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Q8TC94

- ACTL9_HUMAN

UniProt

Q8TC94 - ACTL9_HUMAN

Protein

Actin-like protein 9

Gene

ACTL9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 3 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Enzyme and pathway databases

    SignaLinkiQ8TC94.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Actin-like protein 9
    Gene namesi
    Name:ACTL9
    Synonyms:ACTL7C
    ORF Names:HSD21
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:28494. ACTL9.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165392996.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 416416Actin-like protein 9PRO_0000332297Add
    BLAST

    Proteomic databases

    PaxDbiQ8TC94.
    PRIDEiQ8TC94.

    PTM databases

    PhosphoSiteiQ8TC94.

    Expressioni

    Gene expression databases

    BgeeiQ8TC94.
    GenevestigatoriQ8TC94.

    Organism-specific databases

    HPAiHPA019231.
    HPA026693.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000316674.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TC94.
    SMRiQ8TC94. Positions 52-415.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the actin family.Curated

    Phylogenomic databases

    eggNOGiCOG5277.
    HOGENOMiHOG000233340.
    InParanoidiQ8TC94.
    OMAiCKESSHF.
    OrthoDBiEOG7VTDMX.
    PhylomeDBiQ8TC94.
    TreeFamiTF354237.

    Family and domain databases

    InterProiIPR004000. Actin-related.
    [Graphical view]
    PANTHERiPTHR11937. PTHR11937. 1 hit.
    PfamiPF00022. Actin. 1 hit.
    [Graphical view]
    PRINTSiPR00190. ACTIN.
    SMARTiSM00268. ACTIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TC94-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDASRPKSSE SQSSLEAPRP GPNPSPNVVN KPLQRDFPGM VADRLPPKTG    50
    VVVIDMGTGT CKVGFAGQAS PTYTVATILG CQPKKPATSG QSGLQTFIGE 100
    AARVLPELTL VQPLRSGIVV DWDAAELIWR HLLEHDLRVA THDHPLLFSD 150
    PPFSPATNRE KLVEVAFESL RSPAMYVASQ SVLSVYAHGR VSGLVVDTGH 200
    GVTYTVPVFQ GYNLLHATER LDLAGNHLTA FLAEMLLQAG LPLGQQDLDL 250
    VENIKHHYCY VASDFQKEQA RPEQEYKRTL KLPDGRTVTL GKELFQCPEL 300
    LFNPPEVPGL SPVGLSTMAK QSLRKLSLEM RADLAQNVLL CGGSSLFTGF 350
    EGRFRAELLR ALPAETHVVV AAQPTRNFSV WIGGSILASL RAFQSCWVLR 400
    EQYEEQGPYI VYRKCY 416
    Length:416
    Mass (Da):45,627
    Last modified:October 5, 2010 - v3
    Checksum:i7159E4A663798DCF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti148 – 1481F → S in AAP20052. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti37 – 371F → S.2 Publications
    Corresponds to variant rs2340550 [ dbSNP | Ensembl ].
    VAR_043000
    Natural varianti42 – 421A → D in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_043001
    Natural varianti51 – 511V → A.2 Publications
    Corresponds to variant rs10410943 [ dbSNP | Ensembl ].
    VAR_043002
    Natural varianti227 – 2271H → N.1 Publication
    Corresponds to variant rs4804079 [ dbSNP | Ensembl ].
    VAR_043003
    Natural varianti332 – 3321A → T in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_043004

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY248901 mRNA. Translation: AAP20052.1.
    AK292258 mRNA. Translation: BAF84947.1.
    AC093230 Genomic DNA. No translation available.
    BC024028 mRNA. Translation: AAH24028.1.
    BC045752 mRNA. Translation: AAH45752.1.
    CCDSiCCDS12207.1.
    RefSeqiNP_848620.3. NM_178525.4.
    UniGeneiHs.209206.

    Genome annotation databases

    EnsembliENST00000324436; ENSP00000316674; ENSG00000181786.
    GeneIDi284382.
    KEGGihsa:284382.
    UCSCiuc002mkl.2. human.

    Polymorphism databases

    DMDMi308153636.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY248901 mRNA. Translation: AAP20052.1 .
    AK292258 mRNA. Translation: BAF84947.1 .
    AC093230 Genomic DNA. No translation available.
    BC024028 mRNA. Translation: AAH24028.1 .
    BC045752 mRNA. Translation: AAH45752.1 .
    CCDSi CCDS12207.1.
    RefSeqi NP_848620.3. NM_178525.4.
    UniGenei Hs.209206.

    3D structure databases

    ProteinModelPortali Q8TC94.
    SMRi Q8TC94. Positions 52-415.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000316674.

    PTM databases

    PhosphoSitei Q8TC94.

    Polymorphism databases

    DMDMi 308153636.

    Proteomic databases

    PaxDbi Q8TC94.
    PRIDEi Q8TC94.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000324436 ; ENSP00000316674 ; ENSG00000181786 .
    GeneIDi 284382.
    KEGGi hsa:284382.
    UCSCi uc002mkl.2. human.

    Organism-specific databases

    CTDi 284382.
    GeneCardsi GC19M008807.
    H-InvDB HIX0019093.
    HGNCi HGNC:28494. ACTL9.
    HPAi HPA019231.
    HPA026693.
    neXtProti NX_Q8TC94.
    PharmGKBi PA165392996.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5277.
    HOGENOMi HOG000233340.
    InParanoidi Q8TC94.
    OMAi CKESSHF.
    OrthoDBi EOG7VTDMX.
    PhylomeDBi Q8TC94.
    TreeFami TF354237.

    Enzyme and pathway databases

    SignaLinki Q8TC94.

    Miscellaneous databases

    GenomeRNAii 284382.
    NextBioi 94810.
    PROi Q8TC94.

    Gene expression databases

    Bgeei Q8TC94.
    Genevestigatori Q8TC94.

    Family and domain databases

    InterProi IPR004000. Actin-related.
    [Graphical view ]
    PANTHERi PTHR11937. PTHR11937. 1 hit.
    Pfami PF00022. Actin. 1 hit.
    [Graphical view ]
    PRINTSi PR00190. ACTIN.
    SMARTi SM00268. ACTIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A new spermatogenesis-related gene."
      Yang C.B., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F.
      Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-37 AND ALA-51.
      Tissue: Testis.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-37; ALA-51 AND ASN-227.
      Tissue: Testis.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASP-42 AND THR-332.

    Entry informationi

    Entry nameiACTL9_HUMAN
    AccessioniPrimary (citable) accession number: Q8TC94
    Secondary accession number(s): A8K893, Q6X960
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 86 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3