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Protein

Ecto-NOX disulfide-thiol exchanger 1

Gene

ENOX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock.4 Publications

Cofactori

Cu cation1 Publication

Enzyme regulationi

Not inhibited by the antitumor sulfonylurea LY181984, the vabilloid capsaicin, and retinoids.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Biological rhythms, Electron transport, Transport

Keywords - Ligandi

Copper, NAD

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120658-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ecto-NOX disulfide-thiol exchanger 1
Alternative name(s):
Candidate growth-related and time keeping constitutive hydroquinone [NADH] oxidase
Short name:
cCNOX
Cell proliferation-inducing gene 38 protein
Constitutive Ecto-NOX
Short name:
cNOX
Including the following 2 domains:
Hydroquinone [NADH] oxidase (EC:1.-.-.-)
Protein disulfide-thiol oxidoreductase (EC:1.-.-.-)
Gene namesi
Name:ENOX1
ORF Names:PIG38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:25474. ENOX1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi55068.
OpenTargetsiENSG00000120658.
PharmGKBiPA162385069.

Polymorphism and mutation databases

BioMutaiENOX1.
DMDMi74760449.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002959001 – 643Ecto-NOX disulfide-thiol exchanger 1Add BLAST643

Proteomic databases

MaxQBiQ8TC92.
PaxDbiQ8TC92.
PeptideAtlasiQ8TC92.
PRIDEiQ8TC92.

PTM databases

iPTMnetiQ8TC92.
PhosphoSitePlusiQ8TC92.

Expressioni

Tissue specificityi

Expressed in lymphocyte cells, breast and breast cancer (at protein level). Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Found also in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells.

Gene expression databases

BgeeiENSG00000120658.
CleanExiHS_ENOX1.
ExpressionAtlasiQ8TC92. baseline and differential.
GenevisibleiQ8TC92. HS.

Organism-specific databases

HPAiHPA038355.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ENOX2Q16206-23EBI-713221,EBI-10179508
GORASP2Q9H8Y83EBI-713221,EBI-739467
LNX1Q8TBB13EBI-713221,EBI-739832
SDCBPO005603EBI-713221,EBI-727004
TRIM43Q96BQ35EBI-713221,EBI-2129899
ZMYND19Q96E355EBI-713221,EBI-746595

Protein-protein interaction databases

BioGridi120385. 14 interactors.
IntActiQ8TC92. 13 interactors.
MINTiMINT-1407436.
STRINGi9606.ENSP00000261488.

Structurei

3D structure databases

ProteinModelPortaliQ8TC92.
SMRiQ8TC92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini142 – 221RRMPROSITE-ProRule annotationAdd BLAST80

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili307 – 342Sequence analysisAdd BLAST36
Coiled coili425 – 570Sequence analysisAdd BLAST146

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi89 – 139Pro-richAdd BLAST51

