Reviewed,
UniProtKB/Swiss-Prot Q8TC94 (ACTL9_HUMAN)
Last modified
December 15, 2009.
Version 53.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Actin-like protein 9 | ||||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 416 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Subcellular location | Cytoplasm › cytoskeleton By similarity. |
| Sequence similarities | Belongs to the actin family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm Cytoskeleton |
| Coding sequence diversity | Polymorphism |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeletonInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | protein binding Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 416 | 416 | Actin-like protein 9 | PRO_0000332297 | |||||
Natural variations | |||||||||
| Natural variant | 37 | 1 | S → F: dbSNP rs2340550. Ref.2 | VAR_043000 | |||||
| Natural variant | 42 | 1 | A → D in a colorectal cancer sample; somatic mutation. Ref.4 | VAR_043001 | |||||
| Natural variant | 51 | 1 | V → A: dbSNP rs10410943. Ref.1 Ref.3 | VAR_043002 | |||||
| Natural variant | 227 | 1 | H → N: dbSNP rs4804079. Ref.3 | VAR_043003 | |||||
| Natural variant | 332 | 1 | A → T in a colorectal cancer sample; somatic mutation. Ref.4 | VAR_043004 | |||||
Experimental info | |||||||||
| Sequence conflict | 148 | 1 | F → S in AAP20052. Ref.1 | ||||||
Sequences
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References
| [1] | "A new spermatogenesis-related gene." Yang C.B., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F. Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-51. Tissue: Testis. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-37. Tissue: Testis. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-51 AND ASN-227. Tissue: Testis. |
| [4] | "The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E.Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASP-42 AND THR-332. |
Cross-references
Sequence databases | |
|---|---|
| AY248901 mRNA. Translation: AAP20052.1. AK292258 mRNA. Translation: BAF84947.1. BC024028 mRNA. Translation: AAH24028.1. BC045752 mRNA. Translation: AAH45752.1. | |
| IPI | IPI00152321. |
| RefSeq | NP_848620.2. |
| UniGene | Hs.209206 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1U2V based on UniProtKB P61157. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000324436; ENSP00000316674; ENSG00000181786; Homo sapiens. [Genome view] |
| GeneID | 284382. |
| KEGG | hsa:284382. |
| UCSC | uc002mkl.1. human. |
Organism-specific databases | |
| CTD | 284382. |
| GeneCards | GC19M008668. |
| HGNC | HGNC:28494. ACTL9. |
| HPA | HPA019231. HPA026693. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q8TC94. |
| InParanoid | Q8TC94. |
Gene expression databases | |
| ArrayExpress | Q8TC94. |
| Bgee | Q8TC94. |
| Genevestigator | Q8TC94. |
Family and domain databases | |
| InterPro | IPR004000. Actin-like. [Graphical view] |
| PANTHER | PTHR11937. Actin_like. 1 hit. |
| Pfam | PF00022. Actin. 1 hit. [Graphical view] |
| PRINTS | PR00190. ACTIN. |
| SMART | SM00268. ACTIN. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 94810. |
Entry information
| Entry name | ACTL9_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8TC94 Secondary accession number(s): A8K893, Q6X960 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

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