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Protein

Actin-like protein 9

Gene

ACTL9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ8TC94.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-like protein 9
Gene namesi
Name:ACTL9
Synonyms:ACTL7C
ORF Names:HSD21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000181786.4.
HGNCiHGNC:28494. ACTL9.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi284382.
PharmGKBiPA165392996.

Polymorphism and mutation databases

DMDMi308153636.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003322971 – 416Actin-like protein 9Add BLAST416

Proteomic databases

PaxDbiQ8TC94.
PeptideAtlasiQ8TC94.
PRIDEiQ8TC94.

PTM databases

iPTMnetiQ8TC94.
PhosphoSitePlusiQ8TC94.

Expressioni

Gene expression databases

BgeeiENSG00000181786.
GenevisibleiQ8TC94. HS.

Organism-specific databases

HPAiHPA019231.
HPA026693.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000316674.

Structurei

3D structure databases

ProteinModelPortaliQ8TC94.
SMRiQ8TC94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
HOGENOMiHOG000233340.
InParanoidiQ8TC94.
OrthoDBiEOG091G07P4.
PhylomeDBiQ8TC94.
TreeFamiTF354237.

Family and domain databases

InterProiView protein in InterPro
IPR004000. Actin.
IPR030074. ACTL9.
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF194. PTHR11937:SF194. 1 hit.
PfamiView protein in Pfam
PF00022. Actin. 2 hits.
PRINTSiPR00190. ACTIN.
SMARTiView protein in SMART
SM00268. ACTIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TC94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDASRPKSSE SQSSLEAPRP GPNPSPNVVN KPLQRDFPGM VADRLPPKTG
60 70 80 90 100
VVVIDMGTGT CKVGFAGQAS PTYTVATILG CQPKKPATSG QSGLQTFIGE
110 120 130 140 150
AARVLPELTL VQPLRSGIVV DWDAAELIWR HLLEHDLRVA THDHPLLFSD
160 170 180 190 200
PPFSPATNRE KLVEVAFESL RSPAMYVASQ SVLSVYAHGR VSGLVVDTGH
210 220 230 240 250
GVTYTVPVFQ GYNLLHATER LDLAGNHLTA FLAEMLLQAG LPLGQQDLDL
260 270 280 290 300
VENIKHHYCY VASDFQKEQA RPEQEYKRTL KLPDGRTVTL GKELFQCPEL
310 320 330 340 350
LFNPPEVPGL SPVGLSTMAK QSLRKLSLEM RADLAQNVLL CGGSSLFTGF
360 370 380 390 400
EGRFRAELLR ALPAETHVVV AAQPTRNFSV WIGGSILASL RAFQSCWVLR
410
EQYEEQGPYI VYRKCY
Length:416
Mass (Da):45,627
Last modified:October 5, 2010 - v3
Checksum:i7159E4A663798DCF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti148F → S in AAP20052 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04300037F → S2 PublicationsCorresponds to variant dbSNP:rs2340550Ensembl.1
Natural variantiVAR_04300142A → D in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_04300251V → A2 PublicationsCorresponds to variant dbSNP:rs10410943Ensembl.1
Natural variantiVAR_043003227H → N1 PublicationCorresponds to variant dbSNP:rs4804079Ensembl.1
Natural variantiVAR_043004332A → T in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY248901 mRNA. Translation: AAP20052.1.
AK292258 mRNA. Translation: BAF84947.1.
AC093230 Genomic DNA. No translation available.
BC024028 mRNA. Translation: AAH24028.1.
BC045752 mRNA. Translation: AAH45752.1.
CCDSiCCDS12207.1.
RefSeqiNP_848620.3. NM_178525.4.
UniGeneiHs.209206.

Genome annotation databases

EnsembliENST00000324436; ENSP00000316674; ENSG00000181786.
ENST00000612068; ENSP00000482603; ENSG00000181786.
GeneIDi284382.
KEGGihsa:284382.
UCSCiuc032hly.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiACTL9_HUMAN
AccessioniPrimary (citable) accession number: Q8TC94
Secondary accession number(s): A8K893, Q6X960
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 5, 2010
Last modified: October 25, 2017
This is version 104 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families