Sequence similaritiesi

Belongs to the ENOX family.Curated
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEVY. Eukaryota.
ENOG410XVWG. LUCA.
GeneTreeiENSGT00390000006788.
HOGENOMiHOG000049275.
HOVERGENiHBG051083.
InParanoidiQ8TC92.
OMAiDANEINV.
OrthoDBiEOG091G038C.
PhylomeDBiQ8TC92.
TreeFamiTF323802.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TC92-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVDAGGVENI TQLPQELPQM MAAAADGLGS IAIDTTQLNM SVTDPTAWAT
60 70 80 90 100
AMNNLGMVPV GLPGQQLVSD SICVPGFDPS LNMMTGITPI NPMIPGLGLV
110 120 130 140 150
PPPPPTEVAV VKEIIHCKSC TLFPQNPNLP PPSTRERPPG CKTVFVGGLP
160 170 180 190 200
ENATEEIIQE VFEQCGDITA IRKSKKNFCH IRFAEEFMVD KAIYLSGYRM
210 220 230 240 250
RLGSSTDKKD SGRLHVDFAQ ARDDFYEWEC KQRMRAREER HRRKLEEDRL
260 270 280 290 300
RPPSPPAIMH YSEHEAALLA EKLKDDSKFS EAITVLLSWI ERGEVNRRSA
310 320 330 340 350
NQFYSMVQSA NSHVRRLMNE KATHEQEMEE AKENFKNALT GILTQFEQIV
360 370 380 390 400
AVFNASTRQK AWDHFSKAQR KNIDIWRKHS EELRNAQSEQ LMGIRREEEM
410 420 430 440 450
EMSDDENCDS PTKKMRVDES ALAAQAYALK EENDSLRWQL DAYRNEVELL
460 470 480 490 500
KQEKEQLFRT EENLTKDQQL QFLQQTMQGM QQQLLTIQEE LNNKKSELEQ
510 520 530 540 550
AKEEQSHTQA LLKVLQEQLK GTKELVETNG HSHEDSNEIN VLTVALVNQD
560 570 580 590 600
RENNIEKRSQ GLKSEKEALL IGIISTFLHV HPFGANIEYL WSYMQQLDSK
610 620 630 640
ISANEIEMLL MRLPRMFKQE FTGVGATLEK RWKLCAFEGI KTT
Length:643
Mass (Da):73,348
Last modified:June 1, 2002 - v1
Checksum:i501DC6905F326610
GO
Isoform 2 (identifier: Q8TC92-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-187: Missing.
     421-422: AL → GA
     423-643: Missing.

Note: No experimental confirmation available.
Show »
Length:235
Mass (Da):27,686
Checksum:i9EDDBF6F6FFD7675
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62L → S in AAT08035 (Ref. 2) Curated1
Sequence conflicti279F → S in AAT08035 (Ref. 2) Curated1
Sequence conflicti279F → S in BAA91442 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05220516E → D.1 PublicationCorresponds to variant rs7338624dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0569851 – 187Missing in isoform 2. 1 PublicationAdd BLAST187
Alternative sequenceiVSP_056986421 – 422AL → GA in isoform 2. 1 Publication2
Alternative sequenceiVSP_056987423 – 643Missing in isoform 2. 1 PublicationAdd BLAST221

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF432052 mRNA. Translation: ABO28524.1.
AY513282 mRNA. Translation: AAT08035.1.
AK000956 mRNA. Translation: BAA91442.1.
AK299053 mRNA. Translation: BAH12937.1.
AL136959 Genomic DNA. No translation available.
AL161714 Genomic DNA. No translation available.
AL162713 Genomic DNA. No translation available.
AL445703 Genomic DNA. No translation available.
AL607148, AL138823, AL627430 Genomic DNA. Translation: CAH70584.2.
AL627430, AL138823, AL607148 Genomic DNA. Translation: CAH72199.2.
AL138823, AL607148, AL627430 Genomic DNA. Translation: CAI16283.2.
CH471075 Genomic DNA. Translation: EAX08693.1.
BC024178 mRNA. Translation: AAH24178.1.
CCDSiCCDS9389.1. [Q8TC92-1]
RefSeqiNP_001121087.1. NM_001127615.1. [Q8TC92-1]
NP_001229792.1. NM_001242863.1. [Q8TC92-1]
NP_060463.2. NM_017993.3. [Q8TC92-1]
XP_005266496.1. XM_005266439.3. [Q8TC92-1]
XP_011533428.1. XM_011535126.2. [Q8TC92-1]
XP_011533429.1. XM_011535127.2. [Q8TC92-1]
XP_011533430.1. XM_011535128.2. [Q8TC92-1]
XP_016876126.1. XM_017020637.1. [Q8TC92-1]
XP_016876127.1. XM_017020638.1. [Q8TC92-1]
XP_016876128.1. XM_017020639.1. [Q8TC92-1]
UniGeneiHs.128258.

