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Protein

Coiled-coil domain-containing glutamate-rich protein 1

Gene

CCER1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing glutamate-rich protein 1
Gene namesi
Name:CCER1
Synonyms:C12orf12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:28373. CCER1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672294.

Polymorphism and mutation databases

BioMutaiCCER1.
DMDMi74730573.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Coiled-coil domain-containing glutamate-rich protein 1PRO_0000288857Add
BLAST

Proteomic databases

PaxDbiQ8TC90.
PRIDEiQ8TC90.

PTM databases

PhosphoSiteiQ8TC90.

Expressioni

Gene expression databases

BgeeiQ8TC90.
CleanExiHS_C12orf12.
ExpressionAtlasiQ8TC90. baseline and differential.
GenevisibleiQ8TC90. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT31Q153233EBI-746041,EBI-948001
KRT40Q6A1623EBI-746041,EBI-10171697
NOTCH2NLQ7Z3S93EBI-746041,EBI-945833

Protein-protein interaction databases

BioGridi128212. 7 interactions.
IntActiQ8TC90. 6 interactions.
MINTiMINT-1450617.
STRINGi9606.ENSP00000351727.

Structurei

3D structure databases

ProteinModelPortaliQ8TC90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili199 – 22527Sequence analysisAdd
BLAST
Coiled coili274 – 35986Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 2511Poly-GlyAdd
BLAST
Compositional biasi266 – 376111Glu-richAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J28X. Eukaryota.
ENOG4111YIJ. LUCA.
GeneTreeiENSGT00730000111529.
HOGENOMiHOG000111754.
HOVERGENiHBG096611.
InParanoidiQ8TC90.
OMAiKKRWGRR.
PhylomeDBiQ8TC90.

Family and domain databases

InterProiIPR027889. CCER1.
[Graphical view]
PfamiPF15482. CCER1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TC90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQTLDTRED PLNLGGGGGG GCGCGWAHSA SLSSWSSCHR RRPGAPAYNR
60 70 80 90 100
PHRYSPKTEY GPPRKQPKQQ HGPGFWFQPP VCSNWGCWGG PWRPPPPGFW
110 120 130 140 150
KFPCPVQVFR VYGLHPLCFC CCSCWSGSWN PGWVKPPGRK KRWGRRGRGL
160 170 180 190 200
RHHPRHSYPR SPPADVSTLP RPVKLYEWRE PGMRAPPNTT QFIMNQIYED
210 220 230 240 250
MRQQEKVERQ QEALRAQKAT VSGEASPARS SGNDAPPGGS KETWGLQETL
260 270 280 290 300
YGFVQNPSLA FSPNPEENQS LAPLLVEEEE EKKNDDEEEY DQEVCDAKEA
310 320 330 340 350
SEEEEEVEDE EEEVEDEEEE EVEEAEYVEE GEEELEEEEL EEEEEVLEEN
360 370 380 390 400
EQRGEEFHLP LEMPLSIFVE AEEKRENFIS CTFLNPEQII PKVPQESLFM

AQDFNC
Length:406
Mass (Da):46,482
Last modified:June 1, 2002 - v1
Checksum:iFBB9072D7F976FE6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti286 – 2861D → E.
Corresponds to variant rs11105882 [ dbSNP | Ensembl ].
VAR_059617
Natural varianti379 – 3791I → M.1 Publication
Corresponds to variant rs17855513 [ dbSNP | Ensembl ].
VAR_032512

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024183 mRNA. Translation: AAH24183.1.
BC026075 mRNA. Translation: AAH26075.1.
BC027600 mRNA. Translation: AAH27600.1.
BC034491 mRNA. Translation: AAH34491.1.
CCDSiCCDS9036.1.
RefSeqiNP_689851.1. NM_152638.3.
UniGeneiHs.128574.

Genome annotation databases

EnsembliENST00000358859; ENSP00000351727; ENSG00000197651.
GeneIDi196477.
KEGGihsa:196477.
UCSCiuc001tbj.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024183 mRNA. Translation: AAH24183.1.
BC026075 mRNA. Translation: AAH26075.1.
BC027600 mRNA. Translation: AAH27600.1.
BC034491 mRNA. Translation: AAH34491.1.
CCDSiCCDS9036.1.
RefSeqiNP_689851.1. NM_152638.3.
UniGeneiHs.128574.

3D structure databases

ProteinModelPortaliQ8TC90.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128212. 7 interactions.
IntActiQ8TC90. 6 interactions.
MINTiMINT-1450617.
STRINGi9606.ENSP00000351727.

PTM databases

PhosphoSiteiQ8TC90.

Polymorphism and mutation databases

BioMutaiCCER1.
DMDMi74730573.

Proteomic databases

PaxDbiQ8TC90.
PRIDEiQ8TC90.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358859; ENSP00000351727; ENSG00000197651.
GeneIDi196477.
KEGGihsa:196477.
UCSCiuc001tbj.3. human.

Organism-specific databases

CTDi196477.
GeneCardsiCCER1.
HGNCiHGNC:28373. CCER1.
neXtProtiNX_Q8TC90.
PharmGKBiPA142672294.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J28X. Eukaryota.
ENOG4111YIJ. LUCA.
GeneTreeiENSGT00730000111529.
HOGENOMiHOG000111754.
HOVERGENiHBG096611.
InParanoidiQ8TC90.
OMAiKKRWGRR.
PhylomeDBiQ8TC90.

Miscellaneous databases

GenomeRNAii196477.
NextBioi89497.
PROiQ8TC90.

Gene expression databases

BgeeiQ8TC90.
CleanExiHS_C12orf12.
ExpressionAtlasiQ8TC90. baseline and differential.
GenevisibleiQ8TC90. HS.

Family and domain databases

InterProiIPR027889. CCER1.
[Graphical view]
PfamiPF15482. CCER1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-379.
    Tissue: Testis.

Entry informationi

Entry nameiCCER1_HUMAN
AccessioniPrimary (citable) accession number: Q8TC90
Secondary accession number(s): Q8TC47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2002
Last modified: November 11, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.