 120 CKVGFAGQAS PTYTVATILG CQPKKPATSG QSGLQTFIGE AARVLPELTL VQPLRSGIVV 130 140 150 160 170 180 DWDAAELIWR HLLEHDLRVA THDHPLLFSD PPFSPATNRE KLVEVAFESL RSPAMYVASQ 190 200 210 220 230 240 SVLSVYAHGR VSGLVVDTGH GVTYTVPVFQ GYNLLHATER LDLAGNHLTA FLAEMLLQAG 250 260 270 280 290 300 LPLGQQDLDL VENIKHHYCY VASDFQKEQA RPEQEYKRTL KLPDGRTVTL GKELFQCPEL 310 320 330 340 350 360 LFNPPEVPGL SPVGLSTMAK QSLRKLSLEM RADLAQNVLL CGGSSLFTGF EGRFRAELLR 370 380 390 400 410 ALPAETHVVV AAQPTRNFSV WIGGSILASL RAFQSCWVLR EQYEEQGPYI VYRKCY

References

[1]	"A new spermatogenesis-related gene." Yang C.B., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F. Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-51. Tissue: Testis.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-37. Tissue: Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-51 AND ASN-227. Tissue: Testis.
[4]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASP-42 AND THR-332.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY248901 mRNA. Translation: AAP20052.1. AK292258 mRNA. Translation: BAF84947.1. BC024028 mRNA. Translation: AAH24028.1. BC045752 mRNA. Translation: AAH45752.1.
IPI	IPI00152321.
RefSeq	NP_848620.2.
UniGene	Hs.209206
3D structure databases
HSSP	HSSP built from PDB template 1U2V based on UniProtKB P61157.
ModBase	Search...
Genome annotation databases
Ensembl	ENST00000324436; ENSP00000316674; ENSG00000181786; Homo sapiens. [Genome view]
GeneID	284382.
KEGG	hsa:284382.
UCSC	uc002mkl.1. human.
Organism-specific databases
CTD	284382.
GeneCards	GC19M008668.
HGNC	HGNC:28494. ACTL9.
HPA	HPA019231. HPA026693.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8TC94.
InParanoid	Q8TC94.
Gene expression databases
ArrayExpress	Q8TC94.
Bgee	Q8TC94.
Genevestigator	Q8TC94.
Family and domain databases
InterPro	IPR004000. Actin-like. [Graphical view]
PANTHER	PTHR11937. Actin_like. 1 hit.
Pfam	PF00022. Actin. 1 hit. [Graphical view]
PRINTS	PR00190. ACTIN.
SMART	SM00268. ACTIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	94810.

Entry information

Entry name

ACTL9_HUMAN

Accession

Primary (citable) accession number: Q8TC94
Secondary accession number(s): A8K893, Q6X960

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	April 29, 2008
Last modified:	December 15, 2009
This is version 53 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.