Genome annotation databases

EnsembliENST00000261488; ENSP00000261488; ENSG00000120658. [Q8TC92-1]
GeneIDi55068.
KEGGihsa:55068.
UCSCiuc001uzc.5. human. [Q8TC92-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF432052 mRNA. Translation: ABO28524.1.
AY513282 mRNA. Translation: AAT08035.1.
AK000956 mRNA. Translation: BAA91442.1.
AK299053 mRNA. Translation: BAH12937.1.
AL136959 Genomic DNA. No translation available.
AL161714 Genomic DNA. No translation available.
AL162713 Genomic DNA. No translation available.
AL445703 Genomic DNA. No translation available.
AL607148, AL138823, AL627430 Genomic DNA. Translation: CAH70584.2.
AL627430, AL138823, AL607148 Genomic DNA. Translation: CAH72199.2.
AL138823, AL607148, AL627430 Genomic DNA. Translation: CAI16283.2.
CH471075 Genomic DNA. Translation: EAX08693.1.
BC024178 mRNA. Translation: AAH24178.1.
CCDSiCCDS9389.1. [Q8TC92-1]
RefSeqiNP_001121087.1. NM_001127615.1. [Q8TC92-1]
NP_001229792.1. NM_001242863.1. [Q8TC92-1]
NP_060463.2. NM_017993.3. [Q8TC92-1]
XP_005266496.1. XM_005266439.3. [Q8TC92-1]
XP_011533428.1. XM_011535126.2. [Q8TC92-1]
XP_011533429.1. XM_011535127.2. [Q8TC92-1]
XP_011533430.1. XM_011535128.2. [Q8TC92-1]
XP_016876126.1. XM_017020637.1. [Q8TC92-1]
XP_016876127.1. XM_017020638.1. [Q8TC92-1]
XP_016876128.1. XM_017020639.1. [Q8TC92-1]
UniGeneiHs.128258.

3D structure databases

ProteinModelPortaliQ8TC92.
SMRiQ8TC92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120385. 14 interactors.
IntActiQ8TC92. 13 interactors.
MINTiMINT-1407436.
STRINGi9606.ENSP00000261488.

PTM databases

iPTMnetiQ8TC92.
PhosphoSitePlusiQ8TC92.

Polymorphism and mutation databases

BioMutaiENOX1.
DMDMi74760449.

Proteomic databases

MaxQBiQ8TC92.
PaxDbiQ8TC92.
PeptideAtlasiQ8TC92.
PRIDEiQ8TC92.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261488; ENSP00000261488; ENSG00000120658. [Q8TC92-1]
GeneIDi55068.
KEGGihsa:55068.
UCSCiuc001uzc.5. human. [Q8TC92-1]

Organism-specific databases

CTDi55068.
DisGeNETi55068.
GeneCardsiENOX1.
H-InvDBHIX0011276.
HGNCiHGNC:25474. ENOX1.
HPAiHPA038355.
MIMi610914. gene.
neXtProtiNX_Q8TC92.
OpenTargetsiENSG00000120658.
PharmGKBiPA162385069.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEVY. Eukaryota.
ENOG410XVWG. LUCA.
GeneTreeiENSGT00390000006788.
HOGENOMiHOG000049275.
HOVERGENiHBG051083.
InParanoidiQ8TC92.
OMAiDANEINV.
OrthoDBiEOG091G038C.
PhylomeDBiQ8TC92.
TreeFamiTF323802.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120658-MONOMER.

Miscellaneous databases

ChiTaRSiENOX1. human.
GenomeRNAii55068.
PROiQ8TC92.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120658.
CleanExiHS_ENOX1.
ExpressionAtlasiQ8TC92. baseline and differential.
GenevisibleiQ8TC92. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiENOX1_HUMAN
AccessioniPrimary (citable) accession number: Q8TC92
Secondary accession number(s): A4GU15
, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q9NWE